Maternal postnatal depression and offspring depression at age 24 years in a UK-birth cohort: the mediating role of maternal nurturing behaviours concerning feeding, crying and sleeping

Background: Maternal postnatal depression (PND) is a risk factor for offspring depression in adulthood. However, few longitudinal studies have examined the role of maternal nurturing parenting behaviours in the association between maternal PND and offspring depression in adulthood. Methods: We examined pathways from maternal PND measured using self-reported Edinburgh Postnatal Depression Scale at 8 weeks to offspring ICD-10 depression diagnosed using the Clinical Interview Schedule-Revised computerised assessment at 24 years through maternal-reported nurturing behaviours concerning feeding, sleeping and crying measured from pregnancy to age 3 years 6 months in 5,881 members of the UK-based birth cohort study, the Avon Longitudinal Study of Parents and Children. Results: The fully adjusted model revealed an indirect effect from PND to adult offspring depression through the combination of all parenting factors (probit regression coefficient [B]=0.038, 95% confidence interval [CI] 0.005, 0.071); however, there was no evidence of a direct effect from early maternal PND to offspring depression once the indirect effect via parenting factors was accounted for (B=0.009, 95%CI -0.075, 0.093). Specificity analyses revealed indirect effects through maternal worries about feeding (B=0.019, 95%CI 0.003, 0.035, p=0.010) and maternal perceptions and responses to crying (B=0.018, 95%CI 0.004, 0.032, p=0.012). Conclusions: The adverse impact of maternal PND on offspring depression in early adulthood was explained by maternal nurturing behaviours concerning feeding, crying and sleeping in early childhood. Residual confounding and measurement error likely limit reliable conclusions. If found causal, interventions providing support to reduce worries around maternal nurturing behaviours and treating depression could reduce adverse outcomes in adult offspring of depressed mothers.

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Maternal postnatal depression and offspring depression at age 24 years in a UK-birth cohort: the mediating role of maternal nurturing behaviours concerning feeding, crying and sleeping

10.1101/2020.06.22.20137331 ◽

2020 ◽

Author(s):

Iryna Culpin ◽

Gemma Hammerton ◽

Marc H Bornstein ◽

Jon Heron ◽

Jonathan Evans ◽

...

Keyword(s):

Longitudinal Study ◽

Indirect Effect ◽

Postnatal Depression ◽

Early Adulthood ◽

Depression Scale ◽

Adverse Outcomes ◽

Adult Offspring ◽

Probit Regression ◽

Mediating Role

AbstractImportanceFew longitudinal studies have examined the role of maternal nurturing parenting behaviours concerning feeding, crying and sleeping in the association between maternal postnatal depression (PND) and offspring depression in adulthood.ObjectiveTo examine the association between PND and offspring depression at age 24 years and the mediating role of maternal nurturing behaviours concerning feeding, crying and sleeping.DesignLongitudinal study of mothers and their offspring in the Avon Longitudinal Study of Parents and Children, followed up through age 24 years. Offspring ICD-10 depression diagnosis at age 24 years was established using the Clinical Interview Schedule-Revised. Symptoms of maternal depression were measured using the Edinburgh Postnatal Depression Scale at 8 months postnatally. Maternal nurturing behaviours concerning feeding, crying and sleeping were assessed using self-reported questionnaires administered from birth to age 3 years.ResultsThe sample with complete data on confounders for the mediation analyses was 5,881. In the fully adjusted model, there was evidence of an indirect effect from PND to offspring depression through the combination of all parenting factors (probit regression coefficient [B]=0.038, 95%CI 0.005, 0.071); however, there was no evidence of a direct effect from early maternal PND to adult offspring depression once the indirect effect via parenting factors was accounted for (B=0.009, 95%CI -0.075, 0.093). There was evidence for specific indirect effects through maternal worries about feeding (B=0.019, 95%CI 0.003, 0.035, p=0.010) and maternal perceptions and responses to crying (B=0.018, 95%CI 0.004, 0.032, p=0.012). Analyses in a larger sample using multiple imputation led to similar results.Conclusions and RelevanceThe adverse impact of PND on offspring depression in early adulthood was explained by maternal nurturing behaviours concerning feeding, crying and sleeping in early infancy. Residual confounding and measurement error are likely, limiting causal conclusions. If found to be causal, reducing worries around early maternal nurturing behaviours could be a target for interventions to reduce adverse outcomes in adult offspring of depressed mothers.

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Is underage abortion associated with adverse outcomes in early adulthood? A longitudinal birth cohort study up to 25 years of age

Human Reproduction ◽

10.1093/humrep/dew178 ◽

2016 ◽

Vol 31 (9) ◽

pp. 2142-2149 ◽

Cited By ~ 15

Author(s):

Suvi Leppälahti ◽

Oskari Heikinheimo ◽

Ilkka Kalliala ◽

Päivi Santalahti ◽

Mika Gissler

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Early Adulthood ◽

Adverse Outcomes ◽

Birth Cohort Study

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Validation of the Edinburgh Postnatal Depression Scale (EPDS) in a sample of mothers from the 2004 Pelotas Birth Cohort Study

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2007001100005 ◽

2007 ◽

Vol 23 (11) ◽

pp. 2577-2588 ◽

Cited By ~ 116

Author(s):

Iná S. Santos ◽

Alicia Matijasevich ◽

Beatriz Franck Tavares ◽

Aluísio J. D. Barros ◽

Iara Picinini Botelho ◽

...

Keyword(s):

Cohort Study ◽

Postpartum Depression ◽

Birth Cohort ◽

Health Care Professionals ◽

Postnatal Depression ◽

Edinburgh Postnatal Depression Scale ◽

Depression Scale ◽

Structured Interview ◽

Cutoff Point ◽

Birth Cohort Study

The aim of this study was to evaluate the Edinburgh Postnatal Depression Scale (EPDS) for screening and diagnosis of postpartum depression. Three months after delivery, EPDS was administered to 378 mothers from the 2004 Pelotas Birth Cohort Study, Rio Grande do Sul State, Brazil. Up to 15 days later, mothers were re-interviewed by mental health care professionals using a semi-structured interview based on ICD-10 (gold standard). We calculated the sensitivity and specificity of each cutoff point, and values were plotted as a receiver operator characteristic curve. The best cutoff point for screening postpartum depression was > 10, with 82.6% (75.3-89.9%) sensitivity and 65.4% (59.8-71.1%) specificity. For screening moderate and severe cases, the best cutoff point was > 11, with 83.8% (73.4-91.3%) sensitivity and 74.7% (69.4-79.5%) specificity. For diagnosis, EPDS was valid only for prevalence of postpartum depression in the 20-25% range, with 60% PPV for the > 13 cutoff point (59.5% sensitivity; 88.4% specificity). The specificities and PPVs for all cutoff points were below those reported by other authors. Small numbers and the calculation of PPV in samples with overrepresentation of cases in the majority of studies appear to account for these differences.

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Trajectories of maternal depressive symptoms and offspring’s risk behavior in early adolescence: data from the 2004 Pelotas birth cohort study

BMC Psychiatry ◽

10.1186/s12888-020-03026-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ana Beatriz Bozzini ◽

Jessica Mayumi Maruyama ◽

Tiago N. Munhoz ◽

Aluísio J. D. Barros ◽

Fernando C. Barros ◽

...

Keyword(s):

Cohort Study ◽

Depressive Symptoms ◽

Alcohol Use ◽

Maternal Depression ◽

Risk Behavior ◽

Birth Cohort ◽

Depression Scale ◽

Self Report ◽

Birth Cohort Study ◽

Maternal Depressive Symptoms

Abstract Background This longitudinal study explored the relationship between trajectories of maternal depressive symptoms and offspring’s risk behavior in adolescence contributing to an extremely scarce literature about the impacts of maternal depression trajectories on offspring risk behaviors. Methods We included 3437 11-year-old adolescents from the 2004 Pelotas Birth Cohort Study. Trajectories of maternal depressive symptoms were constructed using Edinburgh Postnatal Depression Scale (EDPS) from age 3 months to 11 years. We identified five trajectories of maternal depressive symptoms: “low” “moderate low”, “increasing”, “decreasing”, and “chronic high”. The following adolescent outcomes were identified via self-report questionnaire and analyzed as binary outcome –yes/no: involvement in fights and alcohol use at age 11. We used logistic regression models to examine the effects of trajectories of maternal depressive symptoms on offspring’s risk behavior adjusting for potential confounding variable. Results Alcohol use and/or abuse as well as involvement in fights during adolescence, were not significantly associated with any specific trajectory of maternal depressive symptoms neither in the crude nor in the adjusted analyses. Conclusion Alcohol use and involvement in fights at age 11 were not associated with any specific trajectory of maternal depression.

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Child and adolescent externalizing behavior and cannabis use disorders in early adulthood: An Australian prospective birth cohort study

Addictive Behaviors ◽

10.1016/j.addbeh.2007.10.004 ◽

2008 ◽

Vol 33 (3) ◽

pp. 422-438 ◽

Cited By ~ 42

Author(s):

Mohammad R. Hayatbakhsh ◽

Tara R. McGee ◽

William Bor ◽

Jake M. Najman ◽

Konrad Jamrozik ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Externalizing Behavior ◽

Early Adulthood ◽

Child And Adolescent ◽

Cannabis Use ◽

Birth Cohort Study ◽

Cannabis Use Disorders ◽

Prospective Birth Cohort ◽

Prospective Birth Cohort Study

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Wheezing and Bronchial Hyper-responsiveness in Early Childhood as Predictors of Newly Diagnosed Asthma in Early Adulthood: A Longitudinal Birth-Cohort Study

PEDIATRICS ◽

10.1542/peds.2009-1870eee ◽

2009 ◽

Vol 124 (Supplement 2) ◽

pp. S140.2-S141

Author(s):

Michael S. Kaplan

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Birth Cohort ◽

Early Adulthood ◽

Birth Cohort Study ◽

Newly Diagnosed ◽

Bronchial Hyper Responsiveness

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The Role of MIR9-2 in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Study

Genes ◽

10.3390/genes10080626 ◽

2019 ◽

Vol 10 (8) ◽

pp. 626

Author(s):

Luciana Tovo-Rodrigues ◽

Gabriela Quinte ◽

Clarice Brum ◽

Gabriele Ghisleni ◽

Clarissa Bastos ◽

...

Keyword(s):

Psychiatric Disorders ◽

Birth Cohort ◽

Well Being ◽

Externalizing Disorders ◽

Population Based ◽

Current Data ◽

Birth Cohort Study ◽

Structured Interviews ◽

Protein Coding

Background: It has been suggested that microRNAs (miRNAs; short non-protein-coding RNA molecules that mediate post-transcriptional regulation), including mir-9 and mir-34 families, are important for brain development. Current data suggest that mir-9 and mir-34 may have shared effects across psychiatric disorders. This study aims to explore the role of genetic polymorphisms in the MIR9-2 (rs4916723) and MIR34B/C (rs4938723) genes on the susceptibility of psychiatric disorders in children from the 2004 Pelotas Birth Cohort. Methods: Psychiatric disorders were assessed in 3585 individuals using Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria through the application of standard semi-structured interviews (using the Development and Well-Being Assessment, DAWBA) at the six-years-of-age follow-up. The outcome was defined as the presence of any mental disorder. We also considered two broad groups of internalizing and externalizing disorders to further investigate the role of these variants in mental health. Results: We observed an association between rs4916723 (MIR9-2) and the presence of any psychiatric disorder (odds ratios (OR) = 0.820; 95% CI = 0.7130–0.944; p = 0.006) and a suggestive effect on internalizing disorders (OR = 0.830; 95% CI = 0.698–0.987; p = 0.035). rs4938723 (MIR34B/C) was not associated with any evaluated outcome. Conclusion: The study suggests that MIR9-2 may have an important role on a broad susceptibility for psychiatric disorders and may be important mainly for internalization problems.

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