scholarly journals Elucidating the Signal Responses of Multi-Parametric Surface Plasmon Resonance Living Cell Sensing: A Comparison between Optical Modeling and Drug–MDCKII Cell Interaction Measurements

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72192 ◽  
Author(s):  
Tapani Viitala ◽  
Niko Granqvist ◽  
Susanna Hallila ◽  
Manuela Raviña ◽  
Marjo Yliperttula
2016 ◽  
Vol 8 (16) ◽  
pp. 3301-3306 ◽  
Author(s):  
Shijie Deng ◽  
Xinglong Yu ◽  
Peng Wang

A simple but quantitative mathematical formalism was developed for interpretation of the SPR response from living cell attachment.


2020 ◽  
Vol 12 (18) ◽  
pp. 1633-1645
Author(s):  
Wei-Wei Ni ◽  
Hai-Lian Fang ◽  
Ya-Xi Ye ◽  
Wei-Yi Li ◽  
Chu-Ping Yuan ◽  
...  

Background: Identification of novel Ure inhibitors with high potency has received considerable attention. Methodology & results: Ure inhibition was determined using the indophenol method, the affinities to Ure were estimated via surface plasmon resonance. Seventeen new plus ten known N-monosubstituted thiosemicarbazides were synthesized and identified as novel Ure inhibitors. Out of these compounds, compound b5 shows excellent activity against both crude Ure from Helicobacter pylori (IC50 = 0.04 μM) and Ure in living cell (IC50 = 0.27 μM), with the potency being over 600-fold higher than clinical used drug acetohyroxamic acid, respectively. Surface plasmon resonance demonstrated the high affinity ( Kd.#x00A0;= 6.32 nM) of b5 to Ure. Conclusion: This work provides a class of novel and promising Ure inhibitors.


2016 ◽  
Vol 7 (2) ◽  
pp. 228-240 ◽  
Author(s):  
Otto K. Kari ◽  
Tatu Rojalin ◽  
Stefano Salmaso ◽  
Michela Barattin ◽  
Hanna Jarva ◽  
...  

2015 ◽  
Vol 11 (1) ◽  
pp. 77-80 ◽  
Author(s):  
Lu-lu Zhang ◽  
Xing Chen ◽  
Yang Du ◽  
Qian Zhang ◽  
Hui Li ◽  
...  

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