scholarly journals Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report

2006 ◽  
Vol 48 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Antonio Carlos F. do Valle ◽  
Luiz Carlos Moreira ◽  
Rodrigo Almeida-Paes ◽  
João S. Moreira ◽  
Cláudia V. Pizzini ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Systemic Disease ◽  
Signs And Symptoms ◽  
Histopathological Analysis ◽  
Alcoholic Patient ◽  
Oral Lesions ◽  
Disseminated Histoplasmosis ◽  
Immunodeficiency Virus ◽  
Hiv Negative

We report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.

scholarly journals Progressive disseminated histoplasmosis with pulmonary and central nervous system involvement: a case report

2021 ◽  
Author(s):  
Matheus Fellipe Nascimento de Souza ◽  
Ana Paula Teixeira da Silva ◽  
Gabriela Santos Bianchin ◽  
Maria Eduarda Angelo de Mendonça Fileti ◽  
Raddib Eduardo Noleto da Nóbrega de Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Systemic Disease ◽  
Central Nervous System Involvement ◽  
Tnf Alpha ◽  
Cns Involvement ◽  
Necrosis Factor Alpha ◽  
Adequate Treatment ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Context: Histoplasmosis (Histoplasma capsulatum) is a systemic disease that affects the lung and immune system1. The severity of histoplasmosis is directly related to the individual’s immune response since it is an opportunistic pathogen2. It is one of the most prevalent infections in immunocompromised patients due to the use of tumor necrosis factor-alpha (TNF-alpha) inhibitors, resulting in a mortality rate of 20%. The evolution to CNS occurs in 5-10% of patients with disseminated symptoms3. Case Report: M.G.M, a woman, 67 years, was admitted with bilateral tonicclonic seizure with focal onset in the right upper limb. The patient had hypertension, diabetes and rheumatoid arthritis, and was use ASA, glibenclamide, hydrochlorothiazide, losartan, amlodipine, adalimumab and methotrexate. Complementary exams were performed that showed lesions suggestive of microangiopathy on cranial CT; nodular lesions in the pulmonary right upper lobe and prominent lymph nodes in the hilum and mediastinum on chest CT; CSF with increased cytology (monomorphonuclear predominance), without glucose consumption. The biopsy of lung lesions identified Histoplasma capsulatum, confirming the diagnosis of progressive disseminated histoplasmosis with pulmonary and CNS involvement. Thus, treatment with amphotericin B was started, however, the patient died. Conclusions: Histoplasmosis is the most prevalent invasive fungal infection in users of TNF-alpha inhibitors. In these cases, the disease can be more aggressive and have a rapid evolution, with CNS involvement - which confers a worse prognosis. Early diagnosis, suspension of the immunomodulator and adequate treatment for infection control are required.

Disseminated Histoplasmosis Due to Histoplasma capsulatum var. duboisii in a Non-HIV Patient in Togo: A Case Report

2018 ◽  
Vol 6 ◽  
pp. 1-4
Author(s):  
Bayaki Saka ◽  
◽  
Séfako Akakpo ◽  
Julienne Teclessou ◽  
Garba Mahamadou ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Disseminated Histoplasmosis

scholarly journals Tratamento cirúrgico de cisto periapical inflamatório de grande extensão em maxila: relato de caso Surgical treatment of large extension inflammatory periapical cyst in maxilla: a case report

RSBO ◽  
2019 ◽  
Vol 16 (1) ◽  
pp. 68
Author(s):  
Jaiane Aparecida Ribas Pereira ◽  
Kassiane Caciatori Garcia ◽  
Thalyta Verbicaro ◽  
Michele Nascimento Meger ◽  
Paola Fernanda Cotait de Lucas Corso ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Saline Solution ◽  
Buccal Cavity ◽  
Signs And Symptoms ◽  
Histopathological Analysis ◽  
Cystic Lesions ◽  
Anatomical Structures ◽  
Good Healing ◽  
Periapical Cyst

Introduction: Periapical cysts are the most frequent odontogenic cystic lesions, commonly asymptomatic and discovered in routine dental examinations. The treatment may vary according to the size of the cyst. Objective: The objective of this study is to report the diagnosis and treatment of a large periapical inflammatory cyst in the maxilla. Case report: Patient A.B., 38 years old, male with major complaint of pain in the left maxilla region, facial asymmetrywith increased volume in the zygomatic bone region. After the intrabuccal and radiographic examinations, a lesion with a dimension of approximately 6.5 cm was observed, extending throughout the of the upper left side, with well-defined extension. It was performed the extraction of the affected teeth, collection of the biological material for histopathological analysis and installation of a drain for decompression maintained in the buccal cavity for 6 months with periodic irrigations with saline solution. After regression of the lesion, enucleation and curettage were performed. After 36 months following-up it is possible to observe absence of signs and symptoms of lesion recurrence, with good healing and bone neoformation. Conclusion: Decompression followed by enucleation forthe treatment of periapical inflammatory cyst should be considered as a treatment option because it minimizes damage to adjacent anatomical structures.

scholarly journals Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult: A Case Report

2021 ◽  
pp. 1-2
Author(s):  
Henry Koiti Sato ◽  
◽  
Joel Fernando Sanabria Duarte ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Latin America ◽  
Case Report ◽  
Histoplasma Capsulatum ◽  
Clinical Presentation ◽  
Central Nervous System Infection ◽  
Immunocompetent Adult ◽  
Disseminated Histoplasmosis ◽  
The World

Histoplasma capsulatum infection is endemic in many regions around the world, including Latin America [1]. However, cerebral presentation occurs in less than 25% of patients with disseminated histoplasmosis and even rarer as a stand-alone presentation. Three forms are described: meningeal, miliary granulomatous and parenchymal with formation of “histoplasmoma” [2]. Due to the rarity of the case and unusual clinical presentation and topography we describe the case below.

scholarly journals Condyloma Latum on the Lower Lip as an Isolated Manifestation of Secondary Syphilis – a Case Report

2016 ◽  
Vol 8 (1) ◽  
pp. 45-50
Author(s):  
Milan Bjekić ◽  
Kiro Ivanovski
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
World Literature ◽  
Systemic Disease ◽  
Secondary Syphilis ◽  
The Body ◽  
Oral Lesions ◽  
Lower Lip ◽  
Secondary Stage ◽  
History Of

Abstract Oral lesions are described in all stages of syphilis, except in the latent stage. During the secondary stage of infection, oral lesions, saliva and blood of infected person are very contagious. The aim of this case report was to point to the secondary syphilis in differential diagnosis of oral diseases. A 30-year-old homosexual man presented with a three-week history of a painless verrucous lesion on his lower lip. Physical examination revealed a hypertrophic painless papillomatous lesion on the lower lip. The lesion was partly split with peripheral fissures. There were no generalized lymphadenopathies and no evidence of systemic disease. Further examination showed no other mucous membrane or cutaneous lesions elsewhere on the body. The external genitalia were normal. The patient was HIV-negative and otherwise healthy. A review of his medical history was significant for previous well documented treatment of anal chancre, which was successfully commenced at our Institute in 2010. It also revealed a history of a single unprotected receptive oral sex with an unknown partner 3 months before the onset of lesion. The diagnosis of condyloma latum on the lower lip was considered on clinical grounds. Laboratory findings, including complete blood count and blood chemistry were within normal limits. The VDRL (venereal disease research laboratory) test was positive with a titre of 1 : 128. Treponema pallidum hemagglutination assay (TPHA) was positive. HIV serology was non-reactive. The final diagnosis of solitary condyloma latum on the lower lip, as the only sign of secondary syphilis, was confirmed by positive results of routine serologic tests for syphilis. The patient was diagnosed with secondary syphilis and treated with a single intramuscular injection of benzathine penicillin, 2.4 million units. The lesion regressed completely within 2 weeks. Three months later the VDRL titer had fallen to 1 : 8 and HIV serology remained negative. Polymorphic oral manifestations in syphilis indicate that this disease should not be overlooked in the differential diagnosis of not only benign, but even malignant oral lesions. In conclusion, as far as the world literature available to us is concerned, this would be the first report of isolated solitary condyloma latum on the oral lip that, in the absence of any other clinical signs or symptoms of the disease, led to the diagnosis of secondary syphilis.

scholarly journals Cryptococcosis in captive cheetah (Acinonyx jubatus) : two cases : case report

1999 ◽  
Vol 70 (1) ◽  
Author(s):  
L.A. Bolton ◽  
R.G. Lobetti ◽  
D.N. Evezard ◽  
J.A. Picard ◽  
J.W. Nesbit ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Case Report ◽  
Cryptococcus Neoformans ◽  
Feline Immunodeficiency Virus ◽  
Systemic Disease ◽  
Central Nervous System Involvement ◽  
Leukaemia Virus ◽  
Acinonyx Jubatus ◽  
Immunodeficiency Virus ◽  
Feline Leukaemia Virus

Cryptococcus neoformans is a yeast-like organism associated with pulmonary, meningoencephalitic, or systemic disease. This case report documents 2 cases of cryptococcosis with central nervous system involvement in captive cheetah (Acinonyx jubatus). In both cases the predominant post mortal lesions were pulmonary cryptococcomas and extensive meningoencephalomyelitis. Both cheetahs tested negative for feline immunodeficiency virus and feline leukaemia virus. The organism isolated in Case 2 was classified as Cryptococcus neoformans var. gattii, which is mainly associated with disease in immunocompetent hosts.

scholarly journals Disseminated histoplasmosis (Histoplasma capsulatum) in a pet rabbit: case report and review of the literature

2014 ◽  
Vol 26 (1) ◽  
pp. 158-162 ◽  
Author(s):  
João Brandão ◽  
Samantha Woods ◽  
Natalie Fowlkes ◽  
Mary Leissinger ◽  
Robert Blair ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Review Of The Literature ◽  
Disseminated Histoplasmosis

scholarly journals ORAL INJURIES IN A PATIENTE WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION: A CASE REPORT

2019 ◽  
Vol 7 (8) ◽  
pp. 1-8
Author(s):  
Talita Alves De Souza ◽  
Thamires Rodrigues Guedes ◽  
Érica Da Silva Carvalho ◽  
Ângela Xavier Monteiro ◽  
Tirza Almeida Da Silva ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Immune System ◽  
Hiv Infection ◽  
Disease Progression ◽  
Antiretroviral Treatment ◽  
Oral Lesions ◽  
Keywords Hiv ◽  
Immunodeficiency Virus ◽  
Hiv Aids

The first cases of Acquired Immunodeficiency Syndrome (AIDS) were reported in 1981 in patients with a high decline in immune response. Human immunodeficiency virus (HIV) infection can manifest itself through various signs and symptoms. The oral cavity is an extremely important way for diagnosis and prognosis, because oral lesions may present as clinical signs of disease progression or ineffective antiretroviral treatment. The objective of this study was to evaluate, diagnose and intervene in the oral lesions present in a patient with HIV infection. A case report study was conducted on a patient treated at the Dr. Antônio Comte Telles Polyclinic (Specialized Assistance Service for HIV / AIDS) in Manaus, Amazonas, Brazil. Lesions found in the patient were Leukemia, Smoker's Melanosis and Oral Candidiasis, the latter being treated with tongue hygiene and application of VegelipR associated with laser therapy. It was observed that the treatment was effective and in five sessions there was improvement in the lesion. Oral manifestations are closely related to the HIV virus, since they may be associated with infection and / or disease progression, indicating deficiency in the immune system, as well as interruption of antiretroviral treatment. Candidiasis is an opportunistic infection that, if properly diagnosed and treated, contributes to the improvement of the immune system. It is concluded that the knowledge of the dentist regarding the pathologies and their manifestations is important, as well as a multidisciplinary work in the reference centers for HIV.  Keywords: HIV, AIDS, Oral Injury, Dentistry.

scholarly journals DISSEMINATED HISTOPLASMOSIS LEADING TO HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN AN IMMUNOCOMPETENT PATIENT

2020 ◽  
Vol 6 (1) ◽  
pp. 14-18
Author(s):  
I. D. Khan ◽  
M. Brijwal ◽  
I. Joshi ◽  
B. Singh ◽  
B. Poonia ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Plasma Cells ◽  
Fungal Infections ◽  
Unknown Origin ◽  
Immunocompetent Patient ◽  
Chronic Obstructive ◽  
Dimorphic Fungus ◽  
Diabetes Mellitus Type Ii ◽  
Disseminated Histoplasmosis

Background: Emerging fungal infections can pose a serious threat in contemporary healthcare due to host variations, clinical presentation and emerging resistance. Histoplasma capsulatum is a thermally dimorphic fungus, which acts as a Trojan horse by residing inside macrophages. Histoplasmosis is an emerging infection and its association with hemophagocytic lymphohistiocytosis (HLH) in immunocompetent patients has been scantily reported in the literature. Objective. The aim of the study was to explore disseminated histoplasmosis with the help of case report. Methods: A case report of histoid leprosy is presented. Results: A male patient of 47 yearsof age, under treatment for chronic obstructive pulmonary disease for five years and diabetes mellitus Type-II for two years, presented with fever of unknown origin (FUO) with evidence of HLH in the bone marrow. Core biopsy of the liver and spleen showed a dense tissue infiltrate with vacuolated histiocytes containing histoplasma capsulatum, eosinophils, some lymphocytes and plasma cells. Conclusion: Histoid leprosy is a discrete infrequent form of multibacillary leprosy with distinctive clinical, bacteriological and histomorphological features. Histopathologic examination with modified fite stain remains the mainstay of diagnosis.

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