Moraxella Catarrhalis as a Respiratory Tract Pathogen during Umrah and Hajj Seasons

2018 ◽  
Vol 27 (3) ◽  
pp. 59-64
Author(s):  
Aiman M. Momenah
Keyword(s):  
Respiratory Tract ◽  
Moraxella Catarrhalis ◽  
Tract Pathogen

scholarly journals Genome Analysis of Moraxella catarrhalis Strain RH4, a Human Respiratory Tract Pathogen

2012 ◽  
Vol 194 (24) ◽  
pp. 7021-7021
Author(s):  
S. P. W. de Vries ◽  
S. A. F. T. van Hijum ◽  
W. Schueler ◽  
K. Riesbeck ◽  
J. P. Hays ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Genome Analysis ◽  
Moraxella Catarrhalis ◽  
Human Respiratory Tract ◽  
Tract Pathogen

scholarly journals Prevalence of Moraxella catarrhalis in patients of lower respiratory tract infection with underlying risk factors

2017 ◽  
Vol 4 (2) ◽  
pp. 442
Author(s):  
Alex Aiswariya ◽  
Kundoly Velayudhan Suseela ◽  
Das Subi
Keyword(s):  
Risk Factors ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Moraxella Catarrhalis ◽  
Lower Respiratory Tract ◽  
Care Hospital ◽  
Tract Pathogen ◽  
Underlying Risk

Background: Moraxella catarrhalis is a Gram-negative diplococcus, commonly found as a normal flora in the human upper respiratory tract. Recently, M. catarrhalis has emerged as an important and common human respiratory tract pathogen. This study was aimed to determine the rate of isolation of M. Catarrhalis in patients attending a tertiary care hospital with lower respiratory tract infection (LRTI), antibiotic susceptibility pattern and predisposing factors responsible for their infection.Methods: A prospective study was carried out in 1001 lower respiratory specimens from patients (above 20 years’ age) with suspected LRTI.  The study investigated by microscopic examination, culture and antibiotic sensitivity test according to the standard guidelines. Assessment of clinical significance of M. Catarrhalis was ascertained on the basis of preformed criteria.Results: A total of 60 clinically significant M. Catarrhalis were isolated from the 930 culture positive samples. The isolates showed maximum sensitivity to second and third generation cephalosporins (95%), azithromycin (90%) followed by amoxicillin clavulanic acid (85%). Rate of isolation was more in males (70%) and elderly people above 60 years (63.33%) were found to be more affected. Patients (58.33%) with Chronic Obstructive Pulmonary Diseases (COPD) were found to be more prone to get infection by M. Catarrhalis.Conclusions: Moraxella catarrhalis should be considered as significant lower respiratory tract pathogen especially in elderly patients with underlying risk factors like COPD.

PRELP enhances host innate immunity against respiratory tract pathogen Moraxella catarrhalis

Immunobiology ◽  
2016 ◽  
Vol 221 (10) ◽  
pp. 1154
Author(s):  
Guanghui Liu ◽  
David Ermert ◽  
Martin E. Johansson ◽  
Kristian Riesbeck ◽  
Anna M. Blom
Keyword(s):  
Innate Immunity ◽  
Respiratory Tract ◽  
Moraxella Catarrhalis ◽  
Tract Pathogen ◽  
Host Innate Immunity

scholarly journals Moraxella catarrhalis,a Human Respiratory Tract Pathogen

2009 ◽  
Vol 49 (1) ◽  
pp. 124-131 ◽  
Author(s):  
Timothy F. Murphy ◽  
G. Iyer Parameswaran
Keyword(s):  
Respiratory Tract ◽  
Moraxella Catarrhalis ◽  
Human Respiratory Tract ◽  
Tract Pathogen

scholarly journals ATP-Binding Cassette (ABC) Transporters of the Human Respiratory Tract Pathogen, Moraxella catarrhalis: Role in Virulence

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158689 ◽  
Author(s):  
Timothy F Murphy ◽  
Aimee L. Brauer ◽  
Antoinette Johnson ◽  
Charmaine Kirkham
Keyword(s):  
Respiratory Tract ◽  
Abc Transporters ◽  
Moraxella Catarrhalis ◽  
Atp Binding ◽  
Human Respiratory Tract ◽  
Tract Pathogen ◽  
Atp Binding Cassette

scholarly journals Genome Analysis of Moraxella catarrhalis Strain RH4, a Human Respiratory Tract Pathogen

2010 ◽  
Vol 192 (14) ◽  
pp. 3574-3583 ◽  
Author(s):  
Stefan P. W. de Vries ◽  
Sacha A. F. T. van Hijum ◽  
Wolfgang Schueler ◽  
Kristian Riesbeck ◽  
John P. Hays ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Stress Responses ◽  
Moraxella Catarrhalis ◽  
Vaccine Development ◽  
Tricarboxylic Acid Cycle ◽  
Phylogenetic Analyses ◽  
Future Research ◽  
Acetate Metabolism ◽  
Chronic Obstructive ◽  
Tract Pathogen

ABSTRACT Moraxella catarrhalis is an emerging human-restricted respiratory tract pathogen that is a common cause of childhood otitis media and exacerbations of chronic obstructive pulmonary disease in adults. Here, we report the first completely assembled and annotated genome sequence of an isolate of M. catarrhalis, strain RH4, which originally was isolated from blood of an infected patient. The RH4 genome consists of 1,863,286 nucleotides that form 1,886 protein-encoding genes. Comparison of the RH4 genome to the ATCC 43617 contigs demonstrated that the gene content of both strains is highly conserved. In silico phylogenetic analyses based on both 16S rRNA and multilocus sequence typing revealed that RH4 belongs to the seroresistant lineage. We were able to identify almost the entire repertoire of known M. catarrhalis virulence factors and mapped the members of the biosynthetic pathways for lipooligosaccharide, peptidoglycan, and type IV pili. Reconstruction of the central metabolic pathways suggested that RH4 relies on fatty acid and acetate metabolism, as the genes encoding the enzymes required for the glyoxylate pathway, the tricarboxylic acid cycle, the gluconeogenic pathway, the nonoxidative branch of the pentose phosphate pathway, the beta-oxidation pathway of fatty acids, and acetate metabolism were present. Moreover, pathways important for survival under challenging in vivo conditions, such as the iron-acquisition pathways, nitrogen metabolism, and oxidative stress responses, were identified. Finally, we showed by microarray expression profiling that ∼88% of the predicted coding sequences are transcribed under in vitro conditions. Overall, these results provide a foundation for future research into the mechanisms of M. catarrhalis pathogenesis and vaccine development.

scholarly journals Non-susceptibility trends among Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections in the UK and Ireland, 1999-2007

2008 ◽  
Vol 62 (Supplement 2) ◽  
pp. ii97-ii103 ◽  
Author(s):  
I. Morrissey ◽  
K. Maher ◽  
L. Williams ◽  
J. Shackcloth ◽  
D. Felmingham ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Moraxella Catarrhalis ◽  
Respiratory Tract Infections ◽  
The Uk ◽  
Tract Infections

scholarly journals Moraxella catarrhalis: Pathogenic Significance in Respiratory Tract Infections Treated by Community Practitioners

1996 ◽  
Vol 22 (4) ◽  
pp. 632-636 ◽  
Author(s):  
G. M. Wood ◽  
B. C. Johnson ◽  
J. G. McCormack
Keyword(s):  
Respiratory Tract ◽  
Moraxella Catarrhalis ◽  
Respiratory Tract Infections ◽  
Tract Infections
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