Association between Stroke and Hypertension and Deep Vein Thrombosis in Northern Saudi Arabia : Community-Based Study

While the reported annual incidence of venous thrombo-embolism varies widely, ranging from 43.7 to 145 per 100 000, the true incidence in the Kingdom of Saudi Arabia (KSA) remains unknown. Deep Vein Thrombosis (DVT) is a term that refers to blood clots inside a deep vein in the body, most commonly in lower extremities (usually calf or thigh); in rare cases, it can be in upper extremities. The main aim of this study was to assess the public knowledge and extent of DVT and to assess the influence of socio-demographic factors. The objectives were: To test the association between gender and the prevalence of DVT. To test the association between body mass index (BMI) and the prevalence of DVT. To test whether recent or current pregnancy and DVT are significantly associated. To test the significance of a family history of DVT and the prevalence of DVT among members of the same family. To fit binary logistic models that flag the important factors for DVT Methods The study was cross-sectional and it involved the adult population in Saudi Arabia. The total enumeration method was used to include male and female that agreed to answer the questionnaire in this study. The questionnaire included demographic information and knowledge and attitudes towards the symptoms, and risk factors measures. Results The ages of 317 of the 484 respondents who agreed to fill out the questionnaire were between 19 and 30 years. Males were 35.8% and females 64.2%, while 21.8% of the respondents reported having an incidence of DVT. DVT was statistically significantly associated with gender and pregnancy condition p<.05 in both cases while the highest risk factor was gender where females were 2.205 more times likely to have DVT than males [95%CI;1.85,2.63, p < .000]. Conclusions There is a general increase in knowledge for DVT and also a general increase in incidences of DVT in Saudi Arabia compared to previous literature. BMI, gender, and pregnancy condition are the main risk factors of DVT. Keywords: Deep vein thrombosis, risk factors, Surgery, Saudi Arabia

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Prevention of Pulmonary Embolism by Inferior Vena Cava Filter in Patients With Proximal Deep Vein Thrombosis

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)85281-3 ◽

1998 ◽

Vol 31 (2) ◽

pp. 362A

Author(s):

R Faivre

Keyword(s):

Pulmonary Embolism ◽

Deep Vein Thrombosis ◽

Inferior Vena Cava ◽

Inferior Vena Cava Filter ◽

Inferior Vena ◽

Vena Cava ◽

Vena Cava Filter ◽

Proximal Deep Vein Thrombosis ◽

Vein Thrombosis ◽

Deep Vein

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Incidence of Deep Vein Thrombosis After Varicose Vein Surgery

Yearbook of Vascular Surgery ◽

10.1016/s0749-4041(08)70279-3 ◽

2006 ◽

Vol 2006 ◽

pp. 363-364

Author(s):

G.L. Moneta

Keyword(s):

Deep Vein Thrombosis ◽

Varicose Vein ◽

Varicose Vein Surgery ◽

Vein Thrombosis ◽

Deep Vein

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Feasibility Study of Catheter-directed Thrombolysis with Recombinant Staphylokinase in Deep Venous Thrombosis

Thrombosis and Haemostasis ◽

10.1055/s-0037-1614936 ◽

1998 ◽

Vol 79 (03) ◽

pp. 517-519 ◽

Cited By ~ 13

Author(s):

Stephane Heymans ◽

Raymond Verhaeghe ◽

Luc Stockx ◽

Désiré Collen

Keyword(s):

Deep Vein Thrombosis ◽

Continuous Infusion ◽

High Speed ◽

Minor Bleeding ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

Long Term Follow Up ◽

Valve Function ◽

Rotating Impeller ◽

Deep Vein

SummaryThe feasibility of catheter-directed thrombolysis with recombinant staphylokinase was evaluated in six selected patients with deep vein thrombosis. The patients underwent intrathrombus infusion of recombinant staphylokinase (2 mg bolus followed by a continuous infusion of 1 mg/h). Heparin was given via the catheter as a bolus (5000 U) and as a continuous infusion (1000 U/h). Complete lyis was obtained in five patients and partial lysis in one patient. Complications consisted of minor bleeding in four subjects. Symptomatic reocclusion occurred in one. Debulking of the thrombus mass by a high speed rotating impeller (n = 1) and stenting (n = 3) were used as additional interventions. An underlying anatomical abnormality was present in two patients. Long term follow up revealed normal patency in all patients and normal valve function in four patients. Symptomatic venous insufficiency with valve dysfunction was present in the two with a second thrombotic episode.Thus catheter-directed infusion of recombinant staphylokinase in patients with deep vein thrombosis appears feasible and may be associated with a high frequency of thrombolysis. Larger studies to define the clinical benefit of this treatment appear to be warranted.

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Deep Vein Thrombosis and Fibrinolysis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646432 ◽

1991 ◽

Vol 66 (04) ◽

pp. 426-429 ◽

Cited By ~ 16

Author(s):

Marcel Levi ◽

Anthonie W A Lensing ◽

Harry R Büller ◽

Paolo Prandoni ◽

Gerard Dooijewaard ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Tissue Type ◽

Controlled Study ◽

First Episode ◽

Control Group ◽

Vein Thrombosis ◽

Type Plasminogen Activator ◽

Deep Vein

SummaryIn the present study 57 consecutive patients with a first episode of venographically proven deep vein thrombosis were investigated to evaluate the release of tissue-type plasminogen activator (t-PA) and of urokinase-type plasminogen activator (u-PA) in response to DDAVP stimulation as well as the resting plasminogen activator inhibitor (PAI) concentration, comparing this to the results obtained in 66 similar patients with a clinical suspicion of thrombosis but with a normal venogram. All assays were performed without knowledge of the patient's status.Four patients in the deep vein thrombosis-group (7%) had an absent u-PA antigen response upon DDAVP infusion, while a normal response was observed in all control subjects. Patients and controls showed similar increases in t-PA antigen level upon DDAVP. High resting PAI antigen levels were encountered in 5 patients in the deep vein thrombosis-group (9%) and in 6 subjects in the control group (9%).The results from this controlled study indicate that a defective release of u-PA may occur in patients with deep vein thrombosis and may have pathogenetic significance. Furthermore it is concluded that elevation of PAI levels cannot be considered as a specific risk factor for venous thrombosis.

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