scholarly journals Idiopathic Chondrolysis Condition in Two Young, Wild-caught Cynomolgus Monkeys (Macaca fascicularis) Reared in Captivity

2009 ◽  
Vol 46 (3) ◽  
pp. 509-513 ◽  
Author(s):  
S. Rao ◽  
M. Bryant ◽  
R. Herbert ◽  
N. Sullivan ◽  
C. Murray ◽  
...  
Keyword(s):  
Femoral Head ◽  
Laboratory Animal ◽  
Macaca Fascicularis ◽  
Clinical Entity ◽  
Perthes Disease ◽  
Differential Diagnoses ◽  
Cynomolgus Monkeys ◽  
Clinical Symptomatology ◽  
Cynomolgus Macaques ◽  
In Captivity

Idiopathic chondrolysis is a human clinical entity typically reported in adolescent individuals. In this brief communication, we report 2 cases of presumptive idiopathic chondrolysis of the femoral head in Cynomolgus macaques and discuss the clinical symptomatology and pathology of the disease. In detail, we describe the histomorphologic changes of idiopathic chondrolysis and compare these findings with those typically observed in the primary differential diagnoses of Legg-Calve-Perthes disease and nonspecific osteoarthritis. Consideration of this entity among differential diagnoses in young Cynomolgus macaques with unilateral osteoarthritis could be important both for laboratory animal veterinarians and pathologists.

Parasite fauna of Javanese macaques (Macaca fascicularis)

2021 ◽  
Vol 1 (11) ◽  
pp. 72-77
Author(s):  
A. K. Klyueva ◽  
◽  
Alexander A. Deltsov ◽  
T. P. Egorova ◽  
◽  
...  
Keyword(s):  
Large Intestine ◽  
Macaca Fascicularis ◽  
Proximal Colon ◽  
Parasite Fauna ◽  
Balantidium Coli ◽  
Blastocystis Spp ◽  
Cynomolgus Macaques ◽  
In Captivity ◽  
Blastocystis Sp ◽  
Parasitological Study

This paper presents an analysis of the parasite fauna of Javanese macaques kept in captivity in the conditions of the Adler nursery of the FGBNU «NII MP». In the course of the parasitological study, 245 Macaca fascicularis monkeys were examined. As a result, it was revealed that they have 4 varieties of worms of the nematode class: Ancylostoma spp., Trichoceephalus spp., Strongyloides spp., Oesophagostomum spp., As well as 3 species of protozoa: Balantidium coli, Blastocystis spp. and Lamblia intestinalis. During the analysis of the data obtained, it was found that the total invasion of the studied animals was 44.5%. It was found that the most common types of helminths found in the studied animals are Strongyloides spp., Parasitizing in the duodenum and upper jejunum of mammals, the extent of invasion was 6.9%. Of the protozoa, the species Balantidium coli, parasitizing in mammals in the large intestine, was most often found; the extent of invasion was 18.8%. The extensiveness of the invasion of Ancylostoma spp., Localized in the small intestine, in the studied cynomolgus macaques was 5.7%, Blastocystis spp., Found in the cecum and proximal colon, 2.9%, Trichoceephalus spp., Parasitizing in the blind part of the intestine, – 3.3%, Oesophagostomum spp., penetrating into the mucous membrane and submucosa of the large intestine, – 0.8%. Also, the studied macaques were found to have combined invasions. Extensiveness of invasion of Balantidium coli simultaneously with Strongyloides spp. was 0.8%, Balantidium coli simultaneously with Trichoceephalus spp. – 1.2%, Balantidium coli simultaneously with Ancylostoma spp. – 0.4%, Balantidium coli simultaneously with Blastocystis sp. – 0.4%, Balantidium coli simultaneously with Oesophagostomum spp. and Trichoceephalus spp. – 0.4%, Strongyloides spp. simultaneously with Lamblia intestinalis – 0.4%, Strongyloides spp. simultaneously with Trichoceephalus spp. – 1.2%, Blastocystis sp. simultaneously with Ancylostoma spp. – 0.4%, Blastocystis spp. simultaneously with Trichoceephalus spp. – 0.4%, Trichoceephalus spp. simultaneously with Ancylostoma spp. – 0.4%.

Cerebral Infarction in Two Cynomolgus Macaques (Macaca fascicularis) with Hypernatremia

1996 ◽  
Vol 33 (4) ◽  
pp. 431-434 ◽  
Author(s):  
E. S. Harber ◽  
M. G. O'Sullivan ◽  
M. J. Jayo ◽  
C. S. Carlson
Keyword(s):  
Cerebral Infarction ◽  
Water Deprivation ◽  
Macaca Fascicularis ◽  
Human Beings ◽  
Cerebral Lesions ◽  
Cynomolgus Monkeys ◽  
Cellular Dehydration ◽  
Cynomolgus Macaques ◽  
Occipital Lobes ◽  
The Brain

Hypernatremia resulting in neurologic symptoms ranging from lethargy to coma, and with underlying lesions of cerebral hemorrhage and thrombosis, has been reported in human beings. Herein we report two cases of cerebral infarction with venous thrombosis in cynomolgus monkeys. Both animals were severely hypernatremic because of water deprivation, with serum sodium levels of 185 and 193 meq/liter, respectively. At necropsy, there were bilateral multiple hemorrhagic and malacic areas visible on the surface of the cerebrum and extending into the parenchyma, primarily involving the occipital lobes. These lesions were interpreted microscopically as infarcts because, in addition to hemorrhage and necrosis, multiple thrombi were present in small and medium-sized veins of gray matter and meninges. The pathogenesis of hypernatremia-induced cerebral lesions is believed to involve cellular dehydration that caused shrinkage of the brain. Because the vasculature of the brain is tightly adherent to the skull, this shrinkage results in tearing of blood vessels, with consequent hemorrhage and thrombosis.

Reproduction of cynomolgus monkeys (Macaca fascicularis) in harems

1981 ◽  
Vol 15 (2) ◽  
pp. 119-123 ◽  
Author(s):  
P. J. A. Timmermans ◽  
W. G. P. Schouten ◽  
J. C. M. Krijnen
Keyword(s):  
Production Rate ◽  
Live Birth ◽  
Macaca Fascicularis ◽  
Peer Groups ◽  
Maternal Behaviour ◽  
Cynomolgus Monkeys ◽  
In Captivity ◽  
In The Wild ◽  
Significant Factors

Adult monkeys caught in the wild were housed in 2 harems and used for breeding during 7 successive years. Monkeys born in captivity and reared in the parental groups or in peer groups were also used for breeding. The live birth production rate amounted to 80% and reproduction was stable over the 7 year period. All but one of the females born in captivity showed normal maternal behaviour towards their firstborn infants. Aggression between females, breech deliveries, infanticide and reluctance of the male to copulate with females which grew up in his harem, were significant factors that reduced productivity.

scholarly journals Detection of tuberculosis in cynomolgus macaques (Macaca fascicularis) using a supplementary Monkey Interferon Gamma Releasing Assay (mIGRA)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
S. Warit ◽  
P. Billamas ◽  
N. Makhao ◽  
S. Jaitrong ◽  
T. Juthayothin ◽  
...  
Keyword(s):  
Macaca Fascicularis ◽  
Close Contact ◽  
High Sensitivity ◽  
Pharmaceutical Product ◽  
Cynomolgus Monkeys ◽  
Cynomolgus Macaques ◽  
Ifn Γ ◽  
Culture Positive ◽  
Positive Results ◽  
Bidirectional Transmission

Abstract Cynomolgus monkeys (Macaca fascicularis; MF) are commonly used as nonhuman primate models for pharmaceutical product testing. In their habitat range, monkeys have close contact with humans, allowing the possibility of bidirectional transmission of tuberculosis (TB) between the two species. Although the intradermal tuberculin skin test (TST) is used for TB detection in MF, it has limitations. Herein, we established the mIGRA, combining human QuantiFERON-TB Gold-Plus and monkey IFN-γ ELISApro systems, and used it to investigate 39 captive MF who were cage-mates or lived in cages located near a monkey who died from the naturally TB infection. During a 12-month period of study, 14 (36%), 10 (26%), and 8 (21%) monkeys showed TB-positive results using the mIGRA, the TST, and TB culture, respectively. Among the 14 mIGRA-positive monkeys, 8 (57.1%) were TST-positive and 7 (50%) were culture-positive, indicating early TB detection in the latent and active TB stages with the mIGRA. Interestingly, 3 (37.5%) of the TST-negative monkeys were culture-positive. Our study showed that the mIGRA offers many advantages, including high sensitivity and high throughput, and it requires only one on-site visit to the animals. The assay may be used as a supplementary tool for TB screening in MF.

Effects of transdermal mirtazapine on hyporexic rhesus and cynomolgus macaques ( Macaca mulatta and Macaca fascicularis )

2021 ◽  
Vol 50 (2) ◽  
pp. 128-133
Author(s):  
Kriscelle A. Mendoza ◽  
Diane E. Stockinger ◽  
Mira J. Cukrov ◽  
Jeffrey A. Roberts ◽  
Granger G.C. Hwa
Keyword(s):  
Macaca Mulatta ◽  
Macaca Fascicularis ◽  
Cynomolgus Macaques

scholarly journals Gorham Stout disease: a case report from Syria

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Asil Esper ◽  
Sami Alhoulaiby ◽  
Areege Emran ◽  
Safwan Youssef ◽  
Zuheir Alshehabi
Keyword(s):  
Case Report ◽  
Femoral Head ◽  
Bone Formation ◽  
Clinical Picture ◽  
Bone Matrix ◽  
Differential Diagnoses ◽  
Rare Entity ◽  
Relative Improvement ◽  
Cellular Atypia ◽  
Pathologic Fractures

Abstract Gorham-Stout disease (GSD) is a rare entity that destroys the bone matrix resulting mainly in osteolysis, pain and pathologic fractures among a broader clinical picture. We report a case of a 60-year-old female with a sudden discovery of pathologic fractures in the pelvis and the absence of the left femoral head. On biopsy, no cellular atypia was found, instead disturbed bone formation with prominent vascularity with scattered foci of necrosis & osteolysis, which lead to the diagnosis of GSD. Possible differential diagnoses were discussed and excluded. The patient was put on Bisphosphonate that led to a relative improvement in the symptoms. This disease needs a more thorough investigation to identify the key cause, what is beyond the scope of this report.

Cloned blastocysts produced by nuclear transfer from somatic cells in cynomolgus monkeys (Macaca fascicularis)

Primates ◽  
2007 ◽  
Vol 48 (3) ◽  
pp. 232-240 ◽  
Author(s):  
Junko Okahara-Narita ◽  
Hideaki Tsuchiya ◽  
Tatsuyuki Takada ◽  
Ryuzo Torii
Keyword(s):  
Nuclear Transfer ◽  
Macaca Fascicularis ◽  
Somatic Cells ◽  
Cynomolgus Monkeys
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