An experimental erythrocyte rigidity index (Ri) and its correlations with Transcranial Doppler velocities (TAMMV), Gosling Pulsatility Index PI, hematocrit, hemoglobin concentration and red cell distribution width (RDW)

Abstract Background: As a multisystem infectious disease, there is inflammation, which causes an increase in brucellosis. The red cell distribution width (RDW) has been identified as markers of inflammation. The present study aimed to investigate the predictive contribution value of RDW in the diagnosis of brucellosis.Methods: Medical records of 398 patients with brucellosis and 398 age-matched and gender-matched healthy controls in a single center from January 2017 to December 2019 were retrospectively reviewed.Results: The mean age of brucellosis patients was 47.1±12.9 years. The RDW levels were significantly higher in brucellosis group when compared to the control group (p < 0.001); The RDW levels were markedly lower in brucellosis male patients（14.32±2.15%）when compared to the brucellosis female patient（s 15.41±3.13%）(t= -9.56, p < 0.001). The biochemical markers of brucellosis patients included erythrocyte, hemoglobin, HCT, corpuscular volume, hemoglobin, hemoglobin concentration were all negatively correlated with RDW (r = −0.227, -0.383, -0.266, -0.253, -0.311 and -0.225, all p < 0.001). The values of hemoglobin (β coefficient = -0.084, p < 0.001), ESR (β coefficient = -0.020, p = 0.004) were significantly and independently correlated with RDW. Receiver operating characteristic (ROC) curve analysis showed that the best cutoff point for RDW in the diagnosis of brucellosis was 13.45%, which evaluated brucellosis with a sensitivity of 64.1% and a specificity of 83.9%. The area under the ROC curve for RDW was calculated as 0.80 (95% CI 0.769–0.831, P<0.001).Conclusion: This study revealed that the RDW in diagnosing brucellosis had a higher sensitivity and specificity. RDW values may be useful complementary indirect markers for the diagnosis of brucellosis.

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Clinical Significance of Combination of Hemoglobin Concentration and Red Cell Distribution Width in Heart Failure Patients

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2016.07.119 ◽

2016 ◽

Vol 22 (9) ◽

pp. S174

Author(s):

Shin Kawasoe ◽

Takuro Kubozono ◽

Satoko Ojima ◽

Masaaki Miyata ◽

Mitsuru Ohishi

Keyword(s):

Heart Failure ◽

Clinical Significance ◽

Hemoglobin Concentration ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Heart Failure Patients

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Preoperative Mean Corpuscular Hemoglobin Concentration, Red Cell Distribution Width As Predictive Markers For Pancreatic Cancer Patients Who Underwent Radical Pancreatomy

10.21203/rs.3.rs-37763/v1 ◽

2020 ◽

Author(s):

Dan Wang ◽

Xiaona Fan ◽

Lin Fang ◽

Tianshuo Zhou ◽

Qingwei Li ◽

...

Keyword(s):

Pancreatic Cancer ◽

Hemoglobin Concentration ◽

Red Cell Distribution Width ◽

Mean Corpuscular Hemoglobin ◽

Red Cell ◽

Cell Distribution ◽

Mean Corpuscular Hemoglobin Concentration ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Corpuscular Hemoglobin Concentration

Abstract Objective: To explore the value of mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW) for overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer (PC) who underwent radical pancreatomy.Background: Inflammatory factors are important factors in promoting the occurrence and metastasis of malignant tumors. RDW and MCHC are suggested to be relevant to the prognosis of several malignancies. Such as gastric cancer, colon cancer. However, there are few studies to explore the correlation between them and PC.Methods: This study included 532 patients with PC who underwent radical resection between March 2011 and May 2019. Kaplan-Meier curve method and Cox proportional hazard regression model were applied to analyze prognosis. Correlations between categorical variables were analyzed using Chi squared tests.Results: Survival curve showed that OS and PFS were significantly favorable for resectable PC patients with high preoperative MCHC (P=0.02) (P=0.005), RDW in the normal range (P<0.001) (P<0.001). Multivariate analysis suggested that MCHC (HR: 0.612, 95%CI: 0.426-0.879, P=0.008), and RDW (HR: 3.969, 95%CI: 2.952-5.338, P<0.001) were independent prognostic factors for resectable PC patients. MCHC (HR: 0.657, 95%CI: 0.458-0.943, P=0.023), RDW (HR: 3.915, 95%CI: 2.923-5.243, P < 0.001) were also independent recurrent factors for resectable PC patients. Correlation analysis showed that MCHC was related to tumor size, nerve invasion, and anemia-related indicators, meanwhile RDW was connected with carcinoma-embryonic antigen (CEA) and carbohydrate antigen199 (CA19-9).Conclusion: The preoperative MCHC and RDW were simple and convenient predictive factors for prognosis and progression of patients with PC.

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Preoperative red cell distribution width and neutrophil-to-lymphocyte ratio predict survival in patients with epithelial ovarian cancer

10.26226/morressier.5770e29dd462b80290b4be83 ◽

2016 ◽

Author(s):

Zheng Li

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Neutrophil To Lymphocyte Ratio ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Lymphocyte Ratio

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Faculty Opinions recommendation of A retrospective cohort study on the association between elevated preoperative red cell distribution width and all-cause mortality after noncardiac surgery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737641408.793575041 ◽

2020 ◽

Author(s):

Yuguang Huang ◽

Xiaohan Xu

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Noncardiac Surgery ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

All Cause Mortality

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Prognostic Value of the Hemoglobin/Red Cell Distribution Width Ratio in Resected Lung Adenocarcinoma

Cancers ◽

10.3390/cancers13040710 ◽

2021 ◽

Vol 13 (4) ◽

pp. 710

Author(s):

Francesco Petrella ◽

Monica Casiraghi ◽

Davide Radice ◽

Andrea Cara ◽

Gabriele Maffeis ◽

...

Keyword(s):

Prognostic Factor ◽

Lung Adenocarcinoma ◽

Disease Free Survival ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Free Survival ◽

Node Involvement ◽

Disease Free

Background: The ratio of hemoglobin to red cell distribution width (HRR) has been described as an effective prognostic factor in several types of cancer. The aim of this study was to investigate the prognostic role of preoperative HRR in resected-lung-adenocarcinoma patients. Methods: We enrolled 342 consecutive patients. Age, sex, surgical resection, adjuvant treatments, pathological stage, preoperative hemoglobin, red cell distribution width, and their ratio were recorded for each patient. Results: Mean age was 66 years (SD: 9.0). There were 163 females (47.1%); 169 patients (49.4%) had tumors at stage I, 71 (20.8%) at stage II, and 102 (29.8%) at stage III. In total, 318 patients (93.0%) underwent lobectomy, and 24 (7.0%) pneumonectomy. Disease-free survival multivariable analysis disclosed an increased hazard ratio (HR) of relapse for preoperative HRR lower than 1.01 (HR = 2.20, 95%CI: (1.30–3.72), p = 0.004), as well as for N1 single-node (HR = 2.55, 95%CI: (1.33–4.90), p = 0.005) and multiple-level lymph node involvement compared to N0 for both N1 (HR = 9.16, 95%CI:(3.65–23.0), p < 0.001) and N2 (HR = 10.5, 95%CI:(3.44–32.2, p < 0.001). Conclusion: Pre-operative HRR is an effective prognostic factor of disease-free survival in resected-lung-adenocarcinoma patients, together with the level of pathologic node involvement.

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