C-REACTIVE PROTEIN LEVELS - INDICATOR FOR PROGNOSIS OF SPONTANEOUS PRETERM BIRTH IN BULGARIAN WOMEN

It is estimated that every year fifteen million premature babies are born worldwide mainly due to spontaneous preterm birth (sPTB). Furthermore, in clinical settings, there still are no reliable and accurate tools to predict preterm labor. Hence, the aim of this pioneering research was to estimate the relationship between the maternal inflammatory indicator and sPTB in a case-control study between 220 South Bulgarian women. The study was conducted at UMBAL, Stara Zagora, Bulgaria (2017-2020) and enrolled a total of 220 women, determined into two groups: 1) TB (n = 110), who were to give birth at term ≥ 37 to ≤ 39 + 6 gestation weeks with active labor at the time of hospitalization; and 2) sPTB (n = 110), women with preterm birth ≤ 32–34 + 6 gestation weeks and declared active labor, who were to give birth within 5-24 hrs. The inflammatory indicators/CRP concentration was quantified in plasma by immunoturbidimetric methods within 2 hrs. in mg/l. The median maternal CRP (8.77 ± 3.91), with cutoff = 4.9 mg/l was identified as optimal inflammation with highest risk of sPTB (sensitivity = 86.6%; specificity = 53.7%, р < 0.0001). Moreover, a cutoff CRP = 4.9 mg/l was found to be most effective in determining maternal age ≤ 19 years, the sensitivity of 68.6%, and positively correlated OR = 8.122 vs. OR = 2.354, with increased total sPTB risk at ≤ 32-34 + 6 weeks, respectively (p < 0.001). In conclusion, increased CRP concentrations and a decreased maternal age were associated with increased risks of sPTB, before ≤ 32-34 + 6 weeks. Minimal inflammation and other factors in combination may also act as sPTB prognosis.

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C-reactive protein levels and oxidative stress markers as predictors of spontaneous preterm birth in women from South Bulgaria

10.21175/rad.abstr.book.2021.6.7 ◽

2021 ◽

Author(s):

Iliana Koleva ◽

Yanka Karamalakova ◽

Maria Angelova ◽

Galina Nikolova

Keyword(s):

Oxidative Stress ◽

Preterm Birth ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Spontaneous Preterm Birth ◽

Protein Levels ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

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Identification of Indicators for Preterm Birth Using Retinoid Metabolites

Metabolites ◽

10.3390/metabo11070443 ◽

2021 ◽

Vol 11 (7) ◽

pp. 443

Author(s):

Young-Ah You ◽

Soo-Yeon Hwang ◽

Soo-Min Kim ◽

Seojeong Park ◽

Ga-In Lee ◽

...

Keyword(s):

Preterm Birth ◽

Metabolic Pathways ◽

Case Control Study ◽

Retinol Binding Protein ◽

Protein Levels ◽

Retinoid Metabolism ◽

Retinol Metabolism ◽

Nested Case Control ◽

Control Study ◽

Tof Ms

Metabolites reflect the biochemical dynamics for the maintenance of pregnancy and parturition. UPLC-Q/TOF-MS and LC-MS/MS metabolomics were performed to identify and validate the plasma metabolomic signatures of preterm birth (PTB). We recruited pregnant women between 16 and 40 weeks 5 days gestational age at Ewha Womans Mokdong Hospital for a nested case-control study. In untargeted UPLC-Q/TOF-MS, score plots of partial least-squares discriminant analysis clearly separated the PTB group from the term birth (TB, n = 10; PTB, n = 11). Fifteen metabolites were significantly different between the two groups, as indicated by a variable importance in projection >1 and p < 0.05. Metabolic pathways involving retinol, linoleic acid, D-arginine, and D-ornithine were associated with PTB. Verification by LC-MS/MS focused on retinol metabolism (TB, n = 39; PTB, n = 20). Retinol levels were significantly reduced in PTB compared to TB, while retinal palmitate, all-trans-retinal, and 13-cis-retinoic acid (13cis-RA) significantly increased (p < 0.05). Retinol-binding protein levels were also elevated in PTB. Additionally, all-trans-retinal (AUC 0.808, 95% CI: 0.683–0.933) and 13cis-RA (AUC 0.826, 95% CI: 0.723–0.930) showed improved predictions for PTB-related retinol metabolites. This study suggests that retinoid metabolism improves the accuracy of PTB predictions and plays an important role in maintaining pregnancy and inducing early parturition.

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