scholarly journals Elucidating the Signal Responses of Multi-Parametric Surface Plasmon Resonance Living Cell Sensing: A Comparison between Optical Modeling and Drug–MDCKII Cell Interaction Measurements

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72192 ◽  
Author(s):  
Tapani Viitala ◽  
Niko Granqvist ◽  
Susanna Hallila ◽  
Manuela Raviña ◽  
Marjo Yliperttula
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Living Cell ◽  
Cell Interaction ◽  
Parametric Surface ◽  
Optical Modeling

An irregular-shaped homogeneous refractive index model for interpretation of the surface plasmon resonance response from living cell attachment

2016 ◽  
Vol 8 (16) ◽  
pp. 3301-3306 ◽  
Author(s):  
Shijie Deng ◽  
Xinglong Yu ◽  
Peng Wang
Keyword(s):  
Refractive Index ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Living Cell ◽  
Cell Attachment ◽  
Mathematical Formalism ◽  
Index Model ◽  
Resonance Response ◽  
Surface Plasmon Resonance Response

A simple but quantitative mathematical formalism was developed for interpretation of the SPR response from living cell attachment.

N-monosubstituted thiosemicarbazide as novel Ure inhibitors: synthesis, biological evaluation and molecular docking

2020 ◽  
Vol 12 (18) ◽  
pp. 1633-1645
Author(s):  
Wei-Wei Ni ◽  
Hai-Lian Fang ◽  
Ya-Xi Ye ◽  
Wei-Yi Li ◽  
Chu-Ping Yuan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Molecular Docking ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Living Cell ◽  
Biological Evaluation ◽  
High Potency ◽  
High Affinity ◽  
Excellent Activity

Background: Identification of novel Ure inhibitors with high potency has received considerable attention. Methodology & results: Ure inhibition was determined using the indophenol method, the affinities to Ure were estimated via surface plasmon resonance. Seventeen new plus ten known N-monosubstituted thiosemicarbazides were synthesized and identified as novel Ure inhibitors. Out of these compounds, compound b5 shows excellent activity against both crude Ure from Helicobacter pylori (IC50 = 0.04 μM) and Ure in living cell (IC50 = 0.27 μM), with the potency being over 600-fold higher than clinical used drug acetohyroxamic acid, respectively. Surface plasmon resonance demonstrated the high affinity ( Kd.#x00A0;= 6.32 nM) of b5 to Ure. Conclusion: This work provides a class of novel and promising Ure inhibitors.

scholarly journals Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation

2016 ◽  
Vol 7 (2) ◽  
pp. 228-240 ◽  
Author(s):  
Otto K. Kari ◽  
Tatu Rojalin ◽  
Stefano Salmaso ◽  
Michela Barattin ◽  
Hanna Jarva ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Protein Corona ◽  
Parametric Surface ◽  
Corona Formation

A surface plasmon resonance imaging system for the stimulated living cell analysis

2015 ◽  
Vol 11 (1) ◽  
pp. 77-80 ◽  
Author(s):  
Lu-lu Zhang ◽  
Xing Chen ◽  
Yang Du ◽  
Qian Zhang ◽  
Hui Li ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Living Cell ◽  
Imaging System ◽  
Cell Analysis ◽  
Surface Plasmon Resonance Imaging ◽  
Resonance Imaging
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