scholarly journals Some Critical Aspects of Molecular Interactions Between Drugs and Receptors

2014 ◽  
Vol 2 (4) ◽  
pp. 84-102 ◽  
Author(s):  
María J. R. Yunta
Author(s):  
Dean A. Handley ◽  
Jack T. Alexander ◽  
Shu Chien

In situ preparation of cell cultures for ultrastructural investigations is a convenient method by which fixation, dehydration and embedment are carried out in the culture petri dish. The in situ method offers the advantage of preserving the native orientation of cell-cell interactions, junctional regions and overlapping configurations. In order to section after embedment, the petri dish is usually separated from the polymerized resin by either differential cryo-contraction or solvation in organic fluids. The remaining resin block must be re-embedded before sectioning. Although removal of the petri dish may not disrupt the native cellular geometry, it does sacrifice what is now recognized as an important characteristic of cell growth: cell-substratum molecular interactions. To preserve the topographic cell-substratum relationship, we developed a simple method of tapered rotary beveling to reduce the petri dish thickness to a dimension suitable for direct thin sectioning.


2013 ◽  
Vol 7 (3) ◽  
pp. 319-329
Author(s):  
Yu-lin Lee

This paper aims to explore the appropriation of Deleuzian literary theory in the Chinese context and its potential for mapping a new global poetics. The purpose of this treatment is thus twofold: first, it will redefine the East–West literary relationship, and second, it will seek a new ethics of life, as endorsed by Deleuze's philosophy of immanence. One finds an affinity between literature and life in Deleuze's philosophy: in short, literature appears as the passage of life and an enterprise of health and thus seeks new possibilities of life, which consists in the invention of a new language and a new people. But what kind of health may such a view provide for a non-Western individual, people, literature and culture? This investigation further appeals to the medium of translation. This paper argues that the act of translation functions as a means of deterritorialisation that displays continuing variations of a language, and through translation, Deleuze's clinical and critical aspects of literature promote a transversal poetics that transcends the binary, oppositional conception of East–West and an immanent ethics of life that overcomes the sentiment of ressentiment.


Author(s):  
Mwinyihija M.

Africa’s renaissance is inevitable and rapidly emerging as a reality in tandem with the continent’s continued exploration of its natural resources in a more sustained way than previously done. Currently, the clarion call is to value add, avoid plundering and involve its population through the SME’s to adapt modern methods of entrepreneurship. During the study, critical aspects that are envisaged to trigger the growth and development of Africa, included the entry of major countries of the continent into the global emerging markets such as MINT (Mexico, Indonesia, Nigeria and Turkey) and BRICS (Brazil, Russia, India, China and South Africa). For the leather sector, certain socioeconomic indicators such as the youthful participation in the value chain, ownership status, literacy levels and acquired experiences are all contributing to a vibrant sector. It was observed that these indicators if well aligned with individual member states of African Union Commission and structured than productivity and competitiveness of leather products will be attained. As such, ease of either foreign direct investment, local recapitalization and development of the SME’s could become feasible. Indeed, with the emergence of over 300 million youth at middle level income level is construed to start building on the impact of the continents purchasing power. Therefore, Africa needs to respond by address on development of ICT, develop affordable financial support to provide stimulus packages to SME’s (Small and Medium Enterprises) to transform, improve on inter and intra trade to optimize on unexplored synergies and enhance mobility of persons with in Africa as preamble to Africa’s renaissance.


2020 ◽  
Author(s):  
Kseniya A. Mariewskaya ◽  
Denis Larkin ◽  
Yuri Samoilichenko ◽  
Vladimir Korshun ◽  
Alex Ustinov

Molecular fluorescence is a phenomenon that is usually observed in condensed phase. It is strongly affected by molecular interactions. The study of fluorescence spectra in the gas phase can provide a nearly-ideal model for the evaluation of intrinsic properties of the fluorophores. Unfortunately, most conventional fluorophores are not volatile enough to allow study of their fluorescence in the gas phase. Here we report very bright gas phase fluorescence of simple BODIPY dyes that can be readily observed at atmospheric pressure using conventional fluorescence instrumentation. To our knowledge, this is the first example of visible range gas phase fluorescence at near ambient conditions. Evaporation of the dye in vacuum allowed us to demonstrate organic molecular electroluminescence in gas discharge excited by electric field produced by a Tesla coil.


Author(s):  
Navid Gohardani

Historiography marks a relatively unexplored research domain in architecture. Despite the obscure nature of this subject matter, architectural historiography equally illuminates a hidden pathway to the historical interaction of architecture with art or literature. Critical historiography adds another dimension to this emerging research topic that further encapsulates multiple levels of criticism. In recognition of a growing interest for historiography, it can be argued that the critical aspects of historiography may serve as crucial instruments for an enhanced understanding of architectural historiography. In this article, the realm of architectural historiography is investigated through a multidisciplinary perspective that revisits architectural criticism, critical historiography, modern architecture, phenomenology, and a number of aspects of architectural historiography in the Swedish Million Homes Program.


IPRI Journal ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 1-29
Author(s):  
Muhammad Waseem Qutab
Keyword(s):  

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