Filaricidal properties of Lantana camara and Tamarindus indica extracts, and Lantadene A from L. camara against Onchocerca ochengi and Loa loa

Background: Lantana camara L. belongs to the family Verbenaceae. It originated in Tropical America in Southern Georgia and to the North of Texas and was introduced in Calcutta, India in the year 1809 as an ornamental hedge. The plant L. Camara is also distributed in Southeast Asia, China, Australia, Brazil, West Indies, Kenya, Mexico, East Africa, Tanzania. Many of its phytoconstituents possess medicinal properties which are used traditionally to treat fever, uterine hemorrhage, and excess menstrual discharge, chronic ulcers, rheumatism, gonorrhea, toothache, gastrointestinal pain, etc, and has been used in Brazil for curing malaria, mange, headaches, colds, and fevers. Objectives: The review elaborates traditional practices, phytochemistry of Lantana camara L. along with the role of Lantana camara in various types of cancers. Method: The data on L. camara was collected through different online databases like Web of Science, PubMed, Science Direct, Springer, and Google Scholar. Results: Major phytoconstituents isolated from the plant shows anticancer activity specially lantadene A-D, icterogenin, oleanolic acid, lantacamaric acid A, B, oleanonic acid, etc. In vitro and in vivo studies demonstrate its potential for various cancers. Certain extracts, isolated compounds, and their semi-synthetic derivatives have depicted a significant cytotoxic and anti-proliferative effect. Conclusion: Clinical studies are not yet established, therefore, making it crucial to direct future researches in that area.

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Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum

BMC Complementary and Alternative Medicine ◽

10.1186/s12906-016-1319-2 ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 7

Author(s):

Fidelis Cho-Ngwa ◽

Elvis Monya ◽

Boris K. Azantsa ◽

Faustin Pascal T. Manfo ◽

Smith B. Babiaka ◽

...

Keyword(s):

Phytochemical Screening ◽

Loa Loa ◽

Onchocerca Ochengi

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ChemInform Abstract: Structure of Lantadene A, the Major Triterpenoid of Lantana Camara, Red Variety.

ChemInform ◽

10.1002/chin.199129253 ◽

2010 ◽

Vol 22 (29) ◽

pp. no-no

Author(s):

V. PATTABHI ◽

N. SUKUMAR ◽

O. P. SHARMA

Keyword(s):

Lantana Camara ◽

Abstract Structure ◽

Red Variety ◽

Lantadene A

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22b-[(S)-2-Methylbutanoyloxy]-3-oxoolean-12-en-28-oic acid, a new constituent of Lantana camara

Australian Journal of Chemistry ◽

10.1071/ch9831895 ◽

1983 ◽

Vol 36 (9) ◽

pp. 1895 ◽

Cited By ~ 16

Author(s):

SR Johns ◽

JA Lamberton ◽

TC Morton ◽

H Suares ◽

RI Willing

Keyword(s):

Catalytic Hydrogenation ◽

Lantana Camara ◽

Lantadene A ◽

Natural Ester

22β-[(S)-2-Methylbutanoyloxy]-3-oxoolean-12-en-28-oic acid, a new constituent of Lantanu camara L. is closely related to lantadene A and lantadene B. Although hydrolysis gives 2-methylbutanoic acid as a partial racemate, it has been shown by n.m.r. spectroscopy that the natural ester is theoptically pure (S)-isomer. Catalytic hydrogenation of lantadene A gives a mixture of diastereoisomeric esters in which the (S)-2-methylbutanoate predominates, and a 1 : 1 mixture of the (R)- and(S)-esters was obtained by esterification with (RS)-2-methylbutanoyl chloride of 22β-hydroxy-3-oxoolean-12-en-28-oic acid protected as the diphenylmethyl ester.

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Labia and Lingua Histopathology of Bali Cow (Bos sondaicus) on Hepatogenous Photosensitization Symptoms in Pakutatan Village, Jembrana, Bali

Advances in Tropical Biodiversity and Environmental Sciences ◽

10.24843/atbes.2018.v02.i02.p04 ◽

2018 ◽

Vol 2 (2) ◽

pp. 31

Author(s):

Kadek Mardika ◽

Iriani Setyawati ◽

Dwi Ariani Yulihastuti

Keyword(s):

Histopathological Examination ◽

Cell Damage ◽

Lantana Camara ◽

Bacterial Invasion ◽

Average Percentage ◽

Large Numbers ◽

Hematoxylin And Eosin ◽

Lantadene A ◽

One Way Anova ◽

Paraffin Method

Hepatogenous photosensitization is one of the ruminant diseases with symptoms of dermatitis or eczema of the skin accompanied by liver damage. The disease is caused by the compounds of toxic lantadene A and lantadene B which are secondary metabolites of Lantana camara plant. This research was carried out on January 2017. The material used in this study was preserved organs of the labia and lingua of dead three year old cow (Bos sondaicus). Samples were taken from Pakutatan Village, Jembrana, Bali. Identification of organ samples, histological preparation and histopathological examination were conducted at the Disease Investigation Center (DIC) 6, Denpasar, Bali. The preparation of labia and lingua samples used the paraffin method with Hematoxylin and Eosin staining. The tissue structural damages found were necrosis, inflammatory cell infiltration, congestion and tissue bleeding. The data obtained were analyzed statistically by One Way Anova test with a confidence level of 95%. Based on the results, dead Bali cow which consumed a large numbers of Lantana camara plants showed that the highest number of cell damage was at the picnotic stage of cell necrosis (cell death) in the labia organ significantly (P<0.005), while the highest bacterial invasion was found in the labia organ with an average percentage of 12.40%.

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ChemInform Abstract: New Triterpenoids from Lantana camara: Isomerization of the Angeloyl Moiety of Lantadene A During Catalytic Hydrogenation.

ChemInform ◽

10.1002/chin.200040169 ◽

2000 ◽

Vol 31 (40) ◽

pp. no-no

Author(s):

S. B. Mahato ◽

S. Sharma ◽

B. Pramanik ◽

O. P. Sharma

Keyword(s):

Catalytic Hydrogenation ◽

Lantana Camara ◽

Lantadene A

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The effect of anthropogenic disturbance on non-native plant species in Madagascar

Journal of Tropical Ecology ◽

10.1017/s0266467416000481 ◽

2016 ◽

Vol 32 (6) ◽

pp. 543-554 ◽

Cited By ~ 2

Author(s):

A. Andrea Gudiel ◽

Shane C. Nieves ◽

Kim E. Reuter ◽

Brent J. Sewall

Keyword(s):

Plant Species ◽

Native Species ◽

Habitat Degradation ◽

Mangifera Indica ◽

Lantana Camara ◽

Mucuna Pruriens ◽

Native Plant ◽

Tamarindus Indica ◽

Native Plant Species ◽

Anthropogenic Habitat

Abstract:Non-native species impact tropical ecosystems, but the role of different anthropogenic disturbances on the success of non-natives remains unclear, especially in island tropical forests. We sought to understand the influence of anthropogenic habitat degradation and disturbance on non-native plant species in Madagascar. Specifically, we evaluated how densities of non-native species of woody shrub (Lantana camara), climber (Mucuna pruriens) and tree (Mangifera indica, Albizia lebbeck, Tamarindus indica) varied with forest habitat degradation and by disturbance type. We surveyed 60400 m2, recording 482 instances of disturbance and 903 non-native plants in and around the Ankarana National Park. Non-native plant densities were higher in degraded than primary forest. Within degraded forest, densities of non-native trees increased with disturbance. Tree densities correlated with extent of tree damage only in Tamarindus indica, never correlated with extent of tree removal, and always correlated with proximity to roads and trails. Our results suggest roads and trails have relatively greater importance in facilitating the success of non-native tree species than structural changes to habitat. In contrast, densities of Lantana camara and Tamarindus indica did not correlate with any measured type of disturbance; other unmeasured or historical factors may be more important drivers of these smaller, faster-reproducing species.

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