scholarly journals Pressure Injury Care Program Effects on Nurse’s Performance and Patients’ Pressure Injury Wound Healing Outcomes

2021 ◽  
Vol 9 (3) ◽  
pp. 76-84
Author(s):  
Samia Gaballah ◽  
Dalia Salah El-Deen
Keyword(s):  
Wound Healing ◽  
Care Program ◽  
Program Effects ◽  
Pressure Injury

scholarly journals Intervenções de enfermagem para pacientes com lesão por pressão

2019 ◽  
Vol 13 ◽  
Author(s):  
Danielle Martins Oliveira ◽  
Marta Miriam Lopes Costa ◽  
William Malagutti
Keyword(s):  
Wound Healing ◽  
Continuing Education ◽  
Nursing Care ◽  
Wounds And Injuries ◽  
Scientific Production ◽  
Nursing Interventions ◽  
Nursing Process ◽  
Skin Change ◽  
Pressure Injury ◽  
Bibliographic Study

Objetivo: analisar a produção científica acerca das intervenções de enfermagem da CIPE® para pacientes com lesão por pressão. Método: trata-se de um estudo bibliográfico, tipo revisão integrativa em artigos publicados entre 2014 a 2018, realizado nas bases da Biblioteca Virtual de Saúde e portal de periódicos CAPES. Analisaram-se os dados de forma descritiva pelos resultados apresentados em figuras. Resultados: selecionaram-se 31 artigos, que evidenciaram diversas intervenções de enfermagem, como a supervisão periódica da pele, mudança de decúbito, uso de coberturas e escalas, ensino do autocuidado, educação continuada da equipe e desenvolvimento de protocolos. Conclusão: espera-se o desenvolvimento de novos estudos envolvendo a temática, considerando a complexidade do cuidar de lesões, evidenciando a necessidade de mais pesquisas com intervenções direcionadas a sistematizar o cuidado, minimizar o sofrimento e alcançar a cicatrização da lesão. Descritores: Enfermagem; Lesão por Pressão; Processo de Enfermagem; Ferimentos e Lesões; Cuidados de Enfermagem; Terminologia Padronizada em Enfermagem.ABSTRACTObjective: to analyze the scientific production about ICNP® nursing interventions for patients with pressure injury. Method: this is a bibliographic study, integrative review type in articles published from 2014 to 2018, conducted in the bases of the Virtual Health Library and CAPES journal portal. Data were analyzed descriptively by the results presented in figures. Results: 31 articles were selected, which showed various nursing interventions, such as periodic supervision of the skin, change of position, use of covers and scales, self-care teaching, continuing education of the team and development of protocols. Conclusion: it is expected the development of new studies involving the theme, considering the complexity of caring for injuries, highlighting the need for further research with interventions aimed at systematizing care, minimizing suffering and achieving wound healing. Descriptors: Nursing; Pressure Injury; Nursing Process; Wounds and Injuries; Nursing Care; Standardized Nursing Terminology.RESUMEN Objetivo: analizar la producción científica sobre las intervenciones de enfermería ICNP® para pacientes con lesión por presión. Método: este es un estudio bibliográfico, tipo revisión integradora en artículos publicados de 2014 a 2018, realizado en las bases de la Biblioteca Virtual en Salud y el portal de la revista CAPES. Los datos fueron analizados descriptivamente por los resultados presentados en las figuras. Resultados: se seleccionaron 31 artículos que mostraban diversas intervenciones de enfermería, tales como supervisión periódica de la piel, cambio de posición, uso de cubiertas y escalas, enseñanza de autocuidado, educación contínua del equipo y desarrollo de protocolos. Conclusión: se espera el desarrollo de nuevos estudios que involucren el tema, considerando la complejidad del cuidado de las lesiones, destacando la necesidad de una mayor investigación con intervenciones destinadas a sistematizar la atención, minimizar el sufrimiento y lograr la curación de la herida. Descriptores: Enfermería; Lesión por Presión; Proceso de Enfermería; Heridas y Lesiones; Atención de Enfermería; Terminología Normalizada de Enfermería.

Olive oil promotes wound healing of mice pressure injuries through NOS-2 and Nrf2

2019 ◽  
Vol 44 (11) ◽  
pp. 1199-1208 ◽  
Author(s):  
Fernanda Seabra Schanuel ◽  
Bianca Oliveira Saguie ◽  
Andréa Monte-Alto-Costa
Keyword(s):  
Wound Healing ◽  
Protein Expression ◽  
Olive Oil ◽  
Ischemia Reperfusion ◽  
Related Factor ◽  
Type I ◽  
Cutaneous Wound Healing ◽  
External Application ◽  
Cutaneous Wound ◽  
Pressure Injury

The pressure injury environment is characterized by overproduction of reactive oxygen species and exacerbated inflammation, which impair the healing of these lesions. Mediterranean-like diet may be a good intervention to improve the healing of pressure injury owing to its anti-inflammatory and antioxidant components. Thus, this study evaluated the hypothesis that olive oil, as a main source of lipid in Mediterranean diet, could improve cutaneous wound healing of pressure injury in mice. Male Swiss mice were randomly divided into standard, olive oil, or soybean oil plus olive oil groups and fat represented 10% of total calories in all groups. Four weeks after the beginning of diet administration, 2 cycles of ischemia–reperfusion (IR) by external application of 2 magnets disks were performed in the dorsal skin to induce pressure injury formation. Fourteen days after the end of the second IR cycle, olive oil-based diet reduced neutrophils cells and cyclooxygenase-2 protein expression and increased nitric oxide synthase-2 and protein and lipid oxidation. Olive oil based-diet also increased nuclear factor erythroid 2-related factor 2 protein expression and collagen type I precursor protein expression. In addition, administration of olive oil-based diet promoted wound closure at 7, 10, and 14 days after the end of the second IR cycle. These findings support the hypothesis that olive oil-based diet improves cutaneous wound healing of pressure injury in mice through the reduction of inflammation and stimulation of redox equilibrium.

scholarly journals Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment

2020 ◽  
Vol 22 (1) ◽  
pp. 64
Author(s):  
Stephen M. Niemiec ◽  
Amanda E. Louiselle ◽  
Kenneth W. Liechty ◽  
Carlos Zgheib
Keyword(s):  
Immune Response ◽  
Wound Healing ◽  
Pressure Ulcer ◽  
Healthcare Costs ◽  
Chronic Wounds ◽  
Impaired Wound Healing ◽  
Biochemical Pathways ◽  
Patient Morbidity ◽  
Pressure Injury

Pressure ulcers are preventable, yet highly prevalent, chronic wounds that have significant patient morbidity and high healthcare costs. Like other chronic wounds, they are characterized by impaired wound healing due to dysregulated immune processes. This review will highlight key biochemical pathways in the pathogenesis of pressure injury and how this signaling leads to impaired wound healing. This review is the first to comprehensively describe the current literature on microRNA (miRNA, miR) regulation of pressure ulcer pathophysiology.

Nutritional therapy and wound healing in pressure injury situations: an integrative review

Nutrire ◽  
2021 ◽  
Vol 46 (2) ◽  
Author(s):  
Guilherme Vasques Segalla ◽  
Sarah Trindade Teixeira ◽  
Marcelo Macedo Rogero
Keyword(s):  
Wound Healing ◽  
Nutritional Therapy ◽  
Integrative Review ◽  
Pressure Injury

scholarly journals Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Zhiyuan Liu ◽  
Shune Xiao ◽  
Kerong Tao ◽  
Hai Li ◽  
Wenhu Jin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Synergistic Effects ◽  
Platelet Rich Plasma ◽  
Adipose Derived Stem Cells ◽  
Collagen Deposition ◽  
Inflammatory Infiltration ◽  
Control Intervention ◽  
Injury Model ◽  
Pressure Injury

Pressure injury (PI) affects quality of life and results in economic and social burdens. Local transplantation of human adipose-derived stem cells (ASCs) is considered an effective treatment. However, ASC suspension alone is vulnerable to the immune system and results in a shortened cell survival. There is increasing evidence of a synergistic effect of platelet-rich plasma (PRP) combined with ASCs on wound healing. This study investigated the effectiveness, synergy, and mechanism of wound healing following local injection of PRP combined with ASCs in a rodent PI model. PRP or ASCs alone were the control intervention. Wound healing, inflammatory infiltration, collagen deposition, angiogenesis, neurogenesis, and cell homing were investigated. PI healing was promoted by the synergistic effects of PRP combined with ASCs. The combination was more effective than ASCs alone for modulating inflammation, increasing collagen deposition, angiogenesis, neurogenesis, and the persistence of the injected ASCs. These data provide a theoretical foundation for the clinical administration of ASCs combined with PRP in PI healing and skin regeneration.

ultrastructural process of intestinal wound healing

1995 ◽  
Vol 53 ◽  
pp. 1024-1025
Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp
Keyword(s):  
Wound Healing ◽  
Epithelial Cells ◽  
Smooth Muscles ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Ileal Mucosa ◽  
Wound Model ◽  
Serosal Surface ◽  
Complex Process ◽  
Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell
Keyword(s):  
Wound Healing ◽  
Liver Disease ◽  
Hepatic Fibrosis ◽  
Cell Activation ◽  
Stellate Cell ◽  
Factor Xa ◽  
Clinical Trial Data ◽  
Chronic Liver ◽  
Healing Response ◽  
Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

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