scholarly journals Functional characterisation of bioactive peptide derived from terrestrial snailCryptozona bistrialisand its wound-healing property in normal and diabetic-induced Wistar albino rats

2018 ◽  
Vol 15 (3) ◽  
pp. 350-362 ◽  
Author(s):  
Selvakumari Ulagesan ◽  
Kamatchi Sankaranarayanan ◽  
Amutha Kuppusamy
Keyword(s):  
Wound Healing ◽  
Bioactive Peptide ◽  
Albino Rats ◽  
Functional Characterisation ◽  
Healing Property ◽  
Wistar Albino Rats ◽  
Wound Healing Property

scholarly journals Evaluation of wound healing activity of Hibiscus rosa sinensis linn in albino rats

2019 ◽  
Vol 8 (6) ◽  
pp. 1303
Author(s):  
Monil Yogesh Neena Gala ◽  
Swanand S. Pathak
Keyword(s):  
Wound Healing ◽  
Wistar Rat ◽  
Poverty Line ◽  
Control Group ◽  
Albino Rats ◽  
Flower Extract ◽  
Wound Model ◽  
Hibiscus Rosa Sinensis ◽  
Healing Property ◽  
Wound Healing Property

Background: From debridement to the appearance of healthy granulation tissue is the maximum time during which the patient suffers more economically and psychologically. Due to high cost expenditure in hospitalisation, dressing material cost and loss of daily earnings during this period which puts a psychological pressure over patient and family especially in India where majority of the population is still below poverty line. Also access to quick treatment is yet not possible to majority of population living in rural with no access to basic healthcare.Methods: It was an experimental study wherein Wistar rat models were used to check for the wound healing property of Hibiscus Rosa Sinensis (HRS) compared with one of the common standard drugs of treatment for available today, betadine. To observe the wound healing property of the HRS flower extract, the experiment was divided into 2 parts i.e. excision wound model and incision wound model. The groups were treated with respective medication along with a control group of rats.Results: At the end of the experiment, it was observed that HRS flower extract increased the wound breaking strength as compared to control but not as effectively as compared to the betadine ointment.Conclusions: HRS flower extract helps in early epithelization and helps in decreasing the wound size. Betadine is associated with adverse events like life threatening allergic reactions, water retention, etc.

Wound Healing Potential of Polyherbal Formulation in Rats

2021 ◽  
pp. 2195-2199
Author(s):  
Rohit Kumar ◽  
Reena Gupta ◽  
Bimlesh Kumar ◽  
Bhupinder Kapoor
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Albino Rats ◽  
Wound Infections ◽  
Burn Wound ◽  
Polyherbal Formulation ◽  
Medicinal Plant Extracts ◽  
Healing Property ◽  
Wistar Albino Rats ◽  
Conventional Antibiotics

Chronic wound infections are significant medical burden as the patients have to go through severe discomfort and distress. Invasion of various pathogenic microorganisms at the injured site further leads to damage of tissue which may results in resection of the organ. Appropriate wound healing is necessary to regain the functional and anatomical status of the damaged tissue that got disturbed due to wound. Conventional antibiotics used for the treatment of infections are associated with various drawbacks such as high cost and high incidence of resistance. Moreover, the dressing used for wounds are also unable to provide adequate moisture to the injured tissue. All these factors emphasise on the development of new advanced technologies for wound care. Polyherbal formulations, which comprise of various medicinal plant extracts, exhibit antioxidant and anti-inflammatory properties and can be much better alternative to commercial antibiotics for treatment of wound infections. In the present study, wound healing potential of “Septaheal” (a Polyherbal formulation) was evaluated in Wistar albino rats using incision, excision and burn wound models. The formulation exhibited wound healing property due to its angiogenic and mitogenic potential.

Wound healing potential of naturally synthesized silver nano-particles

2020 ◽  
Vol 9 (1) ◽  
pp. 1-5
Author(s):  
Krishna Reddy BV ◽  
Avinash Kumar Reddy G ◽  
Nageswara Rao G
Keyword(s):  
Wound Healing ◽  
Large Scale ◽  
Uv Spectroscopy ◽  
The Body ◽  
Nano Particles ◽  
Albino Rats ◽  
Practical Applications ◽  
Wound Model ◽  
Healing Property ◽  
Wistar Albino Rats

Nanoparticles have been in raising demand in many fields of science and biotechnology and extends its applications in biomedical and pharmaceutical areas. Out of all the metals silver leads the way in this technology in view of its practical applications. They are used to preserve, diagnose many diseases and mainly used in external applications on the body emphasizing their antimicrobial and healing abilities. On the other hand, the synthesis of nano particles has been a very serious concern due to its huge cost of production, toxicity and dosing issues. Bio synthesis or green synthesis using herbals and microbes to synthesize nano particles showed a path to overcome the above hurdles and make the synthesis of silver nanoparticles more commercial and can be adopted on large scale. In this research silver nano particles were synthesized using purified extracts of leaves of Lannea coromandelica and were confirmed using UV spectroscopy. The produced nanoparticles exhibited surface plasmon resonance at 420nm in UV spectroscopy. They were investigated for their wound healing activity in excision wound model in wistar albino rats for a 16 day study. These nano particles were found to be very successful and showed wound healing property. Thus produced nano particles showed similar activity competent enough with that of the standard, Betanidine. These silver nano particles can be used efficiently in therapies that target infections and wounds that are provoked and delayed healing due to infections.

scholarly journals Effect of cow urine on wound healing property in Wister Albino Rats

2011 ◽  
pp. 317 ◽  
Author(s):  
Jagadeesh Sanganal ◽  
JayakumarK JayakumarK ◽  
Jayaramu GM ◽  
VP Tikare ◽  
Paniraj R
Keyword(s):  
Wound Healing ◽  
Albino Rats ◽  
Cow Urine ◽  
Healing Property ◽  
Wound Healing Property

Wound healing property of isolated compounds from Boesenbergia kingii rhizomes

2016 ◽  
Vol 184 ◽  
pp. 42-48 ◽  
Author(s):  
Teeratad Sudsai ◽  
Chatchai Wattanapiromsakul ◽  
Supinya Tewtrakul
Keyword(s):  
Wound Healing ◽  
Healing Property ◽  
Wound Healing Property

scholarly journals Characterization and Applications of Leaf Extracts of Hemigraphis Alternate

2019 ◽  
Vol 9 (1S6) ◽  
pp. 108-114
Keyword(s):  
Wound Healing ◽  
Crude Extract ◽  
Leaf Extract ◽  
Cellular Migration ◽  
Leaf Extracts ◽  
Ic50 Value ◽  
The Gift ◽  
Healing Property ◽  
Low Cytotoxicity ◽  
Wound Healing Property

Natural products carry out various capabilities and a lot of them have thrilling and useful organic activities. The gift take a look at turned into undertaken to analyze the bioactive compounds and the pharmacological capacity of leaf extract of Hemigraphis alternata. The presence of numerous compounds become characterized by way of FTIR and GCMS. ROS effect and wound recuperation assets have been analyzed and it discovered that crude extract is greater powerful inhibiting ROS manufacturing and it has high wound healing property with properly cellular migration in dose based way. The cytotoxic nature of leaf extract also analyzed with the aid of MTT assay and it suggests low IC50 value of 329.95 µG/ml. The result discovered that the crude extract of H.Alternata leaf is a great wound healer with low cytotoxicity.

scholarly journals EVALUATION OF WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII (A. DC.) IN WISTAR ALBINO RATS

2014 ◽  
Vol 1 (1) ◽  
pp. 73-77
Author(s):  
Uma Maheswari P ◽  
Shalimol A ◽  
Arumugasamy A ◽  
Udhaya Sankar M.R
Keyword(s):  
Wound Healing ◽  
Dry Weight ◽  
Wound Contraction ◽  
Albino Rats ◽  
Standard Drug ◽  
Excision Wound ◽  
Wound Model ◽  
Wistar Albino Rats ◽  
Incision Wound ◽  
Wound Healing Activity

The present experimental study was designed to evaluate the wound healing activity of methanolic extract of Smilax wightii A. DC. on incision and excision wound models in Wistar albino rats. The parameters studied were wound breaking strength, wound contraction area, epithelialization period, granulation tissuewet, dry weight and hydroxyproline content in incision wound model, percentage of wound contraction and period of epithelialization in excision wound model. The rats were administered topically with 100mg/kg b.wt. (low dosage), 200mg/kg b.wt. (moderate dosage) and 500mg/kg b.wt. (high dosage) of methanolicextract of Smilax wightii (MESW). The activity of the extract treated groups were compared with that of the control 1% Spirit. Framycetin sulphate 0.2% w/w was used as the standard drug. In incision wound model, there was a significant increase in the wound breaking strength in all the experimental groups treated withMESW than that of the control. Similarly, significant (P<0.001) decrease in wound contraction area and period of epithelialization were also observed in the test group animals treated with MESW and the standard drug treated groups when compared to that of the control. , a significant increase was observed in granulation tissue wet and dry weight and hydroxyproline content in the test groups treated with MESW compared to the control. In exicision wound model, there was a significant increase (P<0.01) in the percentage of wound contraction and decrease in period of epithelialization in the experimental groups treated with 200mg/kgb.wt. (moderate dosage) and 500mg/kgb.wt (high dosage) of MESW. The extract treated groups showed significant improvement in all the wound healing parameters of incision, and excision wound models.

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