Frequency and Predictors of Potential Drug Interactions among Psychiatry Outpatients on Treatment with Antidepressant Medications

2021 ◽  
Vol 14 (3) ◽  
pp. 1209-1218
Author(s):  
Mouza S.R Al Zaabi ◽  
Sathvik Belagodu Sridhar ◽  
Talaat Matar Tadross ◽  
Atiqulla Shariff
Keyword(s):  
Drug Interactions ◽  
Outpatient Setting ◽  
Psychotropic Medications ◽  
Potential Drug ◽  
Cross Sectional ◽  
Antidepressant Medications ◽  
Psychiatric Illnesses ◽  
Risk Patients ◽  
Social Habits ◽  
Clinical Conditions

Antidepressant medications are prescribed to treat depression and related psychiatric illnesses. In patients with depression, many categories of drugs are prescribed to treat clinical conditions and comorbidities. Hence, it is essential to screen such patients for potential drug interactions. The study aimed to assess the frequency of potential drug interactions (pDDIs) associated with antidepressant medications administered to the outpatients of the psychiatry department. This cross-sectional investigation was conducted in a psychiatry outpatient setting. Patients satisfying inclusion criteria were screened for pDDIs by reviewing the patients’ electronic case records. All the identified pDDIs were further evaluated using Micromedex database 2.0.A total of 131 eligible patients’ case records were reviewed. The frequency of pDDIs between antidepressants and other psychotropic medications, antidepressants and non-psychotropic medications, antidepressants,tobacco, antidepressants, and ethanol was 48.1%,9.2%, 7.6%, and 3.8%, respectively. Use of more than three medications [RR: 1.5; CI: 1.1-2.1], presence of total [RR: 7.9; CI: 1.1-52.5] as well as psychiatric polypharmacy [RR: 4.8; CI: 1.3-17.9] were identified as predisposing factors of pDDIs.The results of the multiple regression indicated that the model was a significant predictor of pDDIs (F[3, 127]= 6.368, p<0.01, R2 = 0.13). In comparison,psychiatric polypharmacy was the only variable contributing significantly to the model (B = -0.423, p<.05). Nearly fifty percent of patients taking antidepressant medications were found to have the potential for developing drug interactions. Review of treatment charts for psychotropic, non-psychotropic, and non-prescription medications, along with different medical conditions that patients suffer from and the social habits of patients,is essential to identify and resolve potential drug interactions in at-risk patients.

scholarly journals POTENTIAL DRUG INTERACTIONS IN HYPERTENSIVE PATIENTS IN LIWA DISTRICT HOSPITAL, LAMPUNG BARAT, INDONESIA

2017 ◽  
Vol 9 (6) ◽  
pp. 134
Author(s):  
Erna Yanti ◽  
Erna - Kristin ◽  
Alfi Yasmina
Keyword(s):  
Drug Interactions ◽  
District Hospital ◽  
Antihypertensive Agents ◽  
Potential Interaction ◽  
Multiple Drug ◽  
Potential Drug ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Multiple Drugs ◽  
Potential Interactions

Objective: Patients with hypertension often suffer from other comorbidities, resulting in prescriptions of multiple drugs to treat the conditions. Multiple drug treatment is potentially associated with drug interactions. This aim of the study was to assess potential drug interactions in hypertensive patients in Liwa District Hospital.Methods: The design of the study was cross-sectional. The prescriptions for in-patients with essential hypertension in the Internal Medicine Unit in Liwa District Hospital during April-December 2012 were collected. Potential drug interactions were analyzed with the Drug Interaction Facts version 4.0, and classified into minor, significant, and serious.Results: A total of 60 hypertensive patients were included. They were prescribed 265 prescriptions, with a median total of 6 (range 1-21) drugs prescribed per prescription. There were 1616 potential drug interactions, with 6 (1-31) potential interactions per prescription. Most interactions (75.6%) were classified as significant. Serious potential interactions were most common in the combinations of diltiazem-amlodipine and spironolactone-potassium chloride, while significant potential interaction may occur most often with the combinations of calcium chloride-amlodipine and bisoprolol-amlodipine.Conclusion: Numerous potential drug interactions might occur in hypertensive patients, and most interactions were significant in severity. The largest proportion of the interactions occurred between antihypertensive agents and other drugs. 

scholarly journals The use of qualitative approach to detect and assess potential drug-drug interactions which may decrease the effectiveness of oral contraceptives – pilot study and literature review

2014 ◽  
Vol 83 (3) ◽  
pp. 238-243
Author(s):  
Karolina Kilińska ◽  
Magdalena Cerbin-Koczorowska ◽  
Arleta Matschay ◽  
Michał Mierzwicki ◽  
Karolina Chmaj-Wierzchowska
Keyword(s):  
Pilot Study ◽  
Drug Interactions ◽  
Oral Contraceptives ◽  
Study Protocol ◽  
Qualitative Data ◽  
Potential Drug ◽  
Inclusion Criteria ◽  
Medicinal Products ◽  
Cross Sectional ◽  
Unintended Pregnancies

Aim. The aim of the pilot study was to assess the effectiveness of the tool designed for detecting potential drug-drug interactions of combined oral contraceptives (COCs) with particular emphasis on those which can affect their contraceptive action. A proper study protocol design seems to be essential for further analysis of more data and for establishing correlations between observed interactions and demographic variables.Material and methods. The cross-sectional descriptive, retrospective study was carried out on Polish females from March to May 2013. Gathered data, including products used concomitantly with contraceptive drugs, were derived electronically by patients and underwent thematic analysis.Results. Out of 49 respondents who agreed to participate in the study and fit the inclusion criteria only 15 derived qualitative data about other medicinal products they used. However, some of them sent their monthly report more than once, which gave the total of 158 drugs listed in 25 forms gathered during the whole pilot study. Fifty-three potential drug interactions were found, including 13 (24.53%) which could have decreased the effectiveness of contraceptive drugs.Conclusions. Continuation of the study in accordance with the study protocol will result in identification of common potential drug-related problems, which may enable development of an educational solution for gynecologists, pharmacists and patients increasing their awareness of the potential risk of contraceptive failures and unintended pregnancies.

scholarly journals Assessment of Physician's Knowledge of Potential Drug-Drug Interactions: An Online Survey in China

2021 ◽  
Vol 8 ◽  
Author(s):  
Jing Yuan ◽  
Chunying Shen ◽  
Chengnan Wang ◽  
Gang Shen ◽  
Bing Han
Keyword(s):  
Drug Interactions ◽  
Online Survey ◽  
Mobile Apps ◽  
Least Square ◽  
Common Source ◽  
Potential Drug ◽  
Cross Sectional Survey ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Source Of Information

Background: Drug interactions are the most common preventable cause of adverse drug reaction, which may result in drug toxicity or undesired therapeutic effect with harmful outcomes to patients. Given the rising use of combination therapies, the main objectives of this study were to estimate the degree to which physicians can identify potential drug-drug interactions (PDDIs) correctly and to describe the common source of information used by physicians when they need to check PDDIs.Methods: A cross-sectional survey utilizing a self-administered online questionnaire was conducted among physicians in China. Participants were asked to classify 20 drug pairs as “no interaction,” “may be used together with monitoring,” “contraindication,” and “not sure.” We also collected data on the physician's source of information and altitude toward the PDDIs. An ordinary least square regression model was performed to investigate the potential predictors of PDDI knowledge.Results: Eligible questionnaires were obtained from 618 physicians. The respondents classified correctly 6.7 out of 20 drug pairs, or 33.4% of the drug interactions investigated. The number of drug pairs recognized by respondents was ranged from 0 to 16. The percentage of physicians who recognized specific drug pairs ranged from 8.3% for no interactions between conjugated estrogens and raloxifene, to 64.0% for the interaction between dopamine and phenytoin. When the respondents want to check PDDI information, the most commonly used source of information was package inserts (n = 572, 92.6%), followed by the Internet or mobile Apps (n = 424, 68.6%), consultation with clinical pharmacists (n = 384, 62.1%), medical textbooks (n = 374, 60.5%), knowledge base in Chinese (n = 283, 45.8%), and other physicians (n = 366, 59.2%). In the multiple regression analysis, the significant predictors of a higher number of recognized drug pairs were years of practice and altitudes toward PDDIs.Conclusion: In this online survey accessing physician's ability to detect PDDIs, less than half of the drug pairs were recognized, indicating unsatisfactory level of knowledge about the clinically significant drug interactions. Continuing education and accessible electronic database can help physicians detecting PDDIs and improve drug safety.

scholarly journals Are patients with a nasally placed feeding tube at risk of potential drug-drug interactions? A multicentre cross-sectional study

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0220248
Author(s):  
Fernanda Raphael Escobar Gimenes ◽  
Melissa Baysari ◽  
Scott Walter ◽  
Leticia Alves Moreira ◽  
Rhanna Emanuela Fontenele Lima de Carvalho ◽  
...  
Keyword(s):  
At Risk ◽  
Drug Interactions ◽  
Feeding Tube ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Psychotropic Drugs: Implications For Dental Practice

2008 ◽  
Vol 55 (3) ◽  
pp. 89-99 ◽  
Author(s):  
Daniel E. Becker
Keyword(s):  
Anxiety Disorder ◽  
Side Effects ◽  
Drug Interactions ◽  
Dental Care ◽  
Psychotropic Drugs ◽  
Preoperative Assessment ◽  
Psychotropic Medications ◽  
Dental Practice ◽  
Dental Patients ◽  
Psychiatric Illnesses

Abstract Appropriate preoperative assessment of dental patients should always include analysis of their medications. Psychiatric illnesses including panic/anxiety disorder, depression, psychoses, and manic disorders are prevalent within our society. An impressive number of drug formulations are prescribed for these disorders, and they introduce concern regarding side effects and possible drug interactions with medications the dentist may deem necessary for dental care. This article will address essential pharmacology of these psychotropic medications.

scholarly journals A STUDY ON POTENTIAL DRUG-DRUG INTERACTIONS AMONG PATIENTS ADMITTED UNDER DEPARTMENT OF MEDICINE IN A TERTIARY CARE HOSPITAL IN INDIA

2021 ◽  
Vol 10 (1) ◽  
pp. 29-32
Author(s):  
Sanjib Bandyopadhyay ◽  
Kaushik Mitra ◽  
Dipankar Bhaumik ◽  
Saibal Das
Keyword(s):  
Drug Interactions ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Controlled Study ◽  
Care Hospital ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional ◽  
Different Types

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India. Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used. Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs. Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed. Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.

scholarly journals Drug Therapy Scheduling by Nurses and Resulting Potential Drug Interactions in the Hospital Care Of Adolescents: A Cross-Sectional Study

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Tainá Bastos dos Santos ◽  
Juliana Almeida de Oliveira ◽  
Luanny Cardoso Souza ◽  
Helena Ferraz Gomes ◽  
Dayana Carvalho Leite ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Drug Interactions ◽  
Hospital Care ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yusuke Kunimoto ◽  
Ryosuke Matamura ◽  
Hiroshi Ikeda ◽  
Satoshi Fujii ◽  
Tomoko Kimyo ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Health Care Providers ◽  
Median Number ◽  
Antiretroviral Drugs ◽  
Strand Transfer ◽  
Potential Drug ◽  
Care Providers ◽  
Cross Sectional ◽  
Single Center Study ◽  
Integrase Strand Transfer Inhibitors

Abstract Background Potential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have been reported to cause PDDIs in these patients. However, there are few reports of PDDIs in the era of treatment using integrase strand transfer inhibitors. Therefore, we investigated PDDIs in Japanese PLWH receiving antiretroviral drugs (ARVs). Methods This was a cross-sectional observational study conducted in Japanese outpatients. All eligible patients who had received ARV therapy for at least 48 weeks were enrolled. The primary endpoint was the incidence of PDDIs detected using the Lexicomp® interface. Results Of the 71 eligible patients, 51 (71.8%) were prescribed concomitant non-ARV medications. In 21 patients (29.6%), PDDIs with the potential to reduce the effects of ARVs occurred, although the HIV load was suppressed in all cases. Polypharmacy (the use of ≥5 non-ARVs) was observed in 25 patients (35.2%). There was a significantly higher median number of non-ARV medications in the PDDI group than in the non-PDDI group (6 vs. 3, P <  0.001). Furthermore, the proportion of patients on polypharmacy was significantly higher in those with PDDIs than in those without PDDIs (81.0% vs. 26.7%, P <  0.001). Conclusions The incidence of PDDIs is relatively high in Japanese PLWH, even in the era of treatment using integrase strand transfer inhibitors. Therefore, it is important for patients and health care providers to be constantly aware of PDDIs associated with ARV treatment.

Sign in / Sign up

Export Citation Format

Share Document