scholarly journals Oxidative stress-induced inflammation in susceptible airways by anthropogenic aerosol

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0233425 ◽  
Author(s):  
Zaira Leni ◽  
Laure Estelle Cassagnes ◽  
Kaspar R. Daellenbach ◽  
Imad El Haddad ◽  
Athanasia Vlachou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Mediators ◽  
Apical Cell ◽  
Ambient Air ◽  
Water Soluble ◽  
Ambient Air Pollution ◽  
Anthropogenic Aerosol ◽  
Bronchial Epithelia ◽  
Clear Dose Response ◽  
The Impact

Ambient air pollution is one of the leading five health risks worldwide. One of the most harmful air pollutants is particulate matter (PM), which has different physical characteristics (particle size and number, surface area and morphology) and a highly complex and variable chemical composition. Our goal was first to comparatively assess the effects of exposure to PM regarding cytotoxicity, release of pro-inflammatory mediators and gene expression in human bronchial epithelia (HBE) reflecting normal and compromised health status. Second, we aimed at evaluating the impact of various PM components from anthropogenic and biogenic sources on the cellular responses. Air-liquid interface (ALI) cultures of fully differentiated HBE derived from normal and cystic fibrosis (CF) donor lungs were exposed at the apical cell surface to water-soluble PM filter extracts for 4 h. The particle dose deposited on cells was 0.9–2.5 and 8.8–25.4 μg per cm2 of cell culture area for low and high PM doses, respectively. Both normal and CF HBE show a clear dose-response relationship with increasing cytotoxicity at higher PM concentrations. The concurrently enhanced release of pro-inflammatory mediators at higher PM exposure levels links cytotoxicity to inflammatory processes. Further, the PM exposure deregulates genes involved in oxidative stress and inflammatory pathways leading to an imbalance of the antioxidant system. Moreover, we identify compromised defense against PM in CF epithelia promoting exacerbation and aggravation of disease. We also demonstrate that the adverse health outcome induced by PM exposure in normal and particularly in susceptible bronchial epithelia is magnified by anthropogenic PM components. Thus, including health-relevant PM components in regulatory guidelines will result in substantial human health benefits and improve protection of the vulnerable population.

Key Aspects of Assessing Effectiveness and Efficiency of Implementation of the Federal Clean Air Project on the Example of the Comprehensive Emission Reduction Action Plan in Nizhny Tagil

2020 ◽  
pp. 48-60
Author(s):  
SV Yarushin ◽  
DV Kuzmin ◽  
AA Shevchik ◽  
TM Tsepilova ◽  
VB Gurvich ◽  
...  
Keyword(s):  
Emission Reduction ◽  
Action Plan ◽  
Local Population ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Mortality And Morbidity ◽  
Industrial Enterprises ◽  
Clean Air ◽  
Effectiveness And Efficiency ◽  
The Impact

Introduction: Key issues of assessing effectiveness and economic efficiency of implementing the Federal Clean Air Project by public health criteria are considered based on the example of the Comprehensive Emission Reduction Action Plan realized in the city of Nizhny Tagil, Sverdlovsk Region. Materials and methods: We elaborated method approaches and reviewed practical aspects of evaluating measures taken in 2018–2019 at key urban industrial enterprises accounting for 95 % of stationary source emissions. Results: Summary calculations of ambient air pollution and carcinogenic and non-carcinogenic inhalation health risks including residual risks, evaluation of the impact of air quality on urban mortality and morbidity rates, economic assessment of prevented morbidity and premature mortality cases have enabled us not only to estimate health effects but also to develop guidelines for development and implementation of actions aimed at enhancing effectiveness and efficiency of industrial emission reduction in terms of health promotion of the local population. Conclusions: We substantiate proposals for the necessity and sufficiency of taking remedial actions ensuring achievement of acceptable health risk levels as targets of the Comprehensive Emission Reduction Action Plan in Nizhny Tagil until 2024 and beyond.

scholarly journals Air pollution and out-of-hospital cardiac arrest risk

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L Moderato ◽  
D Lazzeroni ◽  
A Biagi ◽  
T Spezzano ◽  
B Matrone ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cardiac Arrest ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
External Temperature ◽  
Pm 2.5 ◽  
Pm10 And Pm2.5 ◽  
Short Term Exposure ◽  
The Impact ◽  
Hospital Cardiac Arrest

Abstract Introduction Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide; it accounts for up to 50% of all cardiovascular deaths.It is well established that ambient air pollution triggers fatal and non-fatal cardiovascular events. However, the impact of air pollution on OHCA is still controversial. The objective of this study was to investigate the impact of short-term exposure to outdoor air pollutants on the incidence of OHCA in the urban area of Piacenza, Italy, one of the most polluted area in Europe. Methods From 01/01/2010 to 31/12/2017 day-by-day PM10 and PM2.5 levels, as well as climatic data, were extracted from Environmental Protection Agency (ARPA) local monitoring stations. OHCA were extracted from the prospective registry of Community-based automated external defibrillator Cardiac arrest “Progetto Vita”. OHCA data were included: audio recordings, event information and ECG tracings. Logistic regression analysis was used to estimate the association between the risk of OHC, expressed as odds ratios (OR), associated with the PM10 and PM2.5 levels. Results Mean PM10 levels were 33±29 μg/m3 and the safety threshold (50 μg/m3) recommended by both WHO and Italian legislation has been exceeded for 535 days (17.5%). Mean PM 5 levels were 33±29 μg/m3. During the follow-up period, 880 OHCA were recorded on 750 days; the remaining 2174 days without OHCA were used as control days. Mean age of OHCA patients was 76±15 years; male gender was prevalent (55% male vs 45% female; <0.001). Concentration of PM10 and PM 2.5 were significantly higher on days with the occurrence of OHCA (PM10 levels: 37.7±22 μg/m3 vs 32.7±19 μg/m3; p<0.001; PM 2.5 levels: 26±16 vs 22±15 p<0.001). Risk of OHCA was significantly increased with the progressive increase of PM10 (OR: 1.009, 95% CI 1.004–1.015; p<0.001) and PM2.5 levels (OR 1.012, 95% CI 1.007–1.017; p<0.001). Interestingly, the above mentioned results remain independent even when correct for external temperature or season (PM 2.5 levels: p=0.01 – PM 10 levels: p=0.002), Moreover, dividing PM10 values in quintiles, a 1.9 fold higher risk of cardiac arrest has been showed in the highest quintile (Highest quintile cut-off: <48μg/m3) Conclusions In large cohort of patients from a high pollution area, both PM10 and PM2.5 levels are associated with the risk of Out-of-hospital cardiac arrest. PM10 and PM2.5 levels and risk of OHCA Funding Acknowledgement Type of funding source: None

scholarly journals Quantifying the Health and Wealth Benefits of Reducing Point Source Pollution: The Case of the Sugar Industry in Pakistan

2021 ◽  
Vol 13 (23) ◽  
pp. 13252
Author(s):  
Sanaullah Panezai ◽  
Ubaid Ali ◽  
Alam Zeb ◽  
Muhammad Rafiq ◽  
Ayat Ullah ◽  
...  
Keyword(s):  
Air Pollution ◽  
Sugar Industry ◽  
Ambient Air ◽  
Respiratory Illness ◽  
Production Method ◽  
Ambient Air Pollution ◽  
World Health ◽  
Primary Data ◽  
Reduced Form ◽  
The Impact

Air pollution is among the major causes of death and disease all around the globe. The prime impact of ambient air pollution is on the lungs through the respiratory system. This study aims to estimate the health cost due to air pollution from a Sugar Mill in the Mardan district of Khyber Pakhtunkhwa, Pakistan. To determine the impact of pollution on respiratory illness, primary data were collected from 1141 individuals from 200 households living within a 3 km radius of the mill. The Household Production Method was used to drive the reduced-form Dose–Response Function and the Mitigation Cost Function for assessing the impact of pollution on health and then estimating the monetary cost associated with mitigating such illnesses. The results indicate that about 60% of the respondents living in the surrounding area of the mill suffered from different respiratory illnesses. The study estimates that by reducing the suspended particulate matter (SPM) level by 50%, the expected annual welfare gains to an individual living within a 3 km radius of the mill are US $20.21. The whole community residing within a 3 km radius of the mill will enjoy an estimated welfare gain of PKR. 70.67 million (US $0.511 million). If the pollution standard limits prescribed by the World Health Organization are followed, the expected monetary benefits to all the individuals living within a 3 km radius of the mill are PKR. 114.48 million (US $0.27 million) annually.

scholarly journals Biomarkers for Exposure to Ambient Air Pollution. Comparison of Carcinogen-DNA Adduct Levels with Other Exposure Markers and Markers for Oxidative Stress

1999 ◽  
Vol 107 (3) ◽  
pp. 233 ◽  
Author(s):  
Herman Autrup ◽  
Bahram Daneshvar ◽  
Lars Ove Dragsted ◽  
Mikael Gamborg ◽  
Ase Marie Hansen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Air Pollution ◽  
Ambient Air ◽  
Dna Adduct ◽  
Ambient Air Pollution

Ambient air pollution and health

2016 ◽  
Author(s):  
John Reid ◽  
Giovanni Leonardi ◽  
Alex G. Stewart
Keyword(s):  
Air Pollution ◽  
Geographical Information Systems ◽  
Ambient Air ◽  
Geographical Information ◽  
Ambient Air Pollution ◽  
Background Information ◽  
Traffic Density ◽  
Pollution Indices ◽  
Guideline Values ◽  
The Impact

This chapter describes the impact of air pollution, including particulate matter and nitrogen oxides, on human health, through a case scenario where an increase in respiratory disease has been associated with changes in traffic density and increases in pollution indices. Background information on pollutants and air quality measurements is given based on WHO criteria. The importance of multidisciplinary input to such investigations is emphasized, involving specialists in toxicology and environmental science, as well as health protection staff. The role of geographical information systems in mapping air pollution levels to identify localities where guideline values are exceeded is emphasized, together with health impact assessments to monitor public health outcomes. The complex local, social, and political aspects that may arise are considered, and so endure engagement and communication with different interest groups. The final part clearly outlines currently unanswered questions and how they should be studied and managed in the future.

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