Structural and functional condition of the left departments of heart in the patients with bronchial asthma

10.12737/4784 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Ищенко ◽  
O. Ishchenko ◽  
Демко ◽  
I. Demko ◽  
Рязанова ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Diastolic Dysfunction ◽  
Bronchial Asthma ◽  
Color Doppler ◽  
Significant Risk ◽  
Functional Condition ◽  
Diagnostic Value ◽  
Bronchial Obstruction ◽  
External Respiration ◽  
Design Assessment

The purpose of the research was studying of clinical and diagnostic value of bronchial obstruction, hypoxemia, as well structural and functional condition of the left departments of heart in the patients with middle and severe degree of bronchial asthma. This research had prospective open design. Assessment of cardiac remodeling was carried out by means of the echocardiography with color Doppler mapping in period of exacerbation and after 12 months. Indicators of function of external respiration were estimated by means of the spirography and the bodyplethismography at the same periods. According to research data, it was revealed that with the severity of asthma is increasing the size of the left atrium and a decrease in the ratio of the AO/LA. The importance of early identification of a hypertrophy of a left ventricle in the patients with severe bronchial asthma is bound to the fre-quency of accompanying cardiac pathology and the correlation between hypertrophy of a left ventricle and the subsequent adverse clinical course of cardiovascular diseases. In patients with bronchial asthma parallel to the severity of the disease are formed changes of structural and functional state of myocardium of the left ventricle, causing diastolic dysfunction. The most significant risk factors in the formation of diastolic dysfunction of the left ventricle in patients with bronchial asthma are bronchial obstruction and hypoxemia.

The value of functional research methods in the diagnosis of pre-asthma in children

1993 ◽  
Vol 74 (4) ◽  
pp. 251-255
Author(s):  
T. V. Klykova ◽  
A. M. Potemkina ◽  
A. G. Zagidullina
Keyword(s):  
Early Diagnosis ◽  
Research Methods ◽  
Bronchial Asthma ◽  
Diagnostic Value ◽  
External Respiration ◽  
Adequate Treatment ◽  
Respiratory Allergies ◽  
Asthma In Children

Respiratory allergies are one of the most common and severe allergic pathologies in children. Our observations showed that bronchial asthma is formed in more than 80% of children through the stage of pre-asthma. However, its early diagnosis and adequate treatment in 90% of cases can prevent the transition to bronchial asthma. In this regard, the problem of studying the methods of early diagnosis of pre-asthma and ways to prevent its transformation into bronchial asthma is urgent and practically significant. Since the formation of pre-asthma and bronchial asthma is based on a violation of the function of external respiration, the purpose of our work was, firstly, to study the function of external respiration in case of pre-asthma, and secondly, to determine the diagnostic value of various methods for studying FVD in this pathology in children.

scholarly journals MATRIX METALLOPROTEINASES AS MARKERS OF RESPIRATORY TRACT REMODELING AND POTENTIAL THERAPEUTIC TARGET IN PATIENTS WITH BRONCHIAL ASTHMA

2021 ◽  
Vol 9 (2) ◽  
pp. 174-188
Author(s):  
Vladyslava V. Kachkovska
Keyword(s):  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Bronchial Asthma ◽  
Airway Remodeling ◽  
Matrix Metalloproteinase 9 ◽  
Bronchial Obstruction ◽  
Therapeutic Effects ◽  
External Respiration ◽  
Metalloproteinase 9

It is evidently known that chronic inflammatory process in the bronchi of patients with bronchial asthma is associated with the emergence and progression of airway remodeling, resulting in irreversible obstruction. However, the exact mechanisms of connection between inflammation and airway remodeling are not very well understood and that is the reason for delay of development new specific targeted drugs aimed to inhibit the process of inflammation and remodeling. Therefore, our goal was aimed to analyze and systematize data on the role of matrix metalloproteinases in the occurrence of airway remodeling in patients with bronchial asthma and the possibility of therapeutic effects on this process. Materials and methods: search for information on the role and mechanisms of influence of matrix metalloproteinases on airway remodeling processes in patients with bronchial asthma and the possibility of its pharmacological correction in electronic databases such as PubMed and Google Scholar over the past 25 years. Matrix metalloproteinase-9 and tissue proteinase-1 inhibitor have been shown to play the most important role in airway remodeling in the presence of bronchial asthma, supported by numerous experimental and clinical studies. Much attention is paid to the comparison of these indicators in bronchoalveolar lavage, induced sputum and blood on the background of exacerbation and in the presence of a stable course of the disease. The analysis of their content depending on the severity of the course, dysfunction of external respiration and the degree of reversibility of bronchial obstruction. Studies of the possibility of drug effects on the content of remodeling markers have shown low clinical efficacy. The results are contradictory, but most of them prove the important role of matrix metalloproteinase-9, tissue protease inhibitor-1 and their relationship in the occurrence and progression of airway remodeling and, consequently, the severity of the disease, which dictates the need to develop new additional treatments.

Estimation of Left Ventricular Wall Stiffness by Analysis of Late Diastolic Pressure Components

2011 ◽  
Author(s):  
Casandra L. Niebel ◽  
Kelley C. Stewart ◽  
Takahiro Ohara ◽  
John J. Charonko ◽  
Pavlos P. Vlachos ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricle ◽  
Diastolic Dysfunction ◽  
Diastolic Pressure ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Wall ◽  
Ventricular Relaxation ◽  
Wall Stiffness ◽  
Ventricular Diastolic Dysfunction

Left ventricular diastolic dysfunction (LVDD) is any abnormality in the filling of the left ventricle and is conventionally evaluated by analysis of the relaxation driven phase, or early diastole. LVDD has been shown to be a precursor to heart failure and the diagnosis and treatment for diastolic failure is less understood than for systolic failure. Diastole consists of two filling waves, early and late and is primarily dependent on ventricular relaxation and wall stiffness.

Right and left coronary artery to left ventricle fistula detected by color Doppler flow mapping

1987 ◽  
Vol 114 (4) ◽  
pp. 890-894 ◽  
Author(s):  
Toshio Nishikimi ◽  
Hisao Oku ◽  
Kazuyoshi Hirota ◽  
Kayoko Murai ◽  
Takahiko Kawarabayashi ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Left Ventricle ◽  
Left Coronary Artery ◽  
Color Doppler ◽  
Flow Mapping ◽  
Doppler Flow ◽  
Color Doppler Flow

Possibilities of cardiovascular events in patients with chronic obstructive pulmonary disease and newly diagnosed tuberculosis, including those associated with HIV infection, when prescribing long-acting β2-agonists

MedAlliance ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 32-39
Keyword(s):  
Blood Pressure ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Bronchial Obstruction ◽  
External Respiration ◽  
Obstructive Pulmonary Disease ◽  
Tb Treatment ◽  
Long Acting ◽  
Β2 Agonists

Chronic obstructive pulmonary disease (COPD) and pulmonary tuberculosis (TB) are a common pathology among respiratory diseases. Both conditions may have common risk factors, aggravating each other, accom-panied by the development of bronchial obstructive syndrome, requiring mandatory medical correction to increase the effectiveness of therapy for both the main and concomitant pathologies. The aim of the study was to study the effectiveness of treatment of TB in patients with COPD first diagnosed with tuberculosis, including those associated with HIV when prescribing long-acting β2-agonists. Materials and methods. A simple com-parative study included 60 patients of a TB dispensary aged 30–65 years. Patients were divided into 2 groups of 30 people (TB+COPD and TB+COPD+HIV), each of whom for 2 months received a long-acting β-agonist (indacaterol) as an accompanying therapy for the cor-rection of bronchial obstructive syndrome (BOS), with subsequent assessment of the effectiveness of therapy. Results. Subjectively, patients of both groups noted the rapid development of positive dynamics (short-ness of breath decreased from 1–3 days of taking the drug, coughing — within a week, tolerance to physical exertion improved), which was confirmed by indica-tors of the function of external respiration (FEV1). The state of the cardiovascular system was assessed by the results of daily monitoring of blood pressure (BPM). In the COPD+TB group, there is a certain average daily systolic blood pressure (SBP) with a tendency to nor-malize indicators, which is possibly associated with a decrease in the severity of hypoxia during bronchodi-lator therapy. In the COPD+TB+HIV group, the average daily level of SBP increased by 1 mm Hg, but given the very low starting rates, the increase in blood pressure had a positive effect on the patients' condition. The average heart rate (HR) during bronchodilator thera-py did not tend to increase. The best TB treatment re-sults were obtained in the TB+COPD group. In terms of the closure rate of TB+COPD decay cavities — 26.6%, TB+COPD+HIV — 20.0%), the TB+COPD+HIV group had longer periods of abacillation and closure of decay cav-ities, which is associa ted with the severity of the under-lying and associated diseases. The drug was well toler-ated in both groups. Conclusion. The use of 300 mcg long-acting β-adrenomimetics in the complex therapy of β2-adrenergic agonists for patients with TB+COPD and TB+ COPD+HIV can reduce the severity of bronchial obstruction syndrome, improve quality of life, increase adherence to TB treatment, thereby shortening hospi-talization and reduce the likelihood of disability of pa-tients, without the development of side effects from other organs and systems.

Evaluation of disease activity in ankylosing spondylitis; diagnostic value of color Doppler ultrasonography

2012 ◽  
Vol 42 (2) ◽  
pp. 219-224 ◽  
Author(s):  
Afshin Mohammadi ◽  
Mohammad Ghasemi-rad ◽  
Miramir Aghdashi ◽  
Nikol Mladkova ◽  
Paria Baradaransafa
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Doppler Ultrasonography ◽  
Color Doppler ◽  
Diagnostic Value ◽  
Color Doppler Ultrasonography
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