scholarly journals The range of the Oxford Shoulder Score in the asymptomatic population: a marker for post-operative improvement

2011 ◽  
Vol 93 (8) ◽  
pp. 629-633 ◽  
Author(s):  
F Younis ◽  
J Sultan ◽  
S Dix ◽  
PJ Hughes
Keyword(s):  
Normal Population ◽  
Adult Population ◽  
Asymptomatic Group ◽  
Oxford Shoulder Score ◽  
Asymptomatic Volunteers ◽  
Symptom Scores ◽  
Asymptomatic Adult ◽  
The Difference ◽  
Asymptomatic Individuals ◽  
Shoulder Score

INTRODUCTION The Oxford Shoulder Score (OSS) is a validated scoring system used to assess the degree of pain and disability caused by shoulder pathology. To date there is no knowledge of the range of the OSS in the healthy adult population. This study aimed to establish the range in asymptomatic individuals. METHODS The OSS of 100 asymptomatic volunteers was compared with the pre-operative OSS of 100 symptomatic individuals who had had elective shoulder surgery performed at the Royal Preston Hospital. RESULTS The difference in mean scores in the operated group (36.7) and the asymptomatic group (15.3) was statistically significant (p<0.0001). There was, however, a substantial overlap between the scores of the two groups (operated group range: 19–55, asymptomatic group range: 12–47). Factors such as age, sex, body mass index, co-morbidities and smoking did not have a statistically significant impact on the eventual score in the asymptomatic group. CONCLUSIONS This study has established the range of OSS in the asymptomatic adult population. Symptom scores can only be used effectively when the range in the asymptomatic population is known. This is so that disease severity can be gauged in the context of the normal population and post-operative improvements can be forecast more accurately.

Sino-nasal assessment questionnaire: a specific outcome measure for rhinosinusitis, but what is the range in the asymptomatic population?

2006 ◽  
Vol 121 (7) ◽  
pp. 650-652
Author(s):  
F Younis ◽  
S Duvvi ◽  
T Walker ◽  
B Nirmal Kumar
Keyword(s):  
Outcome Measure ◽  
Healthy Adult ◽  
Normal Population ◽  
Adult Population ◽  
Sinus Surgery ◽  
Asymptomatic Group ◽  
Symptom Scores ◽  
Specific Outcome ◽  
The Difference ◽  
Assessment Questionnaire

The sino-nasal assessment questionnaire is a system used for scoring the symptoms of chronic rhinosinusitis. However, the range of scores for this questionnaire in the healthy adult population is unknown. We aimed to establish this by recruiting 100 healthy volunteers and comparing their sino-nasal assessment questionnaire scores with those of 100 individuals who had undergone sinus surgery for rhinosinusitis. The difference in mean scores in the symptomatic group (44.62) and the asymptomatic group (8.46) was statistically significant. However, there was substantial overlap between the scores of the two groups. Factors such as age, gender and smoking did not have a statistically significant impact on the eventual score in the asymptomatic group. We believe that symptom scores can only be used effectively when the range in the asymptomatic population is known. This is so that disease severity can be gauged in the context of the normal population and post-operative improvements can be forecast.

scholarly journals The influence of age and unreported symptoms on the Oxford Shoulder Score

2017 ◽  
Vol 10 (4) ◽  
pp. 262-268 ◽  
Author(s):  
John Dabis ◽  
Henry B. Colaço ◽  
Helen Hingston ◽  
Magnus Arnander ◽  
Duncan Tennent ◽  
...  
Keyword(s):  
Upper Limb ◽  
Local Population ◽  
Important Change ◽  
Minimal Important Change ◽  
Asymptomatic Group ◽  
Medical Opinion ◽  
Oxford Shoulder Score ◽  
Study Population ◽  
Observed Score ◽  
Shoulder Score

Background One potential limitation of interpreting the Oxford Shoulder Score (OSS) in longitudinal studies is that the observed score may be influenced by age and other variables, which may change over time. The purpose of the present study was to investigate the influence of increasing age and unreported non-shoulder upper limb and neck symptoms on the OSS. Methods We collected OSS data from a sample of our ethnically diverse local population. All subjects indicated whether they suffered from any neck, shoulder, elbow or wrist symptoms for which they had not sought a medical opinion. Those reporting no symptoms formed the asymptomatic group. Results We found a significant decline in OSS with increasing age in the whole study population, as well as in both the asymptomatic and symptomatic groups with previously unreported symptoms: Spearman correlation coefficient = −0.27, −0.28 and −0.33 respectively (p < 0.001). The median OSS in the asymptomatic group was 48 [interquartile range (IQR) 48 to 48]. This was significantly higher than the symptomatic group, with a median OSS of 46 (IQR 40 to 47) (p < 0.001). Conclusions We found the OSS to be affected by non-shoulder upper-limb and neck pathology as well as age. Within the limitations of the OSS, the differences we found do not exceed the minimal important change.

scholarly journals Oxford shoulder score in a normal population

2014 ◽  
Vol 8 (1) ◽  
pp. 10 ◽  
Author(s):  
NicholasDavid Clement ◽  
CharlesM Court-Brown
Keyword(s):  
Normal Population ◽  
Oxford Shoulder Score ◽  
Shoulder Score

scholarly journals Prospective analytical performance evaluation of the QuickNavi™-COVID19 Ag for asymptomatic individuals

2021 ◽  
Author(s):  
Yoshihiko Kiyasu ◽  
Yuto Takeuchi ◽  
Yusaku Akashi ◽  
Daisuke Kato ◽  
Miwa Kuwahara ◽  
...  
Keyword(s):  
Real Time ◽  
Diagnostic Performance ◽  
False Positives ◽  
Clinical Samples ◽  
Lower Sensitivity ◽  
Antigen Test ◽  
Rt Pcr ◽  
Asymptomatic Group ◽  
Asymptomatic Volunteers ◽  
Asymptomatic Individuals

AbstractIntroductionAntigen testing may help screen for and detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in asymptomatic individuals. However, limited data regarding the diagnostic performance of antigen tests for this group are available.MethodsWe used clinical samples to prospectively evaluate the analytical and clinical performance of the antigen test QuickNavi™-COVID19 Ag. This study was conducted at a PCR center between October 7, 2020 and January 9, 2021. Two nasopharyngeal samples per patient were obtained with flocked swabs; one was used for the antigen test, and the other for real-time reverse transcription PCR (RT-PCR). The diagnostic performance of the antigen test was compared between asymptomatic and symptomatic patients, and the RT-PCR results were used as a reference.ResultsAmong the 1,934 collected samples, SARS-CoV-2 was detected by real-time RT-PCR in 188 (9.7%); 76 (40.4%) of these samples were from asymptomatic individuals. Over half of the total samples (1,073; 55.5%) were obtained from asymptomatic volunteers. The sensitivity of the antigen test was significantly lower for asymptomatic group than for symptomatic patients (67.1% vs 89.3%, p < 0.001). The specificity was 100% for both groups, and no false positives were observed among all 1,934 samples. The median Ct value for the asymptomatic group was significantly higher than that of the symptomatic group (24 vs 20, p < 0.001).ConclusionsThe QuickNavi™-COVID19 Ag showed a lower sensitivity for asymptomatic group than for symptomatic patients. However, its specificity was consistently high, and no false positives were found in this study.

scholarly journals Detection and Isolation of Asymptomatic Individuals Can Make The Difference in COVID-19 Epidemic Management

2020 ◽  
Author(s):  
Lia Mayorga ◽  
Clara García Samartino ◽  
Gabriel Flores ◽  
Sofía Masuelli ◽  
María V. Sánchez ◽  
...  
Keyword(s):  
Compartmental Model ◽  
Mitigation Measures ◽  
Asymptomatic Group ◽  
Healthcare Burden ◽  
Fundamental Part ◽  
Management Policies ◽  
The Difference ◽  
Asymptomatic Individuals ◽  
The Impact ◽  
The Ideal

Abstract Background: Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Methods: We present a compartmental model for the disease where symptomatic and asymptomatic individuals move separately. We introduced healthcare burden parameters allowing to infer possible containment and suppression strategies. In addition, the model was scaled up to describe different interconnected areas, giving the possibility to trigger regionalized measures. It was specially adjusted to Mendoza-Argentina’s parameters, but is easily adaptable for elsewhere. Results: Overall, the simulations we carried out were notably more effective when mitigation measures were not relaxed in between the suppressive actions. Since asymptomatics or very mildly affected patients are the vast majority, we studied the impact of detecting and isolating them. The removal of asymptomatics from the infectious pool remarkably lowered the effective reproduction number, healthcare burden and overall fatality. Furthermore, different suppression triggers regarding ICU occupancy were attempted. The best scenario was found to be the combination of ICU occupancy triggers (on: 50%, off: 30%) with the detection and isolation of asymptomatic individuals. In the ideal assumption that 45% of the asymptomatics could be detected and isolated, there would be no need for complete lockdown, and Mendoza’s healthcare system would not collapse. Conclusions: Our model and its analysis inform that the detection and isolation of all infected individuals, without leaving aside the asymptomatic group is the key to surpass this pandemic.

scholarly journals Histopathological Features of Symptomatic and Asymptomatic Honeybees Naturally Infected by Deformed Wing Virus

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 874
Author(s):  
Karen Power ◽  
Manuela Martano ◽  
Gennaro Altamura ◽  
Nadia Piscopo ◽  
Paola Maiolino
Keyword(s):  
Viral Load ◽  
Asymptomatic Group ◽  
Deformed Wing Virus ◽  
Stage Of Development ◽  
Pathogenic Action ◽  
Degenerative Alterations ◽  
Flight Muscles ◽  
Asymptomatic Individuals ◽  
Histopathological Results

Deformed wing virus (DWV) is capable of infecting honeybees at every stage of development causing symptomatic and asymptomatic infections. To date, very little is known about the histopathological lesions caused by the virus. Therefore, 40 honeybee samples were randomly collected from a naturally DWV infected hive and subjected to anatomopathological examination to discriminate between symptomatic (29) and asymptomatic (11) honeybees. Subsequently, 15 honeybee samples were frozen at −80° and analyzed by PCR and RTqPCR to determinate the presence/absence of the virus and the relative viral load, while 25 honeybee samples were analyzed by histopathological techniques. Biomolecular results showed a fragment of the expected size (69bp) of DWV in all samples and the viral load was higher in symptomatic honeybees compared to the asymptomatic group. Histopathological results showed degenerative alterations of the hypopharyngeal glands (19/25) and flight muscles (6/25) in symptomatic samples while 4/25 asymptomatic samples showed an inflammatory response in the midgut and the hemocele. Results suggest a possible pathogenic action of DWV in both symptomatic and asymptomatic honeybees, and a role of the immune response in keeping under control the virus in asymptomatic individuals.

scholarly journals Advances in Plant Disease Detection and Monitoring: From Traditional Assays to In-Field Diagnostics

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2129 ◽  
Author(s):  
Ilaria Buja ◽  
Erika Sabella ◽  
Anna Grazia Monteduro ◽  
Maria Serena Chiriacò ◽  
Luigi De Bellis ◽  
...  
Keyword(s):  
Emerging Diseases ◽  
Diagnostic Methods ◽  
Preventive Actions ◽  
Initial Symptoms ◽  
New Frontier ◽  
Information And Communication ◽  
Instruments And Techniques ◽  
The Difference ◽  
Asymptomatic Individuals

Human activities significantly contribute to worldwide spread of phytopathological adversities. Pathogen-related food losses are today responsible for a reduction in quantity and quality of yield and decrease value and financial returns. As a result, “early detection” in combination with “fast, accurate, and cheap” diagnostics have also become the new mantra in plant pathology, especially for emerging diseases or challenging pathogens that spread thanks to asymptomatic individuals with subtle initial symptoms but are then difficult to face. Furthermore, in a globalized market sensitive to epidemics, innovative tools suitable for field-use represent the new frontier with respect to diagnostic laboratories, ensuring that the instruments and techniques used are suitable for the operational contexts. In this framework, portable systems and interconnection with Internet of Things (IoT) play a pivotal role. Here we review innovative diagnostic methods based on nanotechnologies and new perspectives concerning information and communication technology (ICT) in agriculture, resulting in an improvement in agricultural and rural development and in the ability to revolutionize the concept of “preventive actions”, making the difference in fighting against phytopathogens, all over the world.

scholarly journals Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population

BJPsych Open ◽  
2017 ◽  
Vol 3 (5) ◽  
pp. 236-242 ◽  
Author(s):  
Martin Glans ◽  
Susanne Bejerot ◽  
Mats B. Humble
Keyword(s):  
Developmental Coordination Disorder ◽  
Normal Population ◽  
Adult Population ◽  
Autism Spectrum ◽  
Joint Hypermobility ◽  
Swedish Population ◽  
Hyperactivity Disorder ◽  
Coordination Disorder ◽  
Clinical Populations ◽  
Clinical Cases

BackgroundGeneralised joint hypermobility (GJH) is reportedly overrepresented among clinical cases of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and developmental coordination disorder (DCD). It is unknown if these associations are dimensional and, therefore, also relevant among non-clinical populations.AimsTo investigate if GJH correlates with sub-syndromal neurodevelopmental symptoms in a normal population.MethodHakim-Grahame's 5-part questionnaire (5PQ) on GJH, neuropsychiatric screening scales measuring ADHD and ASD traits, and a DCD-related question concerning clumsiness were distributed to a non-clinical, adult, Swedish population (n=1039).ResultsIn total, 887 individuals met our entry criteria. We found no associations between GJH and sub-syndromal symptoms of ADHD, ASD or DCD.ConclusionsAlthough GJH is overrepresented in clinical cases with neurodevelopmental disorders, such an association seems absent in a normal population. Thus, if GJH serves as a biomarker cutting across diagnostic boundaries, this association is presumably limited to clinical populations.

SPINAL DEFORMITY

Neurosurgery ◽  
2008 ◽  
Vol 63 (suppl_3) ◽  
pp. A25-A39 ◽  
Author(s):  
Charles Kuntz ◽  
Christopher I. Shaffrey ◽  
Stephen L. Ondra ◽  
Atiq A. Durrani ◽  
Praveen V. Mummaneni ◽  
...  
Keyword(s):  
Literature Review ◽  
Spinal Deformity ◽  
English Literature ◽  
Spinal Alignment ◽  
New Classification ◽  
Sagittal Spinal Alignment ◽  
Asymptomatic Volunteers ◽  
Asymptomatic Individuals ◽  
Spinal Abnormality

ABSTRACT OBJECTIVE In this literature review, the authors analyze data from previously published studies that evaluated neutral upright spinal alignment (NUSA) from the occiput to the pelvis in asymptomatic individuals. Based on the data for NUSA in asymptomatic volunteers, a new classification is proposed for spinal deformity. METHODS A review of the English literature was conducted to identify studies evaluating NUSA from the occiput to the pelvis in asymptomatic juvenile, adolescent, adult, and geriatric volunteers. From the literature review, 17 angles and displacements were selected to depict neutral upright coronal and axial spinal alignment, and 21 angles and displacements were selected to depict neutral upright sagittal spinal alignment. Pooled estimates of the mean and variance were calculated for the angles and displacements from the articles that met inclusion criteria. A new classification of spinal deformity was then developed based on age-dependent NUSA; spinal abnormality; deformity curve location, pattern, magnitude, and flexibility; and global spinal alignment. RESULTS Despite a wide variation in the regional curves from the occiput to the pelvis in asymptomatic volunteers, global spinal alignment is maintained in a narrow range for preservation of horizontal gaze and balance of the spine over the pelvis and femoral heads. CONCLUSION A new classification of spinal deformity is proposed that provides a structure for defining deformity of all patient ages and spinal abnormalities.

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