Abstract
Stereotactic neurosurgery requires a careful planning of cannulae paths to spare eloquent areas of the brain that, if damaged, will result in loss of essential neurological function such as sensory processing, linguistic ability, vision, or motor function. We present an approach based on modelling, simulation, and optimization to set up a computational assistant tool. Thereby, we focus on the modeling of the brain topology, where we construct ellipsoidal approximations of voxel clouds based on processed MRI data. The outcome is integrated in a path-planning problem either via constraints or by penalization terms in the objective function. The surgical planning problem with obstacle avoidance is solved for different types of stereotactic cannulae using numerical simulations. We illustrate our method with a case study using real MRI data.
Dairy industries have a high environmental impact, with very high energy and water consumption and polluting effluents. To increase the sustainability of these industries it is urgent to implement technologies for wastewater treatment allowing water recycling and energy savings. In this study, dairy wastewater was processed by ultrafiltration and nanofiltration or ultrafiltration and reverse osmosis (UF/RO) and retentates from the second membrane separation processes were assessed for bioenergy production. Lactose-fermenting yeasts were tested in direct conversion of the retentates (lactose-rich streams) into bioethanol. Two Kluyveromyces strains efficiently fermented all the lactose, with ethanol yields higher than 90% (>0.47 g/g yield). Under severe oxygen-limiting conditions, the K. marxianus PYCC 3286 strain reached 70 g/L of ethanol, which is compatible with energy-efficient distillation processes. In turn, the RO permeate is suitable for recycling into the cleaning process. The proposed integrated process, using UF/RO membrane technology, could allow water recycling (RO permeate) and bioenergy production (from RO retentate) for a more sustainable dairy industry.
Integrated Process for Bioenergy Production and Water Recycling in the Dairy Industry: Selection of Kluyveromyces Strains for Direct Conversion of Concentrated Lactose-Rich Streams into Bioethanol
