scholarly journals Assessment of Overlap of Phylogenetic Transmission Clusters and Communities in Simple Sexual Contact Networks: Applications to HIV-1

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148459 ◽  
Author(s):  
Luc Villandre ◽  
David A. Stephens ◽  
Aurelie Labbe ◽  
Huldrych F. Günthard ◽  
Roger Kouyos ◽  
...  
Author(s):  
Bernadien M. Nijmeijer ◽  
Marta Bermejo-Jambrina ◽  
Tanja M. Kaptein ◽  
Carla M. S. Ribeiro ◽  
Doris Wilflingseder ◽  
...  

AbstractSemen is important in determining HIV-1 susceptibility but it is unclear how it affects virus transmission during sexual contact. Mucosal Langerhans cells (LCs) are the first immune cells to encounter HIV-1 during sexual contact and have a barrier function as LCs are restrictive to HIV-1. As semen from people living with HIV-1 contains complement-opsonized HIV-1, we investigated the effect of complement on HIV-1 dissemination by human LCs in vitro and ex vivo. Notably, pre-treatment of HIV-1 with semen enhanced LC infection compared to untreated HIV-1 in the ex vivo explant model. Infection of LCs and transmission to target cells by opsonized HIV-1 was efficiently inhibited by blocking complement receptors CR3 and CR4. Complement opsonization of HIV-1 enhanced uptake, fusion, and integration by LCs leading to an increased transmission of HIV-1 to target cells. However, in the absence of both CR3 and CR4, C-type lectin receptor langerin was able to restrict infection of complement-opsonized HIV-1. These data suggest that complement enhances HIV-1 infection of LCs by binding CR3 and CR4, thereby bypassing langerin and changing the restrictive nature of LCs into virus-disseminating cells. Targeting complement factors might be effective in preventing HIV-1 transmission.


2017 ◽  
Vol 13 (3) ◽  
pp. e1005448 ◽  
Author(s):  
David A. Rasmussen ◽  
Roger Kouyos ◽  
Huldrych F. Günthard ◽  
Tanja Stadler

2017 ◽  
Vol 114 (34) ◽  
pp. 8969-8973 ◽  
Author(s):  
Antoine Allard ◽  
Benjamin M. Althouse ◽  
Samuel V. Scarpino ◽  
Laurent Hébert-Dufresne

Zika virus (ZIKV) exhibits unique transmission dynamics in that it is concurrently spread by a mosquito vector and through sexual contact. Due to the highly asymmetric durations of infectiousness between males and females—it is estimated that males are infectious for periods up to 10 times longer than females—we show that this sexual component of ZIKV transmission behaves akin to an asymmetric percolation process on the network of sexual contacts. We exactly solve the properties of this asymmetric percolation on random sexual contact networks and show that this process exhibits two epidemic transitions corresponding to a core–periphery structure. This structure is not present in the underlying contact networks, which are not distinguishable from random networks, and emerges because of the asymmetric percolation. We provide an exact analytical description of this double transition and discuss the implications of our results in the context of ZIKV epidemics. Most importantly, our study suggests a bias in our current ZIKV surveillance, because the community most at risk is also one of the least likely to get tested.


2015 ◽  
Vol 88 (4) ◽  
pp. 614-621 ◽  
Author(s):  
Lin Li ◽  
Guoqing Sun ◽  
Ping Zhong ◽  
Jingwan Han ◽  
Tianyi Li ◽  
...  

1996 ◽  
Vol 47 (1-2) ◽  
pp. 120
Author(s):  
Yupa Urwijitaroon ◽  
Amornarat Romphruk ◽  
Sahawat Barusrux
Keyword(s):  
Class I ◽  

AIDS ◽  
2000 ◽  
Vol 14 (2) ◽  
pp. F17-F23 ◽  
Author(s):  
Horacio Salomon ◽  
Mark A Wainberg ◽  
Bluma Brenner ◽  
Yudong Quan ◽  
Danielle Rouleau ◽  
...  

2016 ◽  
Author(s):  
David A. Rasmussen ◽  
Roger Kouyos ◽  
Huldrych F. Günthard ◽  
Tanja Stadler

AbstractPhylodynamic models are widely used in infectious disease epidemiology to infer the dynamics and structure of pathogen populations. However, these models generally assume that individual hosts contact one another at random, ignoring the fact that many pathogens spread through highly structured contact networks. We present a new framework for phylodynamics on local contact networks based on pairwise epidemiological models that track the status of pairs of nodes in the network rather than just individuals. Shifting our focus from individuals to pairs leads naturally to coalescent models that describe how lineages move through networks and the rate at which lineages coalesce. These pairwise coalescent models not only consider how network structure directly shapes pathogen phylogenies, but also how the relationship between phylogenies and contact networks changes depending on epidemic dynamics and the fraction of infected hosts sampled. By considering pathogen phylogenies in a probabilistic framework, these coalescent models can also be used to estimate the statistical properties of contact networks directly from phylogenies using likelihood-based inference. We use this framework to explore how much information phylogenies retain about the underlying structure of contact networks and to infer the structure of a sexual contact network underlying a large HIV-1 sub-epidemic in Switzerland.


2019 ◽  
Author(s):  
Hongyu Zheng ◽  
Xiangrui Zeng

AbstractSince 2007, ZIKV outbreaks have been occurring around the world. While ZIKV is mainly spread by mosquito vectors, transmission via sex activities enables the virus to spread in regions without mosquito vectors. Modeling the patterns of ZIKV outbreak in these regions remain challenging. We consider age as an asymmetric factor in transmitting ZIKV, in addition to gender as seen in previous literature, and modify the graph structure for better modeling of such patterns. We derived our results by both solving the underlying differential equations and simulation on population graph. Based on a double asymmetric percolation process on sexual contact networks. we discovered a quadruple ZIKV epidemic transition. Moreover, we explored the double asymmetric percolation on scale-free networks. Our work provides more insight into the ZIKV transmission dynamics through sexual contact networks, which may potentially provide better public health control and prevention means in a ZIKV outbreak.


2013 ◽  
Vol 9 (6) ◽  
pp. e1003105 ◽  
Author(s):  
Katy Robinson ◽  
Nick Fyson ◽  
Ted Cohen ◽  
Christophe Fraser ◽  
Caroline Colijn

1996 ◽  
Vol 7 (1) ◽  
pp. 34-38 ◽  
Author(s):  
E J Beck ◽  
S Mandalia ◽  
K Leonard ◽  
R J Griffith ◽  
J R W Harris ◽  
...  

The aim of the study was to investigate the association between infection with HIV-1 infection and a history of other sexually transmitted diseases (STD). We were able to match 1295 HIV-1 infected patients who attended St Mary's Hospital between 1985 and 1991 with 1273 seronegative controls on gender, sexual orientation, injecting drug use and age at time of test. The cases were 3 times more likely to have a history of ever having had another STD than the controls: multivariate conditional logistic regression showed that, after controlling for sexual behaviour, for known sexual contact with an HIV infected individual or AIDS patient or with a resident from a high HIV prevalence area, area of residence and for year of test, a history of gonorrhoea, syphilis, hepatitis B, genital herpes or genital warts were all significantly associated with HIV-1 seropositive status. These findings reinforce the need for HIV containment strategies to be promoted in conjunction with containment programmes for other STDs.


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