scholarly journals Impact of malaria on haematological parameters of urban, peri-urban and rural patients in the Ashanti region of Ghana: a cross-sectional study

2019 ◽  
Vol 2 ◽  
pp. 27
Author(s):  
Abdul-Hakim Mutala ◽  
Kingsley Badu ◽  
Christian Owusu ◽  
Samuel Kekeli Agordzo ◽  
Austine Tweneboah ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Urban Areas ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Haematological Parameters ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Difference

Background: This study aimed at investigating haematological changes in malaria patients across different demographic settlements. Malaria parasites trigger changes in certain haematological parameters, which may result in a number of clinical manifestations. Differences in demographic settlements, such as rural, peri-urban and urban settlements, may also influence these changes, but this has rarely been studied. Methods: We conducted a hospital-based, cross-sectional study from January to December 2018 in three different settlements. A total of 598 participants were recruited. Giemsa-stained blood smears were examined to detect and quantify malaria parasitaemia, while haematological parameters were measured using a haematology analyser. Results: The rural settlement had the highest malaria prevalence compared to the other study communities (p=0.009). The difference in parasite densities across the three communities was also significant (p=0.0149). When the malaria-infected population was compared to the uninfected, there were differences in red blood cell count (p=0.0170), haemoglobin levels (p=0.0165), mean corpuscular volume (p=0.0139) and platelet counts (p<0.0001). The difference in median white blood cell (p-value <0.0001), neutrophil (p-value <0.0001) and lymphocyte (p-value <0.0269) count were significantly higher in infected patients from the peri-urban area compared to malaria patients from the rural and urban areas. There were also significant differences in platelet (p=0.0002), plateletcrit (p=0.0041), mean platelet volume (p=0.0009) and platelet large cell ratio (p=0.0046) levels between patients from the urban, peri-urban and rural areas. Conclusions: Patients infected with malaria generally had low red blood cell, haemoglobin and platelets in comparison to uninfected patients. There were also significant differences in several haematological parameters between malaria-infected patients from the three demographic settlements. Atypical results from routine haematological assays, especially findings of anaemia and thrombocytopenia, may be indicative of malaria and, in cases where the infection is asymptomatic, may improve diagnosis by prompting a more thorough search for the parasite in the peripheral circulation.

scholarly journals Impact of malaria on haematological parameters of urban, peri-urban and rural residents in the Ashanti region of Ghana: a cross-sectional study

2020 ◽  
Vol 2 ◽  
pp. 27
Author(s):  
Abdul-Hakim Mutala ◽  
Kingsley Badu ◽  
Christian Owusu ◽  
Samuel Kekeli Agordzo ◽  
Austine Tweneboah ◽  
...  
Keyword(s):  
Urban Areas ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Malaria Prevalence ◽  
Haematological Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ashanti Region ◽  
Study Participants ◽  
The Impact

Background: We aimed at investigating the impact of malaria on the haematological parameters of residents from different demographic settlements in the Ashanti Region of Ghana. Malaria parasites trigger changes in certain haematological parameters, which may result in a number of clinical manifestations. Differences in demographic settlements, such as rural, peri-urban and urban settlements may also influence these changes, but this has not been extensively studied in Ghana. Methods: We conducted a hospital-based, cross-sectional study from January to December 2018 in three different settlements. A total of 598 participants were recruited. Blood smears were examined to detect and quantify malaria parasitaemia, while haematological parameters were measured using a haematology analyser. Results: Participants from the rural settlement had the highest malaria prevalence (21.3%) compared to urban (11.8%) and peri-urban areas (13.3%); however, the peri-urban area had the highest median parasite density (568; IQR=190.0-1312.0). Age was significantly associated with the odds of malaria positivity (OR: 0.97; CI:0.96 — 0.99; p=4.96*10-4). When haematological parameters of the malaria-infected study participants were compared to the parameters of uninfected participants, red blood cell count (p=0.017), haemoglobin (p=0.0165), haematocrit (p=0.0015), mean corpuscular volume (p=0.0014), plateletcrit (p<0.0001) and platelet count (p<0.0001) were all significantly lower in the malaria infected group. In addition to age, haemoglobin and plateletcrit levels were also inversely correlated with the odds of testing positive for malaria, suggesting that children who were anaemic and/or thrombocytopaenic were likely to be infected. After fitting the data to a logistic regression model comprising the three variables, the model correctly categorised 78% of uninfected study participants, but only 50% of the malaria-positive participants. Conclusions: Study participants who were positive for malaria were younger and had low haemoglobin and plateletcrit levels compared to uninfected individuals. Further studies are needed to more precisely elucidate the relationship between malaria infection,demographic and haematological parameters.

scholarly journals Impact of malaria on haematological parameters of urban, peri-urban and rural residents in the Ashanti region of Ghana: a cross-sectional study

2020 ◽  
Vol 2 ◽  
pp. 27
Author(s):  
Abdul-Hakim Mutala ◽  
Kingsley Badu ◽  
Christian Owusu ◽  
Samuel Kekeli Agordzo ◽  
Austine Tweneboah ◽  
...  
Keyword(s):  
Urban Areas ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Malaria Prevalence ◽  
Haematological Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ashanti Region ◽  
Study Participants ◽  
The Impact

Background: We aimed at investigating the impact of malaria on the haematological parameters of residents from different demographic settlements in the Ashanti Region of Ghana. Malaria parasites trigger changes in certain haematological parameters, which may result in a number of clinical manifestations. Differences in demographic settlements, such as rural, peri-urban and urban settlements may also influence these changes, but this has not been extensively studied in Ghana. Methods: We conducted a hospital-based, cross-sectional study from January to December 2018 in three different settlements. A total of 598 participants were recruited. Blood smears were examined to detect and quantify malaria parasitaemia, while haematological parameters were measured using a haematology analyser. Results: Participants from the rural settlement had the highest malaria prevalence (21.3%) compared to the urban (11.8%) and peri-urban areas (13.3%); however, the peri-urban area had the highest median parasite density (568; IQR=190.0-1312.0). Age was significantly associated with the odds of malaria positivity (OR: 0.97; CI:0.96 — 0.99). When haematological parameters of the malaria-infected study participants were compared to the parameters of uninfected participants, red blood cell count (p=0.017), haemoglobin (p=0.0165), haematocrit (p=0.0015), mean corpuscular volume (p=0.0014), plateletcrit (p<0.0001) and platelet count (p<0.0001) were all significantly lower in the malaria infected group. In addition to age, haemoglobin and plateletcrit levels were also inversely correlated with the odds of testing positive for malaria, suggesting that children who were anaemic and/or thrombocytopaenic were likely to be infected. After fitting the data to a logistic regression model comprising the three variables, the model correctly categorised 78% of uninfected study participants, but only 50% of the malaria-positive participants. Conclusions: Study participants who were positive for malaria were younger and had low haemoglobin and plateletcrit levels compared to uninfected individuals. Further studies are needed to more precisely elucidate the relationship between malaria infection,demographic and haematological parameters.

scholarly journals Cross-sectional study to compare the biochemical parameters in low normal versus high normal plasma glucose levels in euglycemic individuals

2020 ◽  
Vol 7 (6) ◽  
pp. 997
Author(s):  
Dharmendra Jhavar ◽  
Neha Kirti ◽  
Sumit Kumar Vishwakarma ◽  
Umesh Kumar Chandra ◽  
Vinod Verma
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
General Medicine ◽  
Cross Sectional Study ◽  
Normal Group ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference

Background: Since a long time ago, the experts have realized that determination of cut-off point for diagnosing diabetes will be revised over time with the lower blood glucose level as the more sensitive diagnosis for detecting the occurring complication and biochemical changes.Methods: This cross sectional study was carried out in the department of medicine, M.G.M. Medical College and M.Y. Hospital Indore from July, 2016 to August, 2017 in 200 individuals and patients having euglycemic status attending General Medicine OPD.Results: In the low and high normal group 2 (2.0%) and 8 (8.0%) were having abnormal total cholesterol (TC) level respectively. The mean total cholesterol in the low normal group was 117.16±26.94mg/dl and it was 154.74±28.38mg/dl in the high normal group. The difference was found to be statistically significant (p value 0.000). In the low and high normal group, 4 (4.0%) and 17 (17.0%) were having abnormal triglyceride (TG) levels respectively. The mean TG levels in the low and high normal group were 96.93±22.64mg/dl and 110.55±32.37mg/dl respectively. The difference was found to be statistically significant (p value 0.001). In the low and high normal group, 6 (6.0%) and 14 (14.0%) patient was having abnormal uric acid levels respectively. The mean uric acid levels in the low and high normal group was 4.88±1.10mg/dl and 5.31±1.31mg/dl respectively. The difference was found to be statistically significant (p value 0.013).Conclusions: Higher levels of Cholesterol and Triglycerides were found more commonly in high normal euglycemic group compared to low normal euglycemic group. Mean cholesterol and mean triglyceride levels were higher in high normal euglycemic group.

Hematological alteration among visceral leishmaniasis patients attending in Western Tigrai, Ethiopia, 2018/2019: A cross-sectional study

2020 ◽  
Author(s):  
Gebremedhin Gebremichail ◽  
Brhane Tesfanchal ◽  
Getachew Belay ◽  
Gebreslassie Gebremariam ◽  
Gebreyohans Teklehaymanot ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Blood Cell ◽  
Hematological Parameters ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Red Cell Indices ◽  
Hematological Abnormalities

Abstract Background: Hematological abnormalities are common in visceral leishmaniasis patients, which is one of the main public health problems worldwide. The most common hematological abnormalities are anemia, leucopenia and thrombocytopenia. Therefore, this study aimed to assess the hematological alteration among visceral leishmaniasis patients attending Western Tigrai, Ethiopia, 2019. Method: Hospital based comparative cross sectional study was conducted from November 2018 to March 2019 in Western Tigrai, Ethiopia. A total of 100 Visceral Leishmaniasis patients and 100 control groups were included in this study. Blood was collected and analyzed by mindray BC-5800 hematology analyzer. Data was entered and analyzed using Statistical package for social science version 23. Student independent t-test was used for data analysis. P value <0.05 was considered as statistically significant at 95% confidence level. Result: From the total 100 visceral leishmaniasis patients the following abnormalities were reported: 96(96%) anemia, 95(95%) leucopenia, 92(92%) neutropenia, 73(73%) Lymphopenia, 45(45%) eosinopenia and 97(97%) had thrombocytopenia. Red blood cell, hemoglobin, hematocrit, red cell indices and platelet were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Similarly the total White blood cell, neutrophil, lymphocyte, eosinophil and basophil count were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Conclusion: The major changes in peripheral blood of patient with visceral leishmaniasis are reduced number of red blood cells, reduction in leukocytes and decreased platelet count. Visceral leishmaniasis patients presented with anemia, leucopenia and thrombocytopenia. So this finding indicates that visceral leishmaniasis causes alterations of hematological parameters. Key words: Amastigote, Anemia, Hematological Parameters, Promastigote, Visceral leishmaniasis, Ethiopia .

scholarly journals Epidemiological Pattern of Poisoning in Children under the Age of 15 Admitted to the Referral Teaching Hospitals of Yazd and Taft Cities (2014-2019)

2021 ◽  
Author(s):  
Mahdieh Momayyezi ◽  
Parisa Peigan ◽  
Hossein Fallahzadeh
Keyword(s):  
Urban Areas ◽  
Pearson Correlation ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Epidemiological Pattern ◽  
Poisoning In Children

Introduction: Understanding the epidemiological pattern and causes of poisoning is the first step to prevent and reduce complications and mortality due to poisoning in children. Given that no study has been conducted on this subject in Yazd, this study aimed to determine the epidemiology pattern of poisoning in children admitted to the referral teaching hospitals in Yazd and Taft cities during 2014-2019. Materials and Methods: This descriptive cross-sectional study was conducted on 238 children under the age of 15 who have been admitted to Shahid Sadoughi hospital in Yazd and Shahid Beheshti hospital in Taft city during 2014-2019. The data were analyzed by SPSS version 20.0 using descriptive statistics, Pearson correlation, and Chi-square. In all the statistical analyses, a P-value of less than 0.05 was considered significant. Results: The results showed that the frequency of poisonings was higher in girls (58%), in summer (31.1%), and in urban areas (82.8%). Most cases of poisoning aged less than 15 years (75.1%). The main cause of poisoning in children was drug poisoning (60.5%), followed by cleansing products (10.1%). The most common clinical manifestations included neurological signs (33.6%). During 2014-2019, the frequency of drugs and pesticide poisonings decreased; while poisoning due to drug-opioids and cleansing products increased (P = 0.04). Also, 3 deaths occurred due to poisoning during this period. Conclusion: The higher prevalence of drug and cleansing products poisoning in children under the age of 15 indicates involuntary poisoning in this group. Therefore, proper storage of these substances and more parental care can reduce poisonings in children.

scholarly journals Maternal haemoglobin and neo-natal haemoglobin status: a hospital based study in Ranchi, Jharkhand, India

2018 ◽  
Vol 5 (3) ◽  
pp. 774
Author(s):  
Priyanka Chaturvedi ◽  
Deepak Chaturvedi ◽  
Prita Naz Dubraj ◽  
A. K. Chaudhary
Keyword(s):  
First Trimester ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Pregnant Mother ◽  
Third Trimester ◽  
Cross Sectional ◽  
Cord Clamping ◽  
Iron Requirement ◽  
The Difference

Background: Haemoglobin of foetus increases with advancing gestational age. During pregnancy, fetal demand for iron increases maternal daily iron requirement from first trimester to third trimester. Late cord clamping may result in delivery of extra blood as well as iron to newborn. The cause of worry here is that maternal anaemia is a significant cause of direct and indirect morbidity and mortality both for pregnant mother and her foetus/neonate.Methods: To determine maternal and neonatal haemoglobin status we conducted a cross sectional study comprising 217 pregnant women and their children in Ranchi, Jharkhand, India.Results: Mean neonatal haemoglobin in controls was 18.13±1.14 g/dl whereas that in cases was 17.21±1.38 g/dl and the difference was statistically significant. Among the 97 cases 23 mothers had babies with neonatal haemoglobin below 14g/dl. In controls only 17 out of 120 mothers had babies with neonatal haemoglobin below 14g/dl (p value<0.01).Conclusions: Present study demonstrated that the neonatal haemoglobin is lower in anemic mothers and that the decrease appears to be proportional to the degree of anemia.

scholarly journals Factors associated with red blood cell transfusion among hospitalized patients: a cross-sectional study

2021 ◽  
Vol 22 (12) ◽  
pp. 1060-1064
Author(s):  
Peiwen Zhang ◽  
Dandan Xu ◽  
Xinhan Zhang ◽  
Mengyin Wu ◽  
Xuecheng Yao ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
Red Blood Cell Transfusion ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated
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