scholarly journals High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47155 ◽  
Author(s):  
Jedrzej Hoffmann ◽  
Karel Fiser ◽  
Jolanta Weaver ◽  
Ian Dimmick ◽  
Monika Loeher ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cell ◽  
High Throughput ◽  
Cell Compartment

scholarly journals CD8+T-Cells Count in Acute Myocardial Infarction in HIV Disease in a Predominantly Male Cohort

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Oluwatosin A. Badejo ◽  
Chung-Chou Chang ◽  
Kaku A. So-Armah ◽  
Russell P. Tracy ◽  
Jason V. Baker ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cell ◽  
Cell Count ◽  
Hiv Viral Load ◽  
Cvd Risk ◽  
Infected People ◽  
Cell Counts ◽  
Immunodeficiency Virus ◽  
Male Cohort

Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4+T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8+T-cell count is associated with CVD risk is not clear. We investigated the association between CD8+T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8+T-cell counts (>1065 cells/mm3) had increased AMI risk (adjustedHR=1.82, P<0.001, 95% CI: 1.46 to 2.28). There was evidence that the effect of CD8+T-cell tertiles on AMI risk differed by CD4+T-cell level: compared to uninfected people, HIV-infected people with CD4+T-cell counts ≥200 cells/mm3had increased AMI risk with high CD8+T-cell count, while those with CD4+T-cell counts <200 cells/mm3had increased AMI risk with low CD8+T-cell count. CD8+T-cell counts may add additional AMI risk stratification information beyond that provided by CD4+T-cell counts alone.

Interplay of antibody and T cell responses in acute myocardial infarction

2001 ◽  
Vol 138 (2) ◽  
pp. 112-118 ◽  
Author(s):  
Abdul W. Elahi ◽  
Asha N. Vijayakumar ◽  
Edgar Lichstein ◽  
Foroozan Mokhtarian
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses

scholarly journals Assessment of regulatory/effector T cell balance along with pro/anti-inflammatory cytokines level in acute myocardial infarction

2014 ◽  
Vol 66 ◽  
pp. S17
Author(s):  
Saibal Mukhopadhyay ◽  
Hariram Maharia ◽  
Jamal Yusuf ◽  
Vimal Mehta ◽  
Vijay Trehan ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cell ◽  
Inflammatory Cytokines ◽  
Effector T Cell ◽  
Anti Inflammatory ◽  
Cell Balance

scholarly journals CD100 modulates cytotoxicity of CD8+ T cells in patients with acute myocardial infarction

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yan Li ◽  
Li Qin ◽  
Qijun Bai ◽  
Jingjing Zhang ◽  
Ruixue Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cells ◽  
T Cell ◽  
Angina Pectoris ◽  
Cell Activity ◽  
Regulatory Function ◽  
Indirect Contact ◽  
Direct Cytotoxicity ◽  
Membrane Bound

Abstract Background CD100 is an immune semaphorin family member that highly expressed on T cells, which take part in the development of acute myocardial infarction (AMI). Matrix metalloproteinases (MMPs) are important mediators for membrane-bound CD100 (mCD100) shedding from T cells to generate soluble CD100 (sCD100), which has immunoregulatory effect on T cells. The aim of this study was to investigate modulatory role of CD100 on CD8+ T cell activity in AMI patients. Methods Peripheral sCD100 and MMP-2 level, as well as mCD100 level on T cells was assessed in patients with stable angina pectoris (SAP), unstable angina pectoris (UAP), and AMI. The regulatory function of MMP-2 on mCD100 shedding, sCD100 formation, and cytotoxicity of CD8+ T cells was analyzed in direct and indirect contact co-culture system. Results AMI patients had higher peripheral sCD100 and lower mCD100 expression on CD8+ T cells in comparison with SAP, UAP, and controls. CD8+ T cells in AMI patients showed elevated direct cytotoxicity, enhanced cytokine production, and increased perforin/granzyme B secretion. Recombinant sCD100 stimulation promoted cytolytic function of CD8+ T cells in controls and AMI patients. Furthermore, AMI patients also had elevated circulating MMP-2 level. Recombinant MMP-2 stimulation induced mCD100 shedding from CD8+ T cells and sCD100 generation, resulting in enhancement of CD8+ T cell cytotoxicity in AMI patients. Conclusion Up-regulation of MMP-2 might contribute to elevation of mCD100 shedding and sCD100 formation, leading to increased cytotoxicity CD8+ T cells in AMI patients.

scholarly journals Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation

2015 ◽  
Vol 37 (6) ◽  
pp. 2415-2424 ◽  
Author(s):  
Xiaomei Teng ◽  
Lei Chen ◽  
Weiqian Chen ◽  
Junjie Yang ◽  
Ziying Yang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cell Proliferation ◽  
T Cell ◽  
Cell Function ◽  
Heart Function ◽  
Umbilical Vein ◽  
Tube Formation ◽  
Sprague Dawley

Background/Aims: Bone marrow mesenchymal stem cells (MSCs) widely applied for treating myocardial infarction face survival challenges in the inflammatory and ischemia microenvironment of acute myocardial infarction. The study hypothesized that MSC-derived exosomes play a significant role in improving microenvironment after acute myocardial infarction and aimed to investigate the paracrine effects of exosomes on angiogenesis and anti-inflammatory activity. Methods: MSCs were cultured in DMEM/F12 supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin for 48 h. MSC-derived exosomes were isolated using ExoQuick-TC. Tube formation and T-cell proliferation assays were performed to assess the angiogenic potency of MSC-derived exosomes. Acute myocardial infarction was induced in Sprague-Dawley rats, and myocardium bordering the infarcted zone was injected at four different sites with phosphate-buffered saline (PBS, control), MSC-derived exosomes, and exosome-depleted MSC culture medium. Results: MSC-derived exosomes significantly enhanced the tube formation of human umbilical vein endothelial cells, impaired T-cell function by inhibiting cell proliferation in vitro, reduced infarct size, and preserved cardiac systolic and diastolic performance compared with PBS markedly enhancing the density of new functional capillary and hence blood flow recovery in rat myocardial infarction model. Conclusions: Exosomes stimulate neovascularization and restrain the inflammation response, thus improving heart function after ischemic injury.

Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction

2003 ◽  
Vol 168 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Mitsuharu Hosono ◽  
Onno J de Boer ◽  
Allard C van der Wal ◽  
Chris M van der Loos ◽  
Peter Teeling ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T Cell ◽  
Unstable Angina ◽  
T Cell Activation ◽  
Cell Activation ◽  
Activation Markers

An electron microscopic study of the intra-myocardial lesions in cases of acute myocardial infarction

1978 ◽  
Vol 36 (2) ◽  
pp. 484-485
Author(s):  
Masahiro Ono ◽  
Kaoru Aihara ◽  
Gompachi Yajima
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Vessels ◽  
Vascular Wall ◽  
Vascular Changes ◽  
Electron Microscopic ◽  
Main Trunk ◽  
Mechanical Destruction ◽  
Transmission Electron ◽  
Myocardial Lesions

The pathogenesis of the arteriosclerosis in the acute myocardial infarction is the matter of the extensive survey with the transmission electron microscopy in experimental and clinical materials. In the previous communication,the authors have clarified that the two types of the coronary vascular changes could exist. The first category is the case in which we had failed to observe no occlusive changes of the coronary vessels which eventually form the myocardial infarction. The next category is the case in which occlusive -thrombotic changes are observed in which the myocardial infarction will be taken placed as the final event. The authors incline to designate the former category as the non-occlusive-non thrombotic lesions. The most important findings in both cases are the “mechanical destruction of the vascular wall and imbibition of the serous component” which are most frequently observed at the proximal portion of the coronary main trunk.

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