Formulation Development and Optimization of Press Coated Tablets of Ranitidine HCL by Using 32 Factorial Design = صياغة التنمية والتحسين للصحافة مغلفة ألواح من رانيتيدين HCL باستخدام 32 تصميم مضروب

2017 ◽  
Vol 10 (1) ◽  
pp. 57-75 ◽  
Author(s):  
Prasanthi Boddu ◽  
Nagabhusan Rao Mudili ◽  
Uma Devi Ponokumati
Keyword(s):  
Factorial Design ◽  
Formulation Development ◽  
32 Factorial Design

Formulation Development of Aceclofenac Loaded Nanosupension by Three Square (32) Factorial Design

2012 ◽  
Vol 4 (4) ◽  
pp. 1575-1583
Author(s):  
Atul A Patak ◽  
Jorwekar, P ◽  
P D Chaudhari
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Factorial Design ◽  
In Vivo Studies ◽  
Differential Scanning Calorimetric ◽  
Formulation Development ◽  
Drug Release Profile ◽  
Calorimetric Analysis ◽  
32 Factorial Design

In the present study, aceclofenac loaded polymeric nanosuspension were formulated and evaluated.  Aceclofenac is a potent analgesic under BCS Class II. Due to the need for its frequent dosing, aceclofenac is an ideal candidate for sustained or controlled drug delivery. For optimization of prepared formulation, the three square (32) factorial design was used.  Tween 80 (X1) and combination of Eudragit RL 100 and RS 100 (X2) were used as independent variables and particle size (Y1), entrapment efficiency (Y2), and Percent drug release (Y3) were taken as dependent variables. The formulations were evaluated for particle size, zeta potential and drug entrapment. The in vitro drug release profile supports nanosuspension form to be used as a sustained release vehicle for aceclofenac. The formulation was characterized by differential scanning calorimetric analysis, in vivo studies and stability testing.

scholarly journals Formulation development, characterization and assessment of In-Vitro antifungal efficacy against Candida albicans of diallyl disulphide liposomal gel using 32 factorial design

2019 ◽  
Vol 9 (2) ◽  
pp. 105-117
Author(s):  
Sneha Birju Gupta ◽  
Srinivas Rajesham Bhairy ◽  
Rajashree Shreeram Hirlekar
Keyword(s):  
Sustained Release ◽  
Factorial Design ◽  
Gelling Agent ◽  
Stability Studies ◽  
Formulation Development ◽  
Liposomal System ◽  
32 Factorial Design ◽  
The Stability ◽  
Antifungal Efficacy

Objective: The aim of this study was to develop the diallyl disulphide (DADS) liposomal dispersion and further the dispersion was to formulate into gel. Methods: The DADS liposomal system was developed using thin film hydration method. 32 factorial design was employed to study the effect of various factors to obtain the optimized liposomal system. Further, it was converted to gel using suitable gelling agent. The optimized liposomal system and gel formulations were evaluated for various parameters. The optimized gel was evaluated for its in-vitro antifungal efficacy. The stability studies for gel were carried as per International conference on harmonisation (ICH) guidelines. Results: The optimized liposomal system was having vesicle size of 208.6nm, % entrapment was 91.7±1.16% and loading was 11.12±0.23%. % drug permeation was 61.10±0.85%. The zeta potential showed moderate stability. The optimized DADS liposomal gel showed satisfactory results. Ex-vivo permeation studies showed that DADS liposomal gel possesses sustained release and drug retention study proved better retention of DADS from liposomal gel than conventional gel in skin. The stability studies showed DADS liposomal gel was stable for 30 days at 25℃/60%RH, 40℃/75%RH and refrigeration (5±3℃). Conclusion:  The results from the present study show that the sustained release profile of optimized DADS liposomal gel. The retention of DADS from liposomal gel was more than from conventional gel which helps in better pharmacological activity with least side effects. Keywords: Diallyl disulphide (DADS), liposomal gel, permeation, sustained release and antifungal activity.

scholarly journals Formulation Development and Evaluation of Mouth Dissolving Tablet of Aspirin by Using QbD Approach

2021 ◽  
Vol 20 (1) ◽  
pp. 19-29
Author(s):  
Nilima A Thombre ◽  
Pradeep S Ahire ◽  
Sanjay J Kshirsagar
Keyword(s):  
Drug Release ◽  
Quality By Design ◽  
Formulation Development ◽  
Compression Method ◽  
Disintegration Time ◽  
In Vitro Drug Release ◽  
Design Expert ◽  
32 Factorial Design ◽  
Mouth Dissolving Tablet

In the current investigations, mouth dissolving tablets (MDT) were developed by applying quality by design (QbD) approach. Direct compression method was applied for the preparation of MDT containing aspirin using 32 factorial design with quantity of drug, microcrystalline cellulose (MCC) and crosscarmellose sodium (CCS) as dependant variables. MCC and CCS were used as superdisintegrants. Sodium stearyl fumarate was used as lubricant. Developed MDT were evaluated for characteristics like hardness, friability, disintegration time (DT) and in vitro drug release . Design Expert 11.0 described adequately impact of selected variables (MCC and CCS) at various levels for response under study (DT and friability). The optimized batch showed disintegration time of 15-28 secs, friability within 1% and in vitro drug release of 75-98% after 30 mins, respectively. The present study of experimental design revealed that MCC and CCS are fruitful at low concentration to develop the optimized formulation. As per the results obtained from the experiments, it can be concluded that QbD is an effective and efficient approach for the development of quality into MDT with the application of QTPP, risk assessment and critical quality attributes (CQA). Dhaka Univ. J. Pharm. Sci. 20(1): 19-29, 2021 (June)

scholarly journals Formulation and Development of Stable Metaxalone Nanosuspension Using 32 Factorial Design

2016 ◽  
Vol 8 (04) ◽  
Author(s):  
Paras R. Vasanani ◽  
L. Patel ◽  
Chetan Detroja
Keyword(s):  
Particle Size ◽  
Factorial Design ◽  
Surfactant Concentration ◽  
Class Ii ◽  
Poloxamer 407 ◽  
Saturation Solubility ◽  
Poor Solubility ◽  
Bcs Class Ii ◽  
Stirring Time ◽  
32 Factorial Design

Nanosuspensions are the dispersions of nanosized particles in a suitable vehicle prepared using surfactants or solubilizers to aid in nanosize distribution. Nanosuspension is best suited for dosage form development of poorly soluble drugs. According to the biopharmaceutical classification system, drugs with poor solubility fall either in BCS class II or BCS class IV. BCS class II drugs show poor solubility and good permeability; hence their bioavailability problems can be overcome by improving their solubility. Metaxalone is one such BCS class II drug from an oxazolidin-2-one class of centrally acting muscle relaxant drugs, indicated for relief of discomforts associated with acute, painful musculoskeletal conditions. Therefore, in present investigation, nanosuspension of Metaxalone has been formulated as an attempt to improve solubility and hence the overall bioavailability of Metaxalone. Media milling technique has been employed for nanosuspension preparation. Surfactant concentration (Poloxamer 407) and stirring time has been optimized using 32 factorial design to achieve desired particle size and saturation solubility responses as dependent variables. The particle size (PS) of 215.3 nm and maximum saturation solubility (SS) of 2805μg/ml was obtained as suggested solutions from factorial design which was further confirmed using check point analysis. Interaction of surfactant concentration and stirring time and their effect on particle size and saturation solubility was predicted using the contour plots and response surface plots. The optimized formulation showed around 99% metaxalone in vitro dissolution in comparison to around 46% dissolution from SKELAXIN® tablet at 30 minutes. These methodologies could therefore be employed successfully to improve solubility of any BCS class II drug and to predict effects and interactions of many experimental variables at the same time.

USE OF FACTORIAL DESIGN IN OPTIMIZATION OF MICROWAVE ASSISTED ORGANIC SYNTHESIS OF SOME AZOLES

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (10) ◽  
pp. 24-33
Author(s):  
R. R Somani ◽  
◽  
G. J. Sanap ◽  
P. K Chaskar
Keyword(s):  
Factorial Design ◽  
Organic Synthesis ◽  
Maximum Yield ◽  
Minimum Time ◽  
Organic Reactions ◽  
Design Approach ◽  
Environment Friendly ◽  
Microwave Assisted ◽  
Synthetic Reactions ◽  
32 Factorial Design

In the era of environment friendly chemistry, Microwave Assisted Organic Synthesis (MAOS) has proved to be an effective tool to achieve maximum yield in minimum time without compromising on quality. The present work focuses on synthesis of some bioactive heterocyclic azoles using MAOS. However, the synthetic reactions are optimized using a known technique of factorial designing. Here, 32 factorial design approach is used to achieve the set targets of yields and purity. The outcome has been very promising and opens up new avenues for organic chemists who face challenges in optimizing organic reactions.

Formulation Development and Evaluation of Migraine Almotriptan Loaded Ethosomes Using Box Behnken Design

2021 ◽  
pp. 214-223
Author(s):  
Megha Parashar ◽  
Ashish Jain
Keyword(s):  
Factorial Design ◽  
Film Formation ◽  
Entrapment Efficiency ◽  
Tween 80 ◽  
Quadratic Model ◽  
Sonication Time ◽  
Formulation Development ◽  
Vesicle Size ◽  
Formation Method ◽  
Chronic Headaches

One of the most common nervous system illnesses is headache disorders, which are characterized by chronic headaches. In Present investigation Almotriptan loaded Ethosomes were prepared by water phase addition method. The three independent factors including Phosphotidylcholine: Cholestrol: DSPE (6:3:1molar ratio), Surfactant concentration and sonication time. A factorial design 3*3(3 factor 3 level) was applied to prepare 17 formulation. Optimization of ethosomal preparation was carried out by applying Box Behnken response surface randomized factorial design following quadratic model using Design of Experiment (DOE) software version 11.04.0.  The factor Soya PC: Cholesterol: DSPE in molar ration (6:3:1), Concentration of Tween-80 and sonication time were selected as dependable process and formulation factors that can be effect formulation characteristics like entrapment efficiency, average vesicle size, Polydispersity Index (PDI). All other factors like sonication speed and rotation speed was kept constant All the formulation were prepared by simple solvent evaporation thin film formation method and characterized for the drug entrapment, average vesicle size and PDI, shape morphology. Formulations were optimized on the basis of responses such as average vesicle size, PDI, and entrapment efficiency. All the characterized values of the responses were putted in the formulation design table and analyse to best fitted model for the design. It was observed that, quadaratic model is best fitted model for the design. The prepared ethosomes formulation can further incorporated in situ gel for effective treatment of migraine.

Evaluation and Formulation of Biodegradable Levodopa Microspheres Using 32 Factorial Design

1998 ◽  
pp. 41-49
Author(s):  
Betül Arıca ◽  
H. Süheyla Kaş ◽  
A. Atilla Hıncal
Keyword(s):  
Factorial Design ◽  
32 Factorial Design
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