Disseminated Histoplasmosis Due to Histoplasma capsulatum var. duboisii in a Non-HIV Patient in Togo: A Case Report

2018 ◽  
Vol 6 ◽  
pp. 1-4
Author(s):  
Bayaki Saka ◽  
◽  
Séfako Akakpo ◽  
Julienne Teclessou ◽  
Garba Mahamadou ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Disseminated Histoplasmosis

scholarly journals Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report

2006 ◽  
Vol 48 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Antonio Carlos F. do Valle ◽  
Luiz Carlos Moreira ◽  
Rodrigo Almeida-Paes ◽  
João S. Moreira ◽  
Cláudia V. Pizzini ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Systemic Disease ◽  
Signs And Symptoms ◽  
Histopathological Analysis ◽  
Alcoholic Patient ◽  
Oral Lesions ◽  
Disseminated Histoplasmosis ◽  
Immunodeficiency Virus ◽  
Hiv Negative

We report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.

scholarly journals Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult: A Case Report

2021 ◽  
pp. 1-2
Author(s):  
Henry Koiti Sato ◽  
◽  
Joel Fernando Sanabria Duarte ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Latin America ◽  
Case Report ◽  
Histoplasma Capsulatum ◽  
Clinical Presentation ◽  
Central Nervous System Infection ◽  
Immunocompetent Adult ◽  
Disseminated Histoplasmosis ◽  
The World

Histoplasma capsulatum infection is endemic in many regions around the world, including Latin America [1]. However, cerebral presentation occurs in less than 25% of patients with disseminated histoplasmosis and even rarer as a stand-alone presentation. Three forms are described: meningeal, miliary granulomatous and parenchymal with formation of “histoplasmoma” [2]. Due to the rarity of the case and unusual clinical presentation and topography we describe the case below.

scholarly journals Progressive disseminated histoplasmosis with pulmonary and central nervous system involvement: a case report

2021 ◽  
Author(s):  
Matheus Fellipe Nascimento de Souza ◽  
Ana Paula Teixeira da Silva ◽  
Gabriela Santos Bianchin ◽  
Maria Eduarda Angelo de Mendonça Fileti ◽  
Raddib Eduardo Noleto da Nóbrega de Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Systemic Disease ◽  
Central Nervous System Involvement ◽  
Tnf Alpha ◽  
Cns Involvement ◽  
Necrosis Factor Alpha ◽  
Adequate Treatment ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Context: Histoplasmosis (Histoplasma capsulatum) is a systemic disease that affects the lung and immune system1. The severity of histoplasmosis is directly related to the individual’s immune response since it is an opportunistic pathogen2. It is one of the most prevalent infections in immunocompromised patients due to the use of tumor necrosis factor-alpha (TNF-alpha) inhibitors, resulting in a mortality rate of 20%. The evolution to CNS occurs in 5-10% of patients with disseminated symptoms3. Case Report: M.G.M, a woman, 67 years, was admitted with bilateral tonicclonic seizure with focal onset in the right upper limb. The patient had hypertension, diabetes and rheumatoid arthritis, and was use ASA, glibenclamide, hydrochlorothiazide, losartan, amlodipine, adalimumab and methotrexate. Complementary exams were performed that showed lesions suggestive of microangiopathy on cranial CT; nodular lesions in the pulmonary right upper lobe and prominent lymph nodes in the hilum and mediastinum on chest CT; CSF with increased cytology (monomorphonuclear predominance), without glucose consumption. The biopsy of lung lesions identified Histoplasma capsulatum, confirming the diagnosis of progressive disseminated histoplasmosis with pulmonary and CNS involvement. Thus, treatment with amphotericin B was started, however, the patient died. Conclusions: Histoplasmosis is the most prevalent invasive fungal infection in users of TNF-alpha inhibitors. In these cases, the disease can be more aggressive and have a rapid evolution, with CNS involvement - which confers a worse prognosis. Early diagnosis, suspension of the immunomodulator and adequate treatment for infection control are required.

scholarly journals Disseminated histoplasmosis (Histoplasma capsulatum) in a pet rabbit: case report and review of the literature

2014 ◽  
Vol 26 (1) ◽  
pp. 158-162 ◽  
Author(s):  
João Brandão ◽  
Samantha Woods ◽  
Natalie Fowlkes ◽  
Mary Leissinger ◽  
Robert Blair ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Review Of The Literature ◽  
Disseminated Histoplasmosis

scholarly journals DISSEMINATED HISTOPLASMOSIS LEADING TO HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN AN IMMUNOCOMPETENT PATIENT

2020 ◽  
Vol 6 (1) ◽  
pp. 14-18
Author(s):  
I. D. Khan ◽  
M. Brijwal ◽  
I. Joshi ◽  
B. Singh ◽  
B. Poonia ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Plasma Cells ◽  
Fungal Infections ◽  
Unknown Origin ◽  
Immunocompetent Patient ◽  
Chronic Obstructive ◽  
Dimorphic Fungus ◽  
Diabetes Mellitus Type Ii ◽  
Disseminated Histoplasmosis

Background: Emerging fungal infections can pose a serious threat in contemporary healthcare due to host variations, clinical presentation and emerging resistance. Histoplasma capsulatum is a thermally dimorphic fungus, which acts as a Trojan horse by residing inside macrophages. Histoplasmosis is an emerging infection and its association with hemophagocytic lymphohistiocytosis (HLH) in immunocompetent patients has been scantily reported in the literature. Objective. The aim of the study was to explore disseminated histoplasmosis with the help of case report. Methods: A case report of histoid leprosy is presented. Results: A male patient of 47 yearsof age, under treatment for chronic obstructive pulmonary disease for five years and diabetes mellitus Type-II for two years, presented with fever of unknown origin (FUO) with evidence of HLH in the bone marrow. Core biopsy of the liver and spleen showed a dense tissue infiltrate with vacuolated histiocytes containing histoplasma capsulatum, eosinophils, some lymphocytes and plasma cells. Conclusion: Histoid leprosy is a discrete infrequent form of multibacillary leprosy with distinctive clinical, bacteriological and histomorphological features. Histopathologic examination with modified fite stain remains the mainstay of diagnosis.

Disseminated histoplasmosis caused by Histoplasma capsulatum var. duboisii in a non-HIV patient in Burkina Faso: Case report

2015 ◽  
Vol 25 (2) ◽  
pp. 159-162 ◽  
Author(s):  
A. Zida ◽  
P. Niamba ◽  
F. Barro-Traoré ◽  
N. Korsaga-Somé ◽  
P. Tapsoba ◽  
...  
Keyword(s):  
Case Report ◽  
Burkina Faso ◽  
Histoplasma Capsulatum ◽  
Disseminated Histoplasmosis

scholarly journals Disseminated histoplasmosis in an apparently immunocompetent individual from north India: a case report and review

2013 ◽  
Vol 51 (7) ◽  
pp. 774-778 ◽  
Author(s):  
Sushruta Kathuria ◽  
Malini Rajinder Capoor ◽  
Sachin Yadav ◽  
Avninder Singh ◽  
V. Ramesh
Keyword(s):  
Case Report ◽  
North India ◽  
Immunocompetent Individual ◽  
Disseminated Histoplasmosis

scholarly journals Disseminated Histoplasmosis in a 13-year-old girl: A case report

2013 ◽  
Vol 13 (2) ◽  
Author(s):  
AC Ubesie ◽  
OC Okafo ◽  
NS Ibeziako ◽  
VO Onukwuli ◽  
NR Mbanefo ◽  
...  
Keyword(s):  
Case Report ◽  
Disseminated Histoplasmosis

scholarly journals Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

2011 ◽  
Vol 44 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Vicente Sperb Antonello ◽  
Vanice Ferrazza Zaltron ◽  
Marcela Vial ◽  
Flávio Mattos de Oliveira ◽  
Luiz Carlos Severo
Keyword(s):  
Medical Records ◽  
Histoplasma Capsulatum ◽  
Systemic Mycosis ◽  
Database Analysis ◽  
Laboratory Findings ◽  
Active Pulmonary Tuberculosis ◽  
Disseminated Histoplasmosis ◽  
Amphotericin B Deoxycholate ◽  
One Year ◽  
Hiv Seropositive

INTRODUCTION: Histoplasmosis is a systemic mycosis endemic in Brazil, especially in the State of Rio Grande do Sul, where Histoplasma capsulatum was isolated from the soil. H. capsulatum may compromise unusual areas, including the oropharynx, particularly in patients presenting disseminated histoplasmosis; which is associated with a state of immunosuppression, such as AIDS. METHODS: During database analysis of a total of 265 cases of histoplasmosis, the medical records of 11 patients with histological or microbiological diagnoses of oral histoplasmosis (OH) between 1987 and 2008 were retrospectively reviewed. RESULTS: This work reports 11 cases of OH, the majority presenting histopathological or microbiological evidence of disseminated histoplasmosis (DH). In the patients with DH, OH was the first manifestation of histoplasmosis. Five of the 11 patients discussed were HIV-seropositive with clinical and laboratory findings of AIDS. Four patients presented active pulmonary tuberculosis concomitant with histoplasmosis. Treatment was based on the use of itraconazole and amphotericin B deoxycholate. Eight patients responded successfully to therapy after one year, two did not come back for reevaluation and one died despite adequate therapy. CONCLUSIONS: Oral histoplasmosis is closely associated with immunosuppression status, especially in patients presenting AIDS; moreover, in many cases, OH is the first sign of disseminated histoplasmosis.

Sign in / Sign up

Export Citation Format

Share Document