scholarly journals Prematurely Condensed Chromosome Rings after Neutron Irradiation of Human Lymphocytes

2011 ◽  
Vol 52 (4) ◽  
pp. 531-535 ◽  
Author(s):  
Ana I. LAMADRID ◽  
Jorge E. GONZÁLEZ ◽  
Omar GARCÍA ◽  
Philippe VOISIN ◽  
Laurence ROY
Keyword(s):  
Neutron Irradiation ◽  
Human Lymphocytes ◽  
Condensed Chromosome

scholarly journals PCC-ring Induction in Human Lymphocytes Exposed to Gamma and Neutron Irradiation

2007 ◽  
Vol 48 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Ana I. LAMADRID ◽  
Omar GARCÍA ◽  
Martine DELBOS ◽  
Philippe VOISIN ◽  
Laurence ROY
Keyword(s):  
Neutron Irradiation ◽  
Human Lymphocytes

scholarly journals The Impact of Dose Rate on DNA Double-Strand Break Formation and Repair in Human Lymphocytes Exposed to Fast Neutron Irradiation

2019 ◽  
Vol 20 (21) ◽  
pp. 5350 ◽  
Author(s):  
Shankari Nair ◽  
Monique Engelbrecht ◽  
Xanthene Miles ◽  
Roya Ndimba ◽  
Randall Fisher ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dose Rate ◽  
Neutron Irradiation ◽  
Low Dose ◽  
Human Lymphocytes ◽  
Strand Break ◽  
Double Strand Break ◽  
Low Dose Rate ◽  
Dna Double Strand Break ◽  
The Impact

The lack of information on how biological systems respond to low-dose and low dose-rate exposures makes it difficult to accurately assess the carcinogenic risks. This is of critical importance to space radiation, which remains a serious concern for long-term manned space exploration. In this study, the γ-H2AX foci assay was used to follow DNA double-strand break (DSB) induction and repair following exposure to neutron irradiation, which is produced as secondary radiation in the space environment. Human lymphocytes were exposed to high dose-rate (HDR: 0.400 Gy/min) and low dose-rate (LDR: 0.015 Gy/min) p(66)/Be(40) neutrons. DNA DSB induction was investigated 30 min post exposure to neutron doses ranging from 0.125 to 2 Gy. Repair kinetics was studied at different time points after a 1 Gy neutron dose. Our results indicated that γ-H2AX foci formation was 40% higher at HDR exposure compared to LDR exposure. The maximum γ-H2AX foci levels decreased gradually to 1.65 ± 0.64 foci/cell (LDR) and 1.29 ± 0.45 (HDR) at 24 h postirradiation, remaining significantly higher than background levels. This illustrates a significant effect of dose rate on neutron-induced DNA damage. While no significant difference was observed in residual DNA damage after 24 h, the DSB repair half-life of LDR exposure was slower than that of HDR exposure. The results give a first indication that the dose rate should be taken into account for cancer risk estimations related to neutrons.

Chromosome Aberrations Induced in Human Lymphocytes by Neutron Irradiation

1976 ◽  
Vol 29 (2) ◽  
pp. 169-182 ◽  
Author(s):  
D.C. LLoyd ◽  
R.J. Purrott ◽  
G.W. Dolphin ◽  
A.A. Edwards
Keyword(s):  
Neutron Irradiation ◽  
Chromosome Aberrations ◽  
Human Lymphocytes

Voids in Irradiated Tungsten and Molybdenum

1969 ◽  
Vol 27 ◽  
pp. 190-191
Author(s):  
Robert C. Rau ◽  
Robert L. Ladd
Keyword(s):  
Melting Point ◽  
Fast Neutron ◽  
Neutron Irradiation ◽  
Elevated Temperatures ◽  
Irradiation Temperature ◽  
The Body ◽  
Face Centered Cubic ◽  
Body Centered Cubic ◽  
Cubic Metals ◽  
Face Centered

Recent studies have shown the presence of voids in several face-centered cubic metals after neutron irradiation at elevated temperatures. These voids were found when the irradiation temperature was above 0.3 Tm where Tm is the absolute melting point, and were ascribed to the agglomeration of lattice vacancies resulting from fast neutron generated displacement cascades. The present paper reports the existence of similar voids in the body-centered cubic metals tungsten and molybdenum.

Production of Sezary-like cells from normal human lymphocytes

1975 ◽  
Vol 111 (1) ◽  
pp. 29-32 ◽  
Author(s):  
J. A. Yeckley
Keyword(s):  
Human Lymphocytes ◽  
Normal Human

CD148 induces tyrosine-phosphorylation and modulates CD3 signalling on human lymphocytes

1997 ◽  
Vol 56 (1-3) ◽  
pp. 3-4
Author(s):  
E Palou
Keyword(s):  
Tyrosine Phosphorylation ◽  
Human Lymphocytes

Complexity of antisperm antibody response by human lymphocytes deposited to SCID mice

1997 ◽  
Vol 56 (1-3) ◽  
pp. 271
Author(s):  
M Kurpisz
Keyword(s):  
Antibody Response ◽  
Human Lymphocytes ◽  
Scid Mice ◽  
Antisperm Antibody
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