Using acupuncture to manage wound healing and chronic back pain in a guinea pig

2021 ◽  
Vol 26 (9) ◽  
pp. 1-10
Author(s):  
Krissy Green
Keyword(s):  
Wound Healing ◽  
Back Pain ◽  
Guinea Pig ◽  
Chronic Back Pain ◽  
Multimodal Analgesia ◽  
Skin Wound ◽  
Manual Acupuncture ◽  
Thickness Skin ◽  
Spinous Processes

Acupuncture is being increasingly used in veterinary medicine in the management of wound healing and chronic pain. In this case study, a guinea pig responded to chronic back pain caused by fractures to multiple thoracic vertebral spinous processes and subsequent vertebral luxation, with severe compulsive self-injurious behaviour. This resulted in a large, full thickness skin wound. Wound healing was managed with a combination of support dressings, multi-model analgesia and manual acupuncture. The underlying back pain was initially managed with manual acupuncture and multimodal analgesia, then subsequently successfully managed long term with non-steroidal anti-inflammatories and electroacupuncture.

scholarly journals Long-term Complications of Unintentional Dural Puncture During Labor Epidural Analgesia: A Case-Control Study.

2021 ◽  
Author(s):  
Alexandre Lacombe ◽  
Kristi Downey ◽  
Xiang Y. Ye ◽  
Jose C.A. Carvalho
Keyword(s):  
Back Pain ◽  
Epidural Analgesia ◽  
Epidural Catheter ◽  
Chronic Headache ◽  
Dural Puncture ◽  
Chronic Back Pain ◽  
Case Control ◽  
Auditory Impairment ◽  
Control Study

Introduction: Epidural analgesia is the preferred method to manage pain during labor and delivery. The insertion of the epidural catheter can be complicated by unintentional dural puncture that may result in postdural puncture headache. There is limited evidence on the long term implications of this complication. We sought to investigate if women who sustained a dural puncture have a higher risk of developing chronic headache, low back pain and visual or auditory impairment. Methods: We conducted a 1:1 case-control study with women who delivered at our institution from January 2015 to December 2019. Cases were women who received epidural analgesia and sustained an unintentional dural puncture and controls were women who received epidural analgesia but did not sustain such complication. We matched cases and controls for date of delivery, age, and BMI. All women completed an online survey with validated questionnaires for diagnosis of chronic headache and chronic back pain. We used dichotomic (yes/no) questions to look for the presence of chronic visual and auditory impairment. Results: Sixty-three case-control pairs were studied. Women who sustained a dural puncture during their epidural catheter insertion had a higher risk of developing chronic headache [14.3%, versus 4.8%, p=0.049, AOR: 3.36 (1.05, 12.82)] and chronic back pain [39.7% versus 19.1%, p=0.009, AOR: 2.67 (1.25, 5.72)] than women who did not sustain a dural puncture. The incidence of chronic auditory impairment was also higher in the dural puncture group [14.3% versus 1.6%, p=0.007, AOR: 9.98 (1.21, 82.62)]. Conclusions: An unintentional dural puncture during epidural catheter insertion in parturients is associated with increased risk of chronic headache, back pain and auditory impairment.

scholarly journals Necrotizing fasciitis caused by the treatment of chronic non-specific back pain

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lilit Floether ◽  
Michael Bucher ◽  
Ralf Benndorf ◽  
Anna-Maria Burgdorff
Keyword(s):  
Back Pain ◽  
Chronic Back Pain ◽  
Intrathecal Injection ◽  
Local Anaesthetics ◽  
Term Therapy ◽  
Negative Effects ◽  
Case Presentation ◽  
Long Term Therapy

Abstract Background Chronic back pain is a multifactorial disease that occurs particularly in adults and has many negative effects on the quality of daily life. Therapeutic strategies are often multimodal and designed for a long-term therapy period. In some cases, one option is joint infiltration or intrathecal injection with local anaesthetics. An adverse effect of this intervention may be necrotic fasciitis, a disease with high mortality and few therapeutic options. Case presentation This case shows a 53-year-old female patient who developed necrotic fasciitis after infiltrations of the sacroiliac joint and after epidural-sacral and intrathecal injections. Conclusion Thanks to early and aggressive surgical intervention, antibiotic treatment and hyperbaric oxygenation, she survived this serious complication and was able to return to life.

scholarly journals Pharmaceutical application of frog skin on full-thickness skin wound healing in mice

2013 ◽  
Vol 51 (12) ◽  
pp. 1600-1606 ◽  
Author(s):  
Mahere Rezazade Bazaz ◽  
Mohammad Mashreghi ◽  
Nasser Mahdavi Shahri ◽  
Mansour Mashreghi ◽  
Ahmad Asoodeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Frog Skin ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Pharmaceutical Application ◽  
Thickness Skin

scholarly journals Carbonic Anhydrase VI in Skin Wound Healing Study on Car6 Knockout Mice

2020 ◽  
Vol 21 (14) ◽  
pp. 5092
Author(s):  
Toini Pemmari ◽  
Jaakko Laakso ◽  
Maarit S. Patrikainen ◽  
Seppo Parkkila ◽  
Tero A. H. Järvinen
Keyword(s):  
Wound Healing ◽  
Knockout Mice ◽  
Wound Closure ◽  
Skin Wound ◽  
Carbonic Anhydrases ◽  
Skin Wound Healing ◽  
Tumor Cell Migration ◽  
Treatment Groups ◽  
Thickness Skin ◽  
Carbonic Anhydrase Vi

Carbonic anhydrases (CAs) contribute to tumor cell migration by generating an acidic environment through the conversion of carbon dioxide to bicarbonate and a proton. CA VI is secreted to milk and saliva, and it could contribute to wound closure, as a potential trophic factor, in animals that typically lick their wounds. Our aim was to investigate whether human CA VI improves skin-wound healing in full-thickness skin-wound models. The effect was studied in Car6 −/− knockout mice and wild type littermates. Half of both mice strains were given topically administered, milk-derived CA VI after wounding and eight hours later. The amount of topically given CA VI exceeded the predicted amount of natural saliva-delivered CA VI. The healing was followed for seven days and studied from photographs and histological sections. Our results showed no significant differences between the treatment groups in wound closure, re-epithelization, or granulation tissue formation, nor did the Car6 genotype affect the healing. Our results demonstrate that CA VI does not play a major role in skin-wound healing and also suggest that saliva-derived CA VI is not responsible for the licking-associated improved wound healing in animals.

scholarly journals Mimicking the Annulus Fibrosus Using Electrospun Polyester Blended Scaffolds

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 537 ◽  
Author(s):  
Alyah Shamsah ◽  
Sarah Cartmell ◽  
Stephen Richardson ◽  
Lucy Bosworth
Keyword(s):  
Back Pain ◽  
Annulus Fibrosus ◽  
Chronic Back Pain ◽  
Electrospun Fiber ◽  
Polymer Composition ◽  
Cell Phenotype ◽  
Intervertebral Disc Herniation ◽  
Chronic Lower Back Pain ◽  
Long Term Treatment

Treatments to alleviate chronic lower back pain, caused by intervertebral disc herniation as a consequence of degenerate annulus fibrosus (AF) tissue, fail to provide long-term relief and do not restore tissue structure or function. This study aims to mimic the architecture and mechanical environment of AF tissue using electrospun fiber scaffolds made from synthetic biopolymers-poly(ε-caprolactone) (PCL) and poly(L-lactic) acid (PLLA). Pure polymer and their blends (PCL%:PLLA%; 80:20, 50:50, and 20:80) are studied and material properties-fiber diameter, alignment, % crystallinity, tensile strength, and water contact angle-characterized. Tensile properties of fibers angled at 0°, 30°, and 60° (single layer scaffolds), and ±0°, ±30°, and ±60° (bilayer scaffolds) yield significant differences, with PCL being significantly stiffer with the addition of PLLA, and bilayer scaffolds considerably stronger. Findings suggest PCL:PLLA 50:50 fibers are similar to human AF properties. Furthermore, in vitro culture of AF cells on 50:50 fibers demonstrates attachment and proliferation over seven days. The optimal polymer composition for production of scaffolds that closely mimic AF tissue both structurally, mechanically, and which also support and guide favorable cell phenotype is identified. This study takes a step closer towards successful AF tissue engineering and a long-term treatment for sufferers of chronic back pain.

Skin Wound Healing: Some Biochemical Parameters in Guinea-pig

1993 ◽  
Vol 45 (9) ◽  
pp. 784-790 ◽  
Author(s):  
F. BUFFONI ◽  
G. BANCHELLI ◽  
S. CAMBI ◽  
G. IGNESTI ◽  
R. PIRISINO ◽  
...  
Keyword(s):  
Wound Healing ◽  
Guinea Pig ◽  
Biochemical Parameters ◽  
Skin Wound ◽  
Skin Wound Healing
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