Blood Pressure Variability at Normal and High Blood Pressure

CHEST Journal ◽  
1983 ◽  
Vol 83 (2) ◽  
pp. 317-320 ◽  
Author(s):  
Giuseppe Mancia
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Blood Pressure Variability

High blood pressure variability predicts 30-day mortality but not 1-year mortality in hospitalized elderly patients

2017 ◽  
Vol 26 (5) ◽  
pp. 259-263 ◽  
Author(s):  
Avraham Weiss ◽  
Yaron Rudman ◽  
Yichayaou Beloosesky ◽  
Amit Akirov ◽  
Tzippy Shochat ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Elderly Patients ◽  
High Blood Pressure ◽  
Blood Pressure Variability ◽  
Hospitalized Elderly ◽  
Hospitalized Elderly Patients

scholarly journals School-based surveillance on visit-to-visit blood pressure variability and high blood pressure in children and adolescents

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiaxiang Wang ◽  
Hui Shen ◽  
Jieyu Liu ◽  
Chengqi Xiao ◽  
Cailong Chen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
High Blood Pressure ◽  
Blood Pressure Variability ◽  
Pediatric Population ◽  
Health Promotion Program ◽  
Logistic Regression Models ◽  
School Based ◽  
Z Scores ◽  
Average Real Variability

Abstract Background The predictive importance of visit-to-visit blood pressure variability (VVV) for high blood pressure (HBP) in a pediatric population has been largely unsettled. We aimed to evaluate it based on Health Promotion Program for Children and Adolescents (HPPCA), a school-based surveillance conducted from 2012 to 2018 in Suzhou, China. Methods A total of 330,618 participants had BP measurement in 2018 and ≥ 3 BP records during 2012–2017, were recruited from HPPCA. Absolute BP values (in mmHg) were converted into age-, sex- and height- normalized z-scores. VVV was expressed as standard deviation (SD), coefficient of variation (CV) or average real variability (ARV) of BP z-scores during 2012–2017. Logistic regression models were used to assess the associations between VVV and HBP in 2018. Results In 2018, 42,554 (12.87%) subjects were defined as HBP. VVV, except for SBP-CV and DBP-CV, was significantly higher in the HBP group than normotensives group. After adjusting for covariates including mean BP values from 2012 to 2017, SBP-SD, SBP-ARV, DBP-SD and DBP-ARV, increased the risk of HBP by 5.70 [95% confidence interval (95% CI) 5.54–5.87], 4.10 (95% CI 4.01–4.20), 4.70 (95% CI 4.50–4.90) and 3.39 (95% CI 3.28–3.50) times, respectively. Notably, SBP-SD significantly improved risk discrimination of HBP based on other risk variables (c-statistics, net reclassification index and integrated discrimination improvement significantly increased). Conclusions Higher SD or ARV of BP, was independently related with higher probability of HBP in Chinese pediatric population. SBP-SD could be potentially helpful for detecting HBP. Future researches investigating the predictive value of VVV are warrant.

scholarly journals Exercise Training Improves High Blood Pressure Variability-induced Cardiac Damage In Normotensive Rats

2020 ◽  
Vol 52 (7S) ◽  
pp. 561-561
Author(s):  
Ivana C. Moraes-Silva ◽  
Katia De Angelis ◽  
Nilsa R. Damaceno-Rodrigues ◽  
Elia G. Caldini ◽  
Maria Claudia Irigoyen
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
High Blood Pressure ◽  
Blood Pressure Variability ◽  
Cardiac Damage

Mechanisms of blood pressure variability-induced cardiac hypertrophy and dysfunction in mice with impaired baroreflex

2005 ◽  
Vol 288 (3) ◽  
pp. R767-R776 ◽  
Author(s):  
Peter Martinka ◽  
Jens Fielitz ◽  
Andreas Patzak ◽  
Vera Regitz-Zagrosek ◽  
Pontus B. Persson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Hypertrophy ◽  
Protein Content ◽  
High Blood Pressure ◽  
Blood Pressure Variability ◽  
Transforming Growth Factor ◽  
Renin Angiotensin System ◽  
Left Ventricular ◽  
Mitogen Activated Protein Kinase ◽  
Cross Sectional

Enhanced blood pressure variability contributes to left ventricular hypertrophy and end-organ damage, even in the absence of hypertension. We hypothesized that the greater number of high-blood pressure episodes associated with enhanced blood pressure variability causes cardiac hypertrophy and dysfunction by activation of mechanosensitive and autocrine pathways. Normotensive mice were subjected to sinoaortic baroreceptor denervation (SAD) or sham surgery. Twelve weeks later, blood pressure variability was doubled in SAD compared with sham-operated mice. Blood pressure did not differ. Cardiac hypertrophy was reflected in greater heart/body weight ratios, larger myocyte cross-sectional areas, and greater left ventricular collagen deposition. Furthermore, left ventricular atrial and brain natriuretic peptide mRNA expression was greater in SAD than in sham-operated mice. SAD had higher left ventricular end-diastolic pressures and lower myocardial contractility indexes, indicating cardiac dysfunction. Cardiac protein content of phosphorylated p125 focal adhesion kinase (p125 FAK) and phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) was greater in SAD than in sham-operated mice, indicating activation of mechanosensitive pathways of cardiac hypertrophy. Furthermore, enhanced cardiac renin and transforming growth factor-β1 (TGFbeta1) protein content indicates activation of autocrine pathways of cardiac hypertrophy. Adrenal tyrosine hydroxylase protein content and the number of renin-positive glomeruli were not different, suggesting that sympathetic activation and the systemic renin-angiotensin system did not contribute to cardiac hypertrophy. In conclusion, more frequent blood pressure rises in subjects with high blood pressure variability activate mechanosensitive and autocrine pathways leading to cardiac hypertrophy and dysfunction even in the absence of hypertension.

Impact of high blood pressure variability on the occurrence of acute type B aortic dissection

Vascular ◽  
2020 ◽  
Vol 28 (4) ◽  
pp. 413-420
Author(s):  
Chao Song ◽  
Guanyu Yu ◽  
Xiang Feng ◽  
Rui Feng ◽  
Junmin Bao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Aortic Dissection ◽  
High Blood Pressure ◽  
Blood Pressure Variability ◽  
False Lumen ◽  
Acute Type ◽  
Type B ◽  
Type B Aortic Dissection ◽  
Low Blood Pressure ◽  
Visceral Arteries

Background Acute type B aortic dissection is a life-threatening medical emergency, and hypertension is believed to be an important predictor of aortic dissection; the impact of blood pressure variability on the onset and development of aortic dissection has attracted increasing attention. Methods A total of 120 acute type B aortic dissection patients and 57 hypertensive patients without aortic dissection were consecutively enrolled and retrospectively reviewed between January 2013 and November 2015. There were 60 acute type B aortic dissection patients in both high and low blood pressure variability groups. Results Blood pressure variability showed higher diagnostic value than hypertension in aortic dissection, and the best threshold of blood pressure variability is 5.71 mmHg. By performing multivariable logistic regression, we found that the history of hypertension was likely to be a risk factor of blood pressure variability (95% CI: 1.155–6.422, P = 0.022). Nine patients from high blood pressure variability group and two from low blood pressure variability group ( χ2 = 4.90, P = 0.027) received emergency surgery within 24 hours after admission. The presence of multiple tears (>2, 55.0% vs. 45.0%, P = 0.001), configuration of the false lumen (spiral false lumen) (50.0% vs. 21.7%, P = 0.001), the diameter of the false lumen (49.6 ± 15.0 mm vs. 37.6 ± 10.8 mm, P < 0.001), the false/true lumen ratio (1.53 ± 1.02 vs. 0.929 ± 0.733, P < 0.001), and the number of visceral arteries involved (1.75 ± 0.942 vs. 0.800 ± 0.927, P < 0.001) showed significant differences between high and low blood pressure variability groups. Nine (30%) patients from the high blood pressure variability group showed a maximum diameter of false lumen over 60 mm, while none was found in the low blood pressure variability group. Conclusions High blood pressure variability, the presence of multiple tears (>2), the configuration of false lumen, the diameter of the false lumen, false/true lumen ratio, and the number of visceral arteries involved were independent risk factors for acute type B aortic dissection.

Hypertension and the Kidney

2019 ◽  
pp. 287-294
Author(s):  
Rupinder K. Sodhi ◽  
Marie D. Philipneri ◽  
Paul G. Schmitz
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Blood Pressure Control ◽  
Blood Pressure Variability ◽  
Renal Fibrosis ◽  
Systolic Hypertension ◽  
Pressure Control ◽  
White Coat Hypertension ◽  
Masked Hypertension

The prevalence of hypertension or high blood pressure (defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) worldwide exceeds 30%, with a steep increase in patients >50 years of age. For example, nearly 75% of patients >80 years of age exhibit high blood pressure. Despite considerable evidence demonstrating the benefits of antihypertensive therapy, <50% are controlled. This chapter will discuss the prevalence and detection of high blood pressure, with a special emphasis on the role of hypertension in progressive renal fibrosis. The authors cover classification and epidemiology of blood pressure control; the pitfalls of blood pressure control, including white coat hypertension, pseudohypertension, nocturnal blood pressure, masked hypertension, isolated systolic hypertension, and blood pressure variability; hypertensive kidney disease; and clinical studies assessing the renal effects of hypertension, concluding with a discussion of control of blood pressure and CKD progression and future directions in research and therapy.

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