Vitamin E levels in patients with controlled and uncontrolled type 2 diabetes mellitus

Background: Diabetes type 2 associates with increased oxidative stress and reduced antioxidant. Vitamin E supplementation reduces oxidative stress in diabetic patients. We intended to measure the level of this vitamin in these patients to assess its relationship in control of patients' diabetes by designing present study.Methods: This is a descriptive and cross-sectional study and carried out on 186 patients with diabetes type 2 diagnosis. The levels of HbA1C (measured by HPLC method), TG, cholesterol, HDL, LDL and Cr were measured, and given to that the level of HbA1C lower than 7 (controlled group) and or more than 7 (uncontrolled group), patients were divided in two groups. Were designed a check list involved questions such as age and information of each patient associated with measured vitamin E level were entered into the check list and after that were analyzed data.Results: In the existing study 186 diabetic patients were examined. From within examined patients, 129 (69.3%) were women and the rest were men and average patients age were 53.33±11.2. In this study was observed there was no direct correlation between the level of cholesterol (p=0.284), LDL (p=0.538( and HDL (p=0.362) with controlled DM II in patients while in uncontrolled diabetic the triglyceride levels was more than those with controlled blood sugar significantly (p=0.046(. The average vitamin E level in patients was 1488.6±692.2 nmol/l its lowest level 114.4 nmol/l and the highest level was 6235 nmol/l.Conclusions: The results of this study show that the vitamin E levels no significant difference between control and non-control diabetic patients.

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Psychological Effects of Fasting on Patients Suffering from Diabetes Type 2

Iranian journal of diabetes and obesity ◽

10.18502/ijdo.v11i4.2874 ◽

2020 ◽

Author(s):

Narjes Hazar ◽

Somaye Gholami ◽

Shima Shafiei ◽

Mozhgan Hemmati ◽

Masoud Rahmanian

Keyword(s):

General Health ◽

General Health Questionnaire ◽

Diabetes Type 2 ◽

Diabetes Type ◽

Psychological Effects ◽

Diabetic Patients ◽

Health Questionnaire ◽

Significant Difference ◽

Before And After

Objective: We conducted this study to compare the psychological effects between diabetic patients taking fast and non-fasting counterparts to better investigate the effects of fasting on mental health of diabetes sufferers. Materials and Methods: This study was a prospective cohort conducted among diabetic patients. In this study, two types of fasting and non-fasting patients were invited to take part. During One week before and after the Ramadan, all patients were asked to complete 28-scale General Health Questionnaire (GHQ). Results: In this study, 116 patients who were suffering from diabetes completed the study. They were compared with each other in format of three groups (two fasting and one non-fasting). Mean changes of total and subscales' score were negative in nearly all groups but there were no significant difference between groups. In addition, total and subscale A, B and C scores significantly increased (positive change) but subscale D score didn’t change in fasting patients during this month. Conclusion: The results of present study revealed that fasting during the whole month of Ramadan can exacerbate patients' general health in comparison with non-fasting patients. However, because we can't determine whether this finding is attributed to fasting regardless of diabetes or has been resulted from the co-existence of fasting and the disease, it is recommended to design a study to compare diabetic and healthy fasting individuals.

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Are recently arrived migrants at higher risk of developing diabetes in Scania, Sweden?

European Journal of Public Health ◽

10.1093/eurpub/ckaa166.1107 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

S Zdravkovic ◽

M Grahn ◽

M Rämgård ◽

M Annersten Gershater

Keyword(s):

At Risk ◽

Health Care Services ◽

Diabetes Type 2 ◽

Diabetes Type ◽

Diabetes Prevalence ◽

Control Group ◽

P Value ◽

Cross Sectional ◽

Significant Difference

Abstract Background The world is facing increased migration as well as increased diabetes prevalence including earlier disease debut than ever before. Sedentary lifestyle and obesity constitute risk factors for development of diabetes type 2, the most common diabetes type among adults. It is thus important to increase the awareness of diabetes prevalence and of those being at risk for the disease. The aim was to focus on self-reported diabetes and weight in recently arrived migrants (RAM) in comparison with the rest of the population of Scania. Methods A cross-sectional study was used to collect data through random sampling using a self-administrated questionnaire. 10 000 questionnaires in Arabic were sent to adult RAM in Scania born in Syria or Iraq and 10 000 questionnaires to a random sample of the Scania population as a control group. The overall response rate was 32.8 %, 3461 were male and 3105 were female and the overall mean age was 44.7 (range 22 -70). Results 170 RAM and 147 controls reported diabetes, 741 RAM and 585 controls reported a body mass index (BMI) ≥ 30 kg/m2. A significantly higher prevalence of self-reported diabetes was observed among RAM (6.2% compared to 4.9%, p-value = 0.02). In comparison with age, significantly (p-value < 0.05) higher prevalence was present in RAM as compared to the control group in all age categories except the age category 65-80 where the difference was borderline significant (p-value = 0.056). With regard to BMI no significant difference was observed between the RAM and the control group having diabetes, but independently of diabetes the prevalence of BMI 25-30 kg/m2 and BMI ≥ 30 kg/m2 was significantly higher in RAM (p-value < 0.01). Conclusions Self-reported diabetes is more prevalent in RAM as compared to a control group representing the rest of the population in Scania. Considerably large amount of the respondents in both groups are overweight or obese and are therefore to be considered at risk for developing diabetes type 2. Key messages Self-reported diabetes in Scania is more prevalent in RAM from Iraq and Syria than in the rest of the population in Scania. Health care services need to address that a large number of the population in Scania is being overweight or obese, which is even more prominent in RAM from Iraq and Syria.

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Effects of Vitamin E on Fasting and Postprandial Oxidative Stress, Inflammatory Markers, Glucose Status, Insulin Resistance, Blood Pressure and Pulse Rate in Type-2 Diabetic Patients: A Randomized Clinical Trial

Galen Medical Journal ◽

10.31661/gmj.v4i3.333 ◽

2015 ◽

Vol 4 (3) ◽

pp. 67-74

Author(s):

Najmeh Hejazi ◽

Mohammad Hossein Dabbaghmanesh ◽

Zohreh Mazloom ◽

Arash Dashtabi

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Vitamin E ◽

Pulse Rate ◽

Diabetic Patients ◽

Short Term ◽

Type 2 Diabetic Patients ◽

Significant Difference ◽

Type 2 Diabetic

Background: Atherosclerosis is one of the prevalent complications in diabetic patients. Increased free radical levels in diabetes activate stress-sensitive signaling pathway, resulting in this outcome. This study examines the effect of short-term supplementation of vitamin E on different biochemical markers in type 2 diabetic patients to prevent from atherosclerosis. Materials and Methods: In this single-blind placebo controlled trial, 30 type 2 diabetic patients were randomly divided into two groups of study to receive vitamin E (400IU) or identical placebo capsules daily for 6 weeks. Serum level of lipoproteins, glucose, insulin, malondialdehyde (MDA), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs CRP), pulse rate and blood pressure were measured in fasting and postprandial (after a fatty meal) states before and after six weeks of supplementation. Results: There was not any significant difference in fasting and postprandial lipid profile (Triglyceride, HDL-, LDL- and total Cholesterol), glucose, insulin and HOMA-IR after six weeks of intervention between the two groups. However, results of our study showed a significant decrease in fasting and postprandial MDA levels and postprandial pulse rate and a significant increase in fasting IL-6 in vitamin E group compared to the controls after supplementation. There were no significant differences between the groups in other markers. Conclusion: This study suggests that short term supplementation of vitamin E can reduce oxidative stress in fasting and postprandial states in type 2 diabetic patients and may prevent diabetic complications; in addition, increment of IL-6 after supplementation may play a role in attenuating Type 2 diabetes by anti-inflammatory effects.[GMJ. 2015;4(3):67-74]

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The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy

The Open Ophthalmology Journal ◽

10.2174/1874364101711010051 ◽

2017 ◽

Vol 11 (1) ◽

pp. 51-58 ◽

Cited By ~ 10

Author(s):

Irini P. Chatziralli ◽

George Theodossiadis ◽

Prodromos Dimitriadis ◽

Michail Charalambidis ◽

Antonios Agorastos ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Vitamin E ◽

Protective Role ◽

Ophthalmological Examination ◽

Significant Difference ◽

Treatment Naïve ◽

Insulin Dependent ◽

The Impact

Background:Several studies have focused on oxidative stress on diabetes mellitus (DM). Our purpose was to investigate the impact of oxidative stress on progression of diabetic retinopathy (DR) in insulin-dependenttype 2DM patients, measuring serum malondialdehyde (MDA), as well as to examine the effect of vitamin E on DR progression in the above-mentioned patients.Methods:Participants in the study were 282 insulin-dependenttype 2DM patients with DR. All participants underwent a thorough ophthalmological examination, so as to grade DR, along with serum MDA measurement. All participants received 300mg vitamin E daily for 3 months and were examined again. Serum MDA pre- and post-intake of Vitamin E was the main outcome.Results:Serum MDA was positively associated with DR stage, while there was a statistically significant difference pre- and post-intake of vitamin E in all DR stages. In a subgroup analysis of patients with proliferative DR, there was a significant difference at baseline between patients who have received prior laser photocoagulation and the treatment naïve patients, while after intake of vitamin E, no statistically significant difference was noticed.Conclusion:Oxidative stress has been found to play significant role in the pathogenesis and progression of DR, while vitamin E seems to reduce MDA levels and subsequent oxidative stress, suggesting that it might have protective role in DR progression.

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Hypertension and Micro-Vascular Complications Among Type 2 Dm Adult Patients in Mukalla, Yemen

Journal of Clinical Research and Reports ◽

10.31579/2690-1919/056 ◽

2020 ◽

Vol 3 (5) ◽

pp. 01-04

Author(s):

Abdullah Ghouth

Keyword(s):

Care Center ◽

Vascular Complications ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Health Care Center ◽

Age Related ◽

Significant Difference ◽

High Prevalence

The Background and Purpose: to assess the prevalence of hypertension and micro-vascular complications among type 2 diabetic patients registered in primary health care center in Mukalla city at eastern Yemen. Methods: A Cross-sectional study was conducted in a randomly selected eligible patients from the diabetic registry of the AL Noor Charity Center (ACC), Mukalla city in Yemen. Results: Prevalence of hypertension in the T2DM patients were 46.7% (56/120). Retinopathy is the most micro-vascular complications among the adults having T2DM (73/120, 60.8%) while nephropathy is the least prevalence (13/120, 10.8%), prevalence of neuropathy was 49.2% (59/120). a high prevalence of retinopathy in males (66%) than females (55.7%) and a high prevalence of neuropathy in male adults (52.2%) than females (46%).No statistical significant difference were exit related to gender for any studied complications. Similar findings were observed regarding age related variations. Conclusion: A high prevalence of hypertension, retinopathy and neuropathy were reported among T2DM patients in Mukalla. Adopting effective and safe treatment strategies are highly recommended to prevent premature death and complications due to DM.

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Quality of Life in Type 2 Diabetic Patients

Acta Facultatis Medicae Naissensis ◽

10.2478/afmnai-2014-0024 ◽

2014 ◽

Vol 31 (3) ◽

pp. 193-200 ◽

Cited By ~ 7

Author(s):

Ana Spasić ◽

Radmila Veličković Radovanović ◽

Aleksandra Catić Đorđević ◽

Nikola Stefanović ◽

Tatjana Cvetković

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Short Form ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Significant Difference ◽

Type 2 Diabetic

Summary The presence of diabetes mellitus leads to a decrease in life quality in all domains. The aim of our study was to evaluate the quality of life (QOL) in diabetic patients and the factors affecting it in type 2 diabetic mellitus patients. We conducted a cross-sectional study that included 86 patients with type 2 diabetes mellitus, in the territory of the City of Niš. Health-related QOL of patients was measured using the short form survey (SF-36) that produces an 8-scale health profile. The average duration of diabetes was 12.76±8.08 years. The best QOL in all areas was observed in patients diagnosed with diabetes less than 10 years ago p<0.05) and younger than 65 years. Male respondents perceived a better QOL compared to women, especially in the vitality and pain domains. The patients with comorbidity (93.64%) had lower QOL score in all domains. There was no significant difference in the QOL of patients with diabetes compared to the level of education. High QOL represents an ultimate goal and an important outcome of all medical interventions in diabetic patients. Factors related to lower QOL included: older age, female gender, and existence of comorbidities. Uncontrolled diabetic patients had a lower QOL than controlled diabetics.

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Lack of association between diabetic nephropathy and human leukocyte antigen type 2 (HLA II-DQ1) in patients with type 2 diabetes mellitus in west of Iran

Journal of Renal Injury Prevention ◽

10.34172/jrip.2021.34 ◽

2020 ◽

Vol 10 (4) ◽

pp. e34-e34

Author(s):

Mahsa Mohammadi ◽

Mohsen Rajabnia ◽

Mohammad Saad Forghani ◽

Khaled Rahmani ◽

Mohammad Bahadoram

Keyword(s):

Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Human Leukocyte Antigen ◽

Human Leukocyte ◽

Diabetes Type 2 ◽

Diabetes Type ◽

Expression Levels ◽

Leukocyte Antigen ◽

Significant Difference

Introduction: Diabetic nephropathy (diabetic kidney disease) is one of the microvascular complications of diabetes mellitus. The human leukocyte antigen (HLA) is a group of genes that is related to autoimmune diseases, infections and inflammation. Studies regarding the association of type 2diabetes and HLA-II are negligible. Objectives: The aim of this study is to determinate association between diabetic nephropathy and HLA II-DQ1 in diabetes type 2 patients. Patients and Methods: In this study, 120 diabetes type 2 patients were divided into two groups of diabetic nephropathy (case group) and without diabetic nephropathy (control group). Blood samples were taken and DNA was isolated. Asymmetric polymerase chain reaction (PCR) was used to amplify the HLA II-DQ1 exon 2 and exon 3. PCR products were hybridized and labeled with probes on the chip. Determination of HLAII-DQ1 gene typing was conducted by scanning hybrid products and analyzed with PerkinElmer ScanArray software. Results: The results of chi-square test showed no significant difference between expression levels of HLA in the two groups (P<0.05). Conclusion: There was no significant difference between expression levels of HLA in two groups of patients. Various factors such as demographic characteristics, lifestyle, geographic region, and race are the factors influencing the relationship between diabetic nephropathy and DQ1-HLA II. Since this study is conducted in one region and one race and with limited population, it is suggested that future studies should be considered and the association between the mentioned variables with HLA should be considered.

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MEAL INDUCED OXIDATIVE STRESS LEVELS IN CONTROLLED AND POORLY CONTROLLED DIABETES

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i6.17814 ◽

2017 ◽

Vol 10 (6) ◽

pp. 105

Author(s):

Sulekha Sinha ◽

Poornima A Manjrekar ◽

Anupama Hegde ◽

Rukmini Ms

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Thiobarbituric Acid ◽

T Test ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Significant Difference ◽

Stress Levels ◽

Group 2

Objective: The postprandial metabolic derangements are accentuated in type-2 diabetes and are important risk factors for cardiovascular disease since they induce oxidative stress and endothelial dysfunction. Aim of the study was to analyse meal induced oxidative stress levels in controlled and poorly controlled diabetes.Methods: Total 60 type 2 diabetic patients on oral hypoglycemics of duration 5-15 years were divided into two groups based on HbA1c values (£7.5% for controlled /Group-1 and ³7.6% for poorly controlled/ Group-2). They were assayed for serum/plasma glucose, thiobarbituric acid reacting substances (TBARS) and oxidised LDL (ox-LDL) parameters both in fasting and 2 hrs post meal in both the groups. Statistical analysis was done using independent t test between the groups and paired t test within each group.Results: The Postprandial TBARS was found significantly higher in both the groups, whereas no significant difference between the two groups. The ox-LDL levels were found similar at two points of time in both the groups.Conclusion: An exaggerated postprandial oxidative stress levels are associated with diabetes and its complications including endothelial dysfunction.

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Oxidative stress and hemorheology in patients myocardial infarction with type 2 diabetes

Journal of New Medical Technologies eJournal ◽

10.12737/17082 ◽

2015 ◽

Vol 9 (4) ◽

pp. 0-0 ◽

Cited By ~ 1

Author(s):

Гончарова ◽

E. Goncharova ◽

Ойноткинова ◽

O. Oynotkinova ◽

Корниенко ◽

...

Keyword(s):

Oxidative Stress ◽

Myocardial Infarction ◽

Heart Failure ◽

Acute Myocardial Infarction ◽

Lipid Peroxidation ◽

Acute Heart Failure ◽

Blood Cells ◽

Diabetes Type 2 ◽

Diabetes Type

This paper highlights the influence of the intensity of the oxidative stress on hemorheology parameters in complicated and uncomplicated acute myocardial infarction in patients with diabetes type 2. The study was performed by analyzing the results of examination and treatment of 66 patients, men aged 65,6 ± 5,8 years old, suffering from coronary heart disease with clinical manifestations of acute myocardial infarction and concomitant diabetes type 2. Depending on the presence of acute heart failure patients were divided into 2 groups. 1st group consisted of 34 patients with myocardial infarction without complications, Group 2 - 32 patients who have myocardial infarction complicated by acute heart failure (II-III class classification T.Killip). Condition pro- and antioxidant systems were evaluated for 3 days by determining in the blood of patients diene conjugates, malonic dialdehyde, α-tocopherol, ceruloplasmin, calculated coefficient of oxidative stress. The rheological properties blood evaluated by the blood coagulation time, the hematocrit, amount the fibrinogen in the blood, and blood plasma viscosity, red blood cells deformability index, the aggregation of red blood cells and thrombocytes. The values obtained were compared with data from 32 healthy donors. It is revealed that the development of congestive heart failure in acute myocardial infarction in patients with diabetes type 2 is accompanied by activation of lipid peroxidation (LPO) by maintaining a high level of primary lipid peroxidation products. Insufficient activity of antioxidant defense can limit oxidative processes, and leads to their further growth. The damaging effect of lipid peroxidation in the cell membranes is reflected in violation of aggregation and blood viscosity indexes.

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