scholarly journals Variables associated with subclinical atherosclerosis in a cohort of rheumatoid arthritis patients: Sex-specific associations and differential effects of disease activity and age

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193690 ◽  
Author(s):  
Delia Taverner ◽  
Joan-Carles Vallvé ◽  
Raimón Ferré ◽  
Silvia Paredes ◽  
Lluís Masana ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Subclinical Atherosclerosis ◽  
Differential Effects

scholarly journals Utility of Select Plasma MicroRNA for Disease and Cardiovascular Risk Assessment in Patients with Rheumatoid Arthritis

2015 ◽  
Vol 42 (10) ◽  
pp. 1746-1751 ◽  
Author(s):  
Michelle J. Ormseth ◽  
Joseph F. Solus ◽  
Kasey C. Vickers ◽  
Annette M. Oeser ◽  
Paolo Raggi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Coronary Artery ◽  
Disease Activity ◽  
Coronary Artery Calcium ◽  
Noncoding Rna ◽  
Coronary Artery Calcium Score ◽  
Subclinical Atherosclerosis ◽  
Plasma Concentrations ◽  
Calcium Score ◽  
Plasma Mirna

Objective.MicroRNA (miRNA) are small noncoding RNA that posttranscriptionally regulate gene expression and serve as potential mediators and markers of disease. Recently, plasma miR-24-3p and miR-125a-5p concentrations were shown to be elevated in rheumatoid arthritis (RA) and useful for RA diagnosis. We assessed the utility of 7 candidate plasma miRNA, selected for biological relevance, for RA diagnosis and use as markers of disease activity and subclinical atherosclerosis in RA.Methods.The cross-sectional study included 168 patients with RA and 91 control subjects of similar age, race, and sex. Plasma concentrations of miR-15a-5p, miR-24-3p, miR-26a-5p, miR-125a-5p, miR-146a-5p, miR-155-5p, and miR-223-3p were measured by quantitative PCR. Utility of plasma miRNA concentrations for RA diagnosis was assessed by area under the receiver-operating characteristic curve (AUROC). Associations between plasma miRNA concentrations and RA disease activity and coronary artery calcium score were assessed by Spearman correlations.Results.Plasma concentrations of miR-15a-5p, miR-24-3p, miR-26a-5p, miR-125a-5p, miR-146a-5p, miR-155-5p, and miR-223-3p were significantly increased in patients with RA. The highest AUROC for diagnosis of RA (AUROC = 0.725) was found in miR-24-3p, including among rheumatoid factor–negative patients (AUROC = 0.772). Among all patients with RA, the combination of miR-24-3p, miR-26a-5p, and miR-125a-5p improved the model modestly (AUROC = 0.747). One miRNA, miR-155-5p, was weakly inversely associated with swollen joint count (p = 0.024), but no other miRNA were associated with disease activity or coronary artery calcium score.Conclusion.The combination of miR-24-3p, miR-26a-5p, and miR-125a-5p had the strongest diagnostic accuracy for RA. Candidate miRNA had little or no association with RA disease activity or subclinical atherosclerosis.

Renin–angiotensin system molecules are associated with subclinical atherosclerosis and disease activity in rheumatoid arthritis

2020 ◽  
Vol 31 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Nayara Felicidade Tomaz Braz ◽  
Maria Raquel C. Pinto ◽  
Érica Leandro Marciano Vieira ◽  
Adriano J. Souza ◽  
Antonio Lucio Teixeira ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Subclinical Atherosclerosis ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Predictors of Cardiovascular Affection in Patients with Active Rheumatoid Arthritis: Secondary Analysis of a Randomized Controlled Trial

2020 ◽  
Vol 16 ◽  
Author(s):  
Eman M. Ibrahem ◽  
Salwa S. El-gendi ◽  
Amal A. Mahmoud ◽  
Sherif M. Abdel-Aal ◽  
Fatma H. El Nouby ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Randomized Controlled Trial ◽  
Matrix Metalloproteinase ◽  
Disease Activity ◽  
Controlled Trial ◽  
Subclinical Atherosclerosis ◽  
Secondary Analysis ◽  
Intima Media Thickness ◽  
Das28 Score ◽  
Randomized Controlled

Objective: This is a secondary analysis of a randomized controlled trial that aimed to assess subclinical atherosclerosis in patients with rheumatoid arthritis (RA) by measuring carotid artery intima-media thickness (CIMT) and correlating it with disease activity and inflammatory markers (including levels of matrix metalloproteinase-3(MMP-3) and matrix metalloproteinase-9 (MMP-9)) and to detect the effectiveness of agents that inhibit matrix metalloproteinases (MMPs) as doxycycline in RA therapy. Methods: One hundred and sixty RA patients were assigned in a randomized clinical trial (clinicaltrial.gov NCT03194204). Disease activity score 28(DAS28), laboratory markers including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MMP-3, and MMP-9 were done and mean CIMT was measured. Subjects were allocated randomly into one of two treatment arms either methotrexate (MTX) only or MTX with doxycycline 200mg per day orally. Follow up ESR, CRP, DAS28, MMP-3, and MMP-9 levels were re-evaluated after 3 months. Results: There were positive significant correlations between CIMT and disease duration (r = 0.461, p = 0.001), age (r=0.459, p= 0.001), DAS28 score (r= 0.547, p = 0.001), ESR (r =0.413, p = 0.001), CRP (r= 0.281, p = 0.001), MMP-3(r = 0.476, p =0.001), and MMP-9 (r= 0.593, p =0.001). Patients treated with MTX and doxycycline showed lower levels of DAS28, ESR, CRP, MMP-3 and MMP-9 and this was statistically significant. Conclusion: CIMT seems to be the ultimate method to screen for subclinical atherosclerosis in RA patients. MMP-3 and 9 play a key role in both RA synovitis and cardiovascular changes making them important therapeutic targets especially with safe and cost-effective agents like doxycycline.

scholarly journals Subclinical atherosclerosis in young patients with rheumatoid arthritis and low disease activity

Reumatismo ◽  
2011 ◽  
Vol 57 (1) ◽  
Author(s):  
E. Bartoloni Bocci ◽  
S. Marchesi ◽  
F. Delle Monache ◽  
G. Vaudo ◽  
A. Giordano ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Subclinical Atherosclerosis ◽  
Young Patients ◽  
Low Disease Activity

scholarly journals Asymptomatic Atherosclerosis in Egyptian Rheumatoid Arthritis Patients and Its Relation to Disease Activity

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Rawhya R. Elshereef ◽  
Aymen Darwish ◽  
Amal Ali ◽  
Mohammed Abdel-kadar ◽  
Lamiaa Hamdy
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Activity Index ◽  
Subclinical Atherosclerosis ◽  
Disease Activity Index ◽  
Significant Difference ◽  
Laboratory Investigations ◽  
Duplex Doppler ◽  
Group 1

Aim. To detect the frequency of subclinical atherosclerosis in rheumatoid arthritis patients without clinically evident atherosclerosis and to correlate its presence with the disease activity.Patients and Methods. Our study includes 112 RA patients (group 1) and 40 healthy controls (group 11). All patients and controls were subjected to full history taking, clinical examination, and laboratory investigations. Carotid intima media wall thickness (IMT) and carotid plaques were measured in both groups by B-mode ultrasonography; also color duplex Doppler ultrasound of the brachial artery was done to detect endothelial function.Results. There is atherosclerosis in 31.3% of asymptomatic RA patients compared with only 5% in controlsP=0.003**. A significant difference was detected in patients with and without atherosclerosis regarding duration of the diseaseP=0.0001***and patient’s ageP=0.01*. There is highly statistical significant correlation between atherosclerosis and disease activity index.Conclusion. The frequency of subclinical atherosclerosis was high in long-term active RA patients.

scholarly journals Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Ewa Klimek ◽  
Tomasz Mikołajczyk ◽  
Joanna Sulicka ◽  
Beata Kwaśny-Krochin ◽  
Mariusz Korkosz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Short Duration ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Peripheral Blood Monocyte ◽  
Blood Monocyte ◽  
Monocyte Subsets ◽  
Hla Dr ◽  
Monocyte Subpopulations

Objectives. To evaluate blood monocyte subsets and functional monocyte properties in patients with rheumatoid arthritis (RA) of short duration in the context of cardiovascular (CV) risk and disease activity.Methods. We studied conventional markers of CV risk, intima media thickness (IMT), and blood monocyte subsets in 27 patients aged 41 ± 10 years with RA of short duration (median 12 months) and 22 healthy controls. The RA subjects were divided into low (DAS28: 2.6–5.1) and high (DAS28 > 5.1) disease activity.Results. RA patients exhibited increased levels of intermediate (CD14++CD16+) monocytes with decreased CD45RA expression compared to controls, increased counts of classical (CD14++CD16−) monocytes, and decreased percentages of nonclassical (CD14+CD16++) monocytes. Patients with high disease activity had lower HLA DR expression on classical monocytes compared to low disease activity patients. There were no differences in monocyte subsets between subjects with DAS > 5.1 and DAS ≤ 5.1. There were no significant intergroup differences in IMT and the majority of classical CV risk factors.Conclusions. Patients with RA of short duration show alteration in peripheral blood monocyte subsets despite the fact that there is no evidence of subclinical atherosclerosis. Disease activity assessed with DAS28 was associated with impaired functional properties but not with a shift in monocyte subpopulations.

scholarly journals Prevalence and associated factors of subclinical atherosclerosis in rheumatoid arthritis at the university hospital of Kinshasa

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Christophe Mulumba ◽  
Pierrot Lebughe ◽  
Jean-Marie Mbuyi-Muamba ◽  
Jean-Robert Makulo ◽  
François Lepira ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Logistic Regression ◽  
Cardiovascular Risk ◽  
Disease Activity ◽  
Cardiovascular Risk Factors ◽  
Subclinical Atherosclerosis ◽  
University Hospital ◽  
Factors Associated ◽  
The University

Abstract Background Rheumatoid arthritis (RA) is associated with a 5 to 10 years reduction in life expectancy due to premature atherosclerosis. This reduction is the consequence of traditional cardiovascular risk factors (TCRF) as well as systemic inflammation. The aim of the present study was to describe the prevalence and factors associated with subclinical atherosclerosis in RA at the University Hospital of Kinshasa (UHK). Methods Patients with a diagnosis of RA based on the 2010 ACR/EULAR criteria were included in this cross-sectional study from 1 June 2014 to 31 May 2015 at the UHK. RA disease activity was measured using the DAS28-ESR. Active RA was defined by a DAS 28 > 2.6. Severe RA was defined by the presence of extra-articular manifestation, joint erosions on X-rays or HAQ ≥0.5. An assessment of subclinical atherosclerosis was performed by the measurement of the carotid intima-media thickness (cIMT) using two-dimensional ultrasonography. Subclinical atherosclerosis was defined by a cIMT ≥0.9 mm. A diagnosis of atheroma plaque was retained when the cIMT was ≥1.5 mm. The association between subclinical atherosclerosis and potential risk factors was modeled using logistic regression analysis. Results We recruited 75 patients. The average age was 51.8 ± 14.6 years, with a sex ratio F/M of 4. The prevalence of subclinical atherosclerosis was 32%. In logistic regression being a woman of ≥55 years old (aOR 10.6, 95% CI [2.087–53.82], p = 0.028), DAS28-ESR > 2.6 (aOR 3.5,95% CI [1.55–10.38], p = 0.044), severe RA (aOR 32.6,95% CI [1.761–60.37],p = 0.035), high blood pressure (aOR 22.4,95% CI [5.04–99.41], p = 0.005) and obesity (aOR 32.3, 95% CI [2.606–40.73], p = 0.026) emerged as factors associated with subclinical atherosclerosis. Conclusion Subclinical atherosclerosis is common in RA patients attending the UHK. It appears to be associated with RA disease activity and severity apart from traditional cardiovascular risk factors. These results suggest that early management of subclinical atherosclerosis targeting remaining RA disease activity and cardiovascular risk factors could slow down progression to clinical cardiovascular disease.

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