A Singlet Molecular Oxygen Imaging Sensor for Photodynamic Therapy

2008 ◽  
Author(s):  
S. Lee ◽  
D.H. Vu ◽  
M.F. Hinds ◽  
S.J. Davis ◽  
J.A. O’Hara ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Molecular Oxygen ◽  
Singlet Molecular Oxygen ◽  
Oxygen Imaging ◽  
Imaging Sensor

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Reaction of indomethacin with singlet molecular oxygen

1980 ◽  
Vol 29 (10) ◽  
pp. 1337-1340 ◽  
Author(s):  
Richard S. Bodaness ◽  
Phillip C. Chan
Keyword(s):  
Molecular Oxygen ◽  
Singlet Molecular Oxygen

Cholesterol Hydroperoxides Generate Singlet Molecular Oxygen [O2(1Δg)]: Near-IR Emission,18O-Labeled Hydroperoxides, and Mass Spectrometry

2011 ◽  
Vol 24 (6) ◽  
pp. 887-895 ◽  
Author(s):  
Miriam Uemi ◽  
Graziella E. Ronsein ◽  
Fernanda M. Prado ◽  
Flávia D. Motta ◽  
Sayuri Miyamoto ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Oxygen ◽  
Singlet Molecular Oxygen ◽  
Near Ir ◽  
Ir Emission

Photosensitized generation of singlet molecular oxygen by aryloxazinones

2008 ◽  
Vol 199 (2-3) ◽  
pp. 345-352 ◽  
Author(s):  
Else Lemp ◽  
Alvaro Cañete ◽  
German Günther ◽  
Nancy Pizarro ◽  
Antonio L. Zanocco
Keyword(s):  
Molecular Oxygen ◽  
Singlet Molecular Oxygen
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