scholarly journals Illustrative examples of probable transfer of resistance determinants from food animals to humans: Streptothricins, glycopeptides, and colistin

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1805 ◽  
Author(s):  
Hattie E. Webb ◽  
Frederick J. Angulo ◽  
Sophie A. Granier ◽  
H. Morgan Scott ◽  
Guy H. Loneragan
Keyword(s):  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Animal Production ◽  
World Health ◽  
Health Concern ◽  
Antimicrobial Use ◽  
Global Public Health ◽  
Resistance Determinants ◽  
Food Animal ◽  
Food Animals

Use, overuse, and misuse of antimicrobials contributes to selection and dissemination of bacterial resistance determinants that may be transferred to humans and constitute a global public health concern. Because of the continued emergence and expansion of antimicrobial resistance, combined with the lack of novel antimicrobial agents, efforts are underway to preserve the efficacy of current available life-saving antimicrobials in humans. As a result, uses of medically important antimicrobials in food animal production have generated debate and led to calls to reduce both antimicrobial use and the need for use. This manuscript, commissioned by the World Health Organization (WHO) to help inform the development of the WHO guidelines on the use of medically important antimicrobials in food animals, includes three illustrations of antimicrobial use in food animal production that has contributed to the selection—and subsequent transfer—of resistance determinants from food animals to humans. Herein, antimicrobial use and the epidemiology of bacterial resistance are described for streptothricins, glycopeptides, and colistin. Taken together, these historical and current narratives reinforce the need for actions that will preserve the efficacy of antimicrobials.

scholarly journals Emerging antibiotic resistant enteric bacterial flora among food animals in Abeokuta, Nigeria

2015 ◽  
Vol 42 (2) ◽  
pp. 255-262
Author(s):  
F. O Olufemi ◽  
P. A. Akinduti ◽  
E. O. Omoshaba ◽  
E. O. Okpara
Keyword(s):  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Bacterial Flora ◽  
Enteric Bacteria ◽  
Enteric Pathogens ◽  
Health Concern ◽  
Occurrence Rate ◽  
Diffusion Method ◽  
Resistant Bacteria ◽  
Food Animals

Bacterial resistance to antibiotic in food animals is an emerging public health concern as a result of increasing multi-resistant bacteria found in Abeokuta. Therefore, occurrence rate and resistant profile of the emerging enteric pathogens were determined in food animals in Abeokuta, Nigeria. Fecal and rectal samples of 82 were randomly collected from food animals such as sheep (30), chicken (37) and pigs (15) in three major farms located in Abeokuta, Nigeria. Enteric bacteria isolates obtained were cultured and identified according to standard protocol. Antibiotic susceptibility testing was performed by disc diffusion method and standard micro-tube dilution assay and resistance profile was carried out. Among the food animals surveyed for resistant enteric pathogens, 46% and 36% were chicken and sheep respectively while 18% were pigs. Complete resistance of 100% was shown by all the enteric bacteria obtained to metronidazole, tetracycline and penicillin while highest rate of Proteus mirabilis (33.5%) and Escherichia coli (20.1%) were multi resistant strains. Uncontrolled use of antimicrobial agents in food animals is shown to be associated with increasing emergence of antimicrobial resistance in food-borne pathogens which could enhance treatment failure and increase morbidity or death among the populace.

scholarly journals Global Governance of Anti-microbial Resistance: A Legal and Regulatory Toolkit

2020 ◽  
pp. 401-420
Author(s):  
Calvin W. L. Ho ◽  
Tsung-Ling Lee
Keyword(s):  
Public Health ◽  
System Approach ◽  
Action Plan ◽  
World Health ◽  
Health Concern ◽  
Global Public Health ◽  
Agricultural Industry ◽  
Treatment And Prevention ◽  
Global Action ◽  
Health Organization

Abstract Recognizing that antimicrobial resistance (AMR) poses a serious threat to global public health, the World Health Organization (WHO) has adopted a Global Action Plan (GAP) at the May 2015 World Health Assembly. Underscoring that systematic misuse and overuse of drugs in human medicine and food production is a global public health concern, the GAP-AMR urges concerted efforts across governments and private sectors, including pharmaceutical industry, medical professionals, agricultural industry, among others. The GAP has a threefold aim: (1) to ensure a continuous use of effective and safe medicines for treatment and prevention of infectious diseases; (2) to encourage a responsible use of medicines; and (3) to engage countries to develop their national actions on AMR in keeping with the recommendations. While the GAP is a necessary step to enable multilateral actions, it must be supported by effective governance in order to realize the proposed aims. This chapter has a threefold purpose: (1) To identify regulatory principles embedded in key WHO documents relating to AMR and the GAP-AMR; (2) To consider the legal and regulatory actions or interventions that countries could use to strengthen their regulatory lever for AMR containment; and (3) To highlight the crucial role of the regulatory lever in enabling other levers under a whole-of-system approach. Effective AMR containment requires a clearer understanding of how the regulatory lever could be implemented or enabled within health systems, as well as how it underscores and interacts with other levers within a whole-of-system approach.

scholarly journals An Algerian perspective on non-typhoidal Salmonella infection

2017 ◽  
Vol 11 (08) ◽  
pp. 583-590
Author(s):  
Bilal Djeghout ◽  
Ammar Ayachi ◽  
Bianca Paglietti ◽  
Gemma C. Langridge ◽  
Salvatore Rubino
Keyword(s):  
Antimicrobial Treatment ◽  
Epidemiological Surveillance ◽  
Health Concern ◽  
Surveillance Systems ◽  
Global Public Health ◽  
Major Health ◽  
Salmonella Infections ◽  
Food Animal ◽  
Food Borne ◽  
And Control

Non-typhoidal Salmonella (NTS) represents a leading cause of food-borne disease worldwide. It is a global public health concern: more than 94 million cases and 115,000 deaths are reported every year, with a disproportionate impact in developing countries. The prevalence of multi-drug-resistant (MDR) Salmonella strains is another major health concern which affects antimicrobial treatment, as many studies report that infections caused by MDR strains are more severe than those caused by susceptible strains. In Algeria, NTS represent one of the primary causes of salmonellosis in both humans and food animal production, especially poultry. Epidemiological surveillance systems and monitoring programs for Salmonella infections are essential requirements to provide data useful for the effective detection and control of Salmonella outbreaks. The present review will supply a perspective on NTS infection, pathogenesis and antimicrobial resistance with a focus on the epidemiology of salmonellosis in Algeria.

Plasmid-mediated colistin resistance in animals: current status and future directions

2017 ◽  
Vol 18 (2) ◽  
pp. 136-152 ◽  
Author(s):  
Jian Sun ◽  
Ximin Zeng ◽  
Xing-Ping Li ◽  
Xiao-Ping Liao ◽  
Ya-Hong Liu ◽  
...  
Keyword(s):  
Production Systems ◽  
Multidrug Resistant ◽  
Animal Production ◽  
Health Concern ◽  
Current Status ◽  
Peptide Antibiotic ◽  
Colistin Resistance ◽  
Significant Public Health ◽  
The Usa ◽  
Food Animals

AbstractColistin, a peptide antibiotic belonging to the polymyxin family, is one of the last effective drugs for the treatment of multidrug resistant Gram-negative infections. Recent discovery of a novel mobile colistin resistance gene,mcr-1, from people and food animals has caused a significant public health concern and drawn worldwide attention. Extensive usage of colistin in food animals has been proposed as a major driving force for the emergence and transmission ofmcr-1; thus, there is a worldwide trend to limit colistin usage in animal production. However, despite lack of colistin usage in food animals in the USA,mcr-1-positiveEscherichia coliisolates were still isolated from swine. In this paper, we provided an overview of colistin usage and epidemiology ofmcr-1in food animals, and summarized the current status of mechanistic and evolutionary studies of the plasmid-mediated colistin resistance. Based on published information, we further discussed several non-colistin usage risk factors that may contribute to the persistence, transmission, and emergence of colistin resistance in an animal production system. Filling the knowledge gaps identified in this review is critical for risk assessment and risk management of colistin resistance, which will facilitate proactive and effective strategies to mitigate colistin resistance in future animal production systems.

scholarly journals Avian Scavengers as Bioindicators of Antibiotic Resistance Due to Livestock Farming Intensification

2020 ◽  
Vol 17 (10) ◽  
pp. 3620
Author(s):  
Guillermo Blanco ◽  
Luis M. Bautista
Keyword(s):  
Bacterial Resistance ◽  
Animal Production ◽  
Commercial Application ◽  
Human Consumption ◽  
Antibiotic Residues ◽  
Farming Practices ◽  
Livestock Farming ◽  
Food Animal ◽  
Wintering Areas ◽  
Milvus Milvus

Industrial food animal production uses huge amounts of antibiotics worldwide. Livestock, their excreta used for manure and meat subproducts not intended for human consumption can all play important roles in the transmission of bacterial resistance to wildlife. Vultures and other scavengers can be directly exposed to active antibiotics ingested while feeding on livestock carcasses. This study evaluates whether bacterial resistance in the red kite (Milvus milvus) differs between two wintering areas selected based on patent differences in farming practices—particularly in the industrial production of food animals (primarily swine and poultry) vs. scarce and declining sheep herding. The results support the hypothesis that intensification in food animal production is associated with increased bacterial multidrug resistance in wildlife. Resistance was positively correlated with time elapsed since the beginning of the commercial application of each antibiotic in human and veterinary medicine, with clear differences depending on farming intensification between areas. Monitoring programs are encouraged to use red kites and other avian scavengers as valuable sentinels of contamination by antibiotics and clinically relevant resistant pathogens from livestock operations of variable intensities. Farms authorized for supplementary feeding of threatened scavengers should avoid supplying carcasses with active antibiotic residues to avoid bacterial resistance in scavenger wildlife.

scholarly journals Co-Management of Active Tuberculosis and Diabetes Mellitus Under Supervised DOTS Strategy—A Saudi Perspective

Reports ◽  
2018 ◽  
Vol 1 (3) ◽  
pp. 25
Author(s):  
Sarvath Ali ◽  
Marepalli Rao ◽  
Ahmed Sahly ◽  
Abdulazeez Alfageeh ◽  
Abdulrahman Bakari
Keyword(s):  
Diabetes Mellitus ◽  
Classification Tree ◽  
Healing Process ◽  
World Health ◽  
Health Concern ◽  
Global Public Health ◽  
Tb Treatment ◽  
Short Course ◽  
Directly Observed Treatment ◽  
Health Organization

Tuberculosis (TB) is a global public health concern, specifically in countries which have high prevalence of HIV/AIDS, malnutrition, unhygienic conditions, etc. Some evidence has been presented that diabetes mellitus (DM) is a risk factor for TB. On the other hand, among those who have DM, TB infection enhances glucose intolerance and worsens glycemic control. The combination of TB and DM, due to immuno-compromised status of DM, can delay the healing process of TB. The focus of this paper is the World Health Organization directly observed treatment, short course (DOTS) program implemented in Gazan province, Saudi Arabia, to treat TB. The data included some patients with both TB and DM. The data has been analyzed to assess how effective the DOTS program was in managing TB. It was found that DM was not a significant factor in the outcome of TB treatment. We used the same data and observed that the non-significance of DM is due to heterogeneity of patient population, Saudis and Non-Saudis. The prevalence of DM was very high among Saudis. This is understandable in view of different lifestyles. Non-Saudis are predominantly Yemenis. For Saudis, DM was indeed found to play a role in the treatment outcome of TB, after an application of a classification tree methodology on the data. This is the main focus of the paper.

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