scholarly journals Dupuytren’s disease: where do we stand?

2019 ◽  
Vol 4 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Rita Grazina ◽  
Sérgio Teixeira ◽  
Renato Ramos ◽  
Henrique Sousa ◽  
Andreia Ferreira ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
State Of The Art ◽  
Treatment Options ◽  
Daily Activities ◽  
Dupuytren’S Disease ◽  
High Morbidity ◽  
Disease Treatment ◽  
Dupuytren's Disease ◽  
Current State ◽  
The World

Dupuytren’s disease is a fibroproliferative disease that involves collagen deposition, leading to hand contractures that ultimately affect hand mobility and grip strength. It is a benign disorder but can cause high morbidity by limiting daily activities. Many factors have been proposed for its aetiology: namely genetics, smoking, alcohol intake and diabetes. However, there is still controversy as to the main aetiological cause of the disease. Treatment is not yet uniform around the world and still varies with the surgeon’s experience and preference. In this review, the authors review the pathogenesis and treatment options for Dupuytren’s disease in an attempt to summarize the current state of the art. Cite this article: EFORT Open Rev 2019;4:63-69. DOI: 10.1302/2058-5241.4.180021.

Sir Charles Parsons and Electrical Power Generation—a Turbine Designer's Perspective

1994 ◽  
Vol 208 (3) ◽  
pp. 159-176 ◽  
Author(s):  
J R Bolter
Keyword(s):  
Power Generation ◽  
Steam Turbine ◽  
Gas Turbine ◽  
Electrical Power Generation ◽  
Analytical Methods ◽  
State Of The Art ◽  
Electrical Power ◽  
Turbine Generator ◽  
Current State ◽  
The World

Sir Charles Parsons died some three years after the author was born. In this paper the author looks back at the pioneering work of Parsons in the field of power generation. It shows how he was able to increase output of the steam turbine generator from 7.5 kW in 1884 to 50000 kW in 1930 while increasing efficiency from 1.6 to 36 per cent, and relates these achievements to the current state of the art. Blading design, rotor construction and other aspects of turbine engineering are considered. The conclusion is that Parsons and his associates charted the course which manufacturers and utilities throughout the world have continued to follow, although increasingly sophisticated design and analytical methods have succeeded the intuitive approach of Parsons. His constant search for improved efficiency was and is highly relevant to today's concern for the environment. Finally, although it did not become a practical proposition in his lifetime, the paper reviews Parsons' vision of, and continuing interest in, the gas turbine, first mentioned in his 1884 patents.

scholarly journals COMMERCIALIZATION OF CARBON CREDITS ON SMALL PROPERTIES

2019 ◽  
Vol 7 (7) ◽  
pp. 156-166
Author(s):  
Jadson Belem De Moura ◽  
Rodrigo Fernandes De Souza ◽  
José Mateus Dos Santos ◽  
Luiz Cesar Lopes Filho ◽  
Willian Marques Pires ◽  
...  
Keyword(s):  
State Of The Art ◽  
Ghg Emissions ◽  
Carbon Credits ◽  
Major Powers ◽  
Average Temperature ◽  
Current State ◽  
Small Producer ◽  
The World ◽  
Reduce Emissions ◽  
Carbon Dioxide Co2

Today the world has turned its attention to the phenomena of climate change on the planet. Excess emissions of greenhouse gases (GHG) from human activity are responsible for this change. Gases such as carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) are part of GHG and have a large capacity to store the energy of the sun in the form of heat, increasing the average temperature in the atmosphere. After the Kyoto treaty, major powers pledged to reduce GHG emissions into the atmosphere, but this practice implies a slowdown in the industrialization and profits of these countries. Countries that can not or do not opt to reduce emissions can buy credits from nations that can generate extra emission reduction values, thus resulting in trade in these credits. Small properties have the potential for credit production, which can generate extra income for the small producer. Therefore, this work aimed at evaluating the potential of commercialization of carbon credits by small properties. The methodology of the work consisted in a systematic literature review on the current state of the art of the proposed theme.

scholarly journals Peritoneal Carcinomatosis: Current State of the Art and Schools of Thought

2021 ◽  
Vol 11 (1) ◽  
pp. 85-91
Author(s):  
Sh. Kh. Gantsev ◽  
M. V. Zabelin ◽  
K. Sh. Gantsev ◽  
A. A. Izmailov ◽  
Sh. R. Kzyrgalin
Keyword(s):  
Peritoneal Carcinomatosis ◽  
State Of The Art ◽  
Global Perspective ◽  
Basic Principles ◽  
Global Challenge ◽  
Current State ◽  
Emerging Therapies ◽  
The World ◽  
The Usa ◽  
Scientific Questions

Peritoneal carcinomatosis (PC) is a global challenge of modern oncology representing the most unfavourable scenario in diverse-locality tumourisation. Despite certain attention by the oncological community, the management of PC patients is currently palliative, which weakly promotes research into the basic principles of this morbidity. This literature review attempts to comprehensively cover the PC problematic from a global perspective and presents a key evidence on the world schools of thought in this area. Briefly taking, peritoneal carcinomatosis is viewed today as a local process in the conventional implantation theory, which imposes a locoregional character on all current or emerging therapies, such as cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Their inadequate efficacy is largely due to pronounced gaps in our understanding of PC logistics and signalling. PSOGI is a key organisation for centralising the specialty effort in peritoneal carcinomatosis. Despite its global geography and approach to PC discussion, a multitude of scientific questions remain unanswered impeding the establishment of novel effective therapies. The seven countries that nurtured distinguished schools of thought in PC studies are the USA, UK, Japan, China, Italy, France and Germany. Taking peritoneal carcinomatosis in a global perspective, an insufficient attention to its problematic in Russia should be addressed. The founding and fostering of national PC institutions will benefit cancer patients and progress in oncological science.

Dupuytren's Disease: An Outcomes-Focused Update

2021 ◽  
Author(s):  
Yasser H. Almadani ◽  
Joshua Vorstenbosch ◽  
Johnny Ionut Efanov ◽  
Liqin Xu
Keyword(s):  
Patient Education ◽  
Genetic Predisposition ◽  
Treatment Options ◽  
Clinical Treatment ◽  
Dupuytren’S Disease ◽  
Treatment Modalities ◽  
Recurrence Rates ◽  
Dupuytren's Disease ◽  
Associated Factor ◽  
Informed Decisions

AbstractDupuytren's disease (DD) remains a common fibroproliferative condition with significant sequelae and impact on patient's lives. The etiology of DD is poorly understood, and genetic predisposition is thought to be a strongly associated factor. Despite remarkable strides in improving our molecular understanding of DD, clinical treatment options have not yet overcome the frequently encountered challenge of recurrence. Recurrence rates continue to shape the prognosis of this fibrotic condition. In this outcomes-focused article, the various treatment modalities are reviewed. This further emphasizes the importance of patient education and providing them with the information to make informed decisions about their treatment.

scholarly journals Immunotherapy in gastroesophageal cancers: Current state and future directions

2020 ◽  
pp. 107815522096353
Author(s):  
Hira Shaikh ◽  
Amir Kamran ◽  
Dulabh K Monga
Keyword(s):  
Patient Outcomes ◽  
Molecular Targeted Therapy ◽  
Treatment Options ◽  
Cell Cycle Checkpoints ◽  
Future Directions ◽  
Alternative Strategies ◽  
Current State ◽  
Dismal Prognosis ◽  
The World ◽  
Improve Patient

While gastroesophageal (GE) cancers are one of the most common cancers worldwide, unfortunately, the mortality remains high. Commonly used treatment options include surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy, which improve survival only minimally; thus, affirming the dire need for exploring alternative strategies to improve patient outcomes. Immunotherapy, which has revolutionized the world of oncology, has somewhat lagged behind in GE malignancies. Tumor-associated microenvironment and regulatory T cells, alongside cell cycle checkpoints, have been proposed by various studies as the mediators of carcinogenesis in GE cancers. Thus, inhibition of each of these could serve as a possible target of treatment. While the approval of pembrolizumab has provided some hope, it is not enough to override the dismal prognosis that this disease confers. Herein, we discuss the prospects of immunotherapy in this variety of cancer.

Dupuytren’s disease

2011 ◽  
Author(s):  
Peter Burge
Keyword(s):  
Surgical Treatment ◽  
Steroid Injection ◽  
Treatment Options ◽  
Genetic Component ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Collagenase Injection ◽  
Operative Complications ◽  
Non Surgical Treatment

♦ Dupuytren’s disease is characterised by contracture of a finger resulting from thickening and shortening of the palmar fascia♦ A genetic component to the aetiology is apparent, smoking, alcohol and diabetes can increase the risk♦ The pathogenesis of Dupuytren’s disease remains elusive♦ Non-surgical treatment options include splintage, steroid injection and collagenase injection♦ Surgery cannot cure the disease but can straighten bent digits and minimize recurrence♦ Operative methods can be considered with regards to incision, management of the diseased fascia and closure techniques♦ Operative complications include injury of digital nerves and arteries

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