scholarly journals Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult: A Case Report

2021 ◽  
pp. 1-2
Author(s):  
Henry Koiti Sato ◽  
◽  
Joel Fernando Sanabria Duarte ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Latin America ◽  
Case Report ◽  
Histoplasma Capsulatum ◽  
Clinical Presentation ◽  
Central Nervous System Infection ◽  
Immunocompetent Adult ◽  
Disseminated Histoplasmosis ◽  
The World

Histoplasma capsulatum infection is endemic in many regions around the world, including Latin America [1]. However, cerebral presentation occurs in less than 25% of patients with disseminated histoplasmosis and even rarer as a stand-alone presentation. Three forms are described: meningeal, miliary granulomatous and parenchymal with formation of “histoplasmoma” [2]. Due to the rarity of the case and unusual clinical presentation and topography we describe the case below.

Central nervous system infection due toClostridium septicum: A case report and review of the literature

Infection ◽  
1997 ◽  
Vol 25 (3) ◽  
pp. 171-174 ◽  
Author(s):  
Y.-T. Cheng ◽  
C.-T. Huang ◽  
H.-S. Leu ◽  
J.-S. Chen ◽  
M.-C. Kiu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Central Nervous System Infection ◽  
Review Of The Literature

Acute Pancreatitis Following Organophosphate Compound Poisoning: A Case Report

2021 ◽  
Vol 1 (4) ◽  
pp. 250-252
Author(s):  
Suman K. Jha ◽  
Sabin Chaulagain ◽  
Shiva Kumar Ojha ◽  
Angela Basnet Neela Sunuwar ◽  
Akanchha Khadka
Keyword(s):  
Central Nervous System ◽  
Acute Pancreatitis ◽  
Nervous System ◽  
Case Report ◽  
Rural Communities ◽  
South Asian ◽  
Asian Countries ◽  
Organophosphate Compounds ◽  
The World ◽  
Agrarian Communities

Organophosphate compounds are chemicals containing central phosphate molecules with alkyl or aromatic substituent’s. They occur in diverse forms and are used as pesticides, herbicides, nerve agents, etc. Organophosphate compounds are frequently used as pesticides in agrarian communities all across the world. South Asian countries such as Nepal use vast quantities of Organophosphate compounds for pest control in agriculture. Therefore, accidental and suicidal ingestion of Organophosphate compound poisoning has been common especially among the agricultural rural communities. Apart from muscarinic, nicotinic and central nervous system effects in rare instances, Organophosphate compounds are known to cause pancreatitis.

scholarly journals Central Nervous System Infection with Histoplasma capsulatum

2019 ◽  
Vol 5 (3) ◽  
pp. 70 ◽  
Author(s):  
James Riddell ◽  
L. Joseph Wheat
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histoplasma Capsulatum ◽  
Central Nervous System Infection ◽  
Treatment Strategies ◽  
Multiple Organ ◽  
Filamentous Form ◽  
Disseminated Infection ◽  
Organ Systems ◽  
The Central Nervous System

Histoplasmosis is an endemic fungal infection that may affect both immune compromised and non-immune compromised individuals. It is now recognized that the geographic range of this organism is larger than previously understood, placing more people at risk. Infection with Histoplasma capsulatum may occur after inhalation of conidia that are aerosolized from the filamentous form of the organism in the environment. Clinical syndromes typically associated with histoplasmosis include acute or chronic pneumonia, chronic cavitary pulmonary infection, or mediastinal fibrosis or lymphadenitis. Disseminated infection can also occur, in which multiple organ systems are affected. In up to 10% of cases, infection of the central nervous system (CNS) with histoplasmosis may occur with or without disseminated infection. In this review, we discuss challenges related to the diagnosis of CNS histoplasmosis and appropriate treatment strategies that can lead to successful outcomes.

Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult

2020 ◽  
Author(s):  
Sérgio M. de Almeida ◽  
Elaine C. M. Imano ◽  
Vania A. Vicente ◽  
Renata R. Gomes ◽  
Ana P. Trentin ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Infection ◽  
Immunocompetent Adult

scholarly journals Histoplasmosis of the Central Nervous System: A Case Series between 1990 and 2019 in French Guiana

2021 ◽  
Author(s):  
Loïc Epelboin ◽  
Aïda Dione ◽  
Alexandra Serris ◽  
Denis Blanchet ◽  
Bastien Bidaud ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
French Guiana ◽  
Histoplasma Capsulatum ◽  
Fungal Infections ◽  
Case Series ◽  
Diagnostic Tools ◽  
Cns Involvement ◽  
European Organization ◽  
Disseminated Histoplasmosis

Disseminated histoplasmosis is the most frequent acquired immunodeficiency syndrome–defining illness in French Guiana. Paradoxically, central nervous system (CNS) involvement has been scarcely described. We aimed to identify CNS histoplasmosis in our territory. We conducted an observational, multicentric, descriptive, and retrospective study including patients with proven or probable CNS histoplasmosis according to the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MGS). The study population consisted of patients admitted in one of the hospitals of French Guiana between January 1, 1990 and December 31, 2019. During the study period, 390 cases of HIV-associated histoplasmosis were recorded, in which six of them had CNS infections with Histoplasma capsulatum. The male to female sex ratio was 0.25, and the median age at diagnosis was 37.5 years. The median CD4 count was 42 cells/mm3 ([IQR: 29–60]). All patients had disseminated histoplasmosis. Usual signs of meningitis were observed in three patients and focal signs in four patients. One patient had no neurological signs. The median time between the first cerebral symptoms and diagnosis was 22.4 days (IQR 9.5–36.2). Two patients died within a month after diagnosis. In conclusion, few proven CNS localizations of histoplasmosis were observed on 30-year study in French Guiana. This low proportion suggests that the documentation of CNS involvement is often not ascertained for lack of awareness of this particular presentation, and for lack of rapid and sensitive diagnostic tools.

scholarly journals COVID-19 induced encephalopathy – a Case Report

2020 ◽  
Author(s):  
Ramy Abdelnaby ◽  
Mohamed Elsayed ◽  
Francis Abele-Haupts ◽  
Mehmet E. Barkin ◽  
Markus A. Rudek ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Global Health ◽  
Health Problem ◽  
Clinical Presentation ◽  
Silent Period ◽  
Global Health Problem

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called coronavirus disease 2019 (COVID-19), first appeared in December 2019 in Wuhan, China. It has rapidly spread to multiple countries and has become a global health problem. The effects of COVID-19 on the CNS (Central Nervous System) are reported in low but increasing numbers. We report a case of COVID-19-induced encephalopathy with a biphasic clinical presentation only after a neurologically silent period.

scholarly journals Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Histoplasma capsulatum Bacteremia in Probable Neurosarcoidosis

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Peter V. Bui
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histoplasma Capsulatum ◽  
Fungal Infections ◽  
Immunosuppressive Agents ◽  
Barrier Dysfunction ◽  
Diagnostic Uncertainty ◽  
Disseminated Histoplasmosis ◽  
History Of ◽  
The Central Nervous System

Introduction. Neurosarcoidosis, either isolated or as part of systemic sarcoidosis, is an uncommon entity and has diagnostic uncertainty. Treatment for neurosarcoidosis can increase the risk of infections, including fungal infections such as disseminated histoplasmosis. Neurosarcoidosis may further predispose patients to infections of the central nervous system. Case Presentation. A 54-year-old male with a history of probable neurosarcoidosis on methotrexate and infliximab presented with encephalopathy, hypoxia, and reported fevers. The patient was found to have disseminated histoplasmosis involving the lungs (miliary histoplasmosis), central nervous system (neurohistoplasmosis), and bloodstream. The Histoplasma capsulatum infection was treated with amphotericin and then voriconazole. Discussion. Patients with neurosarcoidosis are suspected to have blood-brain barrier dysfunction. Lumbar puncture should be considered as part of initial investigative studies for infection. Empiric antimicrobial therapy for a patient with neurosarcoidosis on immunosuppressive agents may need to include antifungal agents.

Histoplasmoma: Isolated central nervous system infection with Histoplasma capsulatum in a patient with AIDS

2007 ◽  
Vol 109 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Omeed Azizirad ◽  
David B. Clifford ◽  
Richard K. Groger ◽  
David Prelutsky ◽  
Robert E. Schmidt
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histoplasma Capsulatum ◽  
Central Nervous System Infection
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