Preclinical Evaluation of the Effect of Antioxidant N­-acetyl-D-Glucosamine on Haematinic Potentials of Lauha Bhasm and Mandura Bhasm

2021 ◽  
Vol 14 (1) ◽  
pp. 163-173
Author(s):  
Khobragade D. S ◽  
Potbhare M. S ◽  
Lote S. B ◽  
Pardeshi K. S ◽  
Wankhede S. B ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Haemoglobin Concentration ◽  
Blood Parameters ◽  
Albino Rats ◽  
Blood Cell Count ◽  
Phenyl Hydrazine ◽  
Mean Cell Volume ◽  
Red Blood Cell Count ◽  
Hb Concentration

The effect of antioxidant N-acetyl-D-Glucosamine on haematinic activity of two ayurvedic haematinic preparations Lauha bhasm and mandura bhasm was studied in albino rats. Anaemia was induced by administration of phenyl hydrazine (80 mg/kg for 24 hrs) by intra-peritoneal injection. Changes in body weight, red blood cell count (RBC), white blood cell count (WBC), haemoglobin (HB) concentration and haematocrit (HCT) were analysed as indices of anaemia. The mean cell haemoglobin (MCH), mean cell volume (MCV) and mean cell haemoglobin concentration (MCHC) which are indicators of macrocytosis were calculated accordingly. Phenyl hydrazine induced a significant decrease (P<0.05) in the blood parameters indicating anaemia and also resulted to significant increase (P<0.05) in the macrocytosis parameter. Combination of bhasm with antioxidant induced a significant (P<0.05) increase in the RBC count, HBG concentration, and HCT% which had been originally decreased by phenylhydrazine administration. The macrocytosis also turned towards normal as the animals recovered from anaemic condition. The results obtained suggested that combination of antioxidant N-acetyl-D-Glucosamine with Lauha bhasm & mandura bhasm shows improved haematinic activity.

Blood Parameters in Natural Populations of Trichosurus Species (Marsupialia: Phalangeridae). I. Age, Sex and Seasonal Variation in T. Caninus and T. Vulpecula. Ii. Influence of Habitat and Population Strategies of T. Caninus and T. Vulpecula.

1979 ◽  
Vol 27 (6) ◽  
pp. 913 ◽  
Author(s):  
JL Barnett ◽  
RA How ◽  
WF Humphreys
Keyword(s):  
Body Weight ◽  
Seasonal Variation ◽  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Plasma Glucose ◽  
Haemoglobin Concentration ◽  
Blood Parameters ◽  
Blood Cell Count ◽  
Red Blood Cell Count

Age, sex and seasonal related changes in body weight and blood parameters were determined for T caninus and T. vulpecula, whose distribution overlapped in part of the study area. In T. caninus age-related changes occurred in body weight, mean plasma glucose and protein concentrations and haematocrit. Seasonal changes occurred in plasma glucose and protein concentrations, haemoglobin concentration and red blood cell count. There were sexual dimorphisms in haematocrit, haemoglobin concentration and red blood cell count in both species; the mean values were greater in males. T. vulpecula also exhibited a sexual dimorphism in body weight (males > females). The only seasonal change in T. vulpecula was in haemoglobin concentration. Comparison of the species as adults showed that T. caninus had higher mean levels of body weight, haematocrit and haemoglobin concentration, while plasma lipid concentration and red blood cell counts were greater in T vulpecula. These species differences may be a reflection of the diets of the two species. In addition the measured parameters showed greater seasonal variation in T. caninus, a K-selected species, than in T. vulpecula, which is more r-selected.

scholarly journals Effect of Anaplasma spp. infection on some blood parameters in Awassi local breed sheep

2008 ◽  
Vol 32 (2) ◽  
pp. 171-180
Author(s):  
H.M. A.S. Al-Rubaii
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Haemoglobin Concentration ◽  
Blood Parameters ◽  
Blood Cell Count ◽  
Local Breed ◽  
Corpuscular Haemoglobin ◽  
Red Blood Cell Count ◽  
Corpuscular Haemoglobin Concentration ◽  
Breed Sheep

The aim of this study to investigation the effect of Anaplasma spp.infection on some blood parameters by collecting 65 blood samplesfrom Awassi local breed sheep. The total infection rate 26.15 % whichdivided into 25 % in males and 26.31 % in females. The parasitemiarange between 0.5-4 % (mean 1.97 %).The infected animals showed anemia represented by decrease meansof packed cell volume (P<0.01), red blood cell count (P<0.05) andhaemoglobin concentration, While increase corpuscular volume,corpuscular haemoglobin and corpuscular haemoglobin concentration(P<0.05). As well as decrease total white blood cell count and monocyteswhile increase lymphocytes, neutrophils , eosinophils, basophils andplatelets comparison to non infected animals.Our conclusion refered to the direct effect of Anaplasma parasite onsome blood parameters in the infected Awassi local breed sheep.

scholarly journals Confounding influences of malnutrition and Plasmodium falciparum and Schistosoma haematobium infections on haematological parameters in school children in Muyuka, Cameroon

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Irene Ule Ngole Sumbele ◽  
Ofon Vitalis Otia ◽  
Lorraine Francis ◽  
Orelien Sylvain Mtopi Bopda ◽  
Calvin Bisong Ebai ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Cell Count ◽  
Schistosoma Haematobium ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
Blood Cell Count ◽  
Malaria Parasites ◽  
Mean Cell Volume ◽  
Distribution Width

Abstract Background School-aged children (SAC) are a high-risk demographic group for infectious diseases and malnutrition. The objective of this study was to assess the burden and the effect of Plasmodium falciparum and Schistosoma haematobium infections on the haematological indices in SAC and the confounding influence of malnutrition on the outcomes. Methods This cross-sectional study was conducted in SAC 4–14 years old living in Ikata, Bafia and Mile 14-Likoko in Muyuka, Cameroon. Anthropometric measures of malnutrition were obtained and blood samples collected were used for detection of malaria parasites by Giemsa-stained blood films using light microscopy and complete blood count analysis using an automated haematology analyser. Urine samples collected were used to detect micro haematuria with the aid of reagent strips and the eggs of S. haematobium by urine filtration technique. Multiple linear regression model was used to examine influence of independent variables on haematological parameters. Results Out of the 606 SAC examined, the prevalence of single infections with Plasmodium or S. haematobium and co-infection with both parasites was 16.2, 16.3 and 8.3%, respectively. Overall, malaria parasite (MP), urogenital schistosomiasis, malnutrition, anaemia, haematuria, microcytosis and thrombocytopenia was prevalent in 24.4, 24.6, 25.9, 74.4, 12.2, 45.4 and 11.1% of SAC, respectively. A significant linear decline (P = 0.023) in prevalence of P. falciparum infection with the severity of stunting was observed. Factors that significantly influenced haematological parameters included haemoglobin: age, stunting and MP; haematocrit: age and MP; white blood cell count: age; red blood cell count; age and MP; lymphocyte counts: stunting; mean cell volume: age; mean cell haemoglobin: age and stunting; mean cell haemoglobin concentration: sex, stunting and red cell distribution width-coefficient of variation: sex, age and stunting. Conclusions Malnutrition, Plasmodium and S. haematobium infections are common while anaemia is a severe public health problem in Muyuka, Cameroon. The interaction between haematological parameters with malaria parasites as well as linear growth index was negative and other interactions indicate systemic inflammation. While findings provide contextual intervention targets to ensure the judicious use of the limited resources, there is need for regular monitoring and proper treatment to improve the health of the underserved population.

scholarly journals Zinc ameliorates lead toxicity by reducing body Pb burden and restoring Pb-induced haematological and biochemical derangements

2020 ◽  
Vol 4 ◽  
pp. 239784732095656
Author(s):  
Emmanuel Ike Ugwuja ◽  
Nweze Vincent ◽  
Ikechukwu C Ikaraoha ◽  
Samuel R Ohayi
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Haemoglobin Concentration ◽  
Lead Toxicity ◽  
Oral Route ◽  
Albino Rats ◽  
Blood Cell Count ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin ◽  
Biochemical Analyses

Background: Studies on nutritional factors, including zinc in ameliorating the deleterious effects of potentially toxic elements have been scarce and the findings have been inconsistent. Aim: The aim of the present study was to evaluate the ameliorative potential of zinc against lead-induced toxicity in rats. Materials and methods: Male albino rats (n = 24) assigned into four groups of six/group: normal control (NC), zinc control (ZnC; 20 mg/kg ZnCl2), lead control (PbC; 50 mg/kg PbCl2) and lead plus zinc (Pb + Zn; 50 mg/kg PbCl2 plus 20 mg/kg ZnCl2), respectively were investigated. All administrations were through oral route and lasted for 42 days after which blood samples were collected for haematological and biochemical analyses using standard techniques. Results: Results showed that packed cell volume (PCV), haemoglobin concentration (HBC), red blood cell count (RBC) were significant (p < 0.05) reduced while total white blood cell count (TWBC), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and platelets were significantly elevated in PbC group in comparison with NC and ZnC. Also liver and renal function parameters as well as the liver and kidney malondialdehyde (MDA) were elevated while antioxidant enzymes; catalase (CAT) and superoxide dismutase (SOD) were significantly (p < 0.05) reduced in PbC group in comparison with NC and ZnC. Concentrations of lead were in the order: blood > liver > kidney in the PbC group. In addition to restoration of the altered parameters, administration of zinc in Pb + Zn group significantly reduced the raised lead concentrations in the plasma and organs. Conclusion: Reduction in body Pb burden and restoration of Pb-induced derangements in haematological and biochemical parameters by Zn strongly support the ameliorative property of Zn against Pb-induced toxicity.

Blood parameters in natural populations of Trichosurus species (Marsupialia : Phalangeridae) II. Influence of habitat and population strategies of T. caninus and T. vulpecula

1979 ◽  
Vol 27 (6) ◽  
pp. 927 ◽  
Author(s):  
JL Barnett ◽  
RA How ◽  
WF Humphreys
Keyword(s):  
Body Weight ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Haemoglobin Concentration ◽  
Plasma Lipid ◽  
Blood Parameters ◽  
Lipid Concentration ◽  
Blood Cell Count ◽  
Preferred Habitat ◽  
Red Blood Cell Count

Body weight and six blood parameters were determined in T. caninus and T. vulpecula from their preferred and peripheral habitats. Habitat had a large effect on T. caninus. Of the seven parameters measured, six (body weight, red blood cell count, haemoglobin concentration, haematocrit and plasma protein and lipid concentrations) were higher in the population from the peripheral habitat than in that from the preferred habitat. Only body weight was different in T. vulpecula, being higher in the peripheral than in the preferred habitat population. There were differences between T. caninus and T. vulpecula in four of the measured parameters (body weight, haematocrit, haemoglobin concentration and red blood cell count) irrespective of habitat, whereas plasma lipid concentration was the same in T. caninus from peripheral habitat and T. vulpecula, but differed in T. caninus between habitats. Four parameters showed significant seasonal variation in preferred-habitat T. caninus, three in peripheral-habitat T. caninus and one in T. vulpecula. However, the pattern of seasonal change in peripheral-habitat T. caninus was more similar to that in T. vulpecula than to that in preferred-habitat T. caninus, suggesting a physiological shift in peripheral-habitat T. caninus towards that of the more r-selected T. vulpecula. No differences were found between resident and dispersing T. caninus. T. caninus which had lost a pouch young and failed to maintain another in the same year had lower haematocrit and plasma lipid concentration than females in other reproductive states. It is suggested that the measurement of physiological responsiveness of populations may aid the understanding of adaptive strategies.

scholarly journals Effect of different proportions of popped amaranth grain (Amaranthus cruentus) as an iron supplement in piglet diets on selected blood indicators

2015 ◽  
Vol 84 (3) ◽  
pp. 277-287
Author(s):  
Miroslav I. Urosevic ◽  
Isabel Hennig-Pauka ◽  
Alexander Tichy ◽  
Nenad Stojanac ◽  
Radomir Ratajac
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Haemoglobin Concentration ◽  
Daily Weight Gain ◽  
Control Group ◽  
Blood Cell Count ◽  
Amaranthus Cruentus ◽  
Amaranth Grain ◽  
Red Blood Cell Count

The aim of our study was to compare the effect of various proportions of popped amaranth grain (Amaranthus cruentus) in piglet diets on selected blood indicators, such as red blood cell count (RBC), haematocrit (HCT), haemoglobin concentration (HB) and mean corpuscular haemoglobin concentration (MCHC), but also growth efficiency (daily weight gain) and tissue morphology of the gastrointestinal tract. Altogether, 122 piglets (12 litters) were divided randomly into four groups (4 × 3 litters). Diet of the piglets in the control group was without popped amaranth grain. Starting from day 5 until day 90 of life, each of the three experimental groups was offered one of the feed mixtures containing different amounts of heat-treated popped amaranth grain: 20% (group A20), 40% (group A40), and 79% (group A79). When comparing the three experimental groups with the control group, in relation to the mean haemoglobin concentration and red blood cell count, higher values were measured in almost all periods of the piglets’ life, except for five-day-old piglets in the experimental groups. Only in 90-day-old piglets, group A79 tended to have a higher body weight compared to the control piglets. In summary, differences in haematologic indices which occurred between groups were inconsistent and of minor practical impact. With regard to the costs of the Amaranthus diet, beneficial effects were not obvious.

scholarly journals Effect of an 1800 MHz electromagnetic field emitted during embryogenesis on the blood picture of one-day-old domestic hen chicks (Gallus gallus domesticus)

2018 ◽  
Vol 87 (1) ◽  
pp. 65-71
Author(s):  
Krzysztof Pawlak ◽  
Bartosz Bojarski ◽  
Zenon Nieckarz ◽  
Marcin Lis ◽  
Tomasz Wojnar
Keyword(s):  
Electromagnetic Field ◽  
Blood Cell ◽  
Cell Count ◽  
Haemoglobin Concentration ◽  
Blood Cell Count ◽  
Blood Picture ◽  
Corpuscular Haemoglobin ◽  
Red Blood Cell Count ◽  
Mean Corpuscular Haemoglobin ◽  
Domestic Hen

Exposure to artificial electromagnetic fields emitted mainly by mobile telephony has been steadily increasing with the development of modern technology. Haematological indices are among the most common indicators of the body’s physiological status. The aim of the study was to determine the effect of an 1800 MHz electromagnetic field emission on the blood picture of one-day-old domestic hen chicks. During the experiment, chick embryos were exposed to artificial electromagnetic fields throughout incubation for 13 ´ 2 min/day, 4 ´ 10 min/day and 1 ´ 40 min/day. After hatching, blood was collected from 10 one-day-old chicks from each group to determine: red blood cell count, haemoglobin concentration, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, white blood cell count, and leukocyte differential count. In addition, the heterophil/lymphocyte ratio was calculated. The present study is probably the first to show an increase in the red blood cell count, haemoglobin concentration, haematocrit, white blood cell count, segmented heterophils and the heterophil/lymphocyte ratio, and a decrease in lymphocyte percentage of embryos exposed to an 1800 MHz electromagnetic field. The observed changes may be indicative of the stress-inducing effect of EMF on living organisms.

scholarly journals Effect of Herbal Extracts on Some Haematological Parameters of Calves During Rearing

2012 ◽  
Vol 56 (4) ◽  
pp. 655-658 ◽  
Author(s):  
Teresa Bombik ◽  
Elżbieta Bombik ◽  
Aneta Frankowska ◽  
Beata Trawińska ◽  
Leon Saba
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Haemoglobin Concentration ◽  
Corpuscular Volume ◽  
Herbal Extracts ◽  
Blood Cell Count ◽  
Group 12 ◽  
Red Blood Cell Count ◽  
Experimental Group

Abstract Clinically healthy Polish Holstein-Friesian calves were divided into two groups: a control group (12 individuals) and an experimental group (12 individuals). The experimental group calves received a mixture of 20% water herbal extracts prepared from Urtica dioica, Hb., Hypericum perforatum, Hb., Melissa officinalis, Fol., Chamomillae recutita Anth., Calendula officinalis, Flos, and Plantago lanceolata, Fol. The mixture was given from the 2nd to 14th week of their life. Control calves received no addition of herbal extracts to their diet. Red blood cell count, white blood cell count, haemoglobin concentration, haematocrit value, and mean corpuscular volume were determined in the 4th, 9th, and 14th week of the experiment. The beneficial effect of the herbal mixture on the level of the examined haematological parameters was demonstrated in all tested weeks. In the calves from experimental group, a significantly higher red blood cell count, haemoglobin concentration, and corpuscular volume, and lower white blood cell count were found. There were no statistically significant differences in the haematocrit values between both groups.

Sign in / Sign up

Export Citation Format

Share Document