Early diagnosis and prevention of cardiovascular risk in the patients with type II diabetes

10.12737/4106 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-5
Author(s):  
Васильева ◽  
L. Vasileva ◽  
Никитин ◽  
A. Nikitin ◽  
Васильева ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Complications ◽  
Diabetes Type 2 ◽  
Cardiovascular Complications ◽  
Diabetes Type ◽  
Lipid Disorders ◽  
High Incidence ◽  
Patients With Diabetes ◽  
Mechanisms Of Formation

In the paper the relevance of research associated with a high incidence in the world diabetes type 2 diabetes, with often development in patients with early and late, micro - and macro-vascular complications leading to disability and mortality is justified. The results of study on the complex clinical and anamnestic, biochemical, metabolic, functional risk factors for cardiovascular diseases are presented. By means of multivariate mathematical modeling the most informative predictors of complications and their combinations, associated with increased susceptibility to the development of macro-angiopathies in the patients with diabetes mellitus type 2, were defined. The importance of lipid disorders, metabolic profile and homocysteine in the development of cardiovascular complications and their progression based on the study of the correlation between homocysteine with lipoproteins in various forms macro-angiopathies of patients with diabetes type 2, has been demonstrated. Timely correction of identified violations promotes positive dynamics of metabolic processes and on this background, to reduce the frequency of cardiovascular complications. The obtained data contribute to a better understanding of the mechanisms of formation, disposition, development, clinical course and outcome of diseases, identification of the population of persons with risk factors for the purpose of prevention activities.

Risk Factors Associated With Hyperuricemia in Patients with Diabetes Type 2: About 190 Cases

2020 ◽  
Vol 2 (1) ◽  
pp. 12-16
Author(s):  
Fennoun H ◽  
Haraj NE ◽  
El Aziz S ◽  
Bensbaa S ◽  
Chadli A
Keyword(s):  
Type 2 Diabetes ◽  
Heart Disease ◽  
Glycemic Control ◽  
Ischemic Heart Disease ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Ischemic Heart ◽  
Factors Associated ◽  
Patients With Diabetes

Introduction: Hyperuricemia is common Type 2 diabetes at very high cardiovascular risk. Objective: Evaluate the relationship between hyperuricemia and diabetes type 2, and determine its predictive factors in this population. Patients and Methods: Retrospective study cross including 190 patients with diabetes type 2 hospitalized Service of Endocrinology of CHU Ibn Rushd Casablanca from January 2015 to December 2017. Hyperuricemia was defined as a serum uric acid concentration> 70 mg/L (men) and> 60 mg/L (women). The variables studied were the anthropometric measurements), cardiovascular factors (tobacco, hypertension, dyslipidemia), and degenerative complications (retinopathy, neuropathy, kidney failure, ischemic heart disease). The analyzes were performed by SPSS software. Results: Hyperuricemia was found in 26.5% of patients with a female predominance (76%), an average age of 55.9 years, and an average age of 12.4ans diabetes. The glycemic control was found in 84.6% of cases with mean glycated hemoglobin 8.6%. Factors associated al hyperuricemia were the blood pressure in 86% (p <0.05), dyslipidemia in 76.3% of cases (p <0.001) with hypertriglyceridemia in 48.3% of cases (p <0.02), and a hypoHDLémie 28% (p <0.001). The age, obesity, smoking, and glycemic control were associated significantly n al hyperuricemia. The research of degenerative complications of hyperuricemia has objectified renal impairment (GFR between 15 and 60ml / min) chez47% (p <0.001), it was kind of moderate in 35.8% (p <0.01) and severe in 5.1% (p <0.02), ischemic heart disease was found in 34% of cases (p <0.01). Conclusion: In our study, hyperuricemia in type 2 diabetes is common in female patients, especially with hypertension, dyslipidemia, and renal failure. Other factors such as age, obesity, smoking is not associated with hyperuricemia in type 2 diabetics.

scholarly journals The Effects of Combined Insulin and Metformin Therapy in Obese Patients with Diabetes Mellits Type 2 in the Early Stage of the Disease

2006 ◽  
Vol 6 (2) ◽  
pp. 54-58
Author(s):  
Belma Aščić - Buturović
Keyword(s):  
Insulin Therapy ◽  
Pancreatic Beta Cells ◽  
Early Stage ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Target Cells ◽  
Obese Patients ◽  
Patients With Diabetes ◽  
Insulin Activity

Combination of insulin and metformin has been shown to improve glycaemic control in clinical trials, particularly in obese patients with diabetes type 2. Insulin therapy can improve function of pancreatic beta cells and periphery insulin activity in target cells in order to enhance glycaemic homeostasis (1, 2, 3). In our study we included obese patients with diabetes type 2 in the early stage of the disease. The study is partially retrospective and partially prospective. The study encompassed 40 patients split in two groups. The first group of 20 patients received insulin therapy combined with metformin, while the patients of the second group were treated with oral antidiabetic drugs, sulfonylureas and metformin. Three months later, the group treated with insulin and metformin showed improvement in the monitored parameters, namely significant reduction in HbA1c (p = 0.003), MFBG (p = 0.0009), PPG (p = 0.028). Insulin therapy administered together with metformin, in obese patients with diabetes type 2, in the early stage of the disease, resulted in well regulated fasting blood glycaemia, as well as post challenge glycaemia and HbA1c.

Efficacy of sodium glucose cotransporter 2 inhibitors as an adjunct treatment for patients with diabetes type 2

2019 ◽  
Vol 152 (11) ◽  
pp. 438-441
Author(s):  
Pedro Pujante ◽  
Jessica Ares ◽  
Carmen Maciá ◽  
Raúl Rodriguez Escobedo ◽  
Edelmiro Menéndez ◽  
...  
Keyword(s):  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Adjunct Treatment ◽  
Sodium Glucose Cotransporter ◽  
Patients With Diabetes

DETECTION OF PULMONARY HYPERTENSION IN COPD PATIENTS WITH DIABETES TYPE 2 (DM2)

CHEST Journal ◽  
2006 ◽  
Vol 130 (4) ◽  
pp. 172S
Author(s):  
Alexander E. Makarevich ◽  
Valentina E. Valevich ◽  
Alexander J. Pochtavcev
Keyword(s):  
Pulmonary Hypertension ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Copd Patients ◽  
Patients With Diabetes

scholarly journals Potential risk factors for developing diabetes mellitus type 2

2010 ◽  
Vol 63 (3-4) ◽  
pp. 231-236 ◽  
Author(s):  
Dusica Zivanovic ◽  
Sandra Sipetic ◽  
Marina Stamenkovic-Radak ◽  
Jelena Milasin
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Family History ◽  
Physical Inactivity ◽  
Positive Family History ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Family History Of Diabetes ◽  
History Of

Introduction Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several genes and environmental factors. The aim of the present study was to investigate the presence of risk factors for developing diabetes type 2 among diabetic individuals and to compare the presence of risk factors among diabetic individuals with and without positive family history for type 2 diabetes. Material and methods This study was conducted in Cuprija during the period from February to June 2002. The case group included 137 individuals having diagnosis type 2 diabetes. The control group included 129 subjects having the following diagnoses: hypertension, angina pectoris, chronic obstructive lung disease, gastric ulcer or duodenal ulcer. All participants were interviewed at the Medical Center Cuprija using structural questionnaire. The data were collected regarding demographic characteristics, exposure to various chemical and physical agents, stress, smoking, obesity, physical inactivity and family history of diabetes. In the statistical analysis chi square test was used. Results The diabetic individuals were statistically significantly older (40 and more years old) (p=0,000), and they came from rural areas more frequently (p=0,006) than the individuals without diabetes. Significantly more diabetics had lower educational level (p=0,000) and they were agriculture workers and housewives significantly more frequently (p=0,000) than nondiabetic individuals. Furthermore, obesity (p=0,000) and physical inactivity (p=0,003) were significantly more frequent among the diabetic individuals than the nondiabetics. The diabetic individuals had significanly (p=0,000) more numbers of relatives with diabetes mellitus type 2 than the nondiabetics. The diabetic individuals with positive family history of diabetes were significantly older (p=0,021) and more frequently from urban areas (p=0,018) than the diabetic individuals without the positive family history of diabetes. Also they were significantly less exposed to physical agents (p=0,004). Discussion In our study, like in many others, age, place of residence, education, occupation, obesity, physical inactivity, positive family history of diabetes type 2 and exposure to physical agents were identified as potential risk factors for diabetes type 2. Conclusion Different risk factors are probably responsible for developing type 2 diabetes among individuals with and without positive family history of type 2 diabetes.

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