scholarly journals Reconfirmation of newly discovered risk factors of diabetic peripheral neuropathy in patients with type 2 diabetes: A case-control study

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0220175
Author(s):  
Yen-Wei Pai ◽  
Ching-Heng Lin ◽  
Shih-Yi Lin ◽  
I-Te Lee ◽  
Ming-Hong Chang
Oncotarget ◽  
2017 ◽  
Vol 8 (40) ◽  
pp. 66940-66950 ◽  
Author(s):  
Mariusz Dąbrowski ◽  
Elektra Szymańska-Garbacz ◽  
Zofia Miszczyszyn ◽  
Tadeusz Dereziński ◽  
Leszek Czupryniak

Author(s):  
Made Krisna Adi Jaya ◽  
Dewa Ayu Swastini ◽  
Baiq Leny Nopitasari ◽  
Putu Rika Veryanti

Background: Diabetic Peripheral Neuropathy (DPN) is a microvascular complication that commonly occurs in people with diabetes mellitus. Geriatrics with type 2 diabetes mellitus is one of the populations most vulnerable to this complication. An epidemiological study states that geriatrics has a 32% greater risk of developing this complication compared to other age groups. There have not been many studies conducted to evaluate the risk factors that influence this DPN complication, so it needs to be done an individual evaluation for the elderly population. Objective: This study aims to explore the risk factors that influence the incidence of DPN in elderly patients with type 2 diabetes mellitus. Methods: A case-control study design was carried out on 70 geriatrics with type 2 diabetes mellitus. The outcome determined was the incidence of DPN to track the cause of DPN exposure retrospectively. Influential risk factors are determined by the Odds Ratio (OR) with a 95% confidence interval (CI). All statistical analyzes were two-tailed, and p-values <0.05 were considered as statistically significant. Results: Seven factors influence the incidence of DPN in the elderly consisting of smoking history (OR=13.1), uncontrolled lipid profile (OR=5.1), non-neuroprotector users (OR=5.6), uncontrolled blood glucose (OR=42.7), history of heart disease (OR=9.0), uncontrolled blood pressure (OR=4.3), and BMI above normal (OR=5.1). Conclusion: Strong recommendation for medical personnel to focus attention on seven significant risk factors affected complications of DPN to reduce its progression or prevent upcoming complications.


Author(s):  
Viresh Nandimath ◽  
Chaithra Swamy ◽  
Santosh Nandimath ◽  
Gajanan Jatti ◽  
Sachin Jadhav

2016 ◽  
Vol 10 (4) ◽  
pp. 300-308 ◽  
Author(s):  
Elisa Martín-Merino ◽  
Joan Fortuny ◽  
Elena Rivero-Ferrer ◽  
Marcus Lind ◽  
Luis Alberto Garcia-Rodriguez

Author(s):  
Sameer Abd AL-Majeed AL- Khawaja ◽  
Sabah Ali Jaber Al-helu ◽  
Yasir Salah Jumaa

Backgrounds: Sudomotor dysfunction is one of the earliest neurophysiologic abnormalities to manifest in distal small fiber neuropathy. SUDOSCAN ® was developed to provide a non invasive, quick, simple and quantitative measurement of sweat function. The aim of this study is to evaluate the value of SUDOSCAN in the diagnosis of neuropathy and its early detection. Methods: This is a case control study was conducted from March 2014 to December2014 on type2 diabetic patient in the center of diabetes and endocrine disease in AL-Najaf . Sweat function was evaluated by measuring the electrochemical skin conductance (ESC) of the hands and feet. Results: 100 patients with type 2 diabetes mellitus including 55 patients with peripheral neuropathy and 45 patients without peripheral neuropathy were involved in this case control study. Hands and feet conductance were lower in patients with type 2 diabetes with peripheral neuropathy when compared to patients with type 2 diabetes without neuropathy (with p value less than 0.001 for hands mean electrochemical skin conductance and feet mean electrochemical skin conductance). Conclusions: SUDOSCAN is a promising, screening tool to detect neuropathy in patients with diabetes mellites. This is a very simple test, easy-to-perform that can be done in the clinical setting in 3–5 min.


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