scholarly journals Diastereoselective Synthesis of some pyrrolidin-2-ones azasugars and study of their stereochemistry

2019 ◽  
Vol 8 (1) ◽  
pp. 42-52 ◽  
Author(s):  
Chahrazed Benhaoua ◽  
Mustapha Rahmouni ◽  
Hadj Benhaoua
Keyword(s):  
Reaction Times ◽  
Diastereoselective Synthesis ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Cyanide Group ◽  
Iminium Ions ◽  
In Situ Generation ◽  
Work Up ◽  
Reaction Profile

The microwave-promoted one-pot multicomponent synthesis of substituted pyrrolidinols using a bifunctional sugar-derived hydroxy-[gamma]-lactone component of amine component or cyanide group is reported. Clean reaction profile, easy work-up procedure, excellent yields and short reaction times are some remarkable features of this method.This modular approach features the in situ-generation of iminium ions intermediate that allows the diastereoselective assembly of the diverse pyrrolidinones efficiently under microwave irradiation has been used.

Diastereoselective Synthesis of Functionalised Trans-Tetrahydrobenzofuran-4-Ones in an Aqueous Medium by using DABCO as an Efficient Catalyst

2017 ◽  
Vol 41 (11) ◽  
pp. 657-660 ◽  
Author(s):  
Mohammad Reza Salari ◽  
Mohammad H. Mosslemin ◽  
Alireza Hassanabadi
Keyword(s):  
Aqueous Medium ◽  
High Purity ◽  
Reaction Times ◽  
Diastereoselective Synthesis ◽  
Efficient Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Pyridinium Bromide ◽  
Work Up

A one-pot, efficient synthesis of 11 novel 2,3-diacylated trans-tetrahydrobenzofuran-4-one derivatives has been achieved via a three-component condensation of a N-(4-halophenacyl)-pyridinium bromide, a cyclic 1,3-diketone such as 5,5-dimethyl-1,3-cyclohexanedione (dimedone) or cyclohexane-1,3-dione and an arylglyoxal in the presence of catalytic amounts of 1,4-diaza-bicyclo[2.2.2]octane (DABCO) in water under reflux conditions. The attractive features of the method are excellent yields and high purity, short reaction times, easy work-up, and use of an inexpensive and non-toxic catalyst.

One-pot, Multicomponent Synthesis under Microwave Conditions of New Imidazole and Acridine Benzamido Acetic Acid Derivatives

2018 ◽  
Vol 42 (2) ◽  
pp. 80-85
Author(s):  
Niloofar Jazi ◽  
Samieh Fozooni ◽  
Hooshang Hamidian
Keyword(s):  
Acetic Acid ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Ammonium Acetate ◽  
Reaction Times ◽  
Solvent Free ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Work Up ◽  
Solvent Free Reaction

Starting from 4-aminohippuric acid (AHA), two novel series of heterocyclic compounds of pharmaceutical interest have been synthesised by one-pot, multicomponent reactions under microwave conditions. Reaction of AHA with various aldehydes and benzil in (1:1) EtOH/acetic acid in the presence of ammonium acetate yielded 1,2,3,5-tetra-arylated imidazole derivatives, whereas a solvent-free reaction of AHA with various aldehydes and dimedone (2 equiv.) in the presence of p-TSA yielded 4,9-diarylated 1,8-dioxo-decahydroacridine derivatives. These reactions produced good yields in short reaction times with an easy work-up, and purification of products was achieved by simple recrystallisation.

scholarly journals A Rapid, Convient and Diversified-Multicomponent Synthesis and Characterization of Pyrano[2,3-b]Indoles

2014 ◽  
Vol 26 ◽  
pp. 69-76
Author(s):  
H.B. Ghodasara ◽  
P.M. Singala ◽  
Viresh H. Shah
Keyword(s):  
Chromatographic Method ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Synthesis And Characterization ◽  
Basic Catalyst ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
High Yields ◽  
Work Up

A series of pyrano[2,3-b]indoles, was efficiently synthesized via one-pot, multi component reaction (MCRs) of 1,3-bifunctional synthon(malononitrile/ethylcyano acetate), aromatic aldehydes and oxiindole in the presence of various basic catalyst. The key advantages of this process are high yields, shorter reaction times, easy work-up, and purification of products by non-chromatographic method.

scholarly journals An Efficient One-Pot Multicomponent Synthesis and Characterization of 5-Cyano-1,2,3,4-Tetrahydropyrimidine Derivatives

2014 ◽  
Vol 40 ◽  
pp. 51-60
Author(s):  
R.G. Vaghasiya ◽  
V.H. Shah
Keyword(s):  
Chromatographic Method ◽  
Reaction Times ◽  
Synthesis And Characterization ◽  
Basic Catalyst ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
High Yields ◽  
Work Up

A series of pyrimidine-5-carbonitrile derivatives was efficiently synthesized via one-pot, multi component reaction (MCRs) of 1,3-bifunctional synthon (ethylcyano acetate), substituted pyrazole-4-carbaldehyde, and thiourea/urea in the presence of basic catalyst. The key advantages of this process are high yields, shorter reaction times, easy work-up, and purification of products by non-chromatographic method.

Rapid and Green One-Pot Synthesis of Novel 2-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-diones

2021 ◽  
Vol 18 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Zahra Ghahremany ◽  
Madieh Sadeghpour
Keyword(s):  
Aromatic Amines ◽  
Low Cost ◽  
Guanidine Hydrochloride ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
The One ◽  
High Yields ◽  
Work Up

: A green and efficient protocol was developed for the one-pot three-component synthesis of novel 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-dione derivatives by the reaction of 4-hydroxycoumarin, ninhydrin and aromatic amines in the presence of guanidine hydrochloride as an organocatalyst under solvent-free conditions. The present approach offers several advantages such as low cost, simple work-up, short reaction times, chromatography-free purification, high yields and greener conditions.

scholarly journals A Facile Solvent-Free Route for One-Pot Multicomponent Synthesis of Benzylpyrazolyl Coumarins Derivatives in Presence of Effective Synergetic Catalytic System

2019 ◽  
Vol 31 (6) ◽  
pp. 1357-1361 ◽  
Author(s):  
NARENDRA R. KAMBLE ◽  
VINOD T. KAMBLE
Keyword(s):  
Room Temperature ◽  
Silver Salt ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Niobium Pentachloride ◽  
Solvent Free Conditions ◽  
Work Up ◽  
Solvent Free Reaction

A combinatorial library of benzylpyrazolyl coumarin derivatives have been synthesized by a green one-pot four-component reaction between aryl hydrazine/hydrazine hydrate (1), ethyl acetoacetate (2), aromatic aldehydes (3) and 4-hydroxycoumarin (4) catalyzed by niobium pentachloride with silver salt under solvent-free conditions has been developed. Experimental simplicity, simple work-up procedure and solvent-free reaction condition at room temperature are important features of the present protocol.

One-pot three-component polymerization for in situ generation of AIE-active poly(tetraarylethene)s using Grignard reagents as building blocks

2020 ◽  
Vol 11 (35) ◽  
pp. 5601-5609
Author(s):  
Zijie Qiu ◽  
Qingqing Gao ◽  
Ting Han ◽  
Xiaolin Liu ◽  
Jacky W. Y. Lam ◽  
...  
Keyword(s):  
Building Blocks ◽  
Grignard Reagents ◽  
One Pot ◽  
Aggregation Induced Emission ◽  
In Situ Generation

A facile polymerization route for in situ generation of polymers with aggregation-induced emission (AIE) characteristics has been developed.

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