scholarly journals Age-related skin changes

2012 ◽  
Vol 65 (5-6) ◽  
pp. 191-195 ◽  
Author(s):  
Aleksandra Levakov ◽  
Nada Vuckovic ◽  
Matilda Djolai ◽  
Mihaela Mocko-Kacanski ◽  
Snezana Bozanic
Keyword(s):  
Inflammatory Infiltrate ◽  
Subcutaneous Fat ◽  
The Sun ◽  
Intercellular Substance ◽  
Dermoepidermal Junction ◽  
Skin Changes ◽  
Age Related ◽  
Fat Reduction ◽  
Males And Females ◽  
Skin Samples

Age-related skin changes can be induced by chronological ageing, manifested in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic substance in the upper dermis, destruction of its fibrilar structure, augmented intercellular substance and moderate inflammatory infiltrate. Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were analyzed. The patients were both males and females, aged from 17 to 81 years. The thickness of the epidermal layers and the number of cellular living layers is greater in younger skin. The amount of keratohyaline granules is enlarged in older skin. Dermoepidermal junction is flattened and the presence of elastotic material in the dermis is pronounced with age. The amount of inflammatory infiltrate is increased, the fibrous trabeculae are thickened in older skin and the atrophy of the hypodermis is observed. Chronological ageing alters the fibroblasts metabolism by reducing their life span, capacity to divide and produce collagen. During ageing, the enlargement of collagen fibrils diminishes the skin elasticity.

MORPHOFUNCTIONAL PARAMETERS OF SKIN DERMIS AND ITS CHANGES DURING AGING (REVIEW)

2016 ◽  
Vol 1 (60) ◽  
pp. 111-116
Author(s):  
Корнеева ◽  
Larisa Korneeva ◽  
Малюк ◽  
Ekaterina Maliuk ◽  
Целуйко ◽  
...  
Keyword(s):  
Mast Cells ◽  
Connective Tissue ◽  
Aging Process ◽  
Physical Factors ◽  
Cellular Composition ◽  
Intercellular Substance ◽  
Skin Changes ◽  
Factors Influencing ◽  
Age Related ◽  
Different Types

The review reveals modern concepts of morphology and biochemistry of the intercellular substance of connective tissue of the skin dermis, as well as the characteristic of its cellular composition (fibroblasts, mast cells, histiocytes). The main physical factors influencing the aging process have been studied. It has been shown that age-related skin changes are associated with the decrease in the number of fibroblasts and the amount of collagen, changes in its structure and the relation between its different types of collagens.

Repeated Occurrence of Skin Necrosis Twice Following Coumarin Intake and Subsequently During Decrease of Vitamin K Dependent Coagulation Factors Associated with Cholestasis

1982 ◽  
Vol 48 (03) ◽  
pp. 245-246 ◽  
Author(s):  
V Hofmann ◽  
P G Frick
Keyword(s):  
Skin Necrosis ◽  
Oral Anticoagulants ◽  
Subcutaneous Fat ◽  
Coagulation Factors ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Skin Changes ◽  
Factors Associated ◽  
Therapeutic Anticoagulation ◽  
Coumarin Necrosis

SummaryA female patient is described who developed skin and subcutaneous fat necrosis on two occasions after intake of acenocoumarol.Several months later identical skin changes occurred during an episode of cholestasis associated with a prolongation of the prothrombin time to an extent comparable with therapeutic anticoagulation; intake of oral anticoagulants could be excluded.This association gives new insights in the pathogenetic mechanisms responsible for the so-called coumarin necrosis and indicates that it may be not due to drug toxicity or allergy.

Thermoregulation during rest and exercise in the cold in pre- and early pubescent boys and in young men

1992 ◽  
Vol 72 (4) ◽  
pp. 1589-1594 ◽  
Author(s):  
J. Smolander ◽  
O. Bar-Or ◽  
O. Korhonen ◽  
J. Ilmarinen
Keyword(s):  
Subcutaneous Fat ◽  
Cycle Ergometer ◽  
Adult Men ◽  
Age Related ◽  
Significant Difference ◽  
Body Sizes ◽  
Equal Work ◽  
Subcutaneous Fat Thickness ◽  
Fat Thickness ◽  
Skin Temperatures

Eight minimally dressed pre- and early pubescent boys (age 11–12 yr) and 11 young adult men (age 19–34 yr) rested for 20 min and exercised on a cycle ergometer for 40 min at approximately 30% of their maximum oxygen consumption (VO2max) at 5 degrees C. To quantify the added increase in metabolic rate because of cold, a separate test was carried out at 21 degrees C at rest and at equal work rates as in the cold. Both groups were similar in subcutaneous fat thickness and VO2max per kilogram body weight. Rectal temperature increased slightly during the exposure to the cold, but no significant difference was observed between the boys and men. In the cold, the boys had lower skin temperatures than the adults in their extremities but not in the trunk. The boys increased their metabolic rates in the cold more than did the men. As a result, the boys maintained their core temperature as effectively as the adults. Similar age-related differences in thermoregulatory responses to cold were observed when two boys and two men with equal body sizes were compared. Our results suggest that there may be maturation-related differences in thermoregulation in the cold between children and adults.

scholarly journals Age-Related Alterations in the Behavior and Serotonin-Related Gene mRNA Levels in the Brain of Males and Females of Short-Lived Turquoise Killifish (Nothobranchius furzeri)

Biomolecules ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1421
Author(s):  
Valentina S. Evsiukova ◽  
Elizabeth A. Kulikova ◽  
Alexander V. Kulikov
Keyword(s):  
Locomotor Activity ◽  
Body Mass ◽  
Mrna Level ◽  
Model Organism ◽  
The Body ◽  
Suitable Model ◽  
Mrna Levels ◽  
Age Related ◽  
Nothobranchius Furzeri ◽  
Males And Females

Short-lived turquoise killifish (Nothobranchius furzeri) have become a popular model organism for neuroscience. In the present paper we study for the first time their behavior in the novel tank diving test and the levels of mRNA of various 5-HT-related genes in brains of 2-, 4- and 6-month-old males and females of N. furzeri. The marked effect of age on body mass, locomotor activity and the mRNA level of Tph1b, Tph2, Slc6a4b, Mao, Htr1aa, Htr2a, Htr3a, Htr3b, Htr4, Htr6 genes in the brains of N. furzeri males was shown. Locomotor activity and expression of the Mao gene increased, while expression of Tph1b, Tph2, Slc6a4b, Htr1aa, Htr2a, Htr3a, Htr3b, Htr4, Htr6 genes decreased in 6-month-old killifish. Significant effects of sex on body mass as well as on mRNA level of Tph1a, Tph1b, Tph2, Slc6a4b, Htr1aa, 5-HT2a, Htr3a, Htr3b, Htr4, and Htr6 genes were revealed: in general both the body mass and the expression of these genes were higher in males. N. furzeri is a suitable model with which to study the fundamental problems of age-related alterations in various mRNA levels related with the brains 5-HT system.

Evaluation of a novel device, high-intensity focused ultrasound with a contact cooling for subcutaneous fat reduction

2016 ◽  
Vol 48 (9) ◽  
pp. 878-886 ◽  
Author(s):  
Heun Joo Lee ◽  
Mi-Hye Lee ◽  
Su Gun Lee ◽  
Un-Cheol Yeo ◽  
Sung Eun Chang
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Subcutaneous Fat ◽  
High Intensity Focused Ultrasound ◽  
Novel Device ◽  
Fat Reduction

Age-related changes in the TRB and IGH repertoires in healthy adult males and females

2021 ◽  
Author(s):  
Mingxing Gong ◽  
Xueying Li ◽  
Anqi Zheng ◽  
Hongxu Xu ◽  
Shi Xie ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Adult Males ◽  
Age Related ◽  
Males And Females ◽  
Age Related Changes

Extending the “Reach” of the Short-Scar Facelift with Energy Devices—An Early Report

2021 ◽  
Vol 37 (02) ◽  
pp. 259-266
Author(s):  
Fred G. Fedok
Keyword(s):  
New Technologies ◽  
Early Report ◽  
Subcutaneous Fat ◽  
Facial Rejuvenation ◽  
Skin Tightening ◽  
Energy Devices ◽  
Age Related ◽  
Facial Attributes ◽  
Facial Changes ◽  
Short Scar

AbstractFacial rejuvenation has become more popular. A wider breadth of the patient population is seeking procedures to preserve their youthful facial attributes and to remedy age-related deleterious changes. Along with this increasing interest in facial rejuvenation is also the expressed desire for any interventions to be relatively low risk, with limited recovery, and with achievable positive results. Many new technologies have become available in an attempt to improve age-related facial changes. The radiofrequency (RF)-based technologies are largely directed toward skin tightening and toward reducing and remodeling subcutaneous fat. It can be contemplated that the combination of RF-based technology with limited surgical procedures may extend the patient selection for less invasive procedures while improving potential results. This is a report of the combination of radiofrequency technologies—percutaneous and transcutaneous—with short scar face techniques in facial rejuvenation.

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