scholarly journals Colonization prevalence and antibiotic susceptibility of Group B Streptococcus in pregnant women over a 6-year period in Dongguan, China

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183083 ◽  
Author(s):  
Wenjing Ji ◽  
Lihua Zhang ◽  
Zhusheng Guo ◽  
Shujin Xie ◽  
Weiqing Yang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Group B

scholarly journals Antibiotic susceptibility pattern of group B streptococcal isolates from maternal genital tract

2019 ◽  
Vol 8 (7) ◽  
pp. 2738
Author(s):  
Vijayan Sharmila ◽  
Thirunavukkarasu Arun Babu
Keyword(s):  
Pregnant Women ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Antibiotic Sensitivity ◽  
Developed Countries ◽  
Susceptibility Pattern ◽  
Antibiotic Susceptibility Pattern ◽  
Sensitivity Pattern ◽  
Prevention And Treatment ◽  
Group B

Background: Group B streptococcus (GBS) is one of the important cause of early onset neonatal sepsis in developed countries leading to increased neonatal morbidity and mortality. Penicillin and Ampicillin are the drugs of choice for prevention of GBS infections. Antibiotic resistance amongst GBS isolates is an emerging health problem affecting neonates. Hence, this study was performed to determine the antibiotic susceptibility pattern of Group B Streptococcus (GBS) in a population of pregnant women.Methods: A prospective study was done to screen pregnant women for vaginal and rectal GBS colonization during their regular visits to antenatal clinic. Todd-Hewitt broth, an enrichment medium for GBS was used for isolation. The antibiotic susceptibility pattern of the isolates were studied.  Results: A total of 300 pregnant women were screened for GBS colonization. GBS colonization rate in our study was 2.3%. The antibiotic susceptibility pattern of the isolates revealed that none of the isolates were resistant to penicillin or clindamycin, while resistance was noted to erythromycin (14.3%) and   tetracycline (71.4%).Conclusions: GBS continues to remain sensitive to Penicillin which is the drug of choice for prevention and treatment of GBS.  Consistent surveillance of antibiotic sensitivity pattern of GBS as well as for other organisms implicated in new born sepsis and maternal infections is required to formulate guidelines for prevention and treatment.

scholarly journals Group B streptococcus colonization, antibiotic susceptibility, and serotype distribution among Saudi pregnant women

2020 ◽  
Vol 52 (1) ◽  
pp. 70
Author(s):  
Amr Mohamed Mohamed ◽  
Mubashir Ahmad Khan ◽  
Aftab Faiz ◽  
Jawwad Ahmad ◽  
Elsheikh Babiker Khidir ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Serotype Distribution ◽  
Group B

Serotype distribution and antibiotic susceptibility of group B streptococci in pregnant women

2009 ◽  
Vol 138 (7) ◽  
pp. 979-981 ◽  
Author(s):  
A. DHANOA ◽  
R. KARUNAKARAN ◽  
S. D. PUTHUCHEARY
Keyword(s):  
Pregnant Women ◽  
Neonatal Sepsis ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Prevention Strategies ◽  
Serotype Distribution ◽  
Group B Streptococci ◽  
Birth Canal ◽  
Group B

SUMMARYGroup B streptococcus (GBS) is a leading cause of neonatal sepsis and is usually acquired via the woman's birth canal. GBS serotypes isolated from 200 pregnant women were determined. Serotypes V (19%) and VI (17%) were the most frequent followed by serotypes III (12%), Ia (11·5%) and IV (10%); 17% of the strains were non-typable. All isolates were susceptible to penicillin, 96% to erythromycin and 97·5% to clindamycin. The emergence of new GBS serotypes has important implications for vaccine prevention strategies.

scholarly journals Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252328
Author(s):  
Dodi Safari ◽  
Septiani Madonna Gultom ◽  
Wisnu Tafroji ◽  
Athiya Azzahidah ◽  
Frida Soesanti ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Bacterial Pathogen ◽  
Neonatal Infection ◽  
Multidrug Resistant ◽  
Latex Agglutination ◽  
Antimicrobial Susceptibility Profile ◽  
Culture Identification ◽  
Group B

Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29–40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment.

scholarly journals An initial survey on the prevalence of group B Streptococcus (GBS) among Yemeni pregnant women.

2021 ◽  
Author(s):  
Ibrahim Hasan AL-Subol ◽  
Maha Abdul-Aziz ◽  
Abdullah A. Almikhlafy ◽  
Talal Y Alqahtani
Keyword(s):  
Pregnant Women ◽  
Antibiotic Susceptibility ◽  
Group B Streptococcus ◽  
Agar Plate ◽  
Blood Agar Plate ◽  
Diffusion Method ◽  
Enrichment Broth ◽  
Antibiotic Susceptibility Test ◽  
Study Results ◽  
Group B

Abstract Background: Neonatal infection with group B Streptococcus (GBS) is still a threat to the life of fetus and mother, especially in developing countries that do not adopt a prenatal screening test policy such as Yemen. Objective: This study aimed to determine the vaginal colonization rates and antibiotic susceptibility pattern of group B Streptococcus among pregnant Yemeni women. Methods: We conducted a cross-sectional study over a four-month period involved 210 pregnant women who visited Gaza medical center (a primary health center in Sana’a city, Yemen) at the 35th to 39th gestational weeks. A vaginal swab from each pregnant woman was inoculated in Todd-Hewitt enrichment broth and after 24h incubation; the subculture on a 5% human blood agar plate was performed from inoculated Todd-Hewitt enrichment broth. All positive cultures identified as group B streptococcus were subjected to antibiotic susceptibility test using the disk-diffusion method. Results: Out of 210 recruited pregnant women, 23 (10.95%) were GBS vaginal carriers. All isolates showed no resistance to penicillin, ampicillin, levofloxacin, cefotaxime, and vancomycin. However, we observed decreased sensitivity to clindamycin (82.8%) and tetracycline (30.5%). Conclusion: Based on the study results; approximately eleven out of every 100 pregnant women were vaginal colonized by GBS in Sana'a governorate. Beta-lactam antibiotics remain the drug of choice for treatment and prophylaxis of GBS infections. Therefore, we recommend implementing a screening policy to detect GBS in Yemeni pregnant women.

scholarly journals Biomarkers for a histological chorioamnionitis diagnosis in pregnant women with or without group B streptococcus infection: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jie Ren ◽  
Zhe Qiang ◽  
Yuan-yuan Li ◽  
Jun-na Zhang
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Peripheral Blood ◽  
Group B Streptococcus ◽  
Diagnostic Value ◽  
Adverse Outcomes ◽  
Intercellular Adhesion Molecule ◽  
Tnf Α ◽  
Group B ◽  
The Impact

Abstract Background Chorioamnionitis may cause serious perinatal and neonatal adverse outcomes, and group B streptococcus (GBS) is one of the most common bacteria isolated from human chorioamnionitis. The present study analyzed the impact of GBS infection and histological chorioamnionitis (HCA) on pregnancy outcomes and the diagnostic value of various biomarkers. Methods Pregnant women were grouped according to GBS infection and HCA detection. Perinatal and neonatal adverse outcomes were recorded with a follow-up period of 6 weeks. The white blood cell count (WBC), neutrophil ratio, and C-reactive protein (CRP) level from peripheral blood and soluble intercellular adhesion molecule-1 (sICAM-1), interleukin 8 (IL-8), and tumor necrosis factor α (TNF-α) levels from cord blood were assessed. Results A total of 371 pregnant women were included. Pregnant women with GBS infection or HCA had a higher risk of pathological jaundice and premature rupture of membranes and higher levels of sICAM-1, IL-8, and TNF-α in umbilical cord blood. Univariate and multivariate regression analysis revealed that sICMA-1, IL-8, TNF-α, WBC, and CRP were significantly related to an increased HCA risk. For all included pregnant women, TNF-α had the largest receiver operating characteristic (ROC) area (area: 0.841; 95% CI: 0.778–0.904) of the biomarkers analyzed. TNF-α still had the largest area under the ROC curve (area: 0.898; 95% CI: 0.814–0.982) for non-GBS-infected pregnant women, who also exhibited a higher neutrophil ratio (area: 0.815; 95% CI: 0.645–0.985) and WBC (area: 0.849; 95% CI: 0.72–0.978), but all biomarkers had lower value in the diagnosis of HCA in GBS-infected pregnant women. Conclusion GBS infection and HCA correlated with several perinatal and neonatal adverse outcomes. TNF-α in cord blood and WBCs in peripheral blood had diagnostic value for HCA in non-GBS-infected pregnant women but not GBS-infected pregnant women.

scholarly journals Poor Adherence to the Screening-Based Strategy of Group B Streptococcus Despite Colonization of Pregnant Women in Greece

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 418
Author(s):  
Maria Maroudia Berikopoulou ◽  
Aikaterini Pana ◽  
Theodota Liakopoulou-Tsitsipi ◽  
Nikos F. Vlahos ◽  
Vasiliki Papaevangelou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Pregnant Women ◽  
Late Onset ◽  
Group B Streptococcus ◽  
Culture Collection ◽  
Carrier Status ◽  
Cross Sectional ◽  
Screening Guidelines ◽  
Group B

Group B streptococcus (GBS) is a leading cause of serious neonatal infections. Maternal GBS colonization is associated with early- and late-onset neonatal disease (EOD/LOD). In Greece, a screening-based strategy is recommended, in which concurrent vaginal-rectal cultures should be obtained between 36 0/7 and 37 6/7 weeks’ gestation. We sought to examine the level of adherence to the GBS screening guidelines and estimate the prevalence of GBS colonization among pregnant women. Although in Greece the screening-based strategy is followed, we also examined known EOD risk factors and linked them to GBS colonization. A cross-sectional study of 604 women postpartum in three hospitals and maternity clinics was conducted. Following written informed consent, data were collected via a short self-completed questionnaire and review of patients’ records. In 34.6% of the enrolled pregnant women, no culture had been taken. Of the remaining, 12.8% had proper vaginal-rectal sample collections. The overall maternal colonization rate was 9.6%. At least one risk factor for EOD was identified in 12.6% of participants. The presence of risk factors was associated with positive cultures (p = 0.014). The rate of culture collection did not differ between women with or without an EOD risk factor. Adherence to a universal screening of pregnant women with vaginal-rectal cultures was poor. Despite probable underestimation of GBS carrier status, almost 1 in 10 participants were GBS positive during pregnancy. Screening of women with risk factors for EOD should, at least, be prioritized to achieve prevention and prompt intervention of EOD.

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