Wound-Healing Property of Momordica charantia L. Fruit Powder

The aim of the present study was to explore the effect of wound healing activity of the whole plant of Momordica charantia Linn. in rats. The effect of aqueous ethanolic extract of Momordica charantia Linn. (Family; Cucurbetaceae) was evaluated on resutured incision, granuloma pouch and excision wound models in rats. The wound healing activity was measured by the rate of wound contraction, skin breaking strength, weight of the granulation tissue, and collagen content. The concentrated ethyl alcohol extract was subject to fractionation by using petroleum ether (40-60o V/V), solvent ether, ethyl acetate, butanol, butanone, ethanol and methanol in succession. All the fractions were screened for wound healing property. The results of pharmacological activity led to the conclusion that the petroleum ether fraction exhibited more significant wound healing promotion property followed by solvent ether and butanone, from all the parameters studied. Ethyl acetate, ethanol and methanol fractions were least effective.

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Functional characterisation of bioactive peptide derived from terrestrial snailCryptozona bistrialisand its wound-healing property in normal and diabetic-induced Wistar albino rats

International Wound Journal ◽

10.1111/iwj.12872 ◽

2018 ◽

Vol 15 (3) ◽

pp. 350-362 ◽

Cited By ~ 3

Author(s):

Selvakumari Ulagesan ◽

Kamatchi Sankaranarayanan ◽

Amutha Kuppusamy

Keyword(s):

Wound Healing ◽

Bioactive Peptide ◽

Albino Rats ◽

Functional Characterisation ◽

Healing Property ◽

Wistar Albino Rats ◽

Wound Healing Property

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Wound healing property of isolated compounds from Boesenbergia kingii rhizomes

Journal of Ethnopharmacology ◽

10.1016/j.jep.2016.03.001 ◽

2016 ◽

Vol 184 ◽

pp. 42-48 ◽

Cited By ~ 10

Author(s):

Teeratad Sudsai ◽

Chatchai Wattanapiromsakul ◽

Supinya Tewtrakul

Keyword(s):

Wound Healing ◽

Healing Property ◽

Wound Healing Property

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Characterization and Applications of Leaf Extracts of Hemigraphis Alternate

International Journal of Engineering and Advanced Technology - Regular Issue ◽

10.35940/ijeat.a1020.1291s619 ◽

2019 ◽

Vol 9 (1S6) ◽

pp. 108-114

Keyword(s):

Wound Healing ◽

Crude Extract ◽

Leaf Extract ◽

Cellular Migration ◽

Leaf Extracts ◽

Ic50 Value ◽

The Gift ◽

Healing Property ◽

Low Cytotoxicity ◽

Wound Healing Property

Natural products carry out various capabilities and a lot of them have thrilling and useful organic activities. The gift take a look at turned into undertaken to analyze the bioactive compounds and the pharmacological capacity of leaf extract of Hemigraphis alternata. The presence of numerous compounds become characterized by way of FTIR and GCMS. ROS effect and wound recuperation assets have been analyzed and it discovered that crude extract is greater powerful inhibiting ROS manufacturing and it has high wound healing property with properly cellular migration in dose based way. The cytotoxic nature of leaf extract also analyzed with the aid of MTT assay and it suggests low IC50 value of 329.95 µG/ml. The result discovered that the crude extract of H.Alternata leaf is a great wound healer with low cytotoxicity.

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Wound healing effect of different extracts of Centaurea pterocaula

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v14i1.38444 ◽

2019 ◽

Vol 14 (1) ◽

pp. 9-16 ◽

Cited By ~ 1

Author(s):

Barış Ötün ◽

Ufuk Mercan Yücel

Keyword(s):

Wound Healing ◽

Healing Process ◽

Punch Biopsy ◽

Pathological Examination ◽

Positive Contribution ◽

Healing Property ◽

Wound Healing Effect ◽

New Drug Development ◽

Ethyl Acetate Extracts ◽

Wound Healing Property

In this study, the effect of different extracts of Centaurea pterocaula were evaluated on 6 mm wound created by punch biopsy on the rat back. The leaves of the plant were powdered and extracted with distilled water, methanol, n-hexane and ethyl acetate. Extracts were obtained in the form of pomade with vaseline and applied topically to the wounds. The wound measurements performed on day 0, 2, 4, 6, 8, 10 and 12 and the histo-pathological examination performed on day 12. The n-hexane extract had an accelerating effect on wound healing and made a positive contribution to the healing process. In conclusion, C. pterocaula has a promising future for new drug development studies by its wound healing property.

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IN VITRO WOUND HEALING AND ANTIMICROBIAL PROPERTY OF COTTON FABRICS COATED OPTIMIZED SILVER NANOPARTICLES SYNTHESIZED USING PELTOPHORUM PTEROCARPUM LEAF EXTRACTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i18.33483 ◽

2019 ◽

pp. 216-222

Author(s):

ANNAMALAI P ◽

BALASHANMUGAM P ◽

KALAICHELVAN PT

Keyword(s):

Wound Healing ◽

Silver Nanoparticles ◽

Incubation Temperature ◽

Cotton Fabrics ◽

Diffusion Method ◽

Leaf Extracts ◽

Potential Measurement ◽

Healing Property ◽

Wound Healing Activity ◽

Wound Healing Property

Objective: The present study was aimed to study at investigating the antibacterial potential of silver nanoparticles (AgNPs) coated cotton fabrics against different pathogens and also for their wound healing property using fibroblasts cells. Materials and Methods: The leaf extracts of Peltophorum pterocarpum were used for the synthesis of AgNPs and were characterizing using ultraviolet-visible spectrophotometer, transmission electron microscopy, energy dispersive X-ray (EDX) spectroscopy, dynamic light scattering analysis, and zeta potential measurement. The AgNPs were coated on cotton fabrics and tested for their antibacterial efficacy using agar well diffusion method. The wound healing property of synthesized AgNPs was tested using fibroblast 3T3 cells. Results: The plant extracts of P. pterocarpum were utilized for AgNPs. The optimum condition for synthesizing AgNPs was found to be 1 mg/ml plant concentration, 7 pH, 1 mM silver nitrate concatenation, and incubation temperature of 37°C. The shape of synthesized AgNPs was found to be spherical with an average size between 20 and 50 nm, and elemental silver peaks were confirmed by EDX spectrum. The cotton fabrics coated with AgNPs show good zone of inhibition against all the tested pathogens and the treated fabrics were also characterized using scanning electron microscope which reveals the presence of AgNPs on the fabrics. The scratch assay reveals that the AgNPs have good wound healing activity when tested against fibroblast 3T3. Conclusion: The present results conclude that the synthesized AgNPs have good stability with potent antimicrobial activity when coated with cotton fabrics. The AgNPs also found to have good activity significant wound healing activity when tested using fibroblast cells.

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