MORPHOFUNCTIONAL PARAMETERS OF SKIN DERMIS AND ITS CHANGES DURING AGING (REVIEW)

2016 ◽  
Vol 1 (60) ◽  
pp. 111-116
Author(s):  
Корнеева ◽  
Larisa Korneeva ◽  
Малюк ◽  
Ekaterina Maliuk ◽  
Целуйко ◽  
...  
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Aging Process ◽  
Physical Factors ◽  
Cellular Composition ◽  
Intercellular Substance ◽  
Skin Changes ◽  
Factors Influencing ◽  
Age Related ◽  
Different Types

The review reveals modern concepts of morphology and biochemistry of the intercellular substance of connective tissue of the skin dermis, as well as the characteristic of its cellular composition (fibroblasts, mast cells, histiocytes). The main physical factors influencing the aging process have been studied. It has been shown that age-related skin changes are associated with the decrease in the number of fibroblasts and the amount of collagen, changes in its structure and the relation between its different types of collagens.

scholarly journals Age-related skin changes

2012 ◽  
Vol 65 (5-6) ◽  
pp. 191-195 ◽  
Author(s):  
Aleksandra Levakov ◽  
Nada Vuckovic ◽  
Matilda Djolai ◽  
Mihaela Mocko-Kacanski ◽  
Snezana Bozanic
Keyword(s):  
Inflammatory Infiltrate ◽  
Subcutaneous Fat ◽  
The Sun ◽  
Intercellular Substance ◽  
Dermoepidermal Junction ◽  
Skin Changes ◽  
Age Related ◽  
Fat Reduction ◽  
Males And Females ◽  
Skin Samples

Age-related skin changes can be induced by chronological ageing, manifested in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic substance in the upper dermis, destruction of its fibrilar structure, augmented intercellular substance and moderate inflammatory infiltrate. Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were analyzed. The patients were both males and females, aged from 17 to 81 years. The thickness of the epidermal layers and the number of cellular living layers is greater in younger skin. The amount of keratohyaline granules is enlarged in older skin. Dermoepidermal junction is flattened and the presence of elastotic material in the dermis is pronounced with age. The amount of inflammatory infiltrate is increased, the fibrous trabeculae are thickened in older skin and the atrophy of the hypodermis is observed. Chronological ageing alters the fibroblasts metabolism by reducing their life span, capacity to divide and produce collagen. During ageing, the enlargement of collagen fibrils diminishes the skin elasticity.

scholarly journals A Closer Look at the Cellular and Molecular Components of the Deep/Muscular Fasciae

2021 ◽  
Vol 22 (3) ◽  
pp. 1411
Author(s):  
Caterina Fede ◽  
Carmelo Pirri ◽  
Chenglei Fan ◽  
Lucia Petrelli ◽  
Diego Guidolin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Connective Tissue ◽  
Treatment Strategies ◽  
Clear Understanding ◽  
Pathological Characteristics ◽  
Appropriate Treatment ◽  
Different Types ◽  
Molecular Components ◽  
Entire Network ◽  
Shed Light

The fascia can be defined as a dynamic highly complex connective tissue network composed of different types of cells embedded in the extracellular matrix and nervous fibers: each component plays a specific role in the fascial system changing and responding to stimuli in different ways. This review intends to discuss the various components of the fascia and their specific roles; this will be carried out in the effort to shed light on the mechanisms by which they affect the entire network and all body systems. A clear understanding of fascial anatomy from a microscopic viewpoint can further elucidate its physiological and pathological characteristics and facilitate the identification of appropriate treatment strategies.

scholarly journals MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection

2019 ◽  
Vol 5 (1) ◽  
pp. eaav0216 ◽  
Author(s):  
Mohammad Arifuzzaman ◽  
Yuvon R. Mobley ◽  
Hae Woong Choi ◽  
Pradeep Bist ◽  
Cristina A. Salinas ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Dendritic Cells ◽  
Mast Cells ◽  
Connective Tissue ◽  
Selective Activation ◽  
Adaptive Immune ◽  
Antigen Presenting ◽  
G Protein Coupled ◽  
Draining Lymph Nodes

Mast cells (MCs) are strategically distributed at barrier sites and prestore various immunocyte-recruiting cytokines, making them ideal targets for selective activation to treat peripheral infections. Here, we report that topical treatment with mastoparan, a peptide MC activator (MCA), enhances clearance ofStaphylococcus aureusfrom infected mouse skins and accelerates healing of dermonecrotic lesions. Mastoparan functions by activating connective tissue MCs (CTMCs) via the MRGPRX2 (Mas-related G protein-coupled receptor member X2) receptor. Peripheral CTMC activation, in turn, enhances recruitment of bacteria-clearing neutrophils and wound-healing CD301b+dendritic cells. Consistent with MCs playing a master coordinating role, MC activation also augmented migration of various antigen-presenting dendritic cells to draining lymph nodes, leading to stronger protection against a second infection challenge. MCAs therefore orchestrate both the innate and adaptive immune arms, which could potentially be applied to combat peripheral infections by a broad range of pathogens.

Canine Extracutaneous Mast-cell Tumours Consisting of Connective Tissue Mast Cells

2000 ◽  
Vol 123 (4) ◽  
pp. 306-310 ◽  
Author(s):  
N. Iwata ◽  
K. Ochiai ◽  
T. Kadosawa ◽  
M. Takiguchi ◽  
T. Umemura
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue

Extensive proliferation of mature connective-tissue type mast cells in vitro

Nature ◽  
1986 ◽  
Vol 324 (6092) ◽  
pp. 65-67 ◽  
Author(s):  
Tatsutoshi Nakahata ◽  
Toshimi Kobayashi ◽  
Akira Ishiguro ◽  
Kohichiro Tsuji ◽  
Kuniaki Naganuma ◽  
...  
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Tissue Type

Physical Factors Influencing Accommodation Pumps

1972 ◽  
Vol 9 (1) ◽  
pp. 252-256 ◽  
Author(s):  
J. P. Hobson ◽  
A. W. Pye
Keyword(s):  
Physical Factors ◽  
Factors Influencing

Age-related alteration of thyroidal and mesenteric mast cells of male albino rat

1981 ◽  
Vol 16 (6) ◽  
pp. 475-479 ◽  
Author(s):  
Sankar N. Banerjee ◽  
S.R. Dasgupta
Keyword(s):  
Mast Cells ◽  
Albino Rat ◽  
Age Related

Mast cell heterogeneity

1984 ◽  
Vol 62 (6) ◽  
pp. 734-737 ◽  
Author(s):  
F. Shanahan ◽  
J. A. Denburg ◽  
J. Bienenstock ◽  
A. D. Befus
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Connective Tissue ◽  
Regulatory Peptides ◽  
Cell Heterogeneity ◽  
Cell Secretion ◽  
Biochemical Basis ◽  
Mucosal Mast Cells ◽  
Mast Cell Heterogeneity

Increasing evidence for the existence of inter- and intra-species mast cell heterogeneity has expanded the potential biological role of this cell. Early studies suggesting that mast cells at mucosal sites differ morphologically and histochemically from connective tissue mast cells have been confirmed using isolated intestinal mucosal mast cells in the rat and more recently in man. These studies also established that mucosal mast cells are functionally distinct from connective tissue mast cells. Thus, mucosal and connective tissue mast cells differ in their responsiveness to a variety of mast cell secretagogues and antiallergic agents. Speculation about the therapeutic use of antiallergic drugs in disorders involving intestinal mast cells cannot, therefore, be based on extrapolation from studies of their effects on mast cells from other sites. Regulatory mechanisms for mast cell secretion may also be heterogeneous since mucosal mast cells differ from connective tissue mast cells in their response to a variety of physiologically occurring regulatory peptides. The development of techniques to purify isolated mast cell sub-populations will facilitate future analysis of the biochemical basis of the functional heterogeneity of mast cells.

Physical factors influencing the production of strawberry aroma byPseudomonas fragi grown in skim milk

1990 ◽  
Vol 12 (12) ◽  
pp. 931-936 ◽  
Author(s):  
Yves Raymond ◽  
Andr� Morin ◽  
Fran�ois Cormier ◽  
Claude P. Champagne ◽  
H�l�ne Dubeau
Keyword(s):  
Skim Milk ◽  
Physical Factors ◽  
Factors Influencing

Mutual Phenotypic Changes between Connective Tissue Type and Mucosal Mast Cells

1987 ◽  
Vol 82 (3-4) ◽  
pp. 244-248 ◽  
Author(s):  
Yukihiko Kitamura ◽  
Yuzuru Kanakura ◽  
Sanae Sonoda ◽  
Hidekazu Asai ◽  
Toru Nakano
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Tissue Type ◽  
Phenotypic Changes ◽  
Mucosal Mast Cells
Sign in / Sign up

Export Citation Format

Share Document