scholarly journals Aldehyde dehydrogenase 1 (ALDH1) expression in serrated colonic polyps

2020 ◽  
Vol 10 (11) ◽  
pp. 219
Author(s):  
M. A. Shyshkin ◽  
T. O. Khrystenko
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Colonic Polyps ◽  
Aldehyde Dehydrogenase 1 ◽  
Aldh1 Expression

scholarly journals Characterization of a Stem-like Subpopulation in Basal-like Ductal Carcinoma in Situ (DCIS) Lesions

2013 ◽  
Vol 289 (3) ◽  
pp. 1303-1312 ◽  
Author(s):  
Qinglin Li ◽  
Gabriel Eades ◽  
Yuan Yao ◽  
Yongshu Zhang ◽  
Qun Zhou
Keyword(s):  
Cancer Cells ◽  
Aldehyde Dehydrogenase ◽  
Breast Cancer Cells ◽  
Ductal Carcinoma ◽  
Chemopreventive Agent ◽  
Aldehyde Dehydrogenase 1 ◽  
Aldh1 Expression ◽  
Migration Potential

Previously, we found that basal-like ductal carcinoma in situ (DCIS) contains cancer stem-like cells. Here, we characterize stem-like subpopulations in a model of basal-like DCIS and identify subpopulations of CD49f+/CD24− stem-like cells that possess aldehyde dehydrogenase 1 activity. We found that these cells show enhanced migration potential compared with non-stem DCIS cells. We also found that the chemopreventive agent sulforaphane can target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decrease mammosphere and progenitor colony formation. Furthermore, we characterized exosomal trafficking of microRNAs in DCIS and found that several microRNAs (miRs) including miR-140, miR-29a, and miR-21 are differentially expressed in exosomes from DCIS stem-like cells. We found that SFN treatment could reprogram DCIS stem-like cells as evidenced by significant changes in exosomal secretion more closely resembling that of non-stem cancer cells. Finally, we demonstrated that exosomal secretion of miR-140 might impact signaling in nearby breast cancer cells.

scholarly journals Prognostic value of aldehyde dehydrogenase 1 (ALDH1) in invasive breast carcinomas

2018 ◽  
Vol 18 (4) ◽  
pp. 313-319
Author(s):  
Hale Demir ◽  
Ozgecan Dulgar ◽  
Bugra Taygun Gulle ◽  
Hande Turna ◽  
Sennur Ilvan
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Statistical Significance ◽  
Case Series ◽  
Disease Free Survival ◽  
Clinicopathological Parameters ◽  
Luminal A ◽  
Poor Prognostic Factor ◽  
Aldehyde Dehydrogenase 1 ◽  
Aldh1 Expression ◽  
Her2 Positivity

Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival. There was a significant association between ALDH1 expression and tumor grade (p < 0.001), i.e., the expression of ALDH1 was higher in high-grade tumors. ALDH1 expression was significantly associated with estrogen and progesterone receptor (ER and PR) negativity (p < 0.001) and HER2 positivity (p = 0.001). ALDH1 expression ratios were higher in HER2 type and TNBC. There was a statistically significant correlation between ALDH1 negativity and luminal A subtype (p < 0.001). The overall and disease free survival were shorter in ALDH1+ tumors, although without statistical significance. We confirm that ALDH1 is a potentially important, poor prognostic factor in BC, associated with high histological grade, ER/PR negativity and HER2 positivity. For more accurate results, ALDH1 expression should be evaluated in larger case series including various types/subtypes of BC.

Aldehyde dehydrogenase 1 (ALDH1) expression is associated with a poor prognosis of bladder cancer

2015 ◽  
Vol 39 (3) ◽  
pp. 375-381 ◽  
Author(s):  
Ning Xu ◽  
Ming-Ming Shao ◽  
Hai-Tao Zhang ◽  
Mei-Shan Jin ◽  
Yi Dong ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Aldehyde Dehydrogenase ◽  
Poor Prognosis ◽  
Aldehyde Dehydrogenase 1 ◽  
Aldh1 Expression

scholarly journals Correlations of Aldehyde dehydrogenase-1 (ALDH1) expression with traditional prognostic parameters and different molecular subtypes of breast carcinoma

2018 ◽  
Vol 91 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Piyabi Sarkar ◽  
Keya Basu ◽  
Pubali Sarkar ◽  
Uttara Chatterjee ◽  
Madhumita Mukhopadhyay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Breast Carcinoma ◽  
Aldehyde Dehydrogenase ◽  
Molecular Subtypes ◽  
Stem Cell Differentiation ◽  
Tumor Stem Cell ◽  
Prognostic Parameters ◽  
Aldehyde Dehydrogenase 1 ◽  
Aldh1 Expression

Background and aim. Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display poor prognosis. Breast cancer heterogeneity and risk of recurrence could be explained with the help of cancer stem cell hypothesis. Stem cells have the capacity to self-renew and differentiate into multiple cell types. Aldehyde dehydrogenase-1 (ALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, contributes to normal and tumor stem cell differentiation. Invasion and metastasis in breast cancer are found to be mediated by a subpopulation of tumor cells which exhibit stem cell-like features and express ALDH1. The aim was to document ALDH1 expression in breast carcinoma and find its association with other clinico-pathologic prognostic parameters.Study design. This was a cross-sectional observational study.Methods. A total of 62 patients with breast carcinoma undergoing mastectomy were included in this study. The tumors were classified into molecular subtypes by assessing immunohistochemical (IHC) expression of ER, PgR, HER2 and Ki-67 according to St. Gallen Consensus Conference 2013. ALDH1 expression was studied by IHC and correlated with clinicoathological parameters.Statistical analysis. Statistical analysis was done using Graph Pad software (Prism 5 version) for Windows 7. A p-value <0.05 was considered statistically significant.Results and analysis. Out of 62 tumors, 35 tumors (56.4%) showed ALDH1 positivity. ALDH1 expression was significantly associated with larger size, lymph node involvement, higher grade, higher stage and HER2+ or triple negative tumors.Conclusion. This study suggests that ALDH1 expression is associated with poor prognostic parameters and aggressive tumor behavior. Larger population-based prospective trials on Indian patients are required to validate these results.

scholarly journals Association of aldehyde dehydrogenase 1 expression and biologically aggressive features in breast cancer

Neoplasma ◽  
2014 ◽  
Vol 61 (03) ◽  
pp. 352-362 ◽  
Author(s):  
E. J. KANG ◽  
H. JUNG ◽  
O. H. WOO ◽  
K. H. PARK ◽  
S. U. WOO ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Aldehyde Dehydrogenase ◽  
Aldehyde Dehydrogenase 1
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