Daily versus stat vitamin D supplementation during pregnancy; A prospective cohort study

Background and aim. We planned this prospective cohort study in term newborn babies, with the objective to determine the incidence of vitamin D deficiency in infancy and to determine the level of vitamin D which triggers the physiological PTH axis of the body so as to differentiate truly deficient from sufficient vitamin D status.Methods. 96 participants at birth were enrolled and followed up till 9 months of age. Serum25OHD was estimated in cord blood at birth and at 14 ± 1 weeks of life. 77 participants were followed up at 9 months for estimation of serum 25OHD, PTH, Alkaline phosphatase (ALP), calcium and phosphorus. Vitamin D deficiency was defined as serum 25OHD <15 ng/mL as per USIOM guidelines.Results. Serum 25OHD levels at 9 months of age (15.78±8.97ng/mL) were significantly increased in comparison to the level of 3 months of age (14.04±7.10ng/mL) and at birth (8.94±2.24ng/mL).At birth all the participants (77) were deficient in 25OHD levels. It was found that 16/94 (17%)and 19/77 (24.7%) participants at 3 and 9 months of age respectively became vitamin D sufficient without any vitamin D supplementation. There was a significant inverse correlation between serum 25OHD and PTH concentration (r=-0.522, p<0.001), serum 25OHD and ALP(r=-.501, p<0.001). It was found that reduction in serum vitamin D level to below 10.25 ng/mL results in surge of serum PTH.Conclusion: Vitamin D deficiency is common from birth to 9 months of age but incidence decreases spontaneously even without supplementation. Also large number of babies may be falsely labelled as vitamin D deficient with currently followed cutoffs. So a new cutoff for vitamin D deficiency needs to be established for neonates and infants.

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Vitamin D status in infants during the first 9 months of age and its effect on growth and other biochemical markers: A Prospective Cohort Study

Journal of Paediatrics and Child Health ◽

10.1111/jpc.13494_175 ◽

2017 ◽

Vol 53 ◽

pp. 60-60

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Biochemical Markers ◽

Vitamin D Status ◽

Effect On Growth

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Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

BMC Cancer ◽

10.1186/1471-2407-10-347 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 58

Author(s):

Hidetoshi Mezawa ◽

Tsutomu Sugiura ◽

Michiaki Watanabe ◽

Chihiro Norizoe ◽

Daisuke Takahashi ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Vitamin ◽

Post Hoc Analysis ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Post Hoc

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5-Hydroxyvitamin D concentration in paediatric cancer patients from Scotland: a prospective cohort study

British Journal Of Nutrition ◽

10.1017/s0007114516004074 ◽

2016 ◽

Vol 116 (11) ◽

pp. 1926-1934 ◽

Cited By ~ 3

Author(s):

Raquel Revuelta Iniesta ◽

Ilenia Paciarotti ◽

Isobel Davidson ◽

Jane M. McKenzie ◽

Celia Brand ◽

...

Keyword(s):

Cohort Study ◽

Relative Risk ◽

Cancer Patients ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Vitamin D Supplementation ◽

Healthy Children ◽

Paediatric Cancer ◽

Hydroxyvitamin D ◽

Nutritional Data

AbstractChildren with cancer are potentially at a high risk of plasma 25-hydroxyvitamin D (25(OH)D) inadequacy, and despite UK vitamin D supplementation guidelines their implementation remains inconsistent. Thus, we aimed to investigate 25(OH)D concentration and factors contributing to 25(OH)D inadequacy in paediatric cancer patients. A prospective cohort study of Scottish children aged <18 years diagnosed with, and treated for, cancer (patients) between August 2010 and January 2014 was performed, with control data from Scottish healthy children (controls). Clinical and nutritional data were collected at defined periods up to 24 months. 25(OH)D status was defined by the Royal College of Paediatrics and Child Health as inadequacy (<50 nmol/l: deficiency (<25 nmol/l), insufficiency (25–50 nmol/l)), sufficiency (51–75 nmol/l) and optimal (>75 nmol/l). In all, eighty-two patients (median age 3·9, interquartile ranges (IQR) 1·9–8·8; 56 % males) and thirty-five controls (median age 6·2, IQR 4·8–9·1; 49 % males) were recruited. 25(OH)D inadequacy was highly prevalent in the controls (63 %; 22/35) and in the patients (64 %; 42/65) at both baseline and during treatment (33–50 %). Non-supplemented children had the highest prevalence of 25(OH)D inadequacy at every stage with 25(OH)D median ranging from 32·0 (IQR 21·0–46·5) to 45·0 (28·0–64·5) nmol/l. Older age at baseline (R −0·46; P<0·001), overnutrition (BMI≥85th centile) at 3 months (P=0·005; relative risk=3·1) and not being supplemented at 6 months (P=0·04; relative risk=4·3) may have contributed to lower plasma 25(OH)D. Paediatric cancer patients are not at a higher risk of 25(OH)D inadequacy than healthy children at diagnosis; however, prevalence of 25(OH)D inadequacy is still high and non-supplemented children have a higher risk. Appropriate monitoring and therapeutic supplementation should be implemented.

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Vitamin D deficiency is associated with hepatic decompensation and inflammation in patients with liver cirrhosis: A prospective cohort study

PLoS ONE ◽

10.1371/journal.pone.0207162 ◽

2018 ◽

Vol 13 (11) ◽

pp. e0207162 ◽

Cited By ~ 12

Author(s):

Alica Kubesch ◽

Leonie Quenstedt ◽

Maged Saleh ◽

Sabrina Rüschenbaum ◽

Katharina Schwarzkopf ◽

...

Keyword(s):

Vitamin D ◽

Liver Cirrhosis ◽

Cohort Study ◽

Vitamin D Deficiency ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Hepatic Decompensation

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Vitamin D status in infants during the first 9 months of age and its effect on growth and other biochemical markers: A prospective cohort study

Advanced Biomedical Research ◽

10.4103/abr.abr_242_19 ◽

2020 ◽

Vol 9 (1) ◽

pp. 8

Author(s):

Manish Gutch ◽

UdayKumar Mandal ◽

Sukriti Kumar

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Biochemical Markers ◽

Vitamin D Status ◽

Effect On Growth

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Questioning the adequacy of standardized vitamin D supplementation protocol in very low birth weight infants: a prospective cohort study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2021-0390 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Hatice Sarıdemir ◽

Ozge Surmeli Onay ◽

Ozge Aydemir ◽

Ayse Neslihan Tekin

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Birth Weight ◽

Low Birth Weight ◽

Prospective Cohort ◽

Very Low Birth Weight ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Vlbw Infants ◽

Vitamin D Levels

Abstract Objectives Preterm infants are at increased risk for vitamin D deficiency (VDD). We aimed to assess the adequacy of standardized vitamin D supplementation protocol in very low birth weight (VLBW) infants. Additionally, vitamin D status of mother/infant couples and the associations between vitamin D status at birth and morbidities of the infants were investigated. Methods In this single-center, prospective cohort study blood samples were collected from 55 mothers just before delivery and from their infants at birth and on the 30th day of life (DOL) for 25 hydroxy vitamin D (25OHD) measurements. Vitamin D was initiated in dose of 160 IU/kg by parenteral nutrition on the first DOL and oral vitamin D supplementation (400 IU/day) was administered when enteral feedings reached 50% of total intake or on the 15th DOL. Results The median 25OHD levels of the infants were 16.12 (9.14–20.50) in cord blood and 36.32 (31.10–44.44) in venous blood on the 30th DOL (p<0.01). In 98% of the VLBW infants 25OHD reached sufficient levels on the 30th DOL. None of the mothers had sufficient vitamin D levels (25OHD >30 ng/mL). Maternal 25OHD levels were correlated with the 25OHD levels of the infants in cord blood (r=0.665, p<0.001). There was a significant difference in mean cord 25OHD levels between winter (13.65 ± 5.69 ng/mL) and summer seasons (19.58 ± 11.67 ng/mL) (p=0.021). No association was found between neonatal morbidity and vitamin D status. Conclusions The results clearly show that by utilizing the current supplementation protocol, the majority of VLBW infants with deficient/insufficient serum 25OHD levels reached sufficient levels on the 30th DOL. Furthermore, vitamin D levels in mother/infant couples were found to be highly correlated.

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