scholarly journals Accurate arterial path length estimation for pulse wave velocity calculation in growing children and adolescents

2021 ◽  
Vol 5 ◽  
pp. 87
Author(s):  
Lee-Roy C. Witbooi ◽  
Ben Page ◽  
Richard D. Pitcher ◽  
Steve Innes
Keyword(s):  
Cardiovascular Disease ◽  
Children And Adolescents ◽  
Path Length ◽  
Pulse Wave ◽  
Recording Site ◽  
Suprasternal Notch ◽  
True Distance ◽  
Surface Anatomy ◽  
Length Estimation ◽  
Path Lengths

Background: Most adult cardiovascular disease begins in childhood. Given the burgeoning obesity pandemic in children worldwide, there is a need for precise and scalable surveillance methods to detect subclinical cardiovascular disease in children and adolescents. Early detection allows early intervention and intensified primary prevention strategies in affected individuals. Carotid-femoral pulse wave velocity (PWV) directly measures arterial wall stiffness, an early feature of atherosclerosis. Calculation of PWV in growing children requires an accurate estimation of the true distance travelled by the aorto-femoral pressure wave, using surface anatomy landmarks. However, a variety of methods are used to estimate this distance, and these have not previously been investigated in growing children and adolescents. We sought to investigate this by comparing true arterial path length measured on computerized tomography (CT) scans, with a variety of estimations based on surface anatomy landmarks. Methods: Arterial path lengths were measured using multi-planar reformation (MPR) imaging software. These measurements were then compared with the surface anatomy measurements obtained using the same MPR imaging software. The fidelity of a variety of arterial path length estimation methods was tested. Results: The surface anatomy distance between the suprasternal notch and the angle of the mandible (PWV recording site in the neck), should be adjusted using the formula y=4.791+(1.0534*x). This value subtracted from the unadjusted distance from the suprasternal notch to the umbilicus, through the mid-inguinal crease to the femoral PWV recording site, provides the simplest reliable approximation of true intraluminal distance travelled. Conclusions: There is high correlation between the surface anatomy distances and the arterial path lengths they represent; however, these are not equal. Most surface anatomy measurements require adjustment using the formulae that we have provided, to accurately estimate the true distance travelled by the pulse wave.

Arterial path length estimation on brachial-ankle pulse wave velocity

2014 ◽  
Vol 32 (4) ◽  
pp. 881-889 ◽  
Author(s):  
Jun Sugawara ◽  
Koichiro Hayashi ◽  
Hirofumi Tanaka
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Path Length ◽  
Pulse Wave ◽  
Length Estimation

Arterial path length estimation for heart-to-brachium pulse wave velocity

2018 ◽  
Vol 41 (6) ◽  
pp. 444-450 ◽  
Author(s):  
Jun Sugawara ◽  
Tsubasa Tomoto ◽  
Hirofumi Tanaka
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Path Length ◽  
Pulse Wave ◽  
Length Estimation

scholarly journals Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Delia Taverner ◽  
Dídac Llop ◽  
Roser Rosales ◽  
Raimon Ferré ◽  
Luis Masana ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Disease Risk ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Epigenetic Biomarkers

AbstractTo validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic microRNAs, which we previously identified and that can facilitate earlier diagnosis of cardiovascular disease in rheumatoid arthritis patients. We identified 10 plasma miRs that were downregulated in male rheumatoid arthritis patients and in patients with acute myocardial infarction compared to controls suggesting that these microRNAs could be epigenetic biomarkers for cardiovascular disease in rheumatoid arthritis patients. Six of those microRNAs were validated in independent plasma samples from 214 rheumatoid arthritis patients and levels of expression were associated with surrogate markers of cardiovascular disease (carotid intima-media thickness, plaque formation, pulse wave velocity and distensibility) and with prior cardiovascular disease. Multivariate analyses adjusted for traditional confounders and treatments showed that decreased expression of microRNA-425-5p in men and decreased expression of microRNA-451 in women were significantly associated with increased (β = 0.072; p = 0.017) and decreased carotid intima-media thickness (β = −0.05; p = 0.013), respectively. MicroRNA-425-5p and microRNA-451 also increased the accuracy to discriminate patients with pathological carotid intima-media thickness by 1.8% (p = 0.036) in men and 3.5% (p = 0.027) in women, respectively. In addition, microRNA-425-5p increased the accuracy to discriminate male patients with prior cardiovascular disease by 3% (p = 0.008). Additionally, decreased expression of microRNA-451 was significantly associated with decreased pulse wave velocity (β = −0.72; p = 0.035) in overall rheumatoid arthritis population. Distensibility showed no significant association with expression levels of the microRNAs studied. We provide evidence of a possible role of microRNA-425-5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.

scholarly journals Pulse wave analysis and prevalent cardiovascular disease in type 1 diabetes

2010 ◽  
Vol 213 (2) ◽  
pp. 469-474 ◽  
Author(s):  
Catherine T. Prince ◽  
Aaron M. Secrest ◽  
Rachel H. Mackey ◽  
Vincent C. Arena ◽  
Lawrence A. Kingsley ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Pulse Wave ◽  
Pulse Wave Analysis ◽  
Wave Analysis

An Algorithm for a Near Optimal NC Path Generation in Staircase (Lase) Traversal of Convex Polygonal Surfaces

1999 ◽  
Vol 122 (1) ◽  
pp. 182-190 ◽  
Author(s):  
S. V. Kamarthi ◽  
S. T. S. Bukkapatnam ◽  
S. Hsieh
Keyword(s):  
Rapid Prototyping ◽  
Path Length ◽  
Tool Path ◽  
Path Generation ◽  
Convex Polygons ◽  
Sweep Angle ◽  
Pocket Milling ◽  
Different Shapes ◽  
Path Lengths ◽  
Better Than

This paper presents an analytical model of the tool path for staircase traversal of convex polygonal surfaces, and an algorithm—referred to as OPTPATH—developed based on the model to find the sweep angle that gives a near optimal tool path length. The OPTPATH algorithm can be used for staircase traversal with or without (i) overlaps between successive sweep passes, and (ii) rapid traversal along edge passes. This flexibility of OPTPATH renders it applicable not only to conventional operations such as face and pocket milling, but also to other processes such as robotic deburring, rapid prototyping, and robotic spray painting. The effective tool path lengths provided by OPTPATH are compared with those given by the following two algorithms: (i) a common industrial heuristic—referred to as the IH algorithm—and (ii) an algorithm proposed by Prabhu et al. (Prabhu, P. V., Gramopadhye, A. K., and Wang, H. P., 1990, Int. J. Prod. Res., 28, No. 1, pp. 101–130) referred to as PGW algorithm. This comparison is conducted using 100 randomly generated convex polygons of different shapes and a set of seven different tool diameters. It is found that OPTPATH performs better than both the IH as well as PGW algorithms. The superiority of OPTPATH over the two algorithms becomes more pronounced for large tool diameters. [S1087-1357(00)71501-2]

scholarly journals Persistent metabolic syndrome and risk of cardiovascular disease in children and adolescents

2018 ◽  
Vol 71 (3) ◽  
pp. 1013-1021 ◽  
Author(s):  
Camilla Ribeiro Lima de Farias ◽  
Carla Campos Muniz Medeiros ◽  
Diogo Rodrigues Souza ◽  
Ivelise Fhrideraid Alves Furtado da Costa ◽  
Mônica Oliveira da Silva Simões ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Demographic Characteristics ◽  
Multiple Logistic Regression ◽  
Overweight Children ◽  
Low Hdl ◽  
Score Method ◽  
Blood Variables ◽  
Age And Sex

ABSTRACT Objective: to verify persistence of metabolic syndrome (MetS) and components in overweight children and adolescents, as well as its relation to socioeconomic and demographic characteristics and to the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score. Method: a two-point longitudinal study: at enrollment and after a 24-month interval, with 133 individuals ages from two to 18 years. The demographic anthropomorphic and blood variables were evaluated. Analysis was carried out by simple and paired association tests, as well as multiple logistic regression. Results: persistent MetS was observed in 38.3% of the sample, associated cardiovascular risk (ACR) in 79.7%, reduction in arterial pressure and do HDL-c. After adjusting for age and sex, excess weight (ExpB: 0.182; CI: 0.059-0.561), low HDL-c (ExpB: 9.247; CI: 1.157-73.930) and high LDL-c (ExpB:1.915; CI: 0.921-3.979) were associated with persistent MetS. Conclusion: persistent MetS was associated with obesity, HDL-c and LDL-c, but not with the PDAY score.

scholarly journals Differences between Tempos of Step Error and Postural Sway in the Stipulated Tempo Step Test for Children and Their Relationships

2021 ◽  
Vol 11 (6) ◽  
pp. 31
Author(s):  
Hiroki Aoki ◽  
Shin-ichi Demura ◽  
Kenji Takahashi ◽  
Hiroshi Hirai
Keyword(s):  
Repeated Measures ◽  
Path Length ◽  
Postural Sway ◽  
Dynamic Balance ◽  
Step Test ◽  
Total Path Length ◽  
Fast Tempo ◽  
Balance Ability ◽  
Path Lengths ◽  
Slow Tempo

Recently, to evaluate dynamic balance ability, a stipulated tempo step test has been developed, and a step error between tempo and contact time of feet has been used as an evaluation variable. The step error, postural sway, and their relationships may differ between the slow tempo (40 bpm) and fast tempo (120 bpm). This study aimed to examine the aforementioned problem with 62 participant children (30 boys and 32 girls). The step error and postural sway variables (X-axis path length, Y-axis path length, total path length, peripheral area, and rectangular area) during stepping while matching both tempos were measured. Means of one minute and three intervals (0–20 sec, 20–40 sec, and 40–60 sec) for each variable were calculated in both tempos. The results of the paired t-test showed that means of all variables were larger in the 40 bpm tempo than in the 120 bpm tempo. In the multiple comparison tests after the results of the two-way repeated measures ANOVA, the means of three intervals in all variables were larger in the 40 bpm tempo than in the 120 bpm tempo; the means of the sway variables, excluding that of the X-axis path length, in the 40 bpm tempo were larger in the 0–20 sec interval than in the 20–40 sec interval or the 40–60 sec interval. Correlations between step errors and those between the step error and sway variables of both tempos were insignificant or under moderation. The correlations between the step error and sway variables in both tempos were insignificant or significant but low, and those among sway variables were high, except between the X- and Y-axis path lengths. The relationship between both axis path lengths differed according to the tempo. In conclusion, in the case of the stipulated tempo step test targeting children, the slow tempo has a greater step error and postural sway than the fast tempo, and the sway in the early step stage is greater in the slow tempo. The relationships between step errors and between the step error and sway variables of both tempos are low; hence, the ability related to the test may differ in both tempos. The relationships among sway variables in both tempos are high, except between the X- and Y-axis path lengths.

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