Fatness but Not Fitness Relative to the Fat-Free Mass Is Related to C-Reactive Protein in 18 Year-Old Adolescents

Background. Tuberculosis causes inflammation and muscle wasting. We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population.Design. Twenty-four patients (23 to 79 years old) with pulmonary tuberculosis and inflammation (pretreatment albumin g/dL, C-reactive protein [CRP] μg/dL, and beta-2-microglobulin μg/L) were evaluated and had BIA over 24 weeks.Results. Weight increased by kg (5.5%; ) at week 4 and by kg (15.6%; ) at week 24. Repletion of body mass was primarily fat, which increased by kg at week 4 and kg at week 24 ( and versus baseline). Fat-free mass (FFM), body cell mass (BCM), and phase angle did not increase until study week 8. Albumin rose to g/dL by week 4 () and slowly increased thereafter. CRP levels declined by~50% at each interval visit.Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.

Download Full-text

Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Frontiers in Neuroscience ◽

10.3389/fnins.2021.715330 ◽

2021 ◽

Vol 15 ◽

Author(s):

Gary S. Goldfield ◽

Jeremy Walsh ◽

Ronald J. Sigal ◽

Glen P. Kenny ◽

Stasia Hadjiyannakis ◽

...

Keyword(s):

Body Composition ◽

Energy Intake ◽

Metabolic Regulation ◽

Fat Free Mass ◽

C Reactive Protein ◽

Metabolic Complications ◽

Val66met Polymorphism ◽

Reactive Protein ◽

Bdnf Val66met Polymorphism ◽

Cardiometabolic Profile

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is functionally related to BDNF, and is associated with obesity and metabolic complications in adults, but limited research exists among adolescents. This study comparatively examined carriers and non-carriers of the BDNF Val66Met polymorphism on body composition, energy intake, and cardiometabolic profile among adolescents with obesity. The sample consisted of 187 adolescents with obesity; 99 were carriers of the homozygous Val (G/G) alleles and 88 were carriers of the Val/Met (G/A) or Met (A/A) alleles. Cardiometabolic profile and DNA were quantified from fasted blood samples. Body composition was assessed by magnetic resonance imaging (MRI). Compared to carriers of the homozygous Val (G/G) allele, carriers of the Val/Met (G/A) or Met/Met (A/A) variants exhibited significantly higher protein (p = 0.01) and fat (p = 0.05) intake, C-Reactive protein (p = 0.05), and a trend toward higher overall energy intake (p = 0.07), fat-free mass (p = 0.07), and lower HDL-C (p = 0.07) Results showed for the first time that among youth with obesity, carriers of the Val66Met BDNF Met-alleles exhibited significantly higher C-reactive protein and energy intake in the form of fat and protein compared to Val-allele carriers, thereby providing support for the possible role of BDNF in appetite, weight, and metabolic regulation during adolescence.Clinical Trial Registration:http://clinicaltrials.gov/, identifier NCT00195858.

Download Full-text