Simultaneous Determination of Rubber Additives by FT-IR Spectrophotometry with Multivariate Calibration

1995 ◽  
Vol 49 (6) ◽  
pp. 747-753 ◽  
Author(s):  
M. Blanco ◽  
J. Coello ◽  
H. Iturriaga ◽  
S. Maspoch ◽  
E. Bertran
Keyword(s):  
Fourier Transform ◽  
Simultaneous Determination ◽  
Partial Least Squares Regression ◽  
Multivariate Calibration ◽  
Least Squares Regression ◽  
First Derivative ◽  
Vulcanized Rubber ◽  
Ir Spectrophotometry ◽  
Ft Ir

A new method for the simultaneous determination of vulcanized rubber additives by Fourier transform infrared (FT-IR) spectrophotometry using partial least-squares regression (PLSR) for multivariate calibration was developed. The effect of various wavenumber ranges and the use of the absorbance and first-derivative spectral modes on performance were studied by applying the method to three different sample batches containing several additives in different proportions, all of which were resolved with satisfactory results.

scholarly journals MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS

2017 ◽  
Vol 1 (1) ◽  
pp. 50-55
Author(s):  
Vitor Todeschini ◽  
Regiane Leite ◽  
Maximiliano Sangoi ◽  
Paulo Oliveira ◽  
Thiago Barth
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Method ◽  
Partial Least Squares Regression ◽  
Fixed Dose ◽  
Least Squares Regression ◽  
Acceptable Range ◽  
Validation Parameters ◽  
Simple Alternative ◽  
Predict Model

A multicomponent ultraviolet (UV) spectrophotometric method was developed and validated for simultaneous determination of delapril (DEL) and indapamide (IND) in tablets employing the partial least squares regression (PLSR) approach. The PLSR method was developed by a multilevel factorial design using 25 synthetic mixtures of drugs and a significant predict model (p < 0.05) were obtained at 225 nm for DEL (r2 = 0.9992) and 243 nm for IND (r2 = 0.9997). Validation parameters such as the specificity, linearity, precision, accuracy and robustness were evaluated in accordance with the ICH requirements, giving satisfactory results within the acceptable range. The proposed PLSR method was successfully applied for simultaneous determination of DEL and IND in fixed dose combinations and can be used as simple alternative to separation techniques.

Sign in / Sign up

Export Citation Format

Share Document