Phytoconstituents of Lantana camara L.: Rekindling Hope in the Cancer Treatment

2021 ◽  
Vol 18 ◽  
Author(s):  
Ishita Kathuria ◽  
Mit Joshi ◽  
Bhoomika M. Patel ◽  
Mahaveer Dhobi
Keyword(s):  
Lantana Camara ◽  
In Vivo Studies ◽  
The North ◽  
Proliferative Effect ◽  
Tropical America ◽  
Oleanonic Acid ◽  
Southern Georgia ◽  
Lantadene A

Background: Lantana camara L. belongs to the family Verbenaceae. It originated in Tropical America in Southern Georgia and to the North of Texas and was introduced in Calcutta, India in the year 1809 as an ornamental hedge. The plant L. Camara is also distributed in Southeast Asia, China, Australia, Brazil, West Indies, Kenya, Mexico, East Africa, Tanzania. Many of its phytoconstituents possess medicinal properties which are used traditionally to treat fever, uterine hemorrhage, and excess menstrual discharge, chronic ulcers, rheumatism, gonorrhea, toothache, gastrointestinal pain, etc, and has been used in Brazil for curing malaria, mange, headaches, colds, and fevers. Objectives: The review elaborates traditional practices, phytochemistry of Lantana camara L. along with the role of Lantana camara in various types of cancers. Method: The data on L. camara was collected through different online databases like Web of Science, PubMed, Science Direct, Springer, and Google Scholar. Results: Major phytoconstituents isolated from the plant shows anticancer activity specially lantadene A-D, icterogenin, oleanolic acid, lantacamaric acid A, B, oleanonic acid, etc. In vitro and in vivo studies demonstrate its potential for various cancers. Certain extracts, isolated compounds, and their semi-synthetic derivatives have depicted a significant cytotoxic and anti-proliferative effect. Conclusion: Clinical studies are not yet established, therefore, making it crucial to direct future researches in that area.

Ethnopharmacology, Phytochemistry and Biological Activities of Native Chilean Plants

2020 ◽  
Vol 26 ◽  
Author(s):  
Bahare Salehi ◽  
Javad Sharifi-Rad ◽  
Jesús Herrera-Bravo ◽  
Luis A. Salazar ◽  
Carla Delporte ◽  
...  
Keyword(s):  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Antioxidant Compounds ◽  
Native Flora ◽  
The North ◽  
Phenolic Components

: The native flora of Chile has unique characteristics due to the geographical situation of the country, with the vast desert in the North, Patagonia in the South, the Andean Mountains on the east and the Pacific Ocean on the west. This exclusivity is reflected in high concentrations of phytochemicals in the fruits and leaves of its native plants. Some examples are Aristotelia chilensis (Molina) Stuntz (maqui), Berberis microphylla G. Forst. (calafate), Peumus boldus Molina (boldo), Ribes magellanicum Poir. (Magellan currant), Ugni molinae Turcz. (murtilla), Rubus geoides Sm. (miñe miñe), Drimys winteri J.R.Forst. & G.Forst. (canelo), Luma apiculata (DC.) Burret (arrayán) distributed throughout the entire Chilean territory. Some of these Chilean plants have been used for centuries in the country's traditional medicine. The most recent studies of phytochemical characterization of parts of Chilean plants show a wide spectrum of antioxidant compounds, phenolic components, terpenoids and alkaloids, which have shown biological activity in both in vitro and in vivo studies. This manuscript covers the entire Chilean territory characterizing the phytochemical profile and reporting some of its biological properties, focusing mainly on antioxidant, anti-inflammatory, antimicrobial, chemopreventive and cytotoxic activity, and potential against diabetes, metabolic syndrome and gastrointestinal disorders.

scholarly journals Ear leucochroism on winter rye cultivars in agroecological conditions of Kirov region

2020 ◽  
Vol 193 (2) ◽  
pp. 27-36
Author(s):  
Lyuciya Schekleina ◽  
Tat'yana Sheshegova
Keyword(s):  
Plant Protection ◽  
In Vivo Studies ◽  
Winter Rye ◽  
Microbiological Analysis ◽  
North East ◽  
The North ◽  
Plant Stand ◽  
Domestic Breeding

Abstract. The purpose of the study is to study the effect of environment and genotype on the expression of ear leucochroism in winter rye plants. Methods. The research was carried out in the laboratory of immunity and plant protection of FASC of the North-East. The conditions and peculiarities of the expression of ear leucochroism and stalk albinosis in 48 domestic varieties of winter rye was studied in field and laboratory experiments. In tested populations, count of such biotypes, phytopathological and microbiological analysis of root system and grain in affected plants were done. Repetition in in vivo studies – 2-fold, in vitro – 4-fold. Results. Five cultivars of a rye bred in FASC of the North-East (Sarmat, Falenskaya universal’naya, Garmoniya, Grafinya, and Perepel) with defeat up to 0.10 %, and 11 domestic cultivars of some Russian research institutions (Moskovskaya 2, Saratovskaya 7, Marusenka, Talovskaya 33, Pamyaty Bambysheva, Solnechnaya, Antares, HBAK-285/15, Slavia, Talovskaya 41, and Alpha) with defeat up to 0.07 % are revealed at a state of this trait at the indicator – 0.31 %. A positive link was found between root infection and plant ear leucochroism (r = 0.15 and r = 0.30), but there was no clear evidence of the dependence of the nature and degree of grain infection on the state of the trait. The level of ear leucochroism is significantly affected by the density of the plant stand due to the resistance to snow mold in regional conditions (r = 0.29 and r = 0.79). The dominant contribution of the genotype to the variability of the sign of ear leucochroism, which amounted to 68.4 % in new populations bred in FASC of the North-East, and in cultivars of domestic breeding – 59.4 %, has been established. A significant effect of the microenvironment (31.0 % and 39.6 %) on pathogenesis, expressed in field test repeats, was also found.

In vitro and in vivo studies of new cationic Zn(II)‐benzonaphthoporphyrazines as photosensitizers for PDT

2001 ◽  
Vol 5 (8) ◽  
pp. 645-651
Author(s):  
M. Peeva ◽  
M. Shopova ◽  
U. Michelsen ◽  
D. Wöhrle ◽  
G. Petrov ◽  
...  
Keyword(s):  
In Vivo Studies

Effect of caffeine on theophyliine on cerebral blood flow response to brain activation: In vitro and in vivo studies

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S198-S198
Author(s):  
Joseph R Meno ◽  
Thien-son K Nguyen ◽  
Elise M Jensen ◽  
G Alexander West ◽  
Leonid Groysman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Activation ◽  
In Vivo Studies ◽  
Blood Flow Response ◽  
Flow Response

Effects of Unfractionated and Low Molecular Weight Heparins on Platelet Thromboxane Biosynthesis “In Vivo”

1994 ◽  
Vol 72 (06) ◽  
pp. 942-946 ◽  
Author(s):  
Raffaele Landolfi ◽  
Erica De Candia ◽  
Bianca Rocca ◽  
Giovanni Ciabattoni ◽  
Armando Antinori ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Unfractionated Heparin ◽  
Low Molecular Weight Heparin ◽  
Primary Source ◽  
In Vivo Studies ◽  
Low Molecular Weight ◽  
Heparin Administration ◽  
To Receive

SummarySeveral “in vitro” and “in vivo” studies indicate that heparin administration may affect platelet function. In this study we investigated the effects of prophylactic heparin on thromboxane (Tx)A2 biosynthesis “in vivo”, as assessed by the urinary excretion of major enzymatic metabolites 11-dehydro-TxB2 and 2,3-dinor-TxB2. Twenty-four patients who were candidates for cholecystectomy because of uncomplicated lithiasis were randomly assigned to receive placebo, unfractionated heparin, low molecular weight heparin or unfractionaed heparin plus 100 mg aspirin. Measurements of daily excretion of Tx metabolites were performed before and during the treatment. In the groups assigned to placebo and to low molecular weight heparin there was no statistically significant modification of Tx metabolite excretion while patients receiving unfractionated heparin had a significant increase of both metabolites (11-dehydro-TxB2: 3844 ± 1388 vs 2092 ±777, p <0.05; 2,3-dinor-TxB2: 2737 ± 808 vs 1535 ± 771 pg/mg creatinine, p <0.05). In patients randomized to receive low-dose aspirin plus unfractionated heparin the excretion of the two metabolites was largely suppressed thus suggesting that platelets are the primary source of enhanced thromboxane biosynthesis associated with heparin administration. These data indicate that unfractionated heparin causes platelet activation “in vivo” and suggest that the use of low molecular weight heparin may avoid this complication.

Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies

2020 ◽  
Vol 72 (5) ◽  
Author(s):  
Mario Fadin ◽  
Maria C. Nicoletti ◽  
Marzia Pellizzato ◽  
Manuela Accardi ◽  
Maria G. Baietti ◽  
...  
Keyword(s):  
In Vivo Studies
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