Oxidative stress and hemorheology in patients myocardial infarction with type 2 diabetes

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0 ◽  
Author(s):  
Гончарова ◽  
E. Goncharova ◽  
Ойноткинова ◽  
O. Oynotkinova ◽  
Корниенко ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Lipid Peroxidation ◽  
Acute Heart Failure ◽  
Blood Cells ◽  
Diabetes Type 2 ◽  
Diabetes Type

This paper highlights the influence of the intensity of the oxidative stress on hemorheology parameters in complicated and uncomplicated acute myocardial infarction in patients with diabetes type 2. The study was performed by analyzing the results of examination and treatment of 66 patients, men aged 65,6 ± 5,8 years old, suffering from coronary heart disease with clinical manifestations of acute myocardial infarction and concomitant diabetes type 2. Depending on the presence of acute heart failure patients were divided into 2 groups. 1st group consisted of 34 patients with myocardial infarction without complications, Group 2 - 32 patients who have myocardial infarction complicated by acute heart failure (II-III class classification T.Killip). Condition pro- and antioxidant systems were evaluated for 3 days by determining in the blood of patients diene conjugates, malonic dialdehyde, α-tocopherol, ceruloplasmin, calculated coefficient of oxidative stress. The rheological properties blood evaluated by the blood coagulation time, the hematocrit, amount the fibrinogen in the blood, and blood plasma viscosity, red blood cells deformability index, the aggregation of red blood cells and thrombocytes. The values obtained were compared with data from 32 healthy donors. It is revealed that the development of congestive heart failure in acute myocardial infarction in patients with diabetes type 2 is accompanied by activation of lipid peroxidation (LPO) by maintaining a high level of primary lipid peroxidation products. Insufficient activity of antioxidant defense can limit oxidative processes, and leads to their further growth. The damaging effect of lipid peroxidation in the cell membranes is reflected in violation of aggregation and blood viscosity indexes.

scholarly journals TCT-377 Impact of New-Onset Acute Heart Failure in Patients with Acute Myocardial infarction Underwent Successful Revascularization

2012 ◽  
Vol 60 (17) ◽  
pp. B108
Author(s):  
Keun-Ho Park ◽  
Myung Ho Jeong ◽  
Youngkeun Ahn ◽  
Jong Hyun Yoo ◽  
Sang Cheol Cho ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Acute Heart Failure ◽  
New Onset

scholarly journals Vitamin E levels in patients with controlled and uncontrolled type 2 diabetes mellitus

2018 ◽  
Vol 5 (3) ◽  
pp. 864 ◽  
Author(s):  
Manouchehr Iranparvar Alamdari ◽  
Shahram Habibzadeh ◽  
Bita Shahbazzadegan ◽  
Mohammad Mazani ◽  
Amir Bigdeli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Antioxidant Vitamin ◽  
Diabetic Patients ◽  
Check List ◽  
Cross Sectional ◽  
Significant Difference

Background: Diabetes type 2 associates with increased oxidative stress and reduced antioxidant. Vitamin E supplementation reduces oxidative stress in diabetic patients. We intended to measure the level of this vitamin in these patients to assess its relationship in control of patients' diabetes by designing present study.Methods: This is a descriptive and cross-sectional study and carried out on 186 patients with diabetes type 2 diagnosis. The levels of HbA1C (measured by HPLC method), TG, cholesterol, HDL, LDL and Cr were measured, and given to that the level of HbA1C lower than 7 (controlled group) and or more than 7 (uncontrolled group), patients were divided in two groups. Were designed a check list involved questions such as age and information of each patient associated with measured vitamin E level were entered into the check list and after that were analyzed data.Results: In the existing study 186 diabetic patients were examined. From within examined patients, 129 (69.3%) were women and the rest were men and average patients age were 53.33±11.2. In this study was observed there was no direct correlation between the level of cholesterol (p=0.284), LDL (p=0.538( and HDL (p=0.362) with controlled DM II in patients while in uncontrolled diabetic the triglyceride levels was more than those with controlled blood sugar significantly (p=0.046(. The average vitamin E level in patients was 1488.6±692.2 nmol/l its lowest level 114.4 nmol/l and the highest level was 6235 nmol/l.Conclusions: The results of this study show that the vitamin E levels no significant difference between control and non-control diabetic patients.

scholarly journals HIGH ADMISSION PLASMA OSMOLALITY VALUE AS IN-HOSPITAL MAJOR ADVERSE CARDIOVASCULAR EVENTS PREDICTOR IN PATIENT WITH ACUTE MYOCARDIAL INFARCTION

2020 ◽  
Vol 7 (11) ◽  
pp. 79-85
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Logistic Regression ◽  
Blood Glucose ◽  
Acute Heart Failure ◽  
Cardiovascular Events ◽  
Plasma Osmolality ◽  
Receiver Operating Curve ◽  
Major Adverse Cardiovascular Events

Background: Elevated blood urea nitrogen (BUN), blood glucose, and alteration sodium levels are common among patients with acute myocardial infarction (AMI). These parameters to be widely investigated to assess the prognosis in AMI patients. However, the combination of these parameters (BUN, blood glucose, and sodium) calculated by a certain formula in the form of plasma osmolality has not been widely studied to assess the prognosis of patients with acute myocardial infarction. This study aims to assess plasma osmolality in predicting hospital major adverse cardiovascular events (MACEs) among AMI patients. Methods: Data were collected from 118 consecutive patients with AMI in Cardiac Centre Haji Adam Malik General Hospital Medan. We measured admission plasma osmolality [1,86 (Na+) + BUN/2,8 + Glucose/18+9]. Then we observed in hospital Major Adverse Cardiovascular Outcomes (MACEs) which consist of cardiovascular mortality, acute heart failure, malignant arrhythmia, and cardiogenic shock. Statistical analysis was performed using mean difference, logistic regression, and receiver operating curve (ROC). Result: Among 118 patients, MACEs were observed in 49 (41.5%) patients with the most common MACEs was acute heart failure (25.4%). Bivariate analysis showed a significant relationship between the plasma osmolality and in hospital MACEs (p < 0.001). The plasma osmolality AUC prediction value was 78.9%. The optimal cut-off value was 279.9 mOsm/kg (sensitivity 81.6%; specificity 75.4%). In multivariate logistic regression analysis, the plasma osmolality was the strongest predictor with an OR value of 10.542 (95% CI 2.694-41.255; p-value <0.001). Conclusions: Among AMI patients, high plasma osmolality value (≥280 mOsm/kg) is a better predictor of in-hospital MACEs than its components separately(BUN, glucose level, sodium).

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