scholarly journals High-throughput, volumetric quantitative phase imaging with multiplexed intensity diffraction tomography

2019 ◽  
Vol 10 (12) ◽  
pp. 6432 ◽  
Author(s):  
Alex Matlock ◽  
Lei Tian
Keyword(s):  
High Throughput ◽  
Phase Imaging ◽  
Diffraction Tomography ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase

scholarly journals From digital holographic microscopy to optical coherence tomography – separate past and a common goal

2021 ◽  
Vol 13 (4) ◽  
pp. 91
Author(s):  
Arkadiusz Kuś ◽  
Wojciech Krauze ◽  
Małgorzata Kujawińska
Keyword(s):  
Optical Coherence Tomography ◽  
Three Dimensional ◽  
Optical Diffraction ◽  
Phase Imaging ◽  
Diffraction Tomography ◽  
Optical Coherence ◽  
Quantitative Phase Imaging ◽  
Isotropic Resolution ◽  
Quantitative Phase ◽  
Transparent Objects

In this paper we briefly present the history and outlook on the development of two seemingly distant techniques which may be brought close together with a unified theoretical model described as common k-space theory. This theory also known as the Fourier diffraction theorem is much less common in optical coherence tomography than its traditional mathematical model, but it has been extensively studied in digital holography and, more importantly, optical diffraction tomography. As demonstrated with several examples, this link is one of the important factors for future development of both techniques. Full Text: PDF ReferencesN. Leith, J. Upatnieks, "Reconstructed Wavefronts and Communication Theory", J. Opt. Soc. Am. 52(10), 1123 (1962). CrossRef Y. Park, C. Depeursinge, G. Popescu, "Quantitative phase imaging in biomedicine", Nat. Photonics 12, 578 (2018). CrossRef D. Huang et al., "Optical Coherence Tomography", Science 254(5035), 1178 (1991). CrossRef D. P. Popescu, C. Flueraru, S. Chang, J. Disano, S. Sherif, M.G. Sowa, "Optical coherence tomography: fundamental principles, instrumental designs and biomedical applications", Biophys. Rev. 3(3), 155 (2011). CrossRef M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, J.S. Duker, "Three-dimensional Retinal Imaging with High-Speed Ultrahigh-Resolution Optical Coherence Tomography", Ophthalmology 112(10), 1734 (2005). CrossRef K.C. Zhou, R. Qian, A.-H. Dhalla, S. Farsiu, J.A. Izatt, "Unified k-space theory of optical coherence tomography", Adv. Opt. Photon. 13(2), 462 (2021). CrossRef A.F. Fercher, C.K. Hitzenberger, G. Kamp, S.Y. El-Zaiat, "Measurement of intraocular distances by backscattering spectral interferometry", Opt. Comm. 117(1-2), 43 (1995). CrossRef E. Wolf, "Determination of the Amplitude and the Phase of Scattered Fields by Holography", J. Opt. Soc. Am. 60(1), 18 (1970). CrossRef E. Wolf, "Three-dimensional structure determination of semi-transparent objects from holographic data", Opt. Comm. 1(4), 153 (1969). CrossRef V. Balasubramani et al., "Roadmap on Digital Holography-Based Quantitative Phase Imaging", J. Imaging 7(12), 252 (2021). CrossRef A. Kuś, W. Krauze, P.L. Makowski, M. Kujawińska, "Holographic tomography: hardware and software solutions for 3D quantitative biomedical imaging (Invited paper)", ETRI J. 41(1), 61 (2019). CrossRef A. Kuś, M. Dudek, M. Kujawińska, B. Kemper, A. Vollmer, "Tomographic phase microscopy of living three-dimensional cell cultures", J. Biomed. Opt. 19(4), 46009 (2014). CrossRef O. Haeberlé, K. Belkebir, H. Giovaninni, A. Sentenac, "Tomographic diffractive microscopy: basics, techniques and perspectives", J. Mod. Opt. 57(9), 686 (2010). CrossRef B. Simon et al., "Tomographic diffractive microscopy with isotropic resolution", Optica 4(4), 460 (2017). CrossRef B.A. Roberts, A.C. Kak, "Reflection Mode Diffraction Tomography", Ultrason. Imag. 7, 300 (1985). CrossRef M. Sarmis et al., "High resolution reflection tomographic diffractive microscopy", J. Mod. Opt. 57(9), 740 (2010). CrossRef L. Foucault et al., "Versatile transmission/reflection tomographic diffractive microscopy approach", J. Opt. Soc. Am. A 36(11), C18 (2019). CrossRef W. Krauze, P. Ossowski, M. Nowakowski, M. Szkulmowski, M. Kujawińska, "Enhanced QPI functionality by combining OCT and ODT methods", Proc. SPIE 11653, 116530B (2021). CrossRef E. Mudry, P.C. Chaumet, K. Belkebir, G. Maire, A. Sentenac, "Mirror-assisted tomographic diffractive microscopy with isotropic resolution", Opt. Lett. 35(11), 1857 (2010). CrossRef P. Hosseini, Y. Sung, Y. Choi, N. Lue, Z. Yaqoob, P. So, "Scanning color optical tomography (SCOT)", Opt. Expr. 23(15), 19752 (2015). CrossRef J. Jung, K. Kim, J. Yoon, Y. Park, "Hyperspectral optical diffraction tomography", Opt. Expr. 24(3), 1881 (2016). CrossRef T. Zhang et al., Biomed. "Multi-wavelength multi-angle reflection tomography", Opt. Expr. 26(20), 26093 (2018). CrossRef R.A. Leitgeb, "En face optical coherence tomography: a technology review [Invited]", Biomed. Opt. Expr. 10(5), 2177 (2019). CrossRef J.F. de Boer, R. Leitgeb, M. Wojtkowski, "Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT [Invited]", Biomed. Opt. Expr. 8(7), 3248 (2017). CrossRef T. Anna, V. Srivastava, C. Shakher, "Transmission Mode Full-Field Swept-Source Optical Coherence Tomography for Simultaneous Amplitude and Quantitative Phase Imaging of Transparent Objects", IEEE Photon. Technol. Lett. 23(11), 899 (2011). CrossRef M.T. Rinehart, V. Jaedicke, A. Wax, "Quantitative phase microscopy with off-axis optical coherence tomography", Opt. Lett. 39(7), 1996 (2014). CrossRef C. Photiou, C. Pitris, "Dual-angle optical coherence tomography for index of refraction estimation using rigid registration and cross-correlation", J. Biomed. Opt. 24(10), 1 (2019). CrossRef Y. Zhou, K.K.H. Chan, T. Lai, S. Tang, "Characterizing refractive index and thickness of biological tissues using combined multiphoton microscopy and optical coherence tomography", Biomed. Opt. Expr. 4(1), 38 (2013). CrossRef K.C. Zhou, R. Qian, S. Degan, S. Farsiu, J.A. Izatt, "Optical coherence refraction tomography", Nat. Photon. 13, 794 (2019). CrossRef

scholarly journals Multi-ATOM: Ultrahigh-throughput single-cell quantitative phase imaging with subcellular resolution

2019 ◽  
Author(s):  
Kelvin C. M. Lee ◽  
Andy K. S. Lau ◽  
Anson H. L. Tang ◽  
Maolin Wang ◽  
Aaron T. Y. Mok ◽  
...  
Keyword(s):  
Single Cell ◽  
High Throughput ◽  
Large Scale ◽  
Phase Retrieval ◽  
Leukemic Cells ◽  
Phase Imaging ◽  
Label Free ◽  
Quantitative Phase Imaging ◽  
Phase Gradient ◽  
Quantitative Phase

AbstractA growing body of evidence has substantiated the significance of quantitative phase imaging (QPI) in enabling cost-effective and label-free cellular assay, which provides useful insights into understanding biophysical properties of cells and their roles in cellular functions. However, available QPI modalities are limited by the loss of imaging resolution at high throughput and thus run short of sufficient statistical power at the single cell precision to define cell identities in a large and heterogeneous population of cells – hindering their utility in mainstream biomedicine and biology. Here we present a new QPI modality, coined multi-ATOM that captures and processes quantitative label-free single-cell images at ultra-high throughput without compromising sub-cellular resolution. We show that multi-ATOM, based upon ultrafast phase-gradient encoding, outperforms state-of-the-art QPI in permitting robust phase retrieval at a QPI throughput of >10,000 cell/sec, bypassing the need for interferometry which inevitably compromises QPI quality under ultrafast operation. We employ multi-ATOM for large-scale, label-free, multi-variate, cell-type classification (e.g. breast cancer sub-types, and leukemic cells versus peripheral blood mononuclear cells) at high accuracy (>94%). Our results suggest that multi-ATOM could empower new strategies in large-scale biophysical single-cell analysis with applications in biology and enriching disease diagnostics.

scholarly journals Simultaneous measurement of neurite and neural body mass accumulation via quantitative phase imaging

The Analyst ◽  
2021 ◽  
Author(s):  
Soorya Pradeep ◽  
Tasmia Tasnim ◽  
Huanan Zhang ◽  
Thomas A. Zangle
Keyword(s):  
Body Mass ◽  
Biomass Production ◽  
Simultaneous Measurement ◽  
Neural Differentiation ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase ◽  
Mass Accumulation

Quantitative phase imaging (QPI) used to quantify the mass of soma (cell bodies) and neurites as well as the rates of biomass production due to neurite maturation and formation during neural differentiation.

scholarly journals High-speed line-field confocal holographic microscope for quantitative phase imaging

2016 ◽  
Vol 24 (9) ◽  
pp. 9251 ◽  
Author(s):  
Changgeng Liu ◽  
Sebastian Knitter ◽  
Zhilong Cong ◽  
Ikbal Sencan ◽  
Hui Cao ◽  
...  
Keyword(s):  
High Speed ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Line Field ◽  
Quantitative Phase
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