ABSTRACT
The genomes of many strains of
Escherichia coli
have been sequenced, as this organism is a classic model bacterium. Here, we report the genome sequence of
Escherichia coli
DH5α, which is resistant to a T4 bacteriophage (CCTCC AB 2015375), while its other homologous
E. coli
strains, such as
E. coli
BL21, DH10B, and MG1655, are not resistant to phage invasions. Thus, understanding of the genome of the DH5α strain, along with comparative analysis of its genome sequence along with other sequences of
E. coli
strains, may help to reveal the bacteriophage resistance mechanism of
E. coli
.