The pathogenetic role of pro- and anti- inflammatory cytokines in developing of diabetic myopathy in children

Inflammation plays a key role in the initiation, progression, and clinical manifestation of atherosclerosis. Cigarette smoking is a risk factor for atherosclerosis and cardiovascular disease. The aim of the current study was to investigate the serum concentrations of 12 cytokines and growth factors (EGF, INF-γ, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1, TNF-α, and VEGF) in an Iranian population, including 192 smokers, comparing these values with concentrations in nonsmokers. One hundred and ninety-two cases were enrolled from the Mashhad University of Medical Sciences. Of these cases, 82 were cigarette smokers and 110 were nonsmokers. Sex and age were matched for the two groups. The serum concentration of 12 cytokines and growth factors were determined using EV-3513-cytokine-biochip arrays, by competitive chemiluminescence immunoassays. The level of serum MCP-1 was significantly ( p < .001) lower in the female group of cigarette smokers (mean = 88.1 dL/ng), compared with nonsmokers (mean = 155.6 dL/ng). There were no significant differences for the other cytokines and growth factors between the groups. Our finding demonstrate the association of MCP-1 with cigarette smoking, supporting further studies in larger population on evaluating the role of cigarette smoking on pro-/anti-inflammatory cytokines.

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Abstract 553: Siglec-1 (CD169) on Monocytes/Macrophages: A New Receptor For Extracellular Self-RNA in Triggering Inflammatory Responses via the Sheddase TACE/ADAM17

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.35.suppl_1.553 ◽

2015 ◽

Vol 35 (suppl_1) ◽

Author(s):

Hector A Cabrera-Fuentes ◽

Klaus T Preissner ◽

William A Boisvert

Keyword(s):

Inflammatory Cytokines ◽

Inflammatory Responses ◽

Transmembrane Protein ◽

Macrophage Polarization ◽

Extracellular Rna ◽

Tnf Α ◽

M1 Phenotype ◽

Phenotype Markers ◽

Anti Inflammatory

As an important component of atherosclerosis, monocytes/macrophages respond to external stimuli with rapid changes in their expression of many inflammation-related genes to undergo polarization towards the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype. Although sialoadhesin (Sn), also known as SIGLEC-1 or CD169, is a transmembrane protein receptor expressed on monocytes and macrophages whether it has a role in macrophage polarization and ultimately, macrophage-driven atherogenesis, has not been investigated. We have previously shown that, independently of Toll-like receptor signaling, extracellular RNA (eRNA) could exert pro-thrombotic and pro-inflammatory properties in the cardiovascular system by inducing cytokine mobilization. In the current study, recombinant mouse macrophage CSF[[Unable to Display Character: –]]driven bone marrow-derived macrophage (BMDM) differentiation was found to be skewed towards the M1 phenotype by exposure of cells to eRNA. This resulted in up-regulation of inflammatory markers, whereas anti-inflammatory genes were significantly down-regulated by eRNA. Interestingly, eRNA was released from BMDM under hypoxia and induced TNF-α liberation by activating TNF-α converting enzyme (TACE) to provoke inflammation. Conversely, TNF-α promoted eRNA release, especially under hypoxia, feeding a vicious cycle of cell damage. Administration of RNase1 or TAPI (a TACE-inhibitor) prevented the production of inflammatory mediators. Murine BMDM isolated from mice deficient in sialoadhesin had the opposite reaction to eRNA treatment with a prominent down-regulation of pro-inflammatory cytokines/M1 phenotype markers, while anti-inflammatory cytokines/M2 phenotype markers were significantly raised. In keeping with the proposed role of eRNA as a pro-inflammatory “alarm signal”, these data further shed light on the role of eRNA in macrophage function in the context of chronic inflammatory diseases such as atherosclerosis. The identification of sialoadhesin as putative eRNA recognition site on macrophages may allow further investigation of the underlying mechanisms of eRNA-macrophage interaction and related signal transduction pathways. Siglec-1 thereby may provides a new target to treat eRNA-mediated vascular diseases.

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In Inflamation Dietary Inflammatory Index and the Role of Different Diet Types

Role of Nutrition in Providing Pro-/Anti-Inflammatory Balance - Advances in Medical Diagnosis, Treatment, and Care ◽

10.4018/978-1-7998-3594-3.ch007 ◽

2020 ◽

pp. 169-201

Author(s):

Ramazan Mert Atan ◽

Uğur Günşen

Keyword(s):

Chronic Diseases ◽

Inflammatory Cytokines ◽

Scientific Evidence ◽

Inflammatory Biomarkers ◽

Dietary Inflammatory Index ◽

Food Groups ◽

Negative Effects ◽

Inflammatory Index ◽

Anti Inflammatory

Inflammation usually occurs as a result of imbalances between pro-inflammatory and anti-inflammatory cytokines. Diet is one of the factors that play a role in their development and prevent them from developing. Therefore, it is important to determine the pro- and anti-inflammatory properties of foods. Diet is an important and modifiable determinant of chronic diseases. There is a lot of scientific evidence to support the fact that foods consumed have positive and negative effects on individuals' health. In addition to being effective whole of diet, it is seen that the food groups contained in the diet affect the inflammatory biomarkers separately. This section provides information about dietary inflammatory index (DII) and diets that are effective on inflammation.

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The role of β-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-κB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients

Immunopharmacology and Immunotoxicology ◽

10.1080/08923973.2020.1742734 ◽

2020 ◽

Vol 42 (3) ◽

pp. 228-236 ◽

Cited By ~ 1

Author(s):

Seyed Shahabeddin Mortazavi-Jahromi ◽

Arman Ahmadzadeh ◽

Zahra Rezaieyazdi ◽

Mona Aslani ◽

Saiedeh Omidian ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Trial ◽

Inflammatory Cytokines ◽

Inflammatory Drug ◽

Mannuronic Acid ◽

Anti Inflammatory ◽

Pro Inflammatory Cytokines

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Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy

Clinical and Developmental Immunology ◽

10.1155/2007/76396 ◽

2007 ◽

Vol 2007 ◽

pp. 1-6 ◽

Cited By ~ 160

Author(s):

Levent Sutcigil ◽

Cagatay Oktenli ◽

Ugur Musabak ◽

Ali Bozkurt ◽

Adnan Cansever ◽

...

Keyword(s):

Major Depression ◽

Inflammatory Cytokines ◽

Antidepressant Treatment ◽

Depression Effect ◽

Immunomodulatory Effects ◽

Cytokine Balance ◽

Anti Inflammatory ◽

Time Of Admission ◽

Anti Inflammatory Cytokine

The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF-α, TGF-β1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF-α) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF-β1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF-β1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment.

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Anti-Inflammatory Cytokines: Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis

Chemotherapy Research and Practice ◽

10.1155/2012/490804 ◽

2012 ◽

Vol 2012 ◽

pp. 1-11 ◽

Cited By ~ 27

Author(s):

Masooma Sultani ◽

Andrea M. Stringer ◽

Joanne M. Bowen ◽

Rachel J. Gibson

Keyword(s):

Inflammatory Cytokines ◽

Proinflammatory Cytokines ◽

Molecular Mechanisms ◽

Tissue Injury ◽

Financial Burden ◽

Interleukin 1 ◽

Treatment Strategies ◽

Inflammatory Reactions ◽

Anti Inflammatory

“Mucositis” is the clinical term used to describe ulceration and damage of the mucous membranes of the entire gastrointestinal tract (GIT) following cytotoxic cancer chemotherapy and radiation therapy common symptoms include abdominal pain, bloating, diarrhoea, vomiting, and constipation resulting in both a significant clinical and financial burden. Chemotherapeutic drugs cause upregulation of stress response genes including NFκB, that in turn upregulate the production of proinflammatory cytokines such as interleukin-1β (IL-1β), Interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α). These proinflammatory cytokines are responsible for initiating inflammation in response to tissue injury. Anti-inflammatory cytokines and specific cytokine inhibitors are also released to limit the sustained or excessive inflammatory reactions. In the past decade, intensive research has determined the role of proinflammatory cytokines in development of mucositis. However, a large gap remains in the knowledge of the role of anti-inflammatory cytokines in the setting of chemotherapy-induced mucositis. This critical paper will highlight current literature available relating to what is known regarding the development of mucositis, including the molecular mechanisms involved in inducing inflammation particularly with respect to the role of proinflammatory cytokines, as well as provide a detailed discussion of why it is essential to consider extensive research in the role of anti-inflammatory cytokines in chemotherapy-induced mucositis so that effective targeted treatment strategies can be developed.

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