scholarly journals Metabolic syndrome and the incidence of knee osteoarthritis: A meta-analysis of prospective cohort studies

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243576
Author(s):  
Daqing Nie ◽  
Guixin Yan ◽  
Wenyu Zhou ◽  
Zhengyi Wang ◽  
Guimei Yu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
General Population ◽  
Knee Osteoarthritis ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Independent Risk Factor ◽  
Meta Analysis ◽  
Prospective Cohort Studies ◽  
Increased Risk

Background Cross-sectional studies suggest an association between metabolic syndrome (MetS) and knee osteoarthritis (KOA). We performed a meta-analysis to evaluate whether MetS is an independent risk factor for KOA. Methods Prospective cohort studies evaluating the association between MetS and KOA in general population were retrieved from PubMed and Embase. Only studies with multivariate analyses were included. Data were pooled with a random-effect model, which is considered to incorporate heterogeneity among the included studies. Results Five studies including 94,965 participants were included, with 18,990 people with MetS (20.0%). With a mean follow-up duration of 14.5 years, 2,447 KOA cases occurred. Pooled results showed that MetS was not significant associated with an increased risk of KOA after controlling of factors including body mass index (adjusted risk ratio [RR]: 1.06, 95% CI: 0.92~1.23, p = 0.40; I2 = 33%). Subgroup analysis showed that MetS was independently associated with an increased risk of severe KOA that needed total knee arthroplasty (RR = 1.16, 95% CI: 1.03~1.30, p = 0.02), but not total symptomatic KOA (RR = 0.84, 95% CI: 0.65~1.08, p = 0.18). Stratified analyses suggested that MetS was independently associated with an increased risk of KOA in women (RR = 1.23, 95% CI: 1.03~1.47, p = 0.02), but not in men (RR = 0.90, 95% CI: 0.70~1.14, p = 0.37). Conclusions Current evidence from prospective cohort studies did not support MetS was an independent risk factor of overall KOA in general population. However, MetS may be associated with an increased risk of severe KOA in general population, or overall KOA risk in women.

Metabolic syndrome and the risk of bone fractures: A Meta-analysis of prospective cohort studies

Bone ◽  
2016 ◽  
Vol 84 ◽  
pp. 52-56 ◽  
Author(s):  
Libo Yang ◽  
Xiaohong Lv ◽  
Dailin Wei ◽  
Feng Yue ◽  
Jinying Guo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Bone Fractures ◽  
Meta Analysis ◽  
Prospective Cohort Studies

scholarly journals Egg Consumption and Risk of Upper Aero-Digestive Tract Cancers: A Systematic Review and Meta-Analysis of Observational Studies

2019 ◽  
Vol 10 (4) ◽  
pp. 660-672 ◽  
Author(s):  
Azadeh Aminianfar ◽  
Roohallah Fallah-Moshkani ◽  
Asma Salari-Moghaddam ◽  
Parvane Saneei ◽  
Bagher Larijani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Esophageal Cancer ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Observational Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Egg Consumption ◽  
Prospective Cohort Studies ◽  
Increased Risk

ABSTRACT Limited data are available that summarize the relation between egg intake and the risk of upper aero-digestive tract (UADT) cancers. This systematic review and meta-analysis was conducted to investigate the association between egg intake and the risk of UADT cancers. Medline/PubMed, ISI web of knowledge, EMBASE, Scopus, and Google Scholar were searched using relevant keywords. Observational studies conducted on humans investigating the association between egg consumption and the risk of UADT cancers were included. Overall, 38 studies with a total of 164,241 subjects (27, 025 cases) were included. Based on 40 effect sizes from 32 case-control studies, we found a 42% increased risk of UADT cancers among those with the highest egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) compared to those with the lowest intake (ranging from 0–20 g/d to never consumed among studies) (overall OR: 1.42; 95% CI: 1.19, 1.68; P < 0.001). However, this association was only evident in hospital-based case-control (HCC) studies (OR = 1.50; 95% CI: 1.34, 1.68; P < 0.001 for ‘oropharyngeal and laryngeal cancer’ and OR: 1.27; 95% CI: 1.08, 1.50; P = 0.004 for esophageal cancer) and not in population-based case-control (PCC) studies (OR = 1.25; 95% CI: 0.59, 2.67; P = 0.56 for ‘oropharyngeal and laryngeal cancer’ and OR: 1.29; 95% CI: 0.92, 1.81; P = 0.13 for esophageal cancer). In addition, the association was not significant in prospective cohort studies (overall OR: 0.86; 95% CI: 0.71, 1.04; P = 0.11). Considering individual cancers, a positive association was observed between the highest egg consumption, compared with the lowest, and risk of oropharyngeal (OR: 1.88; 95% CI: 1.61, 2.20; P < 0.001), laryngeal (OR: 1.83; 95% CI: 1.45, 2.32; P < 0.001), oral & pharyngeal & laryngeal (OR: 1.37; 95% CI: 1.12, 1.67; P < 0.001), and esophageal cancers (OR: 1.28; 95% CI: 1.10,1.48; P = 0.001). We also found an inverse association between egg intake and the risk of oral cancer (OR: 0.78; 95% CI: 0.62, 0.99; P = 0.04). In conclusion, high egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) was associated with increased risk of UADT cancers only in HCC studies but not in PCC or prospective cohort studies. PROSPERO registration number: CRD42018102619.

scholarly journals Smoking as a Risk Factor for Prostate Cancer: A Meta-Analysis of 24 Prospective Cohort Studies

2010 ◽  
Vol 100 (4) ◽  
pp. 693-701 ◽  
Author(s):  
Michael Huncharek ◽  
K. Sue Haddock ◽  
Rodney Reid ◽  
Bruce Kupelnick
Keyword(s):  
Prostate Cancer ◽  
Risk Factor ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Prospective Cohort Studies

scholarly journals Caffeine, Coffee, Tea and Risk of Rheumatoid Arthritis: Systematic Review and Dose- Response Meta-analysis of Prospective Cohort Studies

2021 ◽  
Author(s):  
Farzaneh Asoudeh ◽  
Fatemeh Dashti ◽  
Ahmad Jayedi ◽  
Amirhossein Hemmati ◽  
Abdulmannan Fadel ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Dose Response ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Caffeine Intake ◽  
Prospective Cohort Studies ◽  
Increased Risk ◽  
Different Types ◽  
Decaffeinated Coffee ◽  
Caffeinated Coffee

Abstract Objective: Prospective cohort studies on coffee, tea and caffeine in relation to the risk of rheumatoid arthritis (RA) have shown conflicting results. The aim of this study was to conduct a dose–response meta-analysis of cohort studies on the association between dietary caffeine, different types of coffee and tea consumption and the risk of RA.Methods: PubMed/Medline, Scopus and EMBASE were searched up to July 2021 to identify relevant studies that had considered different types of coffee (caffeinated or decaffeinated), tea or caffeine exposure with RA as the main, or one of the, outcome(s). Two authors independently screened 742 publications. Finally, 5 prospective cohort studies were included in our meta-analysis. Pooled relative risks (RRs) were calculated by using a fixed-effects model. We also performed linear and non-linear dose-response analyses to examine the dose-response relations. Results: Comparing extreme categories, we found a positive, significant association between coffee (RR: 1.30; 95% CI: 1.04-1.62; I2 = 0%, n = 5) and decaffeinated coffee (RR: 1.89; 95% CI: 1.35-2.65; I2 =38.1%, n =3) consumption and risk of RA. One additional cup of coffee consumed per day was associated with an increased risk of RA by 6% (95% CI: 1.02-1.10; I2 = 0%;). This increase in the risk of RA for one cup/d of decaffeinated coffee was 11% 95% CI: 1.05-1.18; I2 = 38). No significant association was observed between caffeinated coffee, tea or caffeine intake and the risk of RA.Conclusion: We found that a higher intake of coffee and decaffeinated coffee was associated with increased risk of RA. No significant association between caffeinated coffee, tea or caffeine intake and the risk of RA was observed.

scholarly journals Associations of Whole Grain and Refined Grain Consumption With Metabolic Syndrome. A Meta-Analysis of Observational Studies

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongbin Guo ◽  
Jun Ding ◽  
Jieyu Liang ◽  
Yi Zhang
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Observational Studies ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Whole Grain ◽  
Cross Sectional ◽  
Prospective Cohort Studies ◽  
Embase Database

Background: The associations of whole grain and refined grain consumption with metabolic syndrome (MetS) has been evaluated in several epidemiological studies with conflicting results. This meta-analysis was therefore employed to further investigate the above associations.Method: We searched the PubMed, Web of Science and Embase database until March 2021 (without restriction for inclusion time), for observational studies on the associations of whole grain and refined grain consumption with MetS. The pooled relative risk (RR) of MetS for the highest vs. lowest category of whole grain and refined grain consumption, as well as their corresponding 95% confidence interval (CI) were calculated.Results: A total of 14 observational studies, which involved seven cross-sectional and seven prospective cohort studies, were identified. Specifically, nine studies were related to whole grain consumption, and the overall multi-variable adjusted RR demonstrated that the whole grain consumption was inversely associated with MetS (RR = 0.80, 95%CI: 0.67–0.97; P = 0.021). With regard to refined grain consumption, 13 studies were included. The overall multi-variable adjusted RR indicated that refined grain consumption was positively associated with MetS (RR = 1.37, 95%CI: 1.02–1.84; P = 0.036).Conclusions: The existing evidence suggests that whole grain consumption is negatively associated with MetS, whereas refined grain consumption is positively associated with MetS. Our result might be helpful to better consider the diet effect on MetS. However, more well-designed prospective cohort studies are needed to elaborate the concerned issues further.

Maternal Smoking During Pregnancy and ADHD: Results From a Systematic Review and Meta-Analysis of Prospective Cohort Studies

2017 ◽  
Vol 24 (12) ◽  
pp. 1637-1647 ◽  
Author(s):  
Yan He ◽  
Jian Chen ◽  
Li-Hua Zhu ◽  
Ling-Ling Hua ◽  
Fang-Fang Ke
Keyword(s):  
Cohort Studies ◽  
Prospective Cohort ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Smoking During Pregnancy ◽  
Prospective Cohort Studies ◽  
Relative Risks ◽  
Increased Risk ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy

Objective: Findings on maternal smoking during pregnancy and ADHD risk in children are inconsistent. A meta-analysis was performed to summarize effects of exposure to maternal smoking during pregnancy on ADHD risk in children. Method: We conducted a systematic literature search to select articles up to June 2016. Only prospective cohort studies were included. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Results: Pooled RR estimates based on 12 cohort studies including 17,304 pregnant women suggested that maternal smoking during pregnancy was associated with an increased risk of ADHD (pooled RR = 1.58, 95% CI = [1.33, 1.88]). Conclusion: Results from this study indicate that maternal smoking during pregnancy is related to an increased risk of ADHD in children. There is an urgent need to increase maternal awareness of smoking risk and quitting smoking to mitigate the ADHD risk in children.

Sign in / Sign up

Export Citation Format

Share Document